KEGG ORTHOLOGY: K03984

ORTHOLOGY: K03984

Entry

K03984                      KO

Symbol

SERPINA1, AAT

Name

alpha-1-antitrypsin

Pathway

map04610

Complement and coagulation cascades

Disease

H01103

Alpha-1-antitrypsin deficiency

H01714

Chronic obstructive pulmonary disease (COPD)

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03984  SERPINA1, AAT; alpha-1-antitrypsin
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03984  SERPINA1, AAT; alpha-1-antitrypsin
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03984  SERPINA1, AAT; alpha-1-antitrypsin
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I4: serpin family
   K03984  SERPINA1, AAT; alpha-1-antitrypsin
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K03984  SERPINA1, AAT; alpha-1-antitrypsin

Other DBs

GO:

0004867

Genes

HSA:	5265(SERPINA1)

PTR:	467541(SERPINA1)

PPS:	100990043(SERPINA1)

GGO:

101147918

PON:	100171544(SERPINA1)

PPYG:

129012123

NLE:	100585221(SERPINA1)

HMH:	116456304(SERPINA1)

SSYN:

129487489(SERPINA1)

MCC:	701361(SERPINA1)

MCF:	102134991(SERPINA1)

MTHB:

126959657

MNI:

105467499

CSAB:

103229609(SERPINA1)

CATY:

105596621

PANU:

101002028(SERPINA1)

TGE:	112629038(SERPINA1)

MLEU:

105547923(SERPINA1)

RRO:	104679071(SERPINA1)

RBB:

108519103

TFN:	117071481(SERPINA1)

PTEH:

111538258(SERPINA1)

CANG:

105518510(SERPINA1)

CJC:	100388369(SERPINA1)

SBQ:	101036735(SERPINA1)

CIMI:

108316878

ANAN:

105721288(SERPINA1)

CSYR:

103250402(SERPINA1)

MMUR:

105856770(SERPINA1)

LCAT:

123644996

ERUF:

138396256

PCOQ:

105819056

OGA:	100959522(SERPINA1)

MMU:	20700(Serpina1a) 20701(Serpina1b) 20702(Serpina1c) 20703(Serpina1d) 20704(Serpina1e)

MCAL:

110306582 110307406

MPAH:

110324428 110324489

RNO:	24648(Serpina1)

MCOC:

116079772

ANU:	117697253(Serpina1)

ASYL:

127687858(Serpina1)

MUN:	110542650 132655346

CGE:	100761387(Serpina1)

MAUA:

101841330(Serpina1)

PROB:

127231103(Serpina1)

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

100135614(Serpina3k) 100379265(Sh2b2) 100379266(Apf)

CCAN:

109700260(Serpina1)

DORD:

105983387 105986366 105986455 105986464

DSP:	122118698(Serpina1) 122118749 122118787 122118789

DMER:

138810480 138810481 138810483 138833102 138833103 138833104

PLOP:

125363364(Serpina1)

NCAR:

124978126

MMMA:

107134779 107135032 107135269 107144696 107144711 107150222

ITI:	101959979 101976685

OCU:

100008986

OPI:

101530529

TUP:	102495980(SERPINA1)

GVR:

103608542

CFA:	111097149 480422(SERPINA1)

CLUD:

112657260 112657481

VVP:	112907345(SERPINA1) 112907352

VLG:	121492491 121493589

NPO:	129496262 129496331

AML:

100478918

UMR:

103669781

UAH:	113267162 113267312

UAR:	123803945(SERPINA1)

ELK:

111148485

LLV:

125105461

MPUF:

101675098

MNP:	132000227(SERPINA1)

MLK:	131836945(SERPINA1)

NVS:

122892982

ORO:

101365253

EJU:	114205398(SERPINA1)

ZCA:

113909083

MLX:

118014694

MANO:

123841249(SERPINA1)

NSU:

123325704

LWW:	102731511(SERPINA1)

FCA:

101080897

PYU:	121032239(SERPINA1)

PCOO:

112855029(SERPINA1)

PBG:

122469486

PVIV:

125168857(SERPINA1)

LRUF:

124512345

LGF:	123584254(SERPINA1)

AJU:	106977456 113601517

PTG:	102965075(SERPINA1)

PPAD:

109274505

PUC:

125909212

PLEZ:

122221419(SERPINA1)

HHV:	120246904 120246917

CCRU:

144245544

BTA:	280699(SERPINA1)

BOM:	102280489(SERPINA1)

BIU:	109575576(SERPINA1)

BBUB:

102389600(SERPINA1)

BKE:	129634384(SERPINA1)

BBIS:

104985845(SERPINA1)

CHX:

102185401

OAS:	443388(SERPINA1)

BTAX:

128066843(SERPINA1)

CSUM:

138094852

ODA:	120875422(SERPINA1)

CCAD:

122454854(SERPINA1)

MREE:

136147283(SERPINA1)

OVR:	110140629(SERPINA1)

MBEZ:

129550617(SERPINA1)

SSC:	397688(SERPINA1)

CFR:	102506231(SERPINA1)

CBAI:

105079895(SERPINA1)

CDK:	105095641(SERPINA1)

VPC:	102526448(SERPINA1)

BACU:

103000652(SERPINA1)

BMUS:

118890630(SERPINA1)

LVE:	103082359(SERPINA1)

OOR:	101273903(SERPINA1)

LALB:

132529324(SERPINA1)

GMF:	115867280(SERPINA1)

DDP:

132420021

DLE:

111176123

PCAD:

102986488

PSIU:

116748940(SERPINA1)

PPHC:

136119397(SERPINA1)

NASI:

112408733(SERPINA1)

ECB:	100065068 100065158(SPI2)

EPZ:	103545168 139079229

MYB:	102238599 102238925

MYD:	102766940(SERPINA1) 102767222

MMYO:

118659578(SERPINA1) 118659588

MLF:	102440783 102441084

MDT:	132229170(SERPINA1) 132229178

MYUM:

138999693 139008818(SERPINA1)

PKL:	118712244(SERPINA1) 118712245 118712254

EFUS:

103302516 103302517

MNA:	107536660 107536661

DRO:	112311466(SERPINA1) 112311528

SHON:

118976667(SERPINA1) 118976698

AJM:	119037857(SERPINA1)

PDIC:

114492788(SERPINA1)

PHAS:

123808248(SERPINA1)

MMF:	118623640 118641255(SERPINA1)

PPAM:

129065701 129065800(SERPINA1)

HAI:	109382721(SERPINA1)

RFQ:	117023787(SERPINA1)

PALE:

102893714(SERPINA1)

PGIG:

120619650(SERPINA1)

PVP:	105305154(SERPINA1)

RAY:	107511269(SERPINA1)

MJV:	108397489 108398548

TOD:

119238353

SARA:

101543720(SERPINA1)

SFUM:

130041119(SERPINA1)

SETR:

126003579 126004279

LAV:	100664453(SERPINA1)

TMU:

101344953

ETF:	101661256(SERPINA1)

DNM:	101423372 101423918 101425400

GAS:	123235663 123237580

SHR:

100920247

AFZ:

127549947

PCW:

110220791

TVP:	118841726(SERPINA1)

PBRV:

MLAO:

TACU:

PRAF:

ZVI:

ARUT:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

140723117 140724715 140724718

FCD:

110858298

PMEO:

129588802 129588804 129599761

BGT:

106065778

SMM:	Smp_003300

» show all

Reference

PMID:25105300

Authors

Shapira MG, Khalfin B, Lewis EC, Parola AH, Nathan I

Title

Regulation of autophagy by alpha1-antitrypsin: "a foe of a foe is a friend".

Journal

Mol Med 20:417-26 (2014)
DOI:10.2119/molmed.2014.00054

Reference

PMID:2985281

Authors

Ciliberto G, Dente L, Cortese R

Title

Cell-specific expression of a transfected human alpha 1-antitrypsin gene.

Journal

Cell 41:531-40 (1985)
DOI:10.1016/S0092-8674(85)80026-X

Sequence

[hsa:5265]

LinkDB

DBGET integrated database retrieval system