KEGG ORTHOLOGY: K06272

ORTHOLOGY: K06272

Entry

K06272                      KO

Symbol

ILK

Name

integrin-linked kinase [EC:2.7.11.1]

Pathway

map03320

PPAR signaling pathway

map04360

Axon guidance

map04510

Focal adhesion

map05100

Bacterial invasion of epithelial cells

map05131

Shigellosis

map05213

Endometrial cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06272  ILK; integrin-linked kinase
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K06272  ILK; integrin-linked kinase
  09158 Development and regeneration
   04360 Axon guidance
    K06272  ILK; integrin-linked kinase
09160 Human Diseases
  09162 Cancer: specific types
   05213 Endometrial cancer
    K06272  ILK; integrin-linked kinase
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K06272  ILK; integrin-linked kinase
   05100 Bacterial invasion of epithelial cells
    K06272  ILK; integrin-linked kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06272  ILK; integrin-linked kinase
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06272  ILK; integrin-linked kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06272  ILK; integrin-linked kinase
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  MLK family
   K06272  ILK; integrin-linked kinase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    K06272  ILK; integrin-linked kinase

Genes

HSA:

3611(ILK)

PTR:	748941(ILK)

PPS:	100968361(ILK)

GGO:	101148955(ILK)

PON:	100173674(ILK)

PPYG:

129007877(ILK)

NLE:	100598379(ILK)

HMH:	116476577(ILK)

SSYN:

129484480(ILK)

MCC:	709944(ILK)

MCF:	102126017(ILK)

MTHB:

126935076

MNI:	105488694(ILK)

CSAB:

103241301(ILK)

CATY:

105575040(ILK)

PANU:

103877691(ILK)

TGE:	112606152(ILK)

MLEU:

105533899(ILK)

RRO:	104678304(ILK)

RBB:	108543237(ILK)

TFN:	117081027(ILK)

PTEH:

111524650(ILK)

CANG:

105520547(ILK)

CJC:	100406751(ILK)

SBQ:	101029493(ILK)

CIMI:

108288320(ILK)

ANAN:

105720313(ILK)

CSYR:

103257950(ILK)

MMUR:

105883444(ILK)

LCAT:

123642363(ILK)

PCOQ:

105818382(ILK)

OGA:	100958529(ILK)

MMU:	16202(Ilk)

MCAL:

110299376(Ilk)

MPAH:

110335784(Ilk)

RNO:	170922(Ilk)

MCOC:

116102736(Ilk)

ANU:	117707752(Ilk)

ASYL:

127663713(Ilk)

MUN:	110559582(Ilk)

CGE:	100689388(Ilk)

MAUA:

101844354(Ilk)

PROB:

127228103(Ilk)

PLEU:

114683843(Ilk)

MORG:

121457500(Ilk)

MFOT:

126494103

AAMP:

119824629(Ilk)

NGI:	103737567(Ilk)

HGL:	101706216(Ilk)

CPOC:

100135559(Ilk)

CCAN:

109696308(Ilk)

DORD:

106000378(Ilk)

DSP:	122117655(Ilk)

PLOP:

125361364(Ilk)

NCAR:

124958328

MMMA:

107135604(Ilk)

ITI:	101964925(Ilk)

OCU:

100355759

OPI:	101516762(ILK)

TUP:	102473651(ILK)

GVR:	103597703(ILK)

CFA:	476836(ILK)

CLUD:

112667559(ILK)

VVP:	112910864(ILK)

VLG:	121475977(ILK)

NPO:	129504791(ILK)

AML:	100473650(ILK)

UMR:	103681403(ILK)

UAH:	113245818(ILK)

UAR:	123782737(ILK)

ELK:	111159342 111159383

LLV:

125078222

MPUF:

101674249(ILK)

MNP:	132023484(ILK)

MLK:	131808688(ILK)

NVS:	122912679(ILK)

ORO:	101363175(ILK) 101375473

EJU:	114219330(ILK)

ZCA:	113915229(ILK) 113927937

MLX:	118000764 118004254(ILK)

NSU:	110576525(ILK)

LWW:	102744007(ILK)

FCA:	101092790(ILK)

PYU:	121021126(ILK)

PCOO:

112865342(ILK)

PBG:	122483502(ILK)

PVIV:

125176251(ILK)

LRUF:

124505228 124527605 124527608 124527611

LGF:	123601302(ILK)

AJU:

106981151

PTG:	102967313(ILK)

PPAD:

109261635 109271076(ILK)

PUC:

125936751

PLEZ:

122199234(ILK)

HHV:	120221442(ILK)

BTA:	540207(ILK)

BOM:	102280066(ILK)

BIU:	109569757(ILK)

BBUB:

102403164(ILK)

BBIS:

104987993(ILK)

CHX:	102177259(ILK)

OAS:	100913157(ILK)

BTAX:

128061035(ILK)

CSUM:

138092361(ILK)

ODA:	120876543(ILK)

CCAD:

122449497(ILK)

MREE:

136174522(ILK)

OVR:	110127318(ILK)

MBEZ:

129554581(ILK)

SSC:	100623256(ILK)

CFR:	102511818(ILK)

CBAI:

105076687(ILK)

CDK:	105097907(ILK)

VPC:	102537970(ILK)

BACU:

103018082(ILK)

BMUS:

118899479(ILK)

LVE:	103083507(ILK)

OOR:	101289017(ILK)

LALB:

132526053(ILK)

DLE:	111169176(ILK)

PCAD:

102995328(ILK)

PSIU:

116758733(ILK)

NASI:

112407651(ILK)

ECB:	100070066(ILK)

EPZ:	103553532(ILK)

EAI:	106838181(ILK)

MYB:	102248130(ILK)

MYD:	102764668(ILK)

MMYO:

118664767(ILK)

MLF:	102419059(ILK)

MDT:	132240917(ILK)

MYUM:

139017252(ILK)

PKL:	118712967(ILK)

EFUS:

103302788(ILK)

MNA:	107540507(ILK)

DRO:	112312782(ILK)

SHON:

118990814(ILK)

AJM:	119041221(ILK)

PDIC:

114500412(ILK)

PHAS:

123819215(ILK)

MMF:	118616774(ILK)

PPAM:

129076407(ILK)

HAI:	109376531(ILK)

RFQ:	117030581(ILK)

PALE:

102887513(ILK)

PGIG:

120590232(ILK)

PVP:	105309085(ILK)

RAY:	107504363(ILK)

MJV:	108384232(ILK)

TOD:	119255543(ILK)

SARA:

101542545(ILK)

SFUM:

130025086(ILK)

SETR:

126018161(ILK)

LAV:	100666830(ILK)

TMU:

101346618

ETF:	101652908(ILK)

DNM:	101430574(ILK)

MDO:	100023322(ILK)

GAS:	123240475(ILK)

SHR:	100915068(ILK)

AFZ:

127555379

PCW:	110200481(ILK)

TVP:	118840388(ILK)

PBRV:

138176926(ILK)

OAA:	114807332(ILK)

TACU:

119921044(ILK)

GGA:	374018(ILK)

PCOC:

116239525(ILK)

MGP:	100548319(ILK)

CJO:	107308571(ILK)

TPAI:

128088605(ILK)

LMUT:

125695698(ILK)

NMEL:

110391748(ILK)

APLA:

101790559(ILK)

ACYG:

106049775(ILK)

CATA:

118259800(ILK)

AFUL:

116501897(ILK)

TGU:	100228455(ILK)

LSR:	110474957(ILK)

SCAN:

103824410(ILK)

PMOA:

120499971(ILK)

OTC:	121334219(ILK)

PRUF:

121355145(ILK)

ATRC:

139591436(ILK)

GFR:	102034600(ILK)

FAB:	101806205(ILK)

OMA:	130248281(ILK)

PHI:	102104711(ILK)

PMAJ:

107198962(ILK)

CCAE:

111943737(ILK)

CCW:	104698082(ILK)

CBRC:

103624045(ILK)

ACOE:

138108405(ILK)

ETL:	114069902(ILK)

ZAB:	102063161 106630186

ZLE:	135444015(ILK)

SVG:	106861767(ILK)

MMEA:

130582733(ILK)

HRT:	120748453(ILK)

SATI:

136358248(ILK)

CCIC:

134041451(ILK)

FPG:	101919060(ILK)

FCH:	102050186(ILK)

CCRI:

104157490(ILK)

SHAB:

115602354(ILK)

TALA:

116962859(ILK)

ACHC:

115353222(ILK)

HALD:

104313323(ILK)

HLE:	104837527(ILK)

AGEN:

126048323

HHAR:

128153192(ILK)

GCL:

127019848

DPUB:

104302339(ILK)

PPUS:

135175799(ILK)

EGZ:	104130615(ILK)

NNI:	104014876(ILK)

PCAO:

104052487(ILK)

PADL:

103924867(ILK)

AFOR:

103901135(ILK)

GSTE:

104256784(ILK)

CBOY:

140646720(ILK)

CLV:	102094280(ILK)

PLET:

104625549(ILK)

CUCA:

104065403(ILK)

TEO:	104375742(ILK)

BREG:

104635708(ILK)

OHA:	104328434(ILK)

CPEA:

104385373(ILK)

CVF:	104284863(ILK)

RTD:	128909839(ILK)

CRID:

134512956(ILK)

AAM:	106497742 106497745(ILK)

AROW:

112964941(ILK)

NPD:	112955056(ILK)

TGT:	104580293(ILK)

DNE:	112993499(ILK)

SCAM:

104148979(ILK)

ASN:	102378418(ILK)

AMJ:	102559647(ILK)

CPOO:

109305564(ILK)

GGN:	109303308(ILK)

PSS:	102443361(ILK)

CMY:	102931035(ILK)

CCAY:

125638817(ILK)

DCC:	119841389(ILK)

CPIC:

101952498(ILK)

CABI:

116818167(ILK)

MRV:	120399168(ILK)

ACS:	100556484(ilk)

ASAO:

132772354(ILK)

PVT:	110078157(ILK)

SUND:

121926893(ILK)

PBI:	103059609(ILK)

PMUR:

107288657(ILK)

CTIG:

120310060(ILK)

TSR:	106541883(ILK)

PGUT:

117670870(ILK)

APRI:

131199221(ILK)

PTEX:

113450420(ILK)

NSS:	113426068(ILK)

VKO:	123022453(ILK)

PMUA:

114595166(ILK)

PRAF:

128412417(ILK)

ZVI:	118084895(ILK)

HCG:	128350067(ILK)

GJA:	107116953(ILK)

STOW:

125431774(ILK)

EMC:	129325550(ILK)

XLA:	444414 446640(ilk.S)

XTR:	100145644(ilk)

NPR:	108799886(ILK)

RTEM:

120928861(ILK)

BBUF:

120996657(ILK)

BGAR:

122932397(ILK)

PWL:	138249676(ILK)

MUO:

115468241

GSH:	117362693(ILK)

DRE:	393543(ilk)

SRX:	107718724 107720653

SANH:

107685015 107701121(ilk)

SGH:	107556859(ilk)

CCAR:

109073624 109103344

CAUA:

113078354 113092442 113109801

CGIB:

127966624 128021203

PTET:

122352853(ilk)

LROH:

127172189(ilk)

OMC:	131548819(ilk)

PPRM:

120482554(ilk)

RKG:	130082856(ilk)

MAMB:

125258610(ilk)

CIDE:

127520263

CERY:

137028752(ilk)

MASI:

127432807 127433397

TROS:

130546460(ilk)

TDW:	130412233(ilk)

MANU:

129446983(ilk)

PDAB:

135779794(ilk)

IPU:

108277251

IFU:	128620511(ilk)

PHYP:

113543442(ilk)

SMEO:

124393556(ilk)

TFD:	113645779(ilk)

TVC:	132863135(ilk)

CGAR:

128545706(ilk)

NGRA:

132873858(ilk)

TRN:	134332406(ilk)

AMEX:

103042782(ilk)

CMAO:

118824455(ilk)

EEE:	113581672(ilk)

CHAR:

122131899(ilk)

SPIL:

134100003(ilk)

TRU:	101064916(ilk) 101074511

TFS:	130534520 130537406(ilk)

TNG:	GSTEN00018916G001 GSTEN00030138G001

LCO:	104919841 104923817

NCC:	104947434 104952256(ilk)

TBEN:

117468842 117490321(ilk)

CGOB:

115018208(ilk) 115018869

PGEO:

117457461 117458898(ilk)

GACU:

117535097(ilk) 117540390

EMAC:

134872604(ilk) 134879980

ELY:	117259759 117262586(ilk)

EFO:	125888378 125898804(ilk)

PLEP:

121943289 121952817(ilk)

SLUC:

116048464 116065003(ilk)

ECRA:

117941692 117955821(ilk)

ESP:	116671424(ilk) 116701018

PFLV:

114552620(ilk) 114567223

GAT:	120822407(ilk) 120829500

PPUG:

119215937(ilk) 119217678

AFB:	129089284 129113436(ilk)

CLUM:

117741397 117743130(ilk)

PSWI:

130188845(ilk) 130210495

CANA:

137790495 137802584(ilk)

CVE:	137875754 137876397(ilk)

MSAM:

119882724 119895407(ilk)

SCHU:

122879053 122888329(ilk)

CUD:	121518875(ilk) 121521052

SPUL:

138596966 138598540(ilk)

LMIX:

132980672 132987934(ilk)

ALAT:

119005623 119031887(ilk)

ASTR:

137596976 137606619(ilk)

MZE:	101477640 101485551(ilk)

ONL:	100690951 100701917

OAU:	116331456(ilk) 116335685

OLA:	101157310 101172012

OML:	112142591(ilk) 112149471

CSAI:

133441905 133459334(ilk)

XMA:	102225759(ilk) 102231522

XCO:	114133688(ilk) 114152747

XHE:	116707863(ilk) 116727825

PRET:

103474125 103475517(ilk)

PFOR:

103140564(ilk) 103148510

PLAI:

106957611(ilk) 106960551

PMEI:

106905085 106914113(ilk)

GAF:	122832365 122845253(ilk)

PPRL:

129368505(ilk) 129369828

CVG:	107087916 107099544(ilk)

CTUL:

119783484(ilk) 119795397

GMU:	124876711(ilk) 124883803

NFU:	107380011 107386970

KMR:	108235923 108236879(ilk)

ALIM:

106514119(ilk) 106529737

NWH:	119410707(ilk)

AOCE:

111566051(ilk) 111567890

EJA:	138196370(ilk) 138205345

BFRE:

138628945 138634324(ilk)

MCEP:

125013895 125021750(ilk)

CSEM:

103378043(ilk) 103395087

POV:	109628344 109630358

SSEN:

122773240 122780136(ilk)

SSOE:

131458929(ilk) 131462588

HHIP:

117772891 117774583(ilk)

HSP:	118106044 118122525(ilk)

PPLT:

128439662 128457102(ilk)

SMAU:

118299001 118300526(ilk)

LCF:	108876077 108893604(ilk)

SDU:	111232291 111234414

SLAL:

111653646(ilk) 111666302

XGL:	120792390 120803000(ilk)

HCQ:	109509738 109527221(ilk)

SSCV:

125972467 125982345

SBIA:

133492183 133505091

PEE:	133405097 133415574

PTAO:

133467408 133481932

BPEC:

110158408 110172714

ENY:	140360641(ilk) 140373210

MALB:

109959317 109969746

BSPL:

114867715 114869209(ilk)

SJO:	128360686 128371143(ilk)

SSCO:

133980327 133993776(ilk)

GMH:	115528978 115546546

SASA:

100194973(ilk) 106581335

STRU:

115163685 115206565

OTW:	112265713 112267274

OMY:	110503160 110507998

OGO:	123992565 124005227

ONE:	115136594 115141983

OKI:	109876055 109905881

OKE:	118390952 118397569

OMM:	135546632 135553130

OCLA:

139382447 139385624

SALP:

111949360 112068900

SNH:	120018092 120028665

CCLU:

121566955 121567784

ELS:	105023567(ilk)

OEP:	134029684 134039768(ilk)

SFM:	108921298(ilk) 108938337

PKI:	111838003 111856818(ilk)

AANG:

118209593 118235628(ilk)

AROT:

135236415 135264323

CCOG:

133108219 133134051

LOC:	102684116(ilk)

PSPA:

121320427(ilk) 121327760

ARUT:

117405915 117407398

PSEX:

120523078(ilk)

LCM:	102365370(ILK)

RTP:	109938352(ilk)

CPLA:

122551091(ilk)

HOC:	132816598(ilk)

LERI:

129698346(ilk)

PMRN:

116958321(ILK)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115922167 581345

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG10504(Ilk)

DER:

6546273

DSE:

6616413

DSI:	Dsimw501_GD14943(Dsim_GD14943)

DYA:	Dyak_GE19735 Dyak_GE23057

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13131

DAZ:

108613105

DNV:

108651892

DHE:

111594364

DVI:	6623860(Ilk)

CCAT:

101454155

BOD:

106627380

BDR:

105227984

RZE:	108368506 108373595

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135954767(Ilk)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ016644

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139109020(Ilk)

TLN:	139820778(Ilk)

HST:

DQU:

CFO:

FEX:

PMEC:

138931741(Ilk)

LHU:	105680032(Ilk)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124223831(Ilk)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138137029(Ilk)

DPA:

109544881

ESIM:

136415415(Ilk)

EFOR:

136344347(Ilk)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

APLN:

PPYR:

OTU:

BMOR:

MSEX:

DPL:	KGM_212388

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137919158(Ilk)

PRAP:

110995055

PBX:

123710029

PNAP:

125048770

ZCE:	119828235 119840846

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

113364092 113376635 113376643

CCRN:

123296922

API:

100163230

DNX:	107168719 107169173

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106682131(Ilk)

NLU:

111056781

HVI:

124362992

MQU:	128994419 128996638

PHU:	Phum_PHUM581860

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138702954(Ilk)

SGRE:

126266971

BROR:

134533757

IEL:

124159142

HAMR:

139691950(Ilk)

FCD:

DMK:

DPZ:

AFRA:

PVM:	113807347(Ilk)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123746414(Ilk)

CQD:

PTRU:

ESN:

MNZ:

MRJ:	136855654(Ilk)

PORN:

139764361(Ilk)

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136987418(Ilk)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C29F9.7(pat-4)

CBR:	CBG_15792(Cbr-pat-4)

CRQ:	GCK72_011810

NAI:	NECAME_11795

BMY:	BM_BM2471(Bma-pat-4)

LOA:	LOAG_00633

TSP:	Tsp_07213 Tsp_07224

HRO:	HELRODRAFT_115085

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_079760.1

SHX:	MS3_00005632(PAT4)

OVI:	T265_00664

EGL:

EGR_02061

LLON:

135493395

NVE:	116604641 5519975

EPA:	110234008 110251611

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:	114521555 114530898 114540628

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_30386

AQU:

CPAP:

CIT:

PVY:

MINC:

TCC:

GRA:

GHI:

GAB:

HSYR:

DZI:

EGR:

RARG:

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

PCOX:

ZJU:

MNT:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PNZ:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

LBB:

NTA:	107772376 107810262

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

DLT:

AOF:

MSIN:

ACAK:

ATR:

CJF:

SPAR:

Reference

PMID:8538749

Authors

Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S

Title

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase.

Journal

Nature 379:91-6 (1996)
DOI:10.1038/379091a0

Sequence

[hsa:3611]

Reference

PMID:18604167

Authors

Fielding AB, Dobreva I, Dedhar S

Title

Beyond focal adhesions: integrin-linked kinase associates with tubulin and regulates mitotic spindle organization.

Journal

Cell Cycle 7:1899-906 (2008)
DOI:10.4161/cc.7.13.6204

LinkDB

DBGET integrated database retrieval system