Klebsiella variicola KP5-1: A593_12085
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Entry
A593_12085 CDS
T03368
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
kpk
Klebsiella variicola KP5-1
Pathway
kpk00270
Cysteine and methionine metabolism
kpk00450
Selenocompound metabolism
kpk00670
One carbon pool by folate
kpk01100
Metabolic pathways
kpk01110
Biosynthesis of secondary metabolites
kpk01230
Biosynthesis of amino acids
kpk04981
Folate transport and metabolism
Module
kpk_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
kpk00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
A593_12085 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
A593_12085 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
A593_12085 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
A593_12085 (metH)
04980 Cobalamin transport and metabolism
A593_12085 (metH)
Enzymes [BR:
kpk01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
A593_12085 (metH)
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Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AIE01245
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Position
2485701..2489384
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AA seq
1227 aa
AA seq
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MSSKVEQLHQQLKERILVLDGGMGTMIQGYRLSEQDFRGERFADWPCDLKGNNDLLVLSK
PEVIREIHDAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARASADAWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTRALVEGGVDLILI
ETVFDTLNAKAAIYAVKEELEALGVDLPLMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMATQIREWAE
AGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRQLPELPVACRLAGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVEPFIHHAKLVRRYGAAV
VVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPGELRDAVEDVILNRRDDSTERLLELAEKYRGSKADDGANAQQAEWRSWDVK
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPYIEASKEQGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIIDL
GVMVPADKILKTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLAAARENDLAFDWESYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAQRLFKDANDLLDKLSAEKTLNPRGVIGLFPANRVGDDIEIYRDETRT
HVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYEAQH
DDYNKIMIKAIADRLAEAFAEYLHEKVRKVYWGYAANENLSNEELIRENYQGIRPAPGYP
ACPEHTEKGTIWQLLDVEAHTGMKLTESFAMWPGASVSGWYFSHPDSKYFAVAQIQRDQV
EDYALRKGMTPAEVERWLAPNLGYDAD
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagttgagcaactgcatcagcagttaaaagaacgtattctggttctggat
gggggcatgggcaccatgatccagggctatcgtctgagtgagcaggactttcgcggtgag
cgctttgctgactggccgtgcgacctgaaaggcaacaacgacctgctggtgctcagcaag
cccgaggtgatccgcgagatccacgacgcctacttcgaggccggtgcggatatcattgag
accaacacctttaactcgacgaccatcgcgatggcggattaccagatggaatccctgtcg
gccgagatcaactttgctgcggcgaagctggcccgcgccagcgccgacgcctggacggcc
cgcacgccggaaaaaccgcgctacgtcgcgggcgtgcttggcccgaccaaccgtaccgcc
tctatctcgcctgatgtgaacgatccggcgttccgtaatattacctttgaccagctggtg
gccgcctatcgcgaatccacccgggcgctggtggaaggtggcgtggatctgatcctgatt
gaaacggtatttgatactctgaacgccaaggcggccatctatgcggtgaaagaggagctg
gaggcgctgggcgttgacctgccgctgatgatctccggcaccatcaccgatgcgtccggc
cgcacgctttccggacagaccaccgaagccttttataactcgctgcgtcacgccgaagcc
ttatcgtttggtctgaactgcgccctcgggccggacgaactgcggcagtatgtccaggag
ctgtcgcgcatcgccgaatgctacgtcacggcgcacccgaacgccggtctgcccaacgcc
ttcggtgaatacgatctggatgccgacaccatggcgacgcaaattcgcgaatgggcggaa
gccggtttcctcaatatcgttggcggctgctgcggtacgactccggagcatatcgccgcc
atgagccgggcggtggccggtttaccgccgcgccagttgccggaactgccggtggcctgc
cgcctcgccggcctggagccgctgaacatcggcgacgacagcctgttcgttaacgtcggc
gaacgtaccaacgtcaccggctcggcgaaatttaagcgcttgatcaaagaagagaagtac
agcgaagcgctggacgttgcccgtcagcaggtcgaaagcggcgcgcagattatcgatatc
aacatggatgaggggatgctcgacgcggaagcggcgatggtgcgcttcctcaacctgatt
gccggcgagccggacattgcccgcgtgccgatcatgatcgactcctccaagtgggaagtc
attgaaaagggtttgaaatgcattcagggcaaaggcattgttaactcgatttcgatgaaa
gagggcgtcgaaccctttatccaccatgcgaagctggttcgccgttatggcgccgcggta
gtggtgatggcctttgacgaagtgggtcaggccgacacccgcgaacgcaaaattgagatt
tgccgtcgcgcttacaaaattctcactgaagaggtcggcttcccgccagaagatatcatc
tttgatcccaatatctttgcggtagcgaccggtatcgaagagcataacaactatgcgcag
gactttatcggcgcctgcgaagacatcaaacgcgagctgccgcatgcgctgatctccggc
ggcgtctccaacgtgtcgttctcgttccgcggtaatgacccggtacgtgaggcgatccac
gccgtgttcctctactacgcgatccgtaacggcatggatatggggatcgtcaacgccggc
cagctggcgatttacgacgatctgccgggcgagctgcgcgacgcggtcgaagatgtgatc
cttaaccgccgcgatgacagtaccgaacggttacttgagctggcggaaaaatatcgcggc
agcaaagcggacgacggcgcgaatgctcagcaggcggaatggcgcagttgggacgtgaaa
aagcgtctcgaatattcgctggtgaagggcattaccgaatttatcgaacaggacaccgaa
gaggcgcgtcagcaggctgcccgcccgattgaggtgattgaagggccgctaatggacggc
atgaacgtggtcggcgacctgttcggcgaaggtaaaatgttcctgccgcaggtggtgaaa
tccgctcgcgtgatgaaacaggcggtggcctacctcgaaccttatatcgaagccagcaaa
gaacagggctccagtaacggcaaaatggtgattgccaccgtaaaaggcgacgttcacgac
atcggtaaaaacatcgtcggcgtggtgctgcagtgtaataactacgaaattatcgatctt
ggcgtgatggtcccggcggataaaattctcaaaaccgccaaagaggtcaatgcggatctg
atcggcctttccgggctgattactccgtcactggacgagatggttaacgtggcgaaagag
atggagcgccagggctttaccatcccgctgctgatcggtggcgcgactacctcgaaagcg
catacggcggtgaaaatcgagcagaactacagtggcccgaccgtttacgtacagaacgcc
tcgcgcaccgtcggggtggtggctgcgctgctctcggatacgcagcgcgatgattttgtc
gcccgcacgcgtaaagagtatgagaccgtgcgtatccagcatgggcgtaaaaaaccgcgc
acgccgccggtgaccctggccgccgcgcgggaaaacgatctggccttcgactgggagagc
tacacgccgccggtggcccatcgcctgggggtacaggaggtggaagcgagcatcgagacg
ctgcgcaactacatcgactggacgccgttcttcatgacctggtcgctggcgggcaaatac
ccgcggattctggaggatgaagtggtgggcgaagaggcacagcgcctgttcaaagacgcc
aacgatttgttagataaactcagcgcagagaaaaccctgaacccgcgcggcgtgatcggg
ttgttcccggccaaccgcgtgggcgacgatattgaaatttatcgcgatgaaacccgcacc
cacgtgctgacggtgagccatcatctgcgtcagcagacggaaaaggtcggcttcgcgaac
tactgcctcgccgattttgtcgcgccgaagctgagcggcaaggcggactacatcggcgcc
tttgccgtgaccggcggcctggaagaggacgcgctggcggacgcctatgaagcgcagcat
gatgactataacaagatcatgatcaaggccatcgccgatcgtctggcggaagccttcgcc
gagtatctgcacgagaaagtgcgtaaggtctactgggggtatgcggccaatgagaacctc
agcaatgaggaacttattcgcgagaattaccaggggatccgtccggcgccggggtatccg
gcctgtccggagcacaccgaaaaaggcaccatctggcagctgctggacgtcgaagcccat
accggcatgaagctgaccgaatcgttcgccatgtggccgggggcatcggtttccggctgg
tacttcagccatccggacagcaagtacttcgccgtggcgcagatccagcgcgaccaggtc
gaagactacgcgctgcgtaaagggatgaccccggcggaagtcgagcgctggttagcgcct
aatctgggctatgatgccgactaa
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