KEGG   Klebsiella variicola KP5-1: A593_12085
Entry
A593_12085        CDS       T03368                                 
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
kpk  Klebsiella variicola KP5-1
Pathway
kpk00270  Cysteine and methionine metabolism
kpk00450  Selenocompound metabolism
kpk00670  One carbon pool by folate
kpk01100  Metabolic pathways
kpk01110  Biosynthesis of secondary metabolites
kpk01230  Biosynthesis of amino acids
kpk04981  Folate transport and metabolism
Module
kpk_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:kpk00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    A593_12085 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    A593_12085 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    A593_12085 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    A593_12085 (metH)
   04980 Cobalamin transport and metabolism
    A593_12085 (metH)
Enzymes [BR:kpk01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     A593_12085 (metH)
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: AIE01245
LinkDB
Position
2485701..2489384
AA seq 1227 aa
MSSKVEQLHQQLKERILVLDGGMGTMIQGYRLSEQDFRGERFADWPCDLKGNNDLLVLSK
PEVIREIHDAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARASADAWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTRALVEGGVDLILI
ETVFDTLNAKAAIYAVKEELEALGVDLPLMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMATQIREWAE
AGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRQLPELPVACRLAGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVEPFIHHAKLVRRYGAAV
VVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPGELRDAVEDVILNRRDDSTERLLELAEKYRGSKADDGANAQQAEWRSWDVK
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPYIEASKEQGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIIDL
GVMVPADKILKTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLAAARENDLAFDWESYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAQRLFKDANDLLDKLSAEKTLNPRGVIGLFPANRVGDDIEIYRDETRT
HVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYEAQH
DDYNKIMIKAIADRLAEAFAEYLHEKVRKVYWGYAANENLSNEELIRENYQGIRPAPGYP
ACPEHTEKGTIWQLLDVEAHTGMKLTESFAMWPGASVSGWYFSHPDSKYFAVAQIQRDQV
EDYALRKGMTPAEVERWLAPNLGYDAD
NT seq 3684 nt   +upstreamnt  +downstreamnt
gtgagcagcaaagttgagcaactgcatcagcagttaaaagaacgtattctggttctggat
gggggcatgggcaccatgatccagggctatcgtctgagtgagcaggactttcgcggtgag
cgctttgctgactggccgtgcgacctgaaaggcaacaacgacctgctggtgctcagcaag
cccgaggtgatccgcgagatccacgacgcctacttcgaggccggtgcggatatcattgag
accaacacctttaactcgacgaccatcgcgatggcggattaccagatggaatccctgtcg
gccgagatcaactttgctgcggcgaagctggcccgcgccagcgccgacgcctggacggcc
cgcacgccggaaaaaccgcgctacgtcgcgggcgtgcttggcccgaccaaccgtaccgcc
tctatctcgcctgatgtgaacgatccggcgttccgtaatattacctttgaccagctggtg
gccgcctatcgcgaatccacccgggcgctggtggaaggtggcgtggatctgatcctgatt
gaaacggtatttgatactctgaacgccaaggcggccatctatgcggtgaaagaggagctg
gaggcgctgggcgttgacctgccgctgatgatctccggcaccatcaccgatgcgtccggc
cgcacgctttccggacagaccaccgaagccttttataactcgctgcgtcacgccgaagcc
ttatcgtttggtctgaactgcgccctcgggccggacgaactgcggcagtatgtccaggag
ctgtcgcgcatcgccgaatgctacgtcacggcgcacccgaacgccggtctgcccaacgcc
ttcggtgaatacgatctggatgccgacaccatggcgacgcaaattcgcgaatgggcggaa
gccggtttcctcaatatcgttggcggctgctgcggtacgactccggagcatatcgccgcc
atgagccgggcggtggccggtttaccgccgcgccagttgccggaactgccggtggcctgc
cgcctcgccggcctggagccgctgaacatcggcgacgacagcctgttcgttaacgtcggc
gaacgtaccaacgtcaccggctcggcgaaatttaagcgcttgatcaaagaagagaagtac
agcgaagcgctggacgttgcccgtcagcaggtcgaaagcggcgcgcagattatcgatatc
aacatggatgaggggatgctcgacgcggaagcggcgatggtgcgcttcctcaacctgatt
gccggcgagccggacattgcccgcgtgccgatcatgatcgactcctccaagtgggaagtc
attgaaaagggtttgaaatgcattcagggcaaaggcattgttaactcgatttcgatgaaa
gagggcgtcgaaccctttatccaccatgcgaagctggttcgccgttatggcgccgcggta
gtggtgatggcctttgacgaagtgggtcaggccgacacccgcgaacgcaaaattgagatt
tgccgtcgcgcttacaaaattctcactgaagaggtcggcttcccgccagaagatatcatc
tttgatcccaatatctttgcggtagcgaccggtatcgaagagcataacaactatgcgcag
gactttatcggcgcctgcgaagacatcaaacgcgagctgccgcatgcgctgatctccggc
ggcgtctccaacgtgtcgttctcgttccgcggtaatgacccggtacgtgaggcgatccac
gccgtgttcctctactacgcgatccgtaacggcatggatatggggatcgtcaacgccggc
cagctggcgatttacgacgatctgccgggcgagctgcgcgacgcggtcgaagatgtgatc
cttaaccgccgcgatgacagtaccgaacggttacttgagctggcggaaaaatatcgcggc
agcaaagcggacgacggcgcgaatgctcagcaggcggaatggcgcagttgggacgtgaaa
aagcgtctcgaatattcgctggtgaagggcattaccgaatttatcgaacaggacaccgaa
gaggcgcgtcagcaggctgcccgcccgattgaggtgattgaagggccgctaatggacggc
atgaacgtggtcggcgacctgttcggcgaaggtaaaatgttcctgccgcaggtggtgaaa
tccgctcgcgtgatgaaacaggcggtggcctacctcgaaccttatatcgaagccagcaaa
gaacagggctccagtaacggcaaaatggtgattgccaccgtaaaaggcgacgttcacgac
atcggtaaaaacatcgtcggcgtggtgctgcagtgtaataactacgaaattatcgatctt
ggcgtgatggtcccggcggataaaattctcaaaaccgccaaagaggtcaatgcggatctg
atcggcctttccgggctgattactccgtcactggacgagatggttaacgtggcgaaagag
atggagcgccagggctttaccatcccgctgctgatcggtggcgcgactacctcgaaagcg
catacggcggtgaaaatcgagcagaactacagtggcccgaccgtttacgtacagaacgcc
tcgcgcaccgtcggggtggtggctgcgctgctctcggatacgcagcgcgatgattttgtc
gcccgcacgcgtaaagagtatgagaccgtgcgtatccagcatgggcgtaaaaaaccgcgc
acgccgccggtgaccctggccgccgcgcgggaaaacgatctggccttcgactgggagagc
tacacgccgccggtggcccatcgcctgggggtacaggaggtggaagcgagcatcgagacg
ctgcgcaactacatcgactggacgccgttcttcatgacctggtcgctggcgggcaaatac
ccgcggattctggaggatgaagtggtgggcgaagaggcacagcgcctgttcaaagacgcc
aacgatttgttagataaactcagcgcagagaaaaccctgaacccgcgcggcgtgatcggg
ttgttcccggccaaccgcgtgggcgacgatattgaaatttatcgcgatgaaacccgcacc
cacgtgctgacggtgagccatcatctgcgtcagcagacggaaaaggtcggcttcgcgaac
tactgcctcgccgattttgtcgcgccgaagctgagcggcaaggcggactacatcggcgcc
tttgccgtgaccggcggcctggaagaggacgcgctggcggacgcctatgaagcgcagcat
gatgactataacaagatcatgatcaaggccatcgccgatcgtctggcggaagccttcgcc
gagtatctgcacgagaaagtgcgtaaggtctactgggggtatgcggccaatgagaacctc
agcaatgaggaacttattcgcgagaattaccaggggatccgtccggcgccggggtatccg
gcctgtccggagcacaccgaaaaaggcaccatctggcagctgctggacgtcgaagcccat
accggcatgaagctgaccgaatcgttcgccatgtggccgggggcatcggtttccggctgg
tacttcagccatccggacagcaagtacttcgccgtggcgcagatccagcgcgaccaggtc
gaagactacgcgctgcgtaaagggatgaccccggcggaagtcgagcgctggttagcgcct
aatctgggctatgatgccgactaa

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