KEGG   Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52): KPN_00045
Entry
KPN_00045         CDS       T00566                                 
Symbol
folA
Name
(GenBank) dihydrofolate reductase type I, trimethoprim resistance
  KO
K00287  dihydrofolate reductase [EC:1.5.1.3]
Organism
kpn  Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52)
Pathway
kpn00670  One carbon pool by folate
kpn00790  Folate biosynthesis
kpn01100  Metabolic pathways
kpn01240  Biosynthesis of cofactors
kpn04981  Folate transport and metabolism
Module
kpn_M00126  Tetrahydrofolate biosynthesis, GTP => THF
Brite
KEGG Orthology (KO) [BR:kpn00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    KPN_00045 (folA)
   00670 One carbon pool by folate
    KPN_00045 (folA)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    KPN_00045 (folA)
Enzymes [BR:kpn01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     KPN_00045 (folA)
SSDB
Motif
Pfam: DHFR_1 DUF7466
Other DBs
NCBI-ProteinID: ABR75505
UniProt: A6T4I4
LinkDB
Position
49985..50464
AA seq 159 aa
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI
VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR
NT seq 480 nt   +upstreamnt  +downstreamnt
atgatcagtctgattgcggcgttagcggtagatcgcgtcattggtatggaaaacgccatg
ccatggaacctgcctgccgatctcgcctggttcaaacgcaacacgttaaataagccggtg
gtgatggggcgtctgacctgggaatccattgggcgcccattgccggggcgtaaaaatatc
gtgatcagcagcaaacccggcagcgacgatcgcgtgcagtgggtctcctccgtagaagaa
gcaattgccgcctgcggcgatgtggaagagattatggtgatcggcggcggccgggtgtat
gagcagttcctgccgaaagcgcagaagctctacttgacccatattgatgcggaagtggaa
ggcgatacccatttcccggattacgatccggacgaatgggagtcggtgttcagcgagttt
catgacgccgacgcgcagaactcccatagctactgctttgagatcctcgaacgccgttaa

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