Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52): KPN_00118
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Entry
KPN_00118 CDS
T00566
Symbol
aceE
Name
(GenBank) pyruvate dehydrogenase (decarboxylase component)
KO
K00163
pyruvate dehydrogenase E1 component [EC:
1.2.4.1
]
Organism
kpn
Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52)
Pathway
kpn00010
Glycolysis / Gluconeogenesis
kpn00020
Citrate cycle (TCA cycle)
kpn00620
Pyruvate metabolism
kpn00785
Lipoic acid metabolism
kpn01100
Metabolic pathways
kpn01110
Biosynthesis of secondary metabolites
kpn01120
Microbial metabolism in diverse environments
kpn01200
Carbon metabolism
kpn01210
2-Oxocarboxylic acid metabolism
Module
kpn_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
kpn00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
KPN_00118 (aceE)
00020 Citrate cycle (TCA cycle)
KPN_00118 (aceE)
00620 Pyruvate metabolism
KPN_00118 (aceE)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
KPN_00118 (aceE)
Enzymes [BR:
kpn01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
KPN_00118 (aceE)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
PDH_E1_M
Transketolase_N
Transketolase_C
Viral_DNA_bp
Motif
Other DBs
NCBI-ProteinID:
ABR75578
UniProt:
A6T4Q7
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Position
137677..140340
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AA seq
887 aa
AA seq
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MSERLHNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLSEARKGGVKVAAGASAGNY
VNTIAVEDEPEYPGNLDLERRIRSAIRWNAIMTVLRASKKDLELGGHMASYQSSATFYEV
CFNHFFRARTEKDGGDLVYFQGHISPGVYARAFLEGRLTEEQMDNFRQEVHGKGLSSYPH
PKLMPEFWQFPTVSMGLGPLGAIYQAKFLKYLEHRGLKDTSEQTVYAFLGDGEMDEPESK
GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFGGAGWNVIKVIWGGRWD
ELLRKDTSGKLIQLMNETVDGDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWAL
NRGGHDPKKVYAALKKAQETKGQPTVILAHTIKGYGMGDTAEGKNIAHQVKKMNMDGVRY
VRDRFNVPVADADLEKLPYVTFPEGSEEHTYLHAQRQKLNGYLPTRQPKFTEKLELPTLA
DFSALLEEQNKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYS
PNGQQYTPQDREQVAYYKEDEKGQILQEGINELGAGASWLAAATSYSTNNLPMIPFYIYY
SMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNCISYD
PAYAYEVAVIMHDGLVRMYGEAQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETI
EGSKGKVQLLGSGSILRHVREAAQILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHP
LETPRVPYIAQVMNDAPAVASTDYMKLFAEQVRTYVPADDYRVLGTDGFGRSDSRENLRH
HFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFDIDAEKVNPRLA
NT seq
2664 nt
NT seq
+upstream
nt +downstream
nt
atgtcagaacgtttacacaatgacgtggatccgatcgaaactcgcgactggctacaggcg
atcgaatcggtcatccgtgaagaaggtgttgagcgcgctcagtatctgattgaccaactc
ctttctgaagcccgtaaaggcggagtgaaggttgctgcaggcgcttccgccggcaactac
gtcaacactattgccgttgaagatgagccggaatacccgggcaatctggatctggaacgt
cgcattcgttctgcgattcgctggaacgccatcatgaccgttctgcgcgcgtcgaaaaaa
gatctcgaactgggcggccacatggcgtcctatcagtcttccgcgaccttctacgaagtc
tgcttcaaccacttcttccgtgcgcgcactgagaaagatggcggcgatctggtgtacttc
cagggtcacatctctccgggcgtatatgcacgtgcgttcctggaaggccgtctgaccgaa
gagcagatggacaacttccgccaggaagttcatggcaagggtctgtcctcttatccgcac
ccgaaactgatgccggaattctggcagttcccgaccgtatccatgggtctggggccgttg
ggcgctatctatcaggccaaattcctgaaatatctggaacaccgcggtctgaaagacacc
tccgaacaaaccgtttacgccttcctgggcgacggcgagatggatgagccggaatcaaaa
ggcgctatcaccatcgccacccgtgaaaaactggacaacctggtcttcgtcatcaactgc
aacctgcagcgtctggacggcccggtcaccggtaacggcaaaatcattaacgaactggaa
ggcatcttcggtggtgctggctggaacgttatcaaggttatctggggcggccgttgggat
gagctgctgcgtaaagacaccagcggtaagctgattcagctgatgaacgaaaccgttgac
ggcgactaccagaccttcaaatccaaagacggcgcttacgttcgtgagcacttcttcggc
aaatatccggaaaccgctgccctggtcgctgactggactgacgagcagatctgggctctg
aaccgcggtggtcacgatccgaagaaagtctacgctgcattgaagaaagcgcaggagacc
aaaggtcagccgaccgtgatcctggcgcataccattaaaggttatggtatgggcgatacc
gctgaaggtaagaacatcgcgcaccaggttaagaaaatgaacatggacggtgttcgctac
gtccgcgatcgtttcaatgtgccggtggcggatgccgatctcgaaaaactgccgtacgta
accttcccggaaggttccgaagagcacacttacctgcacgctcagcgtcagaagctgaac
ggctatctgccgactcgtcagccgaagttcactgagaaactcgagctgccgaccctggcc
gacttcagcgcgctgctggaagagcaaaacaaagaaatctctaccactatcgctttcgtt
cgcgccctgaacgtgatgctgaagaacaagtcgatcaaagatcgtctggtgccgatcatc
gccgacgaagcgcgtaccttcggtatggaaggtctgttccgtcagatcggtatttacagc
ccgaacggccagcagtataccccgcaggaccgtgagcaggttgcttactacaaagaagac
gagaaaggccagattctgcaggaagggatcaacgagctgggcgcaggcgcatcctggctg
gctgctgcgacctcttacagcaccaacaacctgccgatgatcccgttctacatctactac
tcgatgttcggcttccagcgtatcggcgatctgtgctgggcggctggcgatcagcaggct
cgcggcttcctgattggcgggacttccggtcgtactaccctgaacggcgaaggtctgcag
cacgaagatggtcacagccacattcagtcgctgactatcccgaactgtatctcttacgac
ccggcgtacgcctatgaagtggctgtcatcatgcatgatggtctggtccgtatgtacggc
gaagcgcaagagaacgtttactactacatcactacgctgaacgaaaactaccacatgccg
gccatgccggaaggcgccgaggaaggtatccgtaaaggtatctacaaactcgaaaccatc
gaaggtagcaaaggtaaagttcagctgctgggctccggttctatcctgcgtcacgtgcgt
gaagcagcgcagatcctggcgaaagactacggcgtgggttccgacgtgtatagcgttacc
tccttcaccgaactggcgcgtgatggccaggattgcgaacgctggaacatgctgcacccg
ctggaaaccccgcgcgtgccgtatatcgctcaggtaatgaacgacgctccggcagtggca
tccactgactatatgaaactgttcgctgagcaggttcgtacttacgtaccggctgatgat
taccgcgtactgggtaccgatggcttcggtcgttccgacagccgtgaaaacctgcgtcac
cacttcgaagtcgatgcttcctatgtggtcgtagcagcgctgggcgaactggctaaacgt
ggtgaaatcgataagaaagtggtggctgacgctatcgcgaaattcgacatcgatgcagaa
aaagttaacccgcgtctggcgtaa
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