Klebsiella pneumoniae subsp. pneumoniae KPNIH30: KPNIH30_01310
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Entry
KPNIH30_01310 CDS
T03466
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
kpw
Klebsiella pneumoniae subsp. pneumoniae KPNIH30
Pathway
kpw00270
Cysteine and methionine metabolism
kpw00450
Selenocompound metabolism
kpw00670
One carbon pool by folate
kpw01100
Metabolic pathways
kpw01110
Biosynthesis of secondary metabolites
kpw01230
Biosynthesis of amino acids
kpw04980
Cobalamin transport and metabolism
kpw04981
Folate transport and metabolism
Module
kpw_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
kpw00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
KPNIH30_01310 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
KPNIH30_01310 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
KPNIH30_01310 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
KPNIH30_01310 (metH)
04980 Cobalamin transport and metabolism
KPNIH30_01310 (metH)
Enzymes [BR:
kpw01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
KPNIH30_01310 (metH)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AIX76920
UniProt:
A0A235PMU2
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All DBs
Position
270620..274303
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AA seq
1227 aa
AA seq
DB search
MSSKVEQLHQQLKERILVLDGGMGTMIQGYRLSEQDFRGERFADWPCDLKGNNDLLVLSK
PEVIREIHDAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARASADAWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTRALVEGGVDLILI
ETVFDTLNAKAAIYAVKEELEALGVDLPLMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMATQIREWAE
AGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRQLPEIAVACRLAGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVESFIHHAKLVRRYGAAV
VVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPGELRDAVEDVILNRRDDSTERLLELAEKYRGSKADDGANAQQAEWRTWEVK
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIIDL
GVMVPADKILKTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVSALLSDTQRDEFVARTRKEYETVRIQHGRKKPR
TPPVTLAAARENDLAFDWESYTPPVAHRLGVQTVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAQRLFKDANELLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYEAQH
DDYNKIMIKAIADRLAEAFAEYLHEKVRKVYWGYAANENLSNEELIRENYQGIRPAPGYP
ACPEHTEKGTIWQLLDVEAHTGMKLTESFAMWPGASVSGWYFSHPDSKYFAVAQIQRDQV
EDYALRKGMTPAEVERWLAPNLGYDAD
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagttgagcaactgcatcagcagttaaaagaacgtattctggttctggat
gggggcatgggcaccatgatccagggctatcgtctgagtgagcaggactttcgcggtgag
cgctttgctgactggccgtgcgacctgaaaggcaacaacgacctgctggtgctcagcaaa
cccgaagtgatccgcgagatccacgacgcctatttcgaggccggcgcggatatcattgag
accaacacctttaactcgacgaccatcgcgatggcggattaccagatggaatccctgtcg
gccgagatcaactttgccgcggcgaagctggcccgcgccagcgccgacgcctggacggcc
cgcacgccggaaaaaccgcgctatgtcgcgggcgtgcttggcccgaccaaccgcaccgcc
tctatctcgcctgatgtgaacgatccggcgttccgtaatattacctttgaccagctggtg
gccgcctatcgcgaatccacccgggcgctggtggaaggtggcgtggatctgatcctgatt
gaaacggtgtttgatactctgaacgctaaagcggctatatatgcggtgaaagaggagctg
gaggcgttaggcgttgacctgccgctgatgatctccgggaccattaccgatgcctctggc
cgcacgctttccggacagaccaccgaagccttttataactcgctgcgtcacgccgaagcc
ttatcgtttggtctgaactgcgccctcgggccggacgagctgcggcagtacgtccaggag
ctgtcgcgcattgccgaatgctacgtcaccgcgcacccgaacgccggccttcccaacgcc
ttcggcgaatacgatctggacgccgacaccatggcgacgcaaattcgcgaatgggcggaa
gccggtttcctcaatatcgttggcggctgctgcggtaccaccccggagcatatcgccgcc
atgagccgggcggtagcgggcctgccgccgcgtcagttgccggaaattgcggtggcctgc
cgcctcgccggcctggagccgttgaatatcggcgacgatagcctgttcgttaacgtcggt
gaacgaactaacgtcaccggctcggcgaaatttaagcggctgattaaagaagagaagtac
agcgaagcgctggacgttgcgcgtcagcaggtggaaagcggcgcgcagattatcgatatc
aacatggacgaggggatgctcgacgcggaagcggcgatggtgcgtttccttaacctgatt
gccggcgagccggacattgcccgcgtgccgatcatgatcgactcctccaagtgggaagtc
attgaaaagggcctgaaatgtattcagggcaaaggcatcgttaactcgatttcgatgaaa
gagggcgtcgaatcctttatccaccatgcgaaactggttcgccgctacggcgccgcggtg
gtggtgatggctttcgacgaggttggtcaggccgacacccgcgaacgtaaaattgagatt
tgccgtcgcgcctacaaaatcctaaccgaagaggtcggcttcccgccggaagatattatc
ttcgaccccaatatctttgccgtcgccaccggtatcgaagagcataacaactacgcacag
gactttatcggcgcctgcgaagacatcaaacgcgagctgccgcatgcgctaatctccggc
ggggtctccaacgtctccttctccttccgcggtaatgacccggtacgtgaggcgatccac
gccgtattcctctactacgcgatccgcaacggcatggacatggggatcgtcaacgccggt
cagctggccatctatgatgacctcccgggcgagctgcgcgacgcggtcgaagacgtgatc
ctcaaccgccgcgatgacagtaccgaacggttacttgagctggcggaaaaatatcgcggc
agcaaagcggacgacggcgcgaatgcccagcaggcggagtggcgcacctgggaagtgaaa
aaacgcctcgaatattcgctggtgaagggcattaccgaatttatcgaacaggacaccgaa
gaagcgcgtcagcaggccgcccgcccgattgaggtcattgaagggccgctgatggacggc
atgaacgtggtcggcgatctgttcggcgaaggcaaaatgttcctgccgcaggtggtgaaa
tccgcccgtgtaatgaaacaggcggtggcctaccttgagccgtttattgaagccagtaaa
gagcagggctccagtaacggcaaaatggtgattgccacggtaaaaggcgacgttcatgac
attggcaaaaacatcgtcggcgtggtgctgcagtgcaataactacgaaatcatcgatctt
ggcgtgatggtcccggcggataaaattctcaaaacggccaaagaggtaaacgcggatcta
attggtctttccgggctgattaccccatcgctggacgagatggttaatgtggcgaaagag
atggagcgccagggctttaccatcccgctgctgataggcggcgcgaccacctcgaaagcg
catacggcggtgaaaatcgagcagaactacagcggcccgaccgtttacgtacagaacgcc
tcgcgcaccgtcggcgtggtgtctgcgctgctctcggacacgcagcgcgacgagtttgtc
gcccgcacgcgcaaagagtatgaaacggtgcgtatccagcatgggcgtaaaaaaccgcgt
acgccgccggtgacccttgccgccgcgcgggaaaacgatctggcctttgactgggagagc
tacacgccgccggtggctcatcgtctgggagtacagacggtggaagccagtatcgagact
ctgcgcaactacatcgactggacgccgttcttcatgacctggtcgctcgcgggtaaatat
ccgcgcattctggaagatgaagtggtaggggaagaggcgcagcgcctgttcaaagacgct
aacgagctgctggataagctgagcgcagagaaaaccctgaacccgcggggcgtggtgggt
ctgttcccggccaaccgcgtgggcgacgatattgaaatctatcgcgatgaaacccgcacc
cacgtgctgacggtgagccatcatctgcgccagcagacggagaaggttggcttcgccaac
tactgcctcgccgattttgtcgcgccgaagctgagcggcaaggcggactacatcggcgcc
ttcgccgtgaccggcggcctggaagaggacgcgctggcggatgcctatgaagcgcagcat
gatgactataacaagatcatgatcaaggccatcgccgatcgcctggcggaggcctttgcc
gagtatctgcatgagaaagtgcgcaaggtttactggggatatgcggccaatgagaacctc
agcaatgaggagcttattcgcgagaactaccaggggatccgaccggcgccgggatatccg
gcctgtccggagcataccgaaaaggggaccatctggcagctactggacgtcgaagcccat
accggcatgaagctcaccgaatcgttcgccatgtggccgggcgcatcggtttccggctgg
tacttcagccatccggatagcaagtacttcgccgtggcgcagatccagcgcgatcaggtc
gaagattacgcgctgcgtaaaggaatgacgccggcggaggtcgagcgctggttagcgcct
aatctgggctatgatgcggactag
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