Klebsiella pneumoniae subsp. pneumoniae KPNIH31: KPNIH31_01310
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Entry
KPNIH31_01310 CDS
T03467
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
kpy
Klebsiella pneumoniae subsp. pneumoniae KPNIH31
Pathway
kpy00270
Cysteine and methionine metabolism
kpy00450
Selenocompound metabolism
kpy00670
One carbon pool by folate
kpy01100
Metabolic pathways
kpy01110
Biosynthesis of secondary metabolites
kpy01230
Biosynthesis of amino acids
kpy04980
Cobalamin transport and metabolism
kpy04981
Folate transport and metabolism
Module
kpy_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
kpy00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
KPNIH31_01310 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
KPNIH31_01310 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
KPNIH31_01310 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
KPNIH31_01310 (metH)
04980 Cobalamin transport and metabolism
KPNIH31_01310 (metH)
Enzymes [BR:
kpy01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
KPNIH31_01310 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AIX82337
UniProt:
A0A235PMU2
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All DBs
Position
270514..274197
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AA seq
1227 aa
AA seq
DB search
MSSKVEQLHQQLKERILVLDGGMGTMIQGYRLSEQDFRGERFADWPCDLKGNNDLLVLSK
PEVIREIHDAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARASADAWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTRALVEGGVDLILI
ETVFDTLNAKAAIYAVKEELEALGVDLPLMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMATQIREWAE
AGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRQLPEIAVACRLAGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVESFIHHAKLVRRYGAAV
VVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPGELRDAVEDVILNRRDDSTERLLELAEKYRGSKADDGANAQQAEWRTWEVK
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIIDL
GVMVPADKILKTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVSALLSDTQRDEFVARTRKEYETVRIQHGRKKPR
TPPVTLAAARENDLAFDWESYTPPVAHRLGVQTVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAQRLFKDANELLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYEAQH
DDYNKIMIKAIADRLAEAFAEYLHEKVRKVYWGYAANENLSNEELIRENYQGIRPAPGYP
ACPEHTEKGTIWQLLDVEAHTGMKLTESFAMWPGASVSGWYFSHPDSKYFAVAQIQRDQV
EDYALRKGMTPAEVERWLAPNLGYDAD
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagttgagcaactgcatcagcagttaaaagaacgtattctggttctggat
gggggcatgggcaccatgatccagggctatcgtctgagtgagcaggactttcgcggtgag
cgctttgctgactggccgtgcgacctgaaaggcaacaacgacctgctggtgctcagcaaa
cccgaagtgatccgcgagatccacgacgcctatttcgaggccggcgcggatatcattgag
accaacacctttaactcgacgaccatcgcgatggcggattaccagatggaatccctgtcg
gccgagatcaactttgccgcggcgaagctggcccgcgccagcgccgacgcctggacggcc
cgcacgccggaaaaaccgcgctatgtcgcgggcgtgcttggcccgaccaaccgcaccgct
tctatttcgcctgatgtgaacgatccggcgttccgtaatattacctttgaccagctggtg
gccgcctatcgcgaatccacccgggcgctggtggaaggtggcgtggatctgatcctgatt
gaaacggtgtttgacaccctgaacgctaaagcggctatctatgcggtgaaagaggagctg
gaggcgttaggcgttgacctgccgctgatgatctccgggaccattaccgatgcctctggc
cgcacgctttccggacagaccaccgaagccttttataactcgctgcgtcacgccgaagcc
ttatcgtttggtctgaactgcgccctcgggccggacgagctgcggcagtacgtccaggag
ctgtcgcgcattgccgaatgctacgtcactgcgcacccgaacgccggcctgcccaacgcc
ttcggcgaatacgatctggacgccgacaccatggcgacgcaaattcgcgaatgggcggaa
gccggtttcctcaatatcgttggcggctgctgcggtaccaccccggagcatatcgccgcc
atgagccgggcggtagcgggcctgccgccgcgtcagttgccggaaattgcggtggcctgc
cgcctcgccggcctggagccgttgaatatcggcgacgatagcctgttcgttaacgtcggt
gaacgaactaacgtcaccggctcggcgaaatttaagcggctgattaaagaagagaagtac
agcgaagcgctggacgttgcgcgtcagcaggtggaaagcggcgcgcagattatcgatatc
aacatggacgaggggatgctcgacgcggaagcggcgatggtgcgtttccttaacctgatt
gccggcgagccggacattgcccgcgtgccgatcatgatcgactcctccaagtgggaagtc
attgaaaagggcctgaaatgtattcagggcaaaggcatcgttaactcgatttcgatgaaa
gagggcgtcgaatcctttatccaccatgcgaaactggttcgccgctacggcgccgcggtg
gtggtgatggctttcgacgaggttggtcaggccgacacccgcgaacgtaaaattgagatt
tgccgtcgcgcctacaaaatcctcaccgaagaggtcggcttcccgccggaagatattatc
ttcgaccccaatatctttgccgtcgccaccggtatcgaagagcataacaactacgcacag
gactttatcggcgcctgcgaagacatcaaacgcgagctgccgcatgcgctaatctccggc
ggggtctccaacgtctccttctccttccgcggtaatgacccggtacgtgaggcgatccac
gccgtattcctctactacgcgatccgcaacggcatggacatggggatcgtcaacgccggt
cagctggccatctatgatgacctcccgggcgagctgcgcgacgcggtcgaagacgtgatc
ctcaaccgccgcgatgacagtaccgaacggttacttgagctggcggaaaaatatcgcggc
agcaaagcggacgacggcgcgaatgcccagcaggcggagtggcgcacctgggaagtgaaa
aaacgcctcgaatattcgctggtgaagggcattaccgaatttatcgaacaggacaccgaa
gaagcgcgtcagcaggccgcccgcccgattgaggtcattgaagggccgctgatggacggc
atgaacgtggtcggcgatctgttcggcgaaggcaaaatgttcctgccgcaggtggtgaaa
tccgcccgtgtaatgaaacaggcggtggcctaccttgagccgtttattgaagccagtaaa
gagcagggctccagtaacggcaaaatggtgattgccacggtaaaaggcgacgttcatgac
attggcaaaaacatcgtcggcgtggtgctgcagtgcaataactacgaaatcatcgatctt
ggcgtgatggtcccggcggataaaattctcaaaacggccaaagaggtaaacgcggatcta
attggtctttccgggctgattaccccatcgctggacgagatggttaatgtggcgaaagag
atggagcgccagggctttaccatcccgctgctgataggcggcgcgaccacctcgaaagcg
catacggcggtgaaaatcgagcagaactacagcggcccgaccgtttacgtacagaacgcc
tcgcgcaccgtcggcgtggtgtctgcgctgctctcggacacgcagcgcgacgagtttgtc
gcccgcacgcgcaaagagtatgaaacggtgcgtatccagcatgggcgtaaaaaaccgcgt
acgccgccggtgacccttgccgccgcgcgggaaaacgatctggcctttgactgggaaagc
tacacgccgccggtggctcatcgtctgggagtacagacggtggaagccagtatcgagact
ctgcgcaactacatcgactggacgccgttcttcatgacctggtcgctggcgggtaaatat
ccgcgcattctggaagatgaagtggtaggggaagaggcgcagcgcctgttcaaagatgct
aacgagctgctggataagctgagcgcagagaaaaccctgaacccgcggggcgtggtgggt
ctgttcccggccaaccgcgtgggcgacgatattgaaatctatcgcgatgaaacccgcacc
cacgtgctgacggtgagccatcatctgcgccagcagacggagaaggttggcttcgccaac
tactgcctcgccgattttgtcgcgccgaagctgagcggcaaggcggactacatcggcgcc
ttcgccgtgaccggcggcctggaagaggacgcgctggcggacgcctatgaagcgcagcat
gatgactataacaagatcatgatcaaggccatcgccgatcgcctggcggaggcctttgcc
gagtatctgcatgagaaagtgcgcaaggtttactggggatatgcggccaatgagaacctc
agcaatgaggagcttattcgcgagaactaccaggggatccgaccggcgccgggatatccg
gcctgtccggagcataccgaaaaggggaccatctggcagctactggacgtcgaagcccat
accggcatgaagctcaccgaatcgttcgccatgtggccgggcgcatcggtttccggctgg
tacttcagccatccggatagcaagtacttcgccgtggcgcagatccagcgcgatcaggtc
gaagattacgcgctgcgtaaaggaatgacgccggcggaggtcgagcgctggttagcgcct
aatctgggctatgatgcggactag
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