KEGG   Leptospira tipperaryensis: A0128_17725
Entry
A0128_17725       CDS       T04558                                 
Name
(GenBank) multidrug transporter AcrB
  KO
K18138  multidrug efflux pump
Organism
laj  Leptospira tipperaryensis
Pathway
laj01501  beta-Lactam resistance
laj01503  Cationic antimicrobial peptide (CAMP) resistance
Brite
KEGG Orthology (KO) [BR:laj00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    A0128_17725
   01503 Cationic antimicrobial peptide (CAMP) resistance
    A0128_17725
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:laj02000]
    A0128_17725
   01504 Antimicrobial resistance genes [BR:laj01504]
    A0128_17725
Transporters [BR:laj02000]
 Other transporters
  Electrochemical potential-driven transporters [TC:2]
   A0128_17725
Antimicrobial resistance genes [BR:laj01504]
 Gene sets
  Multipdrug resistance modules
   Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]
    A0128_17725
SSDB
Motif
Pfam: ACR_tran MMPL ZT_dimer
Other DBs
NCBI-ProteinID: AOP35516
UniProt: A0A1D7V117
LinkDB
Position
1:complement(3749973..3753152)
AA seq 1059 aa
MMMAAIILFGSIGFSRMGLSQMPDVDFPVVNVSLTLVGANAPVMETDVVDPIEEALMSVE
GVTEVRSISSDGSATITVELELTRDVDVAVQEIQTKLAQVSNKLPENLDPAVITKSNPDD
TPIIWVSLTAVDKTEQEKMLVVKDFLKDKFQKISGVGEIILGGYVDRTINVYLDPAKLSR
NEIAVDDIVNTLKEQNLEVPSGKLENRTSEISLRAVGEVPTADQFGTILLNSRSGSPLFR
SIRLKDIAIVEDGLGEVRRISRFNGISAVGIGIKKLKGANAVQVGDLVKAKVKELKPRLP
KGYDLTISNDNTGYIRDSVNELEFTLLFSAILTGFVCRLFLGNWKSTGNVLLAIPTSVIG
TFLFLYFAGFTINTFTMLGLSLATGIVVDDAIMVLENITRHREMGKSWFAASLEGASEIR
FAALAATLAVVAIFLPVAFMKGIIGRYFLEFGVTISVAVLLSLFEALSFTPMRSSLYAED
KKNQESKLSRYNPFSVTTKEKWNLWIDRVSFFKKLDPQIERFLDYSTGLYSRSIDFVLKH
PKTVVYGSTALFLMSLGFFFLLKKEFIPAQDMGRFIIRARLPLGSSLQRTDDAMRKVEQY
LIGRKEIEKYMSNIGGFGGTESNTAMFFVTMKEMGHRPKNPKTGREMTQSALFGILRKDL
KGLVPEATFSVQDLSQRGFSAGRGYPVELVLTGPDWQKLSAYSVQILDRLKESKAVLDVD
TDYVAGQKELRLVTNREAAALRGVSMANVGNTVGTLMGGKNVSRFTENGRSYDVRVKIQK
DKGETASVISEIGVRNTFGEFVKLKEILSIQEKEALKTITRINRERAIRVFGNPAPALGQ
NASTEKALEIAKEILPDGYSVSVTGSAKTAKESGNSLTLALLFGILLSYMILASQFNSLK
QPLYILLAMPFSFTGALVALYVFGQSFNMYSFIGLILLLGLVKKNSILLVEFVNHVRSEG
KSIKEAIKEGCPIRLRPVLMTSFSSIAAAIPPALALGPGAETRIPMAVTILGGMTLSTLI
TLLVVPAAYYLGEKEKEEMAEEKLILFPEPIAKNKKTKK
NT seq 3180 nt   +upstreamnt  +downstreamnt
atgatgatggccgcgatcattctttttggatcgatcggattttcaagaatgggtttgtct
caaatgccggacgtggactttccggtggtcaacgtttctcttacactcgtcggtgcgaac
gcgcccgtgatggaaacggacgtcgtagatccgatcgaagaagctctcatgtcggtggaa
ggagttacggaagtacgttccatttcttccgatggatccgcgaccattaccgtagagttg
gaactcacaagagacgttgatgtcgccgttcaggaaatacaaacaaagttggcgcaggtc
tcgaacaaacttcctgaaaacttagatcccgcggtgatcacaaaatcgaatccggacgat
accccgatcatctgggtttcactcaccgcagtggataagaccgaacaagagaagatgctc
gttgtgaaggattttttgaaggataaatttcaaaaaatttcaggggttggagaaatcatt
ctcggcggttatgtcgatcgtacaatcaacgtatatctggatccggctaaactttccaga
aatgaaatcgcagtagacgatatcgtcaatactctcaaagaacaaaacttagaagttcct
tccggcaagcttgagaatcgaacgagcgagatcagtctccgcgcggttggagaggttcct
accgccgatcagttcggtacgatactattgaattctagaagcggctctcctctgtttcga
tcgattcgtctgaaagacattgcaatcgttgaagacgggttaggcgaagtaagaagaatt
tcccgattcaacggaatttctgcggtcggaatcggaatcaaaaaactcaaaggcgccaac
gcggttcaagtaggcgatctcgttaaggccaaggtcaaagaattaaaacccagattgccg
aagggttacgatctaacgatttcaaacgataacacgggttatattcgagacagcgtgaac
gagttggaatttactcttcttttttcggccattcttaccggatttgtatgtcgtctcttt
ttaggaaattggaagagcaccgggaacgttctacttgcgattccgacttccgtgatcgga
acctttttattcttatactttgcgggttttacgatcaatacgtttacgatgctcggcctt
tcgttggcaacggggatcgtcgtcgacgatgccattatggttttggaaaatattacgcga
catcgggaaatggggaaatcctggtttgccgcttcattggaaggagcttccgagatccgt
ttcgccgccttggcggctacgttagccgtcgttgctatctttcttcccgtcgcctttatg
aagggaattatcggaagatactttttagaattcggcgttacgatttcggtcgccgttctt
ctttcccttttcgaggcgttgagttttactccgatgcgttcttctttgtatgccgaagat
aagaagaatcaagaatcgaaactttcccggtataatcctttttccgtgaccacaaaagaa
aaatggaatctgtggatcgatcgagtttcgttttttaaaaaattagatcctcagatcgaa
agattcttagattacagtacgggactttattcgagatccatcgacttcgtattaaaacat
cctaagacggttgtctacggatcgaccgctttgtttttaatgtccttaggttttttcttt
cttctgaaaaaggaatttatacctgctcaggacatgggccgttttatcattcgagctcgt
ttacccttgggttcttccctacaaagaacggatgacgcgatgagaaaggtggaacagtat
ttgatcggtaggaaagagattgaaaaatacatgtccaatatcggaggtttcggcggaacc
gaatccaataccgctatgttctttgttacgatgaaagagatgggtcatcgacctaaaaat
cctaaaacaggaagagagatgactcaatcggctttgtttggaattcttcgcaaagacctg
aaagggctcgtaccggaagctacgttttccgtgcaggatctttcacaaaggggattctcc
gccggaagaggttatcccgtcgaactcgtgttaaccggtcccgattggcagaagttgtca
gcttattccgttcagatcttggatcgactgaaagaaagtaaggcggtcttggacgtggat
acggattacgtcgccggtcagaaagaacttagactcgttaccaatcgagaagccgccgct
ctccgcggagtcagtatggcgaacgtaggaaacaccgtaggaactttgatgggtggaaag
aacgtgagtcgttttactgaaaacggaagaagctacgacgtaagagtaaaaattcaaaaa
gacaaaggtgaaaccgcttcggtcatttccgaaatcggagttcgaaacacgttcggagaa
tttgtaaaactaaaagaaattttgagcattcaggaaaaggaagccttgaagacgattacc
cgcatcaaccgagaaagggcaattcgtgtttttggaaatccggccccggcgctcggacaa
aacgcttcgaccgaaaaagccctcgagatcgcaaaggaaattcttccggacggatattcc
gtttccgtaactggttccgcaaaaacggccaaggagtctggaaacagccttacgcttgcg
ttgttattcggaattctcctttcttacatgatcctcgcgagtcagtttaatagtttgaaa
caacccctctatattcttctcgcgatgccttttagttttactggtgcgttagtcgctctt
tatgtcttcggtcagtcgtttaatatgtacagttttatcgggctcattcttcttttgggt
ttggtaaagaaaaattcgattcttcttgtcgagtttgtaaatcacgttcgttcggaagga
aagagtatcaaagaggcgatcaaagaaggttgtccgattcgtctacgaccggtgctcatg
acttcctttagttcgatcgccgccgcgattcctccggctctggcgctcggacccggcgcc
gaaactcgtattccgatggcagtcacaattttgggtgggatgactctttcgactctgatc
acgcttttggtagttcccgcggcgtattatctgggtgaaaaagaaaaggaagaaatggcc
gaggaaaaattgattctttttccagaaccgatcgcaaaaaataaaaaaacaaaaaaatga

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