Loxodonta africana (African savanna elephant): 100665515
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Entry
100665515 CDS
T04351
Symbol
ITCH
Name
(RefSeq) E3 ubiquitin-protein ligase Itchy homolog isoform X1
KO
K05632
E3 ubiquitin-protein ligase Itchy [EC:
2.3.2.26
]
Organism
lav
Loxodonta africana (African savanna elephant)
Pathway
lav04120
Ubiquitin mediated proteolysis
lav04144
Endocytosis
lav04330
Notch signaling pathway
lav04668
TNF signaling pathway
lav04932
Non-alcoholic fatty liver disease
Brite
KEGG Orthology (KO) [BR:
lav00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
100665515 (ITCH)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
100665515 (ITCH)
04668 TNF signaling pathway
100665515 (ITCH)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
100665515 (ITCH)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
100665515 (ITCH)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
lav04131
]
100665515 (ITCH)
04121 Ubiquitin system [BR:
lav04121
]
100665515 (ITCH)
Enzymes [BR:
lav01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
100665515 (ITCH)
Membrane trafficking [BR:
lav04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
100665515 (ITCH)
Ubiquitin system [BR:
lav04121
]
Ubiquitin ligases (E3)
HECT type E3
100665515 (ITCH)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
HECT
WW
C2
PQQ_2
Motif
Other DBs
NCBI-GeneID:
100665515
NCBI-ProteinID:
XP_003411715
LinkDB
All DBs
Position
Unknown
AA seq
862 aa
AA seq
DB search
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
QLVGDKEPTETIGDLSVCLDGLQLESEVVTNGETTCSESTSQNDDGSRPKDETRVNTNGS
DEPEDAGSGENRRVNGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
GSSTGSLPPTNTNTSTSEGATSGLIIPLTISGGAGPRPLNSVAQAPLPPGWEQRVDQHGR
VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
LQRSQLQGAMQQFNQRFIYGNQDLFASSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGISYFVDHNRRTTTYIDPRTGKSALDNGPQ
IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF
PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGL
EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDN
EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
SYEQLKEKLLFAIEETEGFGQE
NT seq
2589 nt
NT seq
+upstream
nt +downstream
nt
atgtctgacagtggatcacaacttggttcaatgggtagcctgaccatgaaatcacaactt
caaatcactgtcatctccgcaaaactcaaagaaaataaaaagaattggttcggaccaagt
ccttacgtggaagtcacagtagatggacagtcaaagaagacagaaaaatgcaacaatacg
aacagtcccaaatggaagcaaccccttacagttatcgtcacccctgtgagtaaattacat
tttcgtgtgtggagccaccagactctgaaatctgatgttttgttgggaactgctgcatta
gatatttatgaaacattaaagtcaaacaatatgaaacttgaagaagtggttgtgactttg
cagcttgtaggtgacaaagagcccacagagacaataggagacttgtcagtgtgtcttgat
gggctgcagttagagtctgaagttgttactaatggtgaaactacgtgctcagaaagtact
tcacagaacgatgacggctccaggcccaaggatgaaacaagagtgaacacaaatggatcc
gatgaacctgaggatgcagggtctggtgaaaataggagggtcaatgggaataattctcca
tcactctcaaatggcggttttaaaccttctaggcctccaagaccttcacgaccgcctcca
cctaccccacgtagaccagcatctgtcaatggttcgccatctgccacctcagaaagtgac
ggatctagcacaggctctctgccaccaacgaatacaaatacaagtacatctgaaggggct
acatctggactaataattcctcttactatatccggaggcgcaggccctaggcccttaaat
tctgtcgctcaagctcctctaccacccggctgggagcagagagtggaccagcatgggcga
gtctactatgtagatcatgttgaaaaaagaacaacgtgggatagaccagaacctctacct
ccgggttgggaacggcgggttgacaacatgggacgtatttattatgttgaccatttcaca
agaacaacaacgtggcagaggccaacgttggaatccgtccgtaactatgaacagtggcag
ctacaacgaagtcaacttcaaggagcaatgcagcagtttaaccagagattcatttacggg
aatcaagatttgtttgcttcatcacaaagtaaagaatttgatccccttggtccgttgcca
cctggatgggagaagagaacggacagcaatggcagagtatattttgtcaaccacaacact
cgtattacacagtgggaagaccccagaagtcaaggtcagttaaatgaaaaacccttacca
gaaggctgggaaatgagattcactgtggatggaatttcatattttgtggaccacaataga
agaacaaccacctatatagatccccgcacaggaaaatctgccctagacaatggaccccag
atagcctatgttcgggacttcaaggcaaaggttcagtatttccggttctggtgtcagcaa
ctggccatgcctcagcacataaagattacagtgacaagaaaaacgttgtttgaggattcc
tttcagcagataatgagcttcagtccccaagacctgcgaagacgtttgtgggtgattttt
ccaggagaagaaggtttagattatggaggtgtagcaagagaatggttctttcttttgtca
catgaggtcttgaacccaatgtattgcctgtttgaatatgcagggaaggataactactgc
ttacagataaaccctgcctcttacatcaatccagatcacctgaaatattttcgttttatt
ggcaggtttattgccatggctctgttccatgggaaattcatagacacgggtttttctttg
ccattctacaagcgtatcttgaacaagccagttggactcaaggatttagaatctattgat
ccagaattttacaattctctcatctgggttaaagaaaacaatattgaagaatgcggtttg
gaaatgtacttctcagttgataaggaaattctaggtgaaattaagagtcatgatttgaaa
cccaatggcggcaatattcttgtaacagaagaaaataaagaggaatacatcagaatggta
gctgagtggaggttgtctcgaggtgttgaagaacagacacaagctttcttcgagggcttt
aatgaaatacttccccagcagtatttgcagtactttgatgcaaaggaattagaggtcctt
ttatgtggaatgcaagagattgatttaaatgactggcaaagacatgccatctaccgtcat
tacaccaggacaagcaagcaaatcatgtggttttggcagtttgttaaagaaattgataat
gagaagagaatgagacttctgcagtttgtaactggaacctgccgattgccagttggagga
tttgctgacctcatggggagcaatggaccacagaagttttgcattgaaaaagttgggaaa
gaaaattggttacctagaagtcatacctgttttaaccgcctggacctgccaccctataag
agttacgagcaactgaaggaaaagctgctgtttgccattgaagaaacagaaggatttgga
caagaatag
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