| Entry |
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| Symbol |
IRS2
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| Name |
(RefSeq) insulin receptor substrate 2 isoform X3
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| KO |
| K07187 | insulin receptor substrate 2 |
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| Organism |
lav Loxodonta africana (African savanna elephant)
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| Pathway |
| lav04213 | Longevity regulating pathway - multiple species |
| lav04920 | Adipocytokine signaling pathway |
| lav04923 | Regulation of lipolysis in adipocytes |
| lav04932 | Non-alcoholic fatty liver disease |
| lav04935 | Growth hormone synthesis, secretion and action |
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| Brite |
KEGG Orthology (KO) [BR:lav00001]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
100676904 (IRS2)
04022 cGMP-PKG signaling pathway
100676904 (IRS2)
04152 AMPK signaling pathway
100676904 (IRS2)
09133 Signaling molecules and interaction
04081 Hormone signaling
100676904 (IRS2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100676904 (IRS2)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
100676904 (IRS2)
04923 Regulation of lipolysis in adipocytes
100676904 (IRS2)
04920 Adipocytokine signaling pathway
100676904 (IRS2)
04935 Growth hormone synthesis, secretion and action
100676904 (IRS2)
09149 Aging
04211 Longevity regulating pathway
100676904 (IRS2)
04213 Longevity regulating pathway - multiple species
100676904 (IRS2)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
100676904 (IRS2)
09164 Neurodegenerative disease
05010 Alzheimer disease
100676904 (IRS2)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
100676904 (IRS2)
04932 Non-alcoholic fatty liver disease
100676904 (IRS2)
04931 Insulin resistance
100676904 (IRS2)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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| AA seq |
1364 aa
MASPPLNALPAPAGAAGGGGSAGGGGPNLNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGP
GGGGGGAGGDEPGAGGGQPPQPPRLEYYENEKKWKNKSGAPKRVIALDCCLNINKRADAK
HKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVNEGRAGAGDAPSARCAASSASCSAS
LPGPGAFGGSAGAADDNYGLIAPATSVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTI
GFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHET
ILEAMKALKELFEFRPRSKSQSSGSSSTHPISVPGARRHHHLVNLPPSQTGLVRRSRTDS
LAATPPAAAGAKGSSCRVRTASEGDGSAGAAGAGGCRPVSVAGSPMSPGPMRTPLSRSHT
LSSGCGGHPSKMLLAPAGGALQHSRSMSMPVSHSPPAATSPGSLSSSSGHGSGSYSLPPG
PHPHLPHPLHHHQGQRPSSGSASASGSPSDPGFISLDEYGSSPGDLRAFCSHRSNTPESI
AETPPAREGSGGELYGYMTMDRPLSHCGRPYRRVSGDGAQDLDKGLRKRTYSLTTPARQR
AVPQPSSASLDEYTLMRATFSGSSGRLCPSCPASSPKVAYNPYPEDYGDIEIGSHRSSSS
NLGVDDGYMPMTPGVAPLVGGGSCKSDDYMPMSPTSVSAPKQILQPRVPTSALPPTGAGV
PAAASAAGRGFAVHGGSYKTSSPAESSPEDSRYMRMWCGSKLSMENPDSKLLSNGDYLNM
SPSDAGTSCTPPDFFSAALHSGGEVLKGVPGYCYSSLPRSYKAPYTCNGDNDQYVLMSSP
VGRILEEDRQEQQTSPQPLATPVSTQSASTFGPSGSSHIQPHHPAVPSPLRQSTSSRPEG
FLNQRCRAVRPTRLSLEGLQTLPSMHEYPLPPEPKSPGEYINIDFVEAGARLSPPAPPLL
ASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGTQSGDPV
GSLDGLLSPEASSPYPPLPPRPSATPSSASSQQPQPPLPPPPGELYRLPAVSVAATSQGP
SAASSSSSETGDNGDYTEMAFGVAATPPQPIAAPPKPESARVTSPTPGVKRLSLMDQVSG
VEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSAS
VENVSLRKSGEGGGSGVGVGLGGGDEPPRSPHQSQPALSVPSLPQQPRPWTQSQSVGLIG
CPGGSGSPMRRETSAGFQNGLNYIAIDVREETGLLPLQQQQQQPGEKNSWGRNHGLGGLI
NTVGGGSTSGVCGGPGPGTLPSTNAYASIDFLSHHLKEAAVVKE |
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| NT seq |
4095 nt +upstreamnt +downstreamnt
atggcgagcccgccgctgaacgcgctccccgccccggccggggccgcgggcggcggcggg
agcgcggggggcggcggccccaatctcaacaacaacaacaacaaccacagcgtgcgcaag
tgcggctacctgaggaagcagaaacacggccacaagcgcttcttcgtgctccgcggcccc
ggcggcggcggcggcggcgcgggcggcgacgagccgggggcgggcggggggcagccgccg
cagcccccccggctcgagtactacgagaacgagaagaagtggaagaacaagtcgggggcc
ccgaagcgggtgatcgcgctggactgctgcctgaacatcaacaagcgcgccgacgccaag
cacaagtacctcatcgccctctacaccaaggacgagtacttcgccgtggcggccgagaac
gagcaggagcaggagggctggtaccgcgcgctcaccgacctggtcaacgagggccgcgcg
ggcgccggcgacgcgccctccgcgcgctgcgccgccagctccgcgtcctgcagcgcctcc
ctgcccggccccggcgccttcgggggctcggccggcgccgccgacgacaactacgggctc
atcgcgcccgccacctcggtctaccgcgaggtctggcaggtgaacctgaagcccaagggc
ctgggccagagcaagaacctgaccggcgtgtaccgcctgtgcctgtcggcgcgcaccatc
ggcttcgtgaagctcaactgcgagcagccgtcggtcacgctgcagctgatgaacattcgc
cgctgcggccactcggatagcttcttcttcatcgaggtgggccgctcggccgtcacgggc
cccggcgagctgtggatgcaggccgacgactcggtggtggcgcagaacatccacgagacc
atcctggaggccatgaaggcgctcaaggagctcttcgagtttcggccgcgcagcaagagc
cagtcttcgggctcctcctccacgcaccccatcagcgtgcccggcgcgcggcgccaccac
cacctggtcaacctgccccccagccagaccggcctggtgcgccgctcgcgcaccgacagc
ctggccgccacgcctccggccgcggcgggcgccaagggcagctcctgccgggtgcgcacg
gccagcgagggagacggtagcgcgggcgcggcgggggcaggcggctgcaggcccgtgtcg
gtggcggggagccccatgagccccggaccgatgaggacgccactgagccgctcgcacacc
ctgagcagcggctgcggcggccatccgagcaagatgctgctggcgccggcagggggtgcc
ctgcaacacagccgctccatgtccatgcccgtgtcccactctcccccggcggccaccagc
cctggcagcctctcgtccagcagtgggcacggctcgggctcctactcgctgcctccaggc
ccacacccgcacctgccgcaccccctgcaccatcaccagggccagcggccctccagtggc
agtgcctctgcctcgggctcccccagcgatcccggtttcatatccctggatgagtatggc
tccagccctggcgacttgagagccttttgcagccaccgaagcaacactcctgagtccatc
gcagagaccccacctgccagagagggcagtgggggtgagctgtacgggtatatgaccatg
gacaggcccctgagccactgtggccgcccctaccgcagagtttcaggggacggggctcag
gacttggacaaagggctgaggaagaggacttattcactgaccacacctgctcgacagcgg
gcagtgccccagccctcctccgcatctctggatgagtacaccctgatgcgggctaccttt
tccggcagctcgggccgtctctgcccctcctgcccggcgtcctctcccaaagtggcttac
aacccctaccccgaggactacggagacatagagatcggctcccacaggagctccagcagt
aacctgggggtagatgatggctacatgccgatgacccctggtgtggccccgctcgtgggt
gggggtagctgtaagagtgacgactacatgcccatgagcccaaccagtgtgtctgccccc
aagcagatcctacagccccgggttcccacttcagccttgccccccactggagctggggta
ccagcagcagcctctgcagctgggagaggctttgcagtccacgggggcagttacaagacc
agctcccctgcagagagctccccagaggacagtcggtacatgcgtatgtggtgtggctcc
aagctgtccatggagaatcctgacagcaagctgctttccaatggggactacctcaacatg
tcccccagtgatgcgggtacttcctgtaccccacccgacttcttctcagctgccttgcac
agtggtggagaagtactcaagggagtacccggctactgctacagctccttgcctcggtct
tataaggctccttacacctgcaatggggacaacgaccagtatgtactcatgagctcccca
gtggggcggatcctggaagaggacagacaagagcaacagaccagtccgcagccgctggcc
accccagtgagcacccaatcggccagcaccttcgggcccagcgggagcagccacatccaa
cctcaccacccagcagtgccttcacccctgaggcagagcaccagcagccggccagaggga
ttcctgaaccaacgctgccgggcagtgcggcccactcgcctgtccctggaggggcttcag
actctgcccagcatgcacgaataccctctgcccccagaacccaagagccccggcgagtac
atcaacattgactttgtcgaggctggagctcgcctttccccaccggctcctccactgctg
gcgtcggcggcctcgtcttcctcgctgctgtcagccagtagcccagcctcctccctgggt
tctggcacccctgggaccagcagcgacagccggcaacgctctcctctctcagattacatg
aaccttgacttcagctcgcccaagtcacccaaaccgggtacccagagcggggaccccgtg
ggctccttggatggccttctgtcgcctgaggcctcctcgccctacccgccgctgccccca
cgcccctccgccactccttcttcagcctcctcccagcagccgcaaccacccctgccgcca
ccaccaggggagctgtaccgcctgcctgcggtgtctgtcgctgccacctcccagggcccc
agcgctgcctcgtcttcatcctccgagactggggataatggtgactacaccgagatggcc
tttggtgtggctgccaccccgccacaacctatcgcggcacccccaaagccagaaagtgcc
cgtgtgaccagcccgacgcctggcgtgaagaggctgagtctcatggatcaggtgtcaggg
gtcgaagccttcctgcaggctagccaacccccagacccacaccggggggccaaggtcatc
cgcgccgacccgcaggggggccgtcgccggcacagctcggagaccttctcctcaaccacc
actgtgacccccgtgtccccgtccttcgctcataatcctaagcgccacaactctgcctcc
gtggaaaatgtctctctcaggaaaagtggcgaaggcggtggcagtggtgtgggggtaggc
cttggagggggagatgagccacccagatccccccaccagtcgcagccggcactttctgtg
ccgtcgcttccccagcagccaaggccttggacacagagccagtctgtggggttaataggc
tgccctgggggcagtggttctcccatgcgtagggagacctctgctggcttccagaatggt
ctcaactacatcgccattgacgtgagggaggagacggggctgttacccctgcagcagcag
cagcagcagccaggagagaagaactcctggggccggaaccatggccttggtggtctcatc
aacactgtaggtggtggcagcaccagtggggtctgtggggggcctggccctggcaccctg
ccctccaccaacgcctacgcgagcattgacttcttgtcacatcacctgaaggaggctgct
gtcgtgaaagagtga |
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