KEGG   Lemur catta (Ring-tailed lemur): 123622735
Entry
123622735         CDS       T08326                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
lcat  Lemur catta (Ring-tailed lemur)
Pathway
lcat00562  Inositol phosphate metabolism
lcat01100  Metabolic pathways
lcat01521  EGFR tyrosine kinase inhibitor resistance
lcat04012  ErbB signaling pathway
lcat04014  Ras signaling pathway
lcat04015  Rap1 signaling pathway
lcat04020  Calcium signaling pathway
lcat04062  Chemokine signaling pathway
lcat04064  NF-kappa B signaling pathway
lcat04066  HIF-1 signaling pathway
lcat04070  Phosphatidylinositol signaling system
lcat04072  Phospholipase D signaling pathway
lcat04360  Axon guidance
lcat04370  VEGF signaling pathway
lcat04613  Neutrophil extracellular trap formation
lcat04650  Natural killer cell mediated cytotoxicity
lcat04658  Th1 and Th2 cell differentiation
lcat04659  Th17 cell differentiation
lcat04660  T cell receptor signaling pathway
lcat04664  Fc epsilon RI signaling pathway
lcat04666  Fc gamma R-mediated phagocytosis
lcat04670  Leukocyte transendothelial migration
lcat04722  Neurotrophin signaling pathway
lcat04750  Inflammatory mediator regulation of TRP channels
lcat04919  Thyroid hormone signaling pathway
lcat04933  AGE-RAGE signaling pathway in diabetic complications
lcat04935  Growth hormone synthesis, secretion and action
lcat05012  Parkinson disease
lcat05022  Pathways of neurodegeneration - multiple diseases
lcat05135  Yersinia infection
lcat05167  Kaposi sarcoma-associated herpesvirus infection
lcat05170  Human immunodeficiency virus 1 infection
lcat05171  Coronavirus disease - COVID-19
lcat05200  Pathways in cancer
lcat05205  Proteoglycans in cancer
lcat05206  MicroRNAs in cancer
lcat05214  Glioma
lcat05223  Non-small cell lung cancer
lcat05225  Hepatocellular carcinoma
lcat05231  Choline metabolism in cancer
lcat05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lcat05417  Lipid and atherosclerosis
Module
lcat_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:lcat00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123622735 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    123622735 (PLCG1)
   04014 Ras signaling pathway
    123622735 (PLCG1)
   04015 Rap1 signaling pathway
    123622735 (PLCG1)
   04370 VEGF signaling pathway
    123622735 (PLCG1)
   04064 NF-kappa B signaling pathway
    123622735 (PLCG1)
   04066 HIF-1 signaling pathway
    123622735 (PLCG1)
   04020 Calcium signaling pathway
    123622735 (PLCG1)
   04070 Phosphatidylinositol signaling system
    123622735 (PLCG1)
   04072 Phospholipase D signaling pathway
    123622735 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    123622735 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    123622735 (PLCG1)
   04660 T cell receptor signaling pathway
    123622735 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    123622735 (PLCG1)
   04659 Th17 cell differentiation
    123622735 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    123622735 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    123622735 (PLCG1)
   04670 Leukocyte transendothelial migration
    123622735 (PLCG1)
   04062 Chemokine signaling pathway
    123622735 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    123622735 (PLCG1)
   04919 Thyroid hormone signaling pathway
    123622735 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    123622735 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123622735 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    123622735 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123622735 (PLCG1)
   05206 MicroRNAs in cancer
    123622735 (PLCG1)
   05205 Proteoglycans in cancer
    123622735 (PLCG1)
   05231 Choline metabolism in cancer
    123622735 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123622735 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    123622735 (PLCG1)
   05214 Glioma
    123622735 (PLCG1)
   05223 Non-small cell lung cancer
    123622735 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    123622735 (PLCG1)
   05171 Coronavirus disease - COVID-19
    123622735 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123622735 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    123622735 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    123622735 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    123622735 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123622735 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123622735 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123622735 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lcat04131]
    123622735 (PLCG1)
Enzymes [BR:lcat01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123622735 (PLCG1)
Membrane trafficking [BR:lcat04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123622735 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123622735 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 PH_12 SH3_2 GDPD EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 123622735
NCBI-ProteinID: XP_045385239
LinkDB
Position
17:complement(18076085..18113896)
AA seq 1327 aa
MAGTASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLSWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNTQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVPHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGRHCGYVLQPGTMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDNAKQKTEFVGESAFPSHP
SEAGKAPPHQSPHLLQGGLKPFPLASAVDNGLNPMWPAKPFLFQISNPEFAFLRFVVYEE
DMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDVFPAKQENGDLSPF
SGTSLRERGSDASGQLFHGRAREGSFEARYQQPFEDFRISQEHLADHFDSRERRAPRRTR
VNGDNRL
NT seq 3984 nt   +upstreamnt  +downstreamnt
atggcgggcaccgcgtccccctgcgccaatggctgcgggcccggcgcgccctcggacgcc
gaggtactgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccgcggcgccgacaagatcgagggggccattgatattcgtgaaatcaaggag
atccgcccagggaagacctcacgggactttgatcgctatcaagaggaccctgctttccgg
ccagaccagtcacactgctttgtcatcctctatgggatggaattccgcctgaagaccctg
agcctgcaagccacatctgaggatgaggtgaacatgtggatcaagggcttatcttggcta
atggaggacacattgcaggcagccacacccctgcagattgagcggtggctccggaagcag
ttctactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgagtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcagcggggacatcacctatgggcagtttgctcagctataccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggct
ggggagcggccagagctttgccgagtgtcccttcctgagttccagcagttcctcctcgac
taccagggggagctatgggctgtagaccggctccaggtgcaagagttcatgctcagcttt
ctccgagaccccttgcgagagattgaagaaccatatttctttctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaatacccagctagatgcggtgtgcccagac
accatgaacaaccctctctcccactactggatctcctcctcgcacaacacgtacctgact
ggggaccagttctccagtgagtcctcgctggaagcctacgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggatggcccagatgggatgccggtcatttaccac
ggacacaccctcaccaccaagatcaagttctcagacgtcctgcacaccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagtacttcaagaaggtgcttggggacacgctcctcactaag
ccagtggacatcgccgctgatgggctgccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggctgagggcagcgcctacgaggaggtgcctacatccgtgatg
tactctgagaacgacattagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccacgaatggtatccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcggc
agcacagagctacactccaacgagaagtggttccacgggaagcttggggcggggcgggat
gggcggcacatcgctgagcgcttgctcaccgagtactgtatcgagaccggggcccccgac
ggctccttcctggtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg
cggaacgggaaggtccagcactgccgtatccactcccggcaggatgctgggacccccaag
ttcttcttgacggacaacctcgtctttgactccctctacgacctcatcacgcactaccag
caggtgcccctgcgctgcaatgagtttgagatgcgcctttcagagcctgtcccacagacc
aatgcccacgagagcaaagagtggtaccatgcaagcctgaccagagcgcaagccgagcac
atgctgatgcgtgtaccccgggatggggcctttctggtgcggaaacggaatgaacccaac
tcatacgccatctccttccgggctgagggcaagatcaagcattgccgcgtccagcaggag
ggccagactgtgatgctgggcaactcggagtttgacagccttgttgacctcatcagctac
tacgagaagcatccgctgtaccgaaagatgaagctgcgctatcccatcaatgaggaggcg
ctggagaagattggcacagctgagcccgactacggggccctgtatgagggacgcaaccct
ggcttctacgtagaggcgaaccctatgccgactttcaagtgtgcagtcaaagccctcttc
gactacaaggcccagagagacgacgagctgacctttaccaagagtgctatcatccagaac
gtggagaagcaggagggaggctggtggcgaggggactatggagggaagaagcagctgtgg
ttcccatcaaactatgtggaagagatggtcagcccagtggcactggagccggagagggag
cacttggacgagaacagccccttgggggacttgctgcggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcctcagtgccccactggtccctggacgttgctgctgactcccaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagactgcagatgccaggctcacggagggg
aagatgatggaacggaggaagaagatcgccctggagctctctgagcttgtcgtctactgc
cggcctgttcccttcgatgaagagaagatcggcacagaacgtgcctgctaccgggacatg
tcatcctttccggaaaccaaggctgagaaatacgtgaacaaggctaaaggcaagaagttc
ctccagtacaatcggctgcagctgtcccgcatctaccccaagggccagcggctggactcc
tccaattacgatcctttgcccatgtggatctgtggcagtcagcttgtggccctcaacttc
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggctggcaggcactgc
ggctacgtgctgcagccaggcactatgcgcgacgaggcctttgacccctttgacaagagc
agcctccgcgggctggagccatgtgccatctgtattgaggtgctgggggcccggcatctg
ccgaagaatggccgaggcattgtgtgtcctttcgtggagatcgaggtggctggagctgag
tatgacaacgctaagcagaagacagagtttgtgggtgagtctgccttccccagtcatcct
tcagaggcagggaaagcccctccccatcagtcacctcatctcctccagggtggcctgaag
ccttttccccttgcttctgcagtggacaatggacttaaccccatgtggccggccaagccc
ttcctcttccagatcagtaaccctgagtttgccttcctgcgcttcgtggtgtatgaggaa
gacatgtttagtgaccagaacttcctggctcaggctactttcccagtaaaaggcctgaag
acaggatacagagcggtgcctttgaagaacaactacagtgaggacctggagttggcctcc
ctgcttatcaagatcgacgttttccctgccaagcaggaaaacggtgacctcagtcccttc
agtggtacgtccctgcgggagcggggctcagatgcctcaggccagctgtttcacggccgg
gcccgggaaggctcctttgaagcccgctaccagcagccatttgaggacttccgcatctcc
caggagcatctcgcagaccattttgacagtcgggaacgaagggccccaagaaggactcgg
gtcaatggagacaaccgcctctag

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