Lemur catta (Ring-tailed lemur): 123624371 Help Entry 123624371         CDS       T08326                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism lcat  Lemur catta (Ring-tailed lemur) Pathway lcat04020   Calcium signaling pathway lcat04371   Apelin signaling pathway lcat04713   Circadian entrainment lcat04730   Long-term depression lcat04921   Oxytocin signaling pathway lcat05017   Spinocerebellar ataxia lcat05020   Prion disease lcat05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:lcat00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     123624371 (RYR1)    04020 Calcium signaling pathway     123624371 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     123624371 (RYR1)   09156 Nervous system    04730 Long-term depression     123624371 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     123624371 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     123624371 (RYR1)    05020 Prion disease     123624371 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     123624371 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:lcat01009]     123624371 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:lcat04147]     123624371 (RYR1)    04040 Ion channels [BR:lcat04040]     123624371 (RYR1) Protein phosphatases and associated proteins [BR:lcat01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      123624371 (RYR1) Exosome [BR:lcat04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    123624371 (RYR1) Ion channels [BR:lcat04040]  Voltage-gated cation channels   Ryanodine receptor    123624371 (RYR1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  123624371 NCBI-ProteinID:  XP_045388053 LinkDB All DBs Position 19:complement(30312170..30417450) Genome browser AA seq 5039 aa AA seqDB search MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD LAICCFILEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSTASGELQVDASFMQTLWNMNPICSRCEEGYVTGGHVLRLFHGHMDECLTISPADSDDQ RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLVV VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTAGLYNQFIKGLDSF SGKPRGSGPPAGTALPIEGVILSLQDLIVYFEPPSEELQHEEKQSKLRSLRNRQSLFQEE GMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRTNCALFS TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTDLINYVTSIRPNIFVGRADGSTQYGK WYFEVMVDEVVPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHL WTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPVV SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVESQSRWDRVRIFRAEKSY AVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR PWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFRDIEIGDGFLPVCSLGPGQVGH LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVARVD GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED EARAAEPDPDYENLRRSAGRWGEAEGGKEGTAKEGAPGGAPQAGGEAPPVRVENEKDATT EKNKKRGFLFKAKKVAMMTQPPATPALPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA GQEPSCVWVGWVTPDYHQHDMNFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV SPGQQGRISHSDLVIGCLVDLATGLMTFTGNGKESNTFFQVEPNTKLFPAVFVLPTHQNV IQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG ERLGWAVQCQEPLTMMALHVPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYVVPLTEE TRSITLFPPGRSAENGPRHHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGVFGDEDVK QILKMIEPEVFTEEEEEGEEEEEEEEEEDEEEKEEDEEEEAQEKEDEEKEEEEAAEGEKE EGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQDNQRSRYGL LMKAFTMSAAETARRTREFRSPPQEQINMLLHFKDGPEEEDCPLPEELRQDLLDFHQDLL LHCGIQLGGEEEEPEEETTLGSRLMSLLEKVRLVKKEEEKPEEEPPAEESHPRSLQELVS HTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSMEDTMSLLECL GQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMQVMVNVLGGGE SKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAAS VIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGSERYLDFLRFAV FVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVRR DRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRS LVPLEDLVGIISLPLQIPTLGKEGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLL HVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMV DSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKM PLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMA MPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFA EYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAW EWTIEKAREGEEEKTEKKKTRKISQSAQTYDAREGYNPQPPDLSGVTLSRELQAMAEQLA ENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTR GLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFA KILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGT DAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQAR TQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTR NAYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEM CPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPTAGAP PPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIMSRARPELLHSHFIPT IGRLRKRAGKVVAEEEQLRLEAKAEAEEMLVRDEFSVLCRDLYALYPLLIRYVDNNRAQW LTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAKSGG SDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIMLAKTRYALKDTDEE VREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLYHLDQ TEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMLLESYKAAWIMTEDHS FEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYIAYADI MAKSCHLEEGEENGGGGAEDEQEEEVEVSFEEKEMEKQRLLYQQARLHNRGAAEMVLQMI SACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLD LNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYL RTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFN SLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDM VVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTD PRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPAREIGFNV AVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGSSRRIERIYFEISETNRA QWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEMQIAAQISEPEGEPETDED EGAGAGAGEAGAEGAEEGAAGPEGAAGAAAAAGMTARAVAAAGQALRRLSYRSLRRRVRR LRRLTAREAATAATALLWAAVTCVGAAGAGAAKGALRLLWGSLFGGGLVEGAKKVTVTEL LAGMPDPTGDEVHGEQPAGPGGDADGEGAGEGAGDAAEGVDDEEVAVHDAGPGGPDGAVA VSDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPIFKRKLGGDGEEEELPPEPEPEPEPEP EPEKADAENGEKEEVPEPPPEPPKKKAPPPPTLKKEEAGGEFWGELEVQRVKFLNYLSRN FYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDLSTAGSGGGSGWGSGAGEE AEGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELA RKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIA ELLGMDLATLEITAHNERKPSPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVM SLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNF FRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDI TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETH TLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15120 nt NT seq  +upstreamnt  +downstreamnt atgggtgacgcagaaggcgaggacgaggtccagttcctgaggacggacgacgaggtggtc ctgcagtgcagcgccaccgtgctcaaggagcagctcaagctctgcctggccgccgagggc ttcgggaaccgcctctgcttcctggaacccaccagcaacgcccagaatgtgccccccgat ctggccatctgctgcttcatcctggagcagtccctgtctgtccgagccctgcaggagatg ctggccaacacggtggaggccggcgtggagtcatcccagggcgggggacacaggacgctc ctgtacggccatgccatcctgctccggcatgcacacagccgcatgtacctgagctgcctc accacctcccgttccatgactgacaagctggccttcgacgtgggactgcaggaggatgcc acaggagaggcctgctggtggacgatgcacccggcctccaagcagaggtccgaaggagaa aaggtccgtgtgggcgatgacctcatccttgtcagtgtctcctctgagcgctacctgcac ctgtcgacagccagcggggagctccaggtcgatgcctccttcatgcagacactgtggaac atgaaccccatctgctctcgctgcgaagagggctacgtgacagggggccatgtcctccgc ctcttccacggacacatggatgagtgtctgaccatttcccctgctgacagtgatgaccag cgcagacttgtctactacgagggcggagccgtgtgtacccacgcccgctccctctggagg ctggagccattgagaatcagctggagtgggagccaccttcgctggggccagccacttcgg atccggcatgtcaccaccgggcggtacctggcgctcactgaggaccagggcctggtggtg gttgacgccagcaaggcccacaccaaggccacctccttctgcttccgcatctccaaggaa aagttggatgtggcccccaagcgggacgtggagggcatgggcccccctgagatcaagtac ggggagtcactgtgctttgtgcagcatgtggcctcgggcctgtggctcacttatgccgcc ccggaccccaaggccctgcggctcggcgtgctcaagaagaaggccatgctgcaccaggaa ggccacatggacgacgcactgtcgcttacccgctgccagcaggaggagtcccaggctgcc cgcatgatccacagcactgccggcctgtacaaccagttcatcaagggccttgacagcttc agcgggaagccacggggctcggggccaccggctggcacggcgctgcccatcgagggcgtc atcttgagcctgcaggacctcatcgtctactttgagccaccctcggaggagctgcagcac gaggagaagcagagcaagctgcgcagcctgcgcaaccgccagagcctcttccaggaggag gggatgctctccctggtcctgaattgcattgaccgcctaaatgtctacaccaccgctgcc cactttgctgaatttgcgggggaggaggcagctgagtcctggaaggagattgtgaatctg ctctatgaactcctggcctctctgatccgcggcaatcgtaccaactgtgccctcttctcc acgaacttggactggctggtcagcaaactggatcggttggaggcctcgtctggcatcctg gaggtgctgtactgtgtcctgattgagagtcccgaggtcttgaacatcatccaggagaac cacatcaagtccatcatctccctcctggacaagcatgggaggaaccacaaggtcctggat gtgctatgctccctgtgtgtgtgcaatggcgtggctgtgcgctccaaccaagatctcatt actgagaacttgctccctggccgtgagcttctgctgcagacagacctcatcaactatgtc accagcatccgccccaacatctttgtgggccgagcggacggctccacgcagtacggcaaa tggtactttgaggtgatggtggacgaggtggttccatttctgacagctcaggccacccac ctgcgggtgggctgggccctcaccgagggctacagcccctatcccgggggcggcgagggc tggggcggcaacggggtcggcgatgacctctactcctacggctttgacgggctgcatctc tggacaggacacgtggcacgcccagtgacttccccagggcagcacctcctggcccctgag gacgtggtcagctgctgcctggacctcagcgtgccatccatctccttccgcatcaacggc tgtcccgtgcagggtgtcttcgaggccttcaacctcgacgggctcttcttccctgtcgtc agcttctcggctggtgtcaaggtgcggttcctccttggtggccgccatggtgaattcaag ttcctcccgccacctggctatgccccatgccacgaggctgtgctccctcgagagcggctc catcttgaacccatcaaggagtatcgacgggaggggccccgggggcctcacctggtgggc cccagtcgctgcctctcacacacggactttgtgccctgccctgtggacactgtccagatt gtcctgcctccccatctggagcgcattcgggagaagctggcggagaacatccacgaactc tgggcgctgactcgcatcgagcagggctggacctacggcccggttcgggatgacaacaag aggctgcacccgtgtcttgtggacttccacagcctgccagagcccgagaggaattacaac ctgcagatgtcgggggagacgctcaagaccctgctggcactgggctgccacgtgggcatg gcggacgagaaggcggaggacaacctgaagaagacaaaactccctaagacgtatatgatg agcaacgggtacaagccggctccgctggacctgagccacgtgcggctgacgccagcgcag acaacactggtggatcgtctggcagaaaatgggcacaacgtgtgggcacgagaccgcgtg ggccagggctggagctacagcgccgtgcaggacatccctgcacgccggaacccccggctc gtgccctaccgcctgctagacgaggccaccaagcgcagcaaccgggacagcctctgccag gccgtgcgcaccctgctgggctacggctacaacattgagccgcctgaccaggagcccagt caagtggagagtcagtctcgatgggaccgggtgcgcatcttccgggcagagaaatcctat gcagtgcagagtggacgctggtactttgaatttgaggcagtcaccacgggtgaaatgcga gtgggctgggcgaggccagagctgaggcctgatgtagagctgggagctgatgagctggca tatgtcttcaatgggcaccgcggccagcgctggcacttgggcagtgaaccatttgggcgc ccctggcagtcgggcgacgtcgtcggctgcatgattgacctcacagagaacaccattatc ttcactcttaatggcgaggtcctcatgtctgactcaggctctgaaacagctttccgggac attgagattggggacggcttcctgcccgtctgcagcttgggaccaggccaggtcggtcac ctgaacctgggccaggacgtgagctccctgcggttttttgccatctgtggcctccaggag ggctttgagccatttgccatcaacatgcagcgtccagtcaccacctggttcagcaagagc cttccccaatttgaggctgtgccccttgaacacccccactatgaggtggcccgcgtggac ggcactgtggacacgcccccctgcctgcgcctgacccaccgcacctggggctcccagaac agcctagtggagatgctcttcctgcggctgagccttccggtccagttccaccagcacttc cgctgcaccgcgggggccacccccctggcaccccccggcctgcagccccccgctgaggac gaggctcgggcggcagagcctgaccccgactatgaaaacctgcgccgctcagctgggcgc tggggtgaggctgagggcggcaaggagggaactgccaaggagggggcacccgggggcgcc ccgcaggctgggggagaggccccgcccgtccgggtggagaatgagaaggacgctaccacg gagaagaacaagaagagaggcttcctattcaaggccaagaaggtcgccatgatgacccaa ccaccagccactcccgctctgccccggctccctcacgatgtggtgcccgctgacaaccgc gatgaccctgagatcatccttaacaccaccacgtactattactccgtgagggtcttcgcc ggccaggagcccagctgcgtgtgggtgggctgggtcacccctgactaccatcagcacgac atgaacttcgacctcagcaaggtccgggcagtgacagtgaccatgggcgatgaacaaggc aacgtccacagcagcctcaagtgcagcaactgctacatggtgtggggcggggacttcgtg agccccgggcagcaaggccggatcagccactcggaccttgtcattggctgcctggtggac ttggccactggcttaatgacctttacaggcaatggcaaagagagcaacacctttttccag gtggaacccaacacaaagctatttcctgccgtctttgtcctgcccacccaccagaacgtc atccagtttgagttggggaagcagaagaacatcatgccattgtcagccgccatgttcctg agtgagcgcaagaacccagccccacagtgcccgccgaggctggagatgcagatgctgatg cccgtgtcctggagccgcatgcccaaccacttcctgcaggtggagacgcggcgcgctggc gagcggctcggctgggctgtgcagtgccaggagccgctgaccatgatggcgctgcacgtc cccgaggagaatcggtgcatggacatcctggagctgtcggagcgcctggacctgcagcgc ttccactcgcacactctccgcctctaccgcgccgtgtgcgccctgggcaacaaccgcgtg gcacacgctctgtgcagccacgtggaccaggcgcagctgctgcacgccctggaggacgcg cacctgcccggcccgctgcgcgcgggctactacgacctcctcatcagcatccacctcgaa agcgcctgccgcagccgccgctccatgctctcggagtacgtcgtgcccctcacggaggag acgcgctccatcacactcttcccacctgggagaagcgcggaaaatggtccccgccaccat ggcctgcctggcgttggagtcaccacctcgctgaggcccccgcaccatttctcacccccc tgcttcgtggccgccctgccagctgctggggcagcggaagccccggcccgcctcagccct gccatccctctggaggccctgcgggacaaggcgctgagaatgctgggggaggccgtgcgg gacggtgggcagcacgcacgcgaccccgtcgggggctctgtggaattccagttcgtgcct gtgctcaagctcgtgtccacgctgctggtgatgggcgtctttggcgatgaggatgtgaaa cagatcttgaagatgattgagcccgaagtgttcactgaggaagaagaggagggggaggaa gaagaagaggaggaagaagaggaggatgaggaggagaaggaggaggatgaggaggaagag gcacaggagaaggaagatgaggaaaaagaggaagaggaggcagcagaaggggaaaaagaa gaaggcttggaggaggggctgctccagatgaagctgccggagtcggtgaagctgcagatg tgccacctgctggagtatttctgtgaccaagagctgcagcaccgcgtggagtccctggca gccttcgcagagcgctatgtggacaagctccaggacaaccagcggagccgctacggcctg ctcatgaaagccttcaccatgtctgccgccgagaccgccagacgcacgcgcgagttccgc tccccgccccaggagcagatcaacatgctactgcacttcaaagatggtccagaggaggaa gactgtcctctccctgaagagcttcggcaggatttgctggactttcatcaagacctgctg ctgcattgtggaattcagctggggggagaggaggaggaaccagaggaagagaccaccctg ggaagccgcctaatgagcctgttggagaaagtgcggctggtgaagaaggaggaggagaag cctgaggaggagcccccagctgaggagagccacccccggtccctgcaggagctggtgtcc cacacggtggtgcgctgggcccaggaggacttcgtgcagagccccgagctggtgcgggcc atgttcagcctcctgcaccggcagtacgatgggctgggcgagctgctgcgagccctgccg cgggcctacaccatctcgccgtcctccatggaggacaccatgagcctgctcgagtgcctg ggccagatccgctcgctgctcatcgtgcagatgggcccccaggaggagaacctcatgatc cagagcatcgggaacatcatgaacaacaaagtcttctaccaacacccgaacctgatgagg gcactgggcatgcacgagacagtcatgcaggtcatggtgaacgtcctcgggggtggcgaa tccaaggagatccgcttccccaagatggtgacaagctgctgccgcttcctctgctatttc tgccgcatcagccggcagaaccagcgctccatgtttgaccacctgagctacctgctggag aacagcggcatcggcctgggcatgcagggctccacgcccctggatgtggctgccgcctct gtcattgacaacaatgagctggctttggcattgcaggaacaggacctggaaaaggtcgtg tcctatctggcaggctgtggcctccaaagctgccccatgctcctcgccaaagggtacccg gacattggctggaacccctgtggcagtgagcgctacctggacttcctgcgcttcgccgtc ttcgtcaacggcgagagcgtggaggagaacgccaacgtggtggtgcggctgctcatccgc aagcccgagtgcttcgggcctgccctgcgcggcgagggcggctcggggctgctggctgcc atcgaagaggccatccgcatctctgaggacccggcgcgggatggcccaggcgtccgcagg gaccggcggcgtgagcacttcggcgaagagccccctgaagaaaaccgggtgcacctggga cacgccatcatgtccttctatgccgccttgatcgacctgcttggacgctgcgcgccagag atgcatctaatccaagccggcaaaggcgaggccctgcgcatccgcgccatcctccgctcc ctcgtgcccctggaggacctcgtgggcatcataagcctcccactgcagatccccaccctg ggcaaagagggggctctggtacagccaaagatgtctgcgtcctttgtgccggaccacaag gcatccatggtgctcttcctggaccgtgtgtatggcatcgagaaccaggacttcttgctg cacgtgctggacgtggggttcctgcccgacatgagggcagccgcctcgctggacacggcc actttcagcaccacggagatggcgttggcgctgaaccgctacctgtgcctggcggtgctg ccgctcattacaaagtgcgcgccgctgttcgcgggaaccgagcaccgcgccatcatggtg gactccatgctgcacacggtgtaccgcctgtcccggggccgctcgcttaccaaggcacag cgcgacgtcatcgaggactgcctgatggcgctctgcaggtacatccgcccgtccatgctg cagcacctgctgcggcgcctggtgtttgatgtgcccatcctgaacgagttcgccaagatg ccgctcaagctcctcaccaaccactatgagcgctgttggaagtactactgcctccccaca ggctgggccaacttcggggtcacctcggaggaagagctgcaccttacgcgtaaactcttc tggggcatctttgactctctggcccataagaagtatgacccagagctgtaccgcatggcc atgccttgtctgtgtgccatcgccggggcgttgccccccgactatgtggacgcgtcatac tcatccaaggcagagaaaaaggccacagtggatgctgaaggcaactttgatccccggcct gtggagactctcaatgtgatcatcccagagaagctggactccttcattaacaagtttgca gagtacacacatgagaagtgggccttcgacaagatccagaacaactggtcctacggagag aacatagatgaggaactgaagacacaccccatgctgaggccctacaagaccttttcagag aaggacaaagagatttaccgctggcccatcaaggagtccttgaaggccatgattgcctgg gaatggacgatagagaaggccagggagggtgaggaggagaagacggagaagaaaaaaacg cggaagatatcacaaagtgcccagacctacgatgcacgagaaggctacaacccccagccc cccgaccttagcggagtcaccctgtcccgggagctgcaggccatggcagaacaactggcg gaaaattaccacaacacgtgggggcggaagaaaaagcaggagctggaagccaagggtggt gggacccaccccctgctggtcccctacgacacgctcaccgccaaggagaaggcgcgagat cgagagaaggcccaggagctgctgaaatttctgcagatgaacggctacgcggtcactaga ggccttaaggacatggagctggactcatcgtccatcgagaagcggtttgcctttggcttc ttgcagcagttgctgcgctggatggacatctcccaggagttcatcgcccacctggaggct gtggtcagcagtggacgagtggaaaagtccccacatgaacaggagattaaattctttgcc aagatcctgctccctttgatcaaccagtacttcaccaaccattgcctctatttcctgtcc acgccggccaaagtgctgggcagtggtggccatgcctccaacaaggagaaggaaatgatc accagcctcttctgcaaacttgccgctcttgtccgccaccgagtctctctctttgggaca gacgctccggctgtggtcaactgtcttcacatcctggcacgctccctggatgccaggaca gtgatgaagtcaggccccgagatcgtgaaggctggcctccgctccttcttcgagagtgcc tcagaggacatcgagaagatggtggagaacctgcggctgggcaaagtgtcgcaggcacgc acccaggtgaagggcgtgggccagaacctcacctacaccacggtggcactgctgccagtc ctcaccaccctcttccagcacatcgcccagcaccagttcggagacgacgtcatcctggac gatgtccaggtctcttgctaccgaacgctgtgcagtatctactctctgggaaccaccagg aacgcgtatgtggaaaagctgcggccggccctcggggagtgcctggcccgcctggcagcg gccatgcccgtggcgttcctggagccgcagctgaacgagtacaacgcctgctccgtctac accaccaagtctccccgagagcgggccatcctggggctccccaacagtgtggaggagatg tgtcctgatatcccggtgctggagcggctcatggcagacattggggggctggccgagtca ggagcccgctacacagagatgccacatgtcatcgagatcacactgcccatgctgtgcagc tacctgccccgctggtgggagcgcgggcccgaggcgccccctcccaccgctggtgccccc ccaccctgcacagctgtcacctcagatcacctcaactccctgttggggaacatcctgcga atcatcgtcaacaacctgggcattgatgaggcctcgtggatgaagcggctcgctgtgttc gcccagcccataatgagccgggcgcggcccgagctgctgcactcgcacttcatccccacc atcgggcggctgcgcaagcgcgccgggaaggtggtggccgaggaggagcagctgcgcctg gaggccaaggccgaagccgaggagatgctggtgcgggacgagttctccgtgctgtgccgg gacctgtacgccctgtacccactgctcatccgctacgtggacaacaacagggcgcagtgg ctgacggagcccaaccccagcgcggaggagctgttcaggatggtgggcgagatcttcatc tactggtccaagtcccataatttcaagcgcgaggagcagaactttgtggtccagaatgaa atcaacaacatgtcctttttgaccgctgacaacaagagcaaaatggccaagtcaggtggc tcagaccaggaacgcaccaagaagaagcgccggggggaccggtactctgtgcagacatcg ctgattgtggctacgctcaagaagatgctgcccatcggcctgaacatgtgtgcgcccacc gaccaggacctcatcatgctggccaagacccgctacgccctgaaagacacagatgaggaa gtgcgggaatttctgcaaaacaaccttcaccttcagggaaaggtggaaggctccccgtct ctacgctggcagatggccctgtaccggggcctccctggccgcgaggaggatgctgacgac cccgagaaaatcgtgcgcagggtccaggaagtgtctgccgtgctctaccatctggaccag accgagcacccttacaagtccaagaaggccgtgtggcacaagcttttgtccaagcagcgc aggcgggcagtcgtggcctgtttccggatgacgcccctgtacaacctgcccacgcaccgg gcatgcaacatgcttctggagagctacaaggccgcatggatcatgactgaagaccacagt tttgaggaccgcatgatagatgacctttcaaaagctggggagcaggaagaagaggaagaa gaagtggaggagaagaagccagaccccctgcaccagctggtcctgcacttcagccgcact gccctgacagaaaagagcaaactagatgaggattacctgtatatcgcctacgctgacatc atggcaaagagctgccacctggaggagggagaggagaacggtggtggtggcgctgaagat gaacaagaggaagaggtggaggtttcctttgaggagaaagagatggagaagcagaggctc ctgtaccagcaggcgcggctccacaaccggggggccgccgagatggtgctccagatgatc agcgcctgcaaaggagagacgggcgccatggtgtcctccaccctgaagctgggcatctcc atcctcaatggcggcaatgctgaggtgcagcagaaaatgctggattatctgaaggacaag aaggaagttggcttcttccagagtatccaggcactaatgcaaacgtgcagcgtcctggat ctcaacgcctttgagagacagaacaaggcagaggggctgggcatggtcaatgaggatgga actgtcatcaatcgccagaacggagagaaggtcatggcagatgatgaattcacacaagac ctgttccgattcctgcaattgctctgcgagggccacaataacgatttccaaaactaccta cggacacagacagggaacacaaccactattaacatcatcatctgcacggtggactacctc ctgcggctgcaggaatccatcagcgacttctactggtactactcgggcaaggatgtcatt gaagagcagggcaagaggaacttctccaaagccatgtcggtggctaagcaggtgttcaac agcctcactgagtacatccagggcccctgcactgggaaccagcagagcctggcgcacagc cgcctctgggacgcggtggtgggattcctgcacgtgttcgcccacatgatgatgaagctc gctcaggactcaagccagatcgagctgttgaaggagctgctggatctacagaaggacatg gtggtgatgttgctgtcgctactagaagggaacgtggtgaacggcatgatcgcccggcag atggtggacatgctcgtggaatcctcatccaatgtggagatgatcctcaagttcttcgac atgttcctgaaactcaaagacatcgtgggctccgaggccttccaggactatgtcactgat ccccgcgggctcatctccaagaaggacttccagaaggccatggacagccagaagcagttc agcggtccggaaatccagttcctgctttcgtgctccgaagcggatgagaacgagatgatc aactgcgaggagttcgccaaccgcttccaggagccggcccgggaaatcggcttcaacgtg gcggtgctgctgaccaacctgtcagagcacgtgccgcacgacccgcgcctgcgcaacttc ctggagctggccgagagcatcctcgagtacttccggccctacctgggccgcatcgagatc atgggctcctcgcgccgcatcgagcgcatctacttcgagatctcggagaccaaccgcgcc cagtgggagatgccccaggtgaaggagtcgaagcgccagttcatcttcgacgtggtgaac gagggcggcgagtccgagaagatggagctgttcgtgagcttctgcgaggacaccatcttc gagatgcagatcgccgcgcagatctcggagcccgagggcgagcccgagacggacgaggac gagggcgcgggcgcgggcgcgggcgaggcgggcgccgagggcgcggaggagggcgcggcg gggccggagggcgcggcgggcgcggcggcggcggcggggatgacagcgcgcgcggtggcg gccgcgggccaggccctgcgccgcctcagctaccgcagcctgcggcggcgcgtgcgacgg ctgcggcggctgaccgcgcgggaggcggccaccgcggccaccgcgctgctctgggcggcc gtgacgtgcgtgggcgccgcgggcgcgggggcggcgaagggcgcgctgcgcctgctctgg ggctcgctcttcggcggcggtctcgtggagggcgccaagaaggtgacggtgaccgagctc ctggcgggcatgcccgaccccaccggcgacgaggtgcacggcgagcagccggctgggccc ggcggtgacgcggacggcgagggtgcgggcgagggtgcaggcgacgccgcggagggcgtg gacgacgaggaggtggcggtgcacgacgccgggccgggcggccccgacggggctgtggcc gtgtccgacgggggcccattccggcccgaaggggctggcggtcttggggacatgggggac acgacgccggcggagccgcccacgcctgagggctcccccatcttcaagaggaagctgggg ggggatggcgaggaggaggagttgccgccggagcccgagccagagccagagcctgagcca gagcccgagaaagccgatgccgagaatggggagaaggaagaagtccctgagcccccacca gagccccctaagaagaaagcacctcctccacccactctgaagaaggaggaagctgggggc gagttctggggagaactggaggtgcagagggtgaagttcctgaactacctctcccggaac ttttacaccctgcgattcctcgccctcttcttggcatttgccatcaatttcatcttgctg ttttataaggtctcagactctccaccaggggaagatgatatggagggctcagccgctggg gacctgtcaactgcagggtctggtggcggctctggctggggctcaggggccggtgaggag gctgagggtgacgaggatgagaacatggtgtactacttcctggaggagagcacgggctac atggagcccgccctgcggtgcttgagcctgctccacacgctggtggcctttctctgcatc attggctacaactgcctcaaggtgcccctggtgatctttaagcgggagaaggagctggcc cgaaagctggagtttgatggcctctacatcacggagcagcctgaggacgacgacgtgaag gggcagtgggaccgactggtgctcaacactccgtctttccccagcaactactgggacaag tttgtcaagcgcaaggtcctggacaaacacggggacatctacgggcgcgagcggattgca gagctgctgggcatggacctggccacgctggagatcacggcgcacaatgagcgcaagccc agcccgccgcccgggctgctgacctggctcatgtccatcgatgtcaagtaccagatctgg aagttcggggtcatcttcacagacaactctttcctctacctgggctggtacatggtgatg tccctcctggggcactacaacaacttcttcttcgctgcccacctcctggacattgccatg ggggtcaagactctgcgcaccatcctgtcctccgtcacccacaatgggaaacagctggtg atgaccgtgggcctcctggcggtggtggtgtacctatacaccgtggtggccttcaacttc ttccgcaagttctacaacaagagcgaggatgaggacgagcctgacatgaagtgtgacgac atgatgacgtgttacctgtttcacatgtacgtgggcgtccgggctggcggaggcatcggg gacgagattgaggacccagcaggcgatgaatacgagctctaccgggtggtcttcgacatc actttcttcttctttgtcatcgtcatcctcctggccatcatccagggtctgatcatcgac gctttcggtgagctcagagaccaacaggagcaagtgaaggaggatatggagaccaagtgt ttcatctgcggaatcggaagcgactacttcgatacgacaccacatgggtttgagactcac acgctagaagagcacaatctggccaattacatgtttttcctgatgtatttgatcaacaag gacgagacagaacacacgggtcaggagtcttatgtctggaagatgtaccaagagagatgt tgggatttcttcccggctggcgattgtttccgcaagcagtatgaggaccagcttagctga

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