KEGG   Leopardus geoffroyi (Geoffroy's cat): 123605114
Entry
123605114         CDS       T10761                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X1
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
lgf  Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf01521  EGFR tyrosine kinase inhibitor resistance
lgf01522  Endocrine resistance
lgf04010  MAPK signaling pathway
lgf04012  ErbB signaling pathway
lgf04014  Ras signaling pathway
lgf04015  Rap1 signaling pathway
lgf04022  cGMP-PKG signaling pathway
lgf04024  cAMP signaling pathway
lgf04066  HIF-1 signaling pathway
lgf04068  FoxO signaling pathway
lgf04071  Sphingolipid signaling pathway
lgf04072  Phospholipase D signaling pathway
lgf04140  Autophagy - animal
lgf04148  Efferocytosis
lgf04150  mTOR signaling pathway
lgf04151  PI3K-Akt signaling pathway
lgf04210  Apoptosis
lgf04218  Cellular senescence
lgf04270  Vascular smooth muscle contraction
lgf04370  VEGF signaling pathway
lgf04371  Apelin signaling pathway
lgf04517  IgSF CAM signaling
lgf04519  Cadherin signaling
lgf04540  Gap junction
lgf04550  Signaling pathways regulating pluripotency of stem cells
lgf04613  Neutrophil extracellular trap formation
lgf04620  Toll-like receptor signaling pathway
lgf04650  Natural killer cell mediated cytotoxicity
lgf04660  T cell receptor signaling pathway
lgf04662  B cell receptor signaling pathway
lgf04664  Fc epsilon RI signaling pathway
lgf04720  Long-term potentiation
lgf04722  Neurotrophin signaling pathway
lgf04730  Long-term depression
lgf04810  Regulation of actin cytoskeleton
lgf04910  Insulin signaling pathway
lgf04912  GnRH signaling pathway
lgf04915  Estrogen signaling pathway
lgf04916  Melanogenesis
lgf04917  Prolactin signaling pathway
lgf04919  Thyroid hormone signaling pathway
lgf04921  Oxytocin signaling pathway
lgf04926  Relaxin signaling pathway
lgf04929  GnRH secretion
lgf04934  Cushing syndrome
lgf04935  Growth hormone synthesis, secretion and action
lgf05010  Alzheimer disease
lgf05022  Pathways of neurodegeneration - multiple diseases
lgf05132  Salmonella infection
lgf05135  Yersinia infection
lgf05160  Hepatitis C
lgf05161  Hepatitis B
lgf05163  Human cytomegalovirus infection
lgf05164  Influenza A
lgf05165  Human papillomavirus infection
lgf05166  Human T-cell leukemia virus 1 infection
lgf05167  Kaposi sarcoma-associated herpesvirus infection
lgf05170  Human immunodeficiency virus 1 infection
lgf05200  Pathways in cancer
lgf05205  Proteoglycans in cancer
lgf05206  MicroRNAs in cancer
lgf05207  Chemical carcinogenesis - receptor activation
lgf05208  Chemical carcinogenesis - reactive oxygen species
lgf05210  Colorectal cancer
lgf05211  Renal cell carcinoma
lgf05213  Endometrial cancer
lgf05214  Glioma
lgf05215  Prostate cancer
lgf05216  Thyroid cancer
lgf05218  Melanoma
lgf05219  Bladder cancer
lgf05220  Chronic myeloid leukemia
lgf05221  Acute myeloid leukemia
lgf05223  Non-small cell lung cancer
lgf05224  Breast cancer
lgf05225  Hepatocellular carcinoma
lgf05226  Gastric cancer
lgf05230  Central carbon metabolism in cancer
lgf05231  Choline metabolism in cancer
lgf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:lgf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123605114 (MAP2K2)
   04012 ErbB signaling pathway
    123605114 (MAP2K2)
   04014 Ras signaling pathway
    123605114 (MAP2K2)
   04015 Rap1 signaling pathway
    123605114 (MAP2K2)
   04370 VEGF signaling pathway
    123605114 (MAP2K2)
   04371 Apelin signaling pathway
    123605114 (MAP2K2)
   04066 HIF-1 signaling pathway
    123605114 (MAP2K2)
   04068 FoxO signaling pathway
    123605114 (MAP2K2)
   04072 Phospholipase D signaling pathway
    123605114 (MAP2K2)
   04071 Sphingolipid signaling pathway
    123605114 (MAP2K2)
   04024 cAMP signaling pathway
    123605114 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    123605114 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    123605114 (MAP2K2)
   04150 mTOR signaling pathway
    123605114 (MAP2K2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    123605114 (MAP2K2)
   04519 Cadherin signaling
    123605114 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    123605114 (MAP2K2)
   04148 Efferocytosis
    123605114 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    123605114 (MAP2K2)
   04218 Cellular senescence
    123605114 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    123605114 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    123605114 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123605114 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    123605114 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    123605114 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    123605114 (MAP2K2)
   04660 T cell receptor signaling pathway
    123605114 (MAP2K2)
   04662 B cell receptor signaling pathway
    123605114 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    123605114 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123605114 (MAP2K2)
   04929 GnRH secretion
    123605114 (MAP2K2)
   04912 GnRH signaling pathway
    123605114 (MAP2K2)
   04915 Estrogen signaling pathway
    123605114 (MAP2K2)
   04917 Prolactin signaling pathway
    123605114 (MAP2K2)
   04921 Oxytocin signaling pathway
    123605114 (MAP2K2)
   04926 Relaxin signaling pathway
    123605114 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    123605114 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    123605114 (MAP2K2)
   04916 Melanogenesis
    123605114 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    123605114 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    123605114 (MAP2K2)
   04730 Long-term depression
    123605114 (MAP2K2)
   04722 Neurotrophin signaling pathway
    123605114 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123605114 (MAP2K2)
   05206 MicroRNAs in cancer
    123605114 (MAP2K2)
   05205 Proteoglycans in cancer
    123605114 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    123605114 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    123605114 (MAP2K2)
   05230 Central carbon metabolism in cancer
    123605114 (MAP2K2)
   05231 Choline metabolism in cancer
    123605114 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123605114 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123605114 (MAP2K2)
   05225 Hepatocellular carcinoma
    123605114 (MAP2K2)
   05226 Gastric cancer
    123605114 (MAP2K2)
   05214 Glioma
    123605114 (MAP2K2)
   05216 Thyroid cancer
    123605114 (MAP2K2)
   05221 Acute myeloid leukemia
    123605114 (MAP2K2)
   05220 Chronic myeloid leukemia
    123605114 (MAP2K2)
   05218 Melanoma
    123605114 (MAP2K2)
   05211 Renal cell carcinoma
    123605114 (MAP2K2)
   05219 Bladder cancer
    123605114 (MAP2K2)
   05215 Prostate cancer
    123605114 (MAP2K2)
   05213 Endometrial cancer
    123605114 (MAP2K2)
   05224 Breast cancer
    123605114 (MAP2K2)
   05223 Non-small cell lung cancer
    123605114 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123605114 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    123605114 (MAP2K2)
   05161 Hepatitis B
    123605114 (MAP2K2)
   05160 Hepatitis C
    123605114 (MAP2K2)
   05164 Influenza A
    123605114 (MAP2K2)
   05163 Human cytomegalovirus infection
    123605114 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123605114 (MAP2K2)
   05165 Human papillomavirus infection
    123605114 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123605114 (MAP2K2)
   05135 Yersinia infection
    123605114 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123605114 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    123605114 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    123605114 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123605114 (MAP2K2)
   01522 Endocrine resistance
    123605114 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lgf01001]
    123605114 (MAP2K2)
Enzymes [BR:lgf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     123605114 (MAP2K2)
Protein kinases [BR:lgf01001]
 Serine/threonine kinases: STE group
  STE7 family
   123605114 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 123605114
NCBI-ProteinID: XP_045347475
LinkDB
Position
A2:complement(3083565..3104944)
AA seq 427 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPHSISPRPRP
PGRPISGHGTDSRPAMAIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKCLIKNPAERADL
KTLTPGEACSSGTSTTRDREGHTCWFSVSGAERHNTRVSQLPERGLSKPRLHQAVRGGGS
GLRRLVV
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgcagag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagcagagcttgaacttgacgagcagcagaaaaagcgtctggaagccttcctcacccag
aaggccaaggtcggagagctcaaggacgatgacttcgaaaggatctcggaactgggggcc
gggaacggcggggtggtcaccaaggttcaacacagaccctccggcctcatcatggcgaga
aagctgatccacctggaaatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctgcacgagtgtaactccccgtacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggacggcggctctctggaccaggtgttgaag
gaagccaagagaattcccgaggagatcctggggaaggtcagcatcgcggttctccggggt
ttggcgtatctccgggaaaagcaccagatcatgcaccgagatgtgaaaccatccaacatc
ctcgtcaactcccgaggggagatcaagctgtgcgattttggggtgagcgggcagcttatc
gactccatggccaactccttcgtgggaactcggtcctacatgtctccagagcggttgcag
ggcactcactactcggtgcagtcggacatctggagcatgggcctgtccctggtggagctg
tccatcggaaggtaccccatccccccgccggatgccaaggagctagaggccatatttggt
cggcccatggttgacggggcagaaggagagcctcacagcatctcaccacggccgagaccc
cctggacgccccatcagtggccacgggacggacagccggccggccatggccatcttcgag
ctgctggactacattgtgaatgagccacctcccaagctgcccagcggtgtcttcacccag
gacttccaggagtttgtaaataaatgcctcattaagaacccagcggagcgagccgacctg
aagacgctcacgcctggggaggcctgctcttcaggcacttccacgacacgagaccgtgag
ggtcacacctgctggttctcggtctctggtgccgagcgtcacaacacgcgtgtctctcaa
ttaccggaacgtggtctttccaaaccacgccttcatcaagcggtccgaggtggaggaagt
ggacttcgccggctggttgtgtaa

DBGET integrated database retrieval system