KEGG   Leopardus geoffroyi (Geoffroy's cat): 123607407
Entry
123607407         CDS       T10761                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
lgf  Leopardus geoffroyi (Geoffroy's cat)
Pathway
lgf01521  EGFR tyrosine kinase inhibitor resistance
lgf01522  Endocrine resistance
lgf01524  Platinum drug resistance
lgf04012  ErbB signaling pathway
lgf04014  Ras signaling pathway
lgf04015  Rap1 signaling pathway
lgf04024  cAMP signaling pathway
lgf04062  Chemokine signaling pathway
lgf04066  HIF-1 signaling pathway
lgf04068  FoxO signaling pathway
lgf04070  Phosphatidylinositol signaling system
lgf04071  Sphingolipid signaling pathway
lgf04072  Phospholipase D signaling pathway
lgf04081  Hormone signaling
lgf04140  Autophagy - animal
lgf04145  Phagocytosis
lgf04150  mTOR signaling pathway
lgf04151  PI3K-Akt signaling pathway
lgf04152  AMPK signaling pathway
lgf04210  Apoptosis
lgf04211  Longevity regulating pathway
lgf04213  Longevity regulating pathway - multiple species
lgf04218  Cellular senescence
lgf04360  Axon guidance
lgf04370  VEGF signaling pathway
lgf04380  Osteoclast differentiation
lgf04510  Focal adhesion
lgf04517  IgSF CAM signaling
lgf04518  Integrin signaling
lgf04550  Signaling pathways regulating pluripotency of stem cells
lgf04611  Platelet activation
lgf04613  Neutrophil extracellular trap formation
lgf04620  Toll-like receptor signaling pathway
lgf04625  C-type lectin receptor signaling pathway
lgf04630  JAK-STAT signaling pathway
lgf04650  Natural killer cell mediated cytotoxicity
lgf04660  T cell receptor signaling pathway
lgf04662  B cell receptor signaling pathway
lgf04664  Fc epsilon RI signaling pathway
lgf04666  Fc gamma R-mediated phagosome formation
lgf04668  TNF signaling pathway
lgf04670  Leukocyte transendothelial migration
lgf04722  Neurotrophin signaling pathway
lgf04725  Cholinergic synapse
lgf04750  Inflammatory mediator regulation of TRP channels
lgf04810  Regulation of actin cytoskeleton
lgf04910  Insulin signaling pathway
lgf04914  Progesterone-mediated oocyte maturation
lgf04915  Estrogen signaling pathway
lgf04917  Prolactin signaling pathway
lgf04919  Thyroid hormone signaling pathway
lgf04923  Regulation of lipolysis in adipocytes
lgf04926  Relaxin signaling pathway
lgf04929  GnRH secretion
lgf04930  Type II diabetes mellitus
lgf04931  Insulin resistance
lgf04932  Non-alcoholic fatty liver disease
lgf04933  AGE-RAGE signaling pathway in diabetic complications
lgf04935  Growth hormone synthesis, secretion and action
lgf04960  Aldosterone-regulated sodium reabsorption
lgf04973  Carbohydrate digestion and absorption
lgf05010  Alzheimer disease
lgf05017  Spinocerebellar ataxia
lgf05020  Prion disease
lgf05100  Bacterial invasion of epithelial cells
lgf05135  Yersinia infection
lgf05142  Chagas disease
lgf05146  Amoebiasis
lgf05160  Hepatitis C
lgf05161  Hepatitis B
lgf05162  Measles
lgf05163  Human cytomegalovirus infection
lgf05164  Influenza A
lgf05165  Human papillomavirus infection
lgf05166  Human T-cell leukemia virus 1 infection
lgf05167  Kaposi sarcoma-associated herpesvirus infection
lgf05168  Herpes simplex virus 1 infection
lgf05169  Epstein-Barr virus infection
lgf05170  Human immunodeficiency virus 1 infection
lgf05171  Coronavirus disease
lgf05200  Pathways in cancer
lgf05203  Viral carcinogenesis
lgf05205  Proteoglycans in cancer
lgf05206  MicroRNAs in cancer
lgf05207  Chemical carcinogenesis - receptor activation
lgf05208  Chemical carcinogenesis - reactive oxygen species
lgf05210  Colorectal cancer
lgf05211  Renal cell carcinoma
lgf05212  Pancreatic cancer
lgf05213  Endometrial cancer
lgf05214  Glioma
lgf05215  Prostate cancer
lgf05218  Melanoma
lgf05220  Chronic myeloid leukemia
lgf05221  Acute myeloid leukemia
lgf05222  Small cell lung cancer
lgf05223  Non-small cell lung cancer
lgf05224  Breast cancer
lgf05225  Hepatocellular carcinoma
lgf05226  Gastric cancer
lgf05230  Central carbon metabolism in cancer
lgf05231  Choline metabolism in cancer
lgf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lgf05415  Diabetic cardiomyopathy
lgf05417  Lipid and atherosclerosis
lgf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lgf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    123607407 (PIK3R2)
   04014 Ras signaling pathway
    123607407 (PIK3R2)
   04015 Rap1 signaling pathway
    123607407 (PIK3R2)
   04370 VEGF signaling pathway
    123607407 (PIK3R2)
   04630 JAK-STAT signaling pathway
    123607407 (PIK3R2)
   04668 TNF signaling pathway
    123607407 (PIK3R2)
   04066 HIF-1 signaling pathway
    123607407 (PIK3R2)
   04068 FoxO signaling pathway
    123607407 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    123607407 (PIK3R2)
   04072 Phospholipase D signaling pathway
    123607407 (PIK3R2)
   04071 Sphingolipid signaling pathway
    123607407 (PIK3R2)
   04024 cAMP signaling pathway
    123607407 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    123607407 (PIK3R2)
   04152 AMPK signaling pathway
    123607407 (PIK3R2)
   04150 mTOR signaling pathway
    123607407 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    123607407 (PIK3R2)
   04517 IgSF CAM signaling
    123607407 (PIK3R2)
   04518 Integrin signaling
    123607407 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    123607407 (PIK3R2)
   04140 Autophagy - animal
    123607407 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    123607407 (PIK3R2)
   04218 Cellular senescence
    123607407 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123607407 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    123607407 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123607407 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123607407 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    123607407 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    123607407 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    123607407 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    123607407 (PIK3R2)
   04660 T cell receptor signaling pathway
    123607407 (PIK3R2)
   04662 B cell receptor signaling pathway
    123607407 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    123607407 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    123607407 (PIK3R2)
   04670 Leukocyte transendothelial migration
    123607407 (PIK3R2)
   04062 Chemokine signaling pathway
    123607407 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123607407 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    123607407 (PIK3R2)
   04929 GnRH secretion
    123607407 (PIK3R2)
   04915 Estrogen signaling pathway
    123607407 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    123607407 (PIK3R2)
   04917 Prolactin signaling pathway
    123607407 (PIK3R2)
   04926 Relaxin signaling pathway
    123607407 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    123607407 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    123607407 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    123607407 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    123607407 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    123607407 (PIK3R2)
   04722 Neurotrophin signaling pathway
    123607407 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123607407 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    123607407 (PIK3R2)
   04380 Osteoclast differentiation
    123607407 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    123607407 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    123607407 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123607407 (PIK3R2)
   05206 MicroRNAs in cancer
    123607407 (PIK3R2)
   05205 Proteoglycans in cancer
    123607407 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    123607407 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    123607407 (PIK3R2)
   05203 Viral carcinogenesis
    123607407 (PIK3R2)
   05230 Central carbon metabolism in cancer
    123607407 (PIK3R2)
   05231 Choline metabolism in cancer
    123607407 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123607407 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123607407 (PIK3R2)
   05212 Pancreatic cancer
    123607407 (PIK3R2)
   05225 Hepatocellular carcinoma
    123607407 (PIK3R2)
   05226 Gastric cancer
    123607407 (PIK3R2)
   05214 Glioma
    123607407 (PIK3R2)
   05221 Acute myeloid leukemia
    123607407 (PIK3R2)
   05220 Chronic myeloid leukemia
    123607407 (PIK3R2)
   05218 Melanoma
    123607407 (PIK3R2)
   05211 Renal cell carcinoma
    123607407 (PIK3R2)
   05215 Prostate cancer
    123607407 (PIK3R2)
   05213 Endometrial cancer
    123607407 (PIK3R2)
   05224 Breast cancer
    123607407 (PIK3R2)
   05222 Small cell lung cancer
    123607407 (PIK3R2)
   05223 Non-small cell lung cancer
    123607407 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123607407 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    123607407 (PIK3R2)
   05161 Hepatitis B
    123607407 (PIK3R2)
   05160 Hepatitis C
    123607407 (PIK3R2)
   05171 Coronavirus disease
    123607407 (PIK3R2)
   05164 Influenza A
    123607407 (PIK3R2)
   05162 Measles
    123607407 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    123607407 (PIK3R2)
   05163 Human cytomegalovirus infection
    123607407 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123607407 (PIK3R2)
   05169 Epstein-Barr virus infection
    123607407 (PIK3R2)
   05165 Human papillomavirus infection
    123607407 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    123607407 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    123607407 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123607407 (PIK3R2)
   05142 Chagas disease
    123607407 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123607407 (PIK3R2)
   05017 Spinocerebellar ataxia
    123607407 (PIK3R2)
   05020 Prion disease
    123607407 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123607407 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    123607407 (PIK3R2)
   05415 Diabetic cardiomyopathy
    123607407 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    123607407 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    123607407 (PIK3R2)
   04931 Insulin resistance
    123607407 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123607407 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123607407 (PIK3R2)
   01524 Platinum drug resistance
    123607407 (PIK3R2)
   01522 Endocrine resistance
    123607407 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lgf04131]
    123607407 (PIK3R2)
Membrane trafficking [BR:lgf04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    123607407 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 ODF2_C ATG11 Ribosomal_L22e SH3_9
Other DBs
NCBI-GeneID: 123607407
NCBI-ProteinID: XP_045352600
LinkDB
Position
A2:13492488..13505426
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPELPAPRTDWSLSDVEQWDATALADGVKGFLLA
LPAPLVTPEAAAEARRALREATGPVGPALEPPTLPLHLALTLRFLLQHLGRVARRAPAPG
PAVRALGATFGPLLLRAPPPSPPPGGAPDGTEPSPDFPALLVEKLLQEHLEEQEVAPPAL
PPKPPKAKPAPAGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGRRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPPATR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggccggcgccgagggcttccagtaccgcgcgctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtggtgagccgagcggccctgcaggtg
ctgggcgtggccgagggcaacgagcgctgcccacagagcgtgggctggatgccgggcctc
aatgagcgcacgcggcagcgaggtgacttccccggcacctacgtcgagttcctgggtcct
gtagccctggcccggcccggccctcgtccgcgtggcccccgcccactgcccgccaggccc
cgggacgggccccctgagccaggcctcacgctccctgacctgccagagcagttctcccca
cctgatgtggctcccccgctcctggtgaagctcgtggaggccattgagcggacagggcta
gacagcgaatccctctacaggcctgagctgcccgccccgcgcacagactggtccctgagc
gacgtggagcagtgggacgccacagccctggcagatggcgtcaagggcttcctgctggcg
ctgcccgcccccctcgtgacgcccgaggctgcggccgaggcgcgccgggccctgcgggag
gccacggggcccgtggggccggcgctggagcccccgacgctgccactgcacctcgcgctc
acgctgcgcttcctgctccagcacctgggccgggtggcccgacgtgccccggctccgggc
cccgccgtgcgagccctgggcgccaccttcgggccgctgctgctgcgcgcgccgcccccc
tcgccgccgccagggggcgcgcccgacgggactgagcccagccctgacttcccggcgttg
ctggtggagaagttgcttcaggaacatctggaagagcaggaggtcgcacccccagcgctg
ccgcccaaaccccccaaggccaagccagcccccgcaggcctagccaatggggggagcccg
ccctccctgcaggatgccgagtggtactggggtgacatctccagggaggaagtgaatgag
aaactccgggacacacccgacggcacctttctggtccgagatgcatccagcaagatccag
ggggaatacacactgaccctcaggaaaggcgggaacaacaagctgattaaggtcttccat
cgtgacgggcactatggcttctcagagccactcaccttctgctccgttgtggacctcatc
acccactaccgccacgagtcgctggcccagtacaatgccaaactggacacacggctcctc
tacccggtgtccaagtaccagcaggaccagatcgtcaaggaggacagcgtggaggcggtg
ggcgcccagctcaaagtctatcaccagcagtaccaggacaagagccgcgagtacgaccag
ctctacgaggagtacacacgcacctcccaggagctgcagatgaagcgcacagcaattgag
gccttcaacgagaccatcaaaatctttgaagagcagggccagacacaagagaagtgtagc
aaggagtatctggagcgcttccggcgtgagggcaatgagaaagagatgcagaggatcctg
ctgaactcagagcggctcaagtctcgcatcgccgagatccacgagagccgcacgaagctg
gaacaggagctgcgggcacaggcctccgacaaccgggagatcgacaagcgcatgaacagc
ctcaagccggacctcatgcagctccgcaagatccgagaccagtacctcgtgtggcttacc
cagaaaggtgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagaccgag
gaccagtatgcgctgatggaagacgaggatgacctcccccaccacgaggaacgcacgtgg
tacgtgggcaagatcaaccgcacgcaggctgaggaaatgctgagtggcaggcgggatggc
accttcctcatccgcgagagcagccagcggggctgctatgcctgctccgtggtggtggac
ggcgacaccaagcactgtgtcatctaccgcacggccaccggcttcggcttcgcggagccc
tacaacctgtacgggtcgctgaaggagctggtgctgcattaccagcacgcctcgctggtg
cagcacaacgacgcgctcaccgtcacgctcgcccaccccgtgcgggcccccgggcccggg
cccccgccggccacccgctga

DBGET integrated database retrieval system