KEGG   Lutra lutra (Eurasian river otter): 125086704
Entry
125086704         CDS       T08100                                 
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv01521  EGFR tyrosine kinase inhibitor resistance
llv01522  Endocrine resistance
llv04010  MAPK signaling pathway
llv04012  ErbB signaling pathway
llv04014  Ras signaling pathway
llv04015  Rap1 signaling pathway
llv04022  cGMP-PKG signaling pathway
llv04024  cAMP signaling pathway
llv04066  HIF-1 signaling pathway
llv04068  FoxO signaling pathway
llv04071  Sphingolipid signaling pathway
llv04072  Phospholipase D signaling pathway
llv04140  Autophagy - animal
llv04148  Efferocytosis
llv04150  mTOR signaling pathway
llv04151  PI3K-Akt signaling pathway
llv04210  Apoptosis
llv04218  Cellular senescence
llv04270  Vascular smooth muscle contraction
llv04370  VEGF signaling pathway
llv04371  Apelin signaling pathway
llv04540  Gap junction
llv04550  Signaling pathways regulating pluripotency of stem cells
llv04613  Neutrophil extracellular trap formation
llv04620  Toll-like receptor signaling pathway
llv04650  Natural killer cell mediated cytotoxicity
llv04660  T cell receptor signaling pathway
llv04662  B cell receptor signaling pathway
llv04664  Fc epsilon RI signaling pathway
llv04720  Long-term potentiation
llv04722  Neurotrophin signaling pathway
llv04730  Long-term depression
llv04810  Regulation of actin cytoskeleton
llv04910  Insulin signaling pathway
llv04912  GnRH signaling pathway
llv04915  Estrogen signaling pathway
llv04916  Melanogenesis
llv04917  Prolactin signaling pathway
llv04919  Thyroid hormone signaling pathway
llv04921  Oxytocin signaling pathway
llv04926  Relaxin signaling pathway
llv04929  GnRH secretion
llv04934  Cushing syndrome
llv04935  Growth hormone synthesis, secretion and action
llv05010  Alzheimer disease
llv05022  Pathways of neurodegeneration - multiple diseases
llv05132  Salmonella infection
llv05135  Yersinia infection
llv05160  Hepatitis C
llv05161  Hepatitis B
llv05163  Human cytomegalovirus infection
llv05164  Influenza A
llv05165  Human papillomavirus infection
llv05166  Human T-cell leukemia virus 1 infection
llv05167  Kaposi sarcoma-associated herpesvirus infection
llv05170  Human immunodeficiency virus 1 infection
llv05200  Pathways in cancer
llv05205  Proteoglycans in cancer
llv05206  MicroRNAs in cancer
llv05207  Chemical carcinogenesis - receptor activation
llv05208  Chemical carcinogenesis - reactive oxygen species
llv05210  Colorectal cancer
llv05211  Renal cell carcinoma
llv05213  Endometrial cancer
llv05214  Glioma
llv05215  Prostate cancer
llv05216  Thyroid cancer
llv05218  Melanoma
llv05219  Bladder cancer
llv05220  Chronic myeloid leukemia
llv05221  Acute myeloid leukemia
llv05223  Non-small cell lung cancer
llv05224  Breast cancer
llv05225  Hepatocellular carcinoma
llv05226  Gastric cancer
llv05230  Central carbon metabolism in cancer
llv05231  Choline metabolism in cancer
llv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:llv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125086704
   04012 ErbB signaling pathway
    125086704
   04014 Ras signaling pathway
    125086704
   04015 Rap1 signaling pathway
    125086704
   04370 VEGF signaling pathway
    125086704
   04371 Apelin signaling pathway
    125086704
   04066 HIF-1 signaling pathway
    125086704
   04068 FoxO signaling pathway
    125086704
   04072 Phospholipase D signaling pathway
    125086704
   04071 Sphingolipid signaling pathway
    125086704
   04024 cAMP signaling pathway
    125086704
   04022 cGMP-PKG signaling pathway
    125086704
   04151 PI3K-Akt signaling pathway
    125086704
   04150 mTOR signaling pathway
    125086704
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125086704
   04148 Efferocytosis
    125086704
  09143 Cell growth and death
   04210 Apoptosis
    125086704
   04218 Cellular senescence
    125086704
  09144 Cellular community - eukaryotes
   04540 Gap junction
    125086704
   04550 Signaling pathways regulating pluripotency of stem cells
    125086704
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125086704
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    125086704
   04620 Toll-like receptor signaling pathway
    125086704
   04650 Natural killer cell mediated cytotoxicity
    125086704
   04660 T cell receptor signaling pathway
    125086704
   04662 B cell receptor signaling pathway
    125086704
   04664 Fc epsilon RI signaling pathway
    125086704
  09152 Endocrine system
   04910 Insulin signaling pathway
    125086704
   04929 GnRH secretion
    125086704
   04912 GnRH signaling pathway
    125086704
   04915 Estrogen signaling pathway
    125086704
   04917 Prolactin signaling pathway
    125086704
   04921 Oxytocin signaling pathway
    125086704
   04926 Relaxin signaling pathway
    125086704
   04935 Growth hormone synthesis, secretion and action
    125086704
   04919 Thyroid hormone signaling pathway
    125086704
   04916 Melanogenesis
    125086704
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    125086704
  09156 Nervous system
   04720 Long-term potentiation
    125086704
   04730 Long-term depression
    125086704
   04722 Neurotrophin signaling pathway
    125086704
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125086704
   05206 MicroRNAs in cancer
    125086704
   05205 Proteoglycans in cancer
    125086704
   05207 Chemical carcinogenesis - receptor activation
    125086704
   05208 Chemical carcinogenesis - reactive oxygen species
    125086704
   05230 Central carbon metabolism in cancer
    125086704
   05231 Choline metabolism in cancer
    125086704
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125086704
  09162 Cancer: specific types
   05210 Colorectal cancer
    125086704
   05225 Hepatocellular carcinoma
    125086704
   05226 Gastric cancer
    125086704
   05214 Glioma
    125086704
   05216 Thyroid cancer
    125086704
   05221 Acute myeloid leukemia
    125086704
   05220 Chronic myeloid leukemia
    125086704
   05218 Melanoma
    125086704
   05211 Renal cell carcinoma
    125086704
   05219 Bladder cancer
    125086704
   05215 Prostate cancer
    125086704
   05213 Endometrial cancer
    125086704
   05224 Breast cancer
    125086704
   05223 Non-small cell lung cancer
    125086704
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125086704
   05170 Human immunodeficiency virus 1 infection
    125086704
   05161 Hepatitis B
    125086704
   05160 Hepatitis C
    125086704
   05164 Influenza A
    125086704
   05163 Human cytomegalovirus infection
    125086704
   05167 Kaposi sarcoma-associated herpesvirus infection
    125086704
   05165 Human papillomavirus infection
    125086704
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125086704
   05135 Yersinia infection
    125086704
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125086704
   05022 Pathways of neurodegeneration - multiple diseases
    125086704
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    125086704
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125086704
   01522 Endocrine resistance
    125086704
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:llv01001]
    125086704
Enzymes [BR:llv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     125086704
Protein kinases [BR:llv01001]
 Serine/threonine kinases: STE group
  STE7 family
   125086704
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 Kdo APH
Other DBs
NCBI-GeneID: 125086704
NCBI-ProteinID: XP_047561996
LinkDB
Position
1:220563968..220584234
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPVVDGVEGEPHSISPRPRP
PGRPISGHGTDSRPAMAIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKCLVKNPAERADL
KMLTSHTFIKRSEVEEVDFAGWLCKTLRLKQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctggcagagctagaactggatgagcagcagaagaagcgactagaagccttcctcacccag
aaggccaaggtcggggagctcaaggatgatgactttgaacggatctcggagctgggtgct
gggaacggcggcgtggtcaccaaggtccagcacagaccatccggactcatcatggcgaga
aagctgatccacttggagatcaagccagccatccggaaccagatcatccgcgagctgcag
gtgctacatgagtgtaactctccgtacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggatggtggctccctggaccaggtgttgaaa
gaagccaagagaattcccgaggagatcctggggaaggtcagcattgcggttctccggggt
ttggcgtatctccgggaaaagcaccagatcatgcaccgagatgtgaaaccttccaacatc
ctcgtcaactcccgaggggagattaagctgtgcgattttggggtgagcgggcagctcatt
gactccatggccaactccttcgtgggaactcggtcctacatgtctccggagcggctgcag
ggcacgcactactccgtgcagtcagacatctggagcatggggctgtccctggtggagctg
tccatcggaaggtaccccatccccccaccagacgccaaggagctggaggccatatttggc
cggcccgtggtggacggggtagaaggagagcctcacagcatctcgccgcggccgagaccc
cctggacgccccatcagcggtcacgggacagacagccggcctgccatggccatcttcgag
ctgctggactatattgtgaatgagccgcctcccaagctccccagtggcgtcttcacccag
gatttccaggagtttgtaaataaatgcctagtaaagaacccagcagagcgagcagatctg
aagatgctcacgagccacaccttcatcaagcggtccgaggtggaagaagtggattttgcc
ggctggttgtgtaaaacgctgcggctgaagcagcccagcacacccacgcgcacggccgtg
tga

DBGET integrated database retrieval system