Lutra lutra (Eurasian river otter): 125089926 Help Entry 125089926         CDS       T08100                                  Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism llv  Lutra lutra (Eurasian river otter) Pathway llv04020   Calcium signaling pathway llv04371   Apelin signaling pathway llv04713   Circadian entrainment llv04730   Long-term depression llv04921   Oxytocin signaling pathway llv05017   Spinocerebellar ataxia llv05020   Prion disease llv05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:llv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     125089926    04020 Calcium signaling pathway     125089926  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     125089926   09156 Nervous system    04730 Long-term depression     125089926   09159 Environmental adaptation    04713 Circadian entrainment     125089926  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     125089926    05020 Prion disease     125089926    05022 Pathways of neurodegeneration - multiple diseases     125089926  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:llv01009]     125089926   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:llv04147]     125089926    04040 Ion channels [BR:llv04040]     125089926 Protein phosphatases and associated proteins [BR:llv01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      125089926 Exosome [BR:llv04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    125089926 Ion channels [BR:llv04040]  Voltage-gated cation channels   Ryanodine receptor    125089926 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 AIF_C Motif Other DBs NCBI-GeneID:  125089926 NCBI-ProteinID:  XP_047568374 LinkDB All DBs Position 17:45710149..45820491 Genome browser AA seq 5040 aa AA seqDB search MGDGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPP DLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHTHSGMYLSC LTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLFHGHMDECLTISPADSED QRRLVHYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLV VVDASKAHTKATSFCFRISKEKLDMAPKRDVDGMGPPEIKYGESLCFVQHVASGLWLTYA APDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIYSTAGLYNQFIKGLDS FSGKPRGSGPPAGTALPIEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQE EGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRTNCALF STNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYG KWYFEVMVDEVAPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLH LWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPV VSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLV GPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDN KRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYM MSNGYKPAPLDLSHVRLTPAQMTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPR LVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVESQSRWDRVRIFRAEKS YTVQSGRWYFEFEAVTTGEMRVGWARPDLRPDVELGADELAYVFNGHRGQRWHLGSEPFG RPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVG HLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVARV DGTVDTPPCLRLSHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAHPGLQPPAE DEARAAEPDPDYENLRRSAGRWGEAEGGKEGNSKEGAPGGNAQAGVEAQPVRVENEKDAT TEKNKKRGFLFKAKKVAMMTQPPATPTLPRLPREVVPADNRDDPEIILSTTTYYYSVRVF AGQEPSCVWVGWVTPDYHQHDMNFELSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDF VSSGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQN VIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVETRRA GERLGWAVQCQEPLTMMALHIPEENRSMDILELSERLDLQRFHSHTLRLYRAVCALGNNR VAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTE ETRAITLFPPERSAEDGPRRHGLPGVGVTTSLRPPHHFSAPCFVAALPAAGVAEAPARLS PSIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFADEDV KQILKMIEPEVFTEEEEEEEEEEEEEEDEEEKEEDEEEEAQEKEDEEKEEEETAEGEKEE GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYGLL MKAFTMSAAETARRTREFRSPPQEQINMLLHFKDGEDEEECPLPEEVRQDLLEFHQDLLA HCGIQLEGEEEEPEEEATLGSRLMSLLEKVRLVKKKEEKPEEEPPAEESKPQSLQELVSH TVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGGE SKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAAS VIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAV FVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVRR DRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRS LVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLL HVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMV DSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKM PLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDAELYRMA MPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFA EYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAW EWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYSPQPPDLSGVTLSRELQAMAEQLA ENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTR GLKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFA KILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGT DAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQAR TQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTK NTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEM CPDIPVLERLMADIGVLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAG APPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLHSHFI PTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNN RAHWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMA KAGDVQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQELITQAKNR YALKDTDEEVREYLQNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEV SAVLYHLEQIEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKA AWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDED YLYMAYADIMAKSCHLEEGGENGEADEEEVEVSFEEKEMEKQRLLYQQARLHNRGAAEMV LQMISACKGETGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQSIQALMQTC SVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDF QNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAK QVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDL QKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQD YVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINCEEFANRFQEPARDI GFNVAVLLTNLSEHVPHDPRLRTFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISE TNRMQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEMQIAAQISEPEGEPE ADEDDGAAEAGAEGAEEGAAGPEGAAGQAAAGVTARAAAAAAARALRGLSYRSLRRRVRR LRRLTAREAAAAVASLLWAAVTRAAGAGAGAAAGALRLLWRSLFGGGLVEGAKKVTVTEL LAGMPDPTGDEVHGEQTAGPGGDADGEGAGEGAGDEAEGAGDEEVAAQEAGPGGADGAVA VADGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPIIKRKLGVDGEEEELPPEPEPEPEPEP EKADAENGEKEEVPEPPPEPPKKTAPPPPLPKKEEAGGGGLEFWGELEVQRVKFLNYLSR NFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDVEGSAAGDLSGAGSGGGSGWGSGAGE EAEGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKEL ARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERI AELLGMDLATLEITAHNERKPEPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMV MSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFN FFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFD ITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFET HTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15123 nt NT seq  +upstreamnt  +downstreamnt atgggtgacggaggagagggcgaggatgaggtccagtttctgcgcacggacgacgaagtg gtccttcagtgcagtgccactgtgctcaaggagcaactgaaactctgcctggccgctgag ggctttggaaaccgcctctgcttcctggagcccaccagcaacgcccagaatgtgcccccc gatctggccatctgttgcttcgtcctggagcagtctttgtctgtccgagccctgcaggag atgctggccaacaccgtggaggctggcgtggagtcatcccagggcggaggccacaggaca ctcctgtatggccatgccatcctgctccggcacacacacagcggcatgtacttgagctgc cttaccacctcccgctccatgactgacaagctggccttcgacgtgggactgcaggaagac gccacaggagaggcctgttggtggacgatgcatccggcctccaagcagaggtcggaagga gagaaagtccgcgtgggggatgacctcatcctcgttagtgtctcctcagagcgctacctg cacctgtccacggccagtggggagctccaggtcgatgcctcctttatgcagacactgtgg aacatgaaccccatctgctctggctgcgaagaaggctatgtaactgggggccatgtcctc cgcctctttcacggacacatggatgaatgtctgaccatttcccccgctgacagtgaggac cagcgcagacttgtccactatgaggggggagctgtgtgcacccatgcccgctccctctgg agactggagccgctgagaatcagctggagtgggagccacctgcgctggggccagccactc cgcatccggcatgtcaccactgggcggtacctggcgctcaccgaggaccagggcctggtg gtggtcgatgccagcaaggcccacaccaaggccacctccttctgcttccgcatctccaag gagaagctggatatggcccccaagcgggatgtggatggcatgggtccccctgagatcaag tatggggagtcactgtgcttcgtgcagcacgtggcctcaggcctgtggctcacctacgcc gccccagaccccaaggccctgcggcttggtgtgctcaagaagaaggccatgctgcaccag gaaggccacatggatgacgcattgtccctgacccgctgccagcaggaggagtcccaggct gcccgcatgatttacagcactgccggcctgtacaaccagttcattaagggcctggatagc ttcagcgggaagccgcggggctcggggccaccagcgggcacagcgctgcccatcgagggt gtcatcctgagcctgcaggacctcatcggctacttcgagccgccctccgaggagctgcag cacgaggagaagcagagcaagctgcgcagcctgcggaaccgccagagcctcttccaggag gaggggatgctctccttggtcctgaactgcattgaccgcctaaatgtctacaccactgcc gcccactttgccgaatttgcaggggaggaggcagctgagtcttggaaagagattgtgaac ctgctctatgaactcctggcctccctgatccgtggcaatcgtaccaactgtgccctcttt tccaccaacctggactggctggtcagcaagctggatcggctggaggcctcctctgggatc ctcgaggtgctgtactgtgtcctgattgagagtcctgaggtactaaacattatccaggag aaccacatcaagtccatcatctccctcctggacaagcacgggaggaaccacaaggtgcta gatgtgctgtgttccctgtgtgtgtgcaatggcgtggctgtgcgctccaaccaagatctc attactgagaacttgctccctggccgtgagcttctgctgcagacaaacctcatcaactat gtcaccagcatccgccccaacatctttgtgggccgagcggagggcaccacacagtatggc aaatggtactttgaggtgatggtggacgaggtggctccattcctgacggctcaggccacc cacctgcgggtgggctgggccctcactgagggctacagcccctacccagggggcggcgag ggctggggcggtaatggtgtcggcgatgacctctattcctacggctttgatgggctgcat ctctggacaggacacgtggcgcgcccggtgacttccccagggcagcacctcctggccccg gaggatgtggtcagctgctgtctggacctcagtgtgccgtccatctccttccgcatcaat ggctgtcctgtgcagggcgtctttgaggccttcaatctggatgggctcttcttccctgtt gttagcttttcggctggtgtcaaggtgcggttcctccttggtggccgccatggcgaattc aagttcctccctccacctggctatgccccatgccacgaggctgtgctccctcgagagcga cttcatctggagcccatcaaggagtatcgacgggaggggcctcgggggccccacctggtg ggccccagccgctgcctctcacacactgactttgtgccctgccccgtggacactgtccag attgtcctgcctccccatctggagcgtattcgggagaagctggcggagaacatccacgaa ctctgggcgctgactcgcattgagcagggctggacctacggcccggttcgggatgacaat aagaggctgcacccgtgtcttgtggacttccacagccttccagagcccgagaggaattac aacctgcagatgtctggggagacgctcaagactctactggcgctgggctgccatgtgggc atggcggacgagaaggcggaggacaacctgaagaagaccaagctccccaagacgtacatg atgagcaacgggtacaagccggcgcccctagacctgagccacgtgcggctgacgccggca cagatgacgctggtggaccggctggcagagaatgggcacaatgtgtgggcacgggaccgc gtggcccagggctggagctacagtgcggtgcaggacatcccagcacgtcgcaaccctcgc cttgtgccctaccgcctgctggacgaggccaccaaacgcagcaaccgggacagcctctgc caggccgtgcgcacgctgctgggctatggctacaacattgagccgcctgaccaggagccc agtcaggtggagagccagtctcgctgggaccgagtgcgtatcttccgggcagagaaatcc tatacggtgcagagtggacgctggtactttgagtttgaagcggtcaccacgggtgagatg cgagtgggctgggcaaggcctgacctgcgacctgatgtggagctgggagctgatgagctg gcctatgtcttcaacgggcaccgaggccagcgatggcacctgggcagtgaaccatttggg cgcccatggcagccaggtgatgtcgtgggctgcatgatcgacctcacagagaacaccatt atcttcaccctcaatggcgaggtcctcatgtccgattcaggctctgagacggccttccgg gaaatcgagattggagatggcttcctgcctgtctgcagcttgggacctggccaggtgggt cacctgaacctgggccaggacgtgagctccctgcggttcttcgccatctgtggcctccag gaaggctttgagccattcgccatcaacatgcagcgcccagtcaccacctggttcagcaag agcctcccccaatttgaggccgtgcccctcgaacacccccactatgaggtggcccgtgtg gatggcaccgtggacacaccgccctgcctgcgcctgagccaccgcacctggggctcccag aacagtctggtggagatgctcttcctccggcttagccttccggtccagttccaccagcac ttccggtgcaccgcaggggccacccccctagcgcacccgggcctgcagccccccgccgag gatgaggcccgggcagcggaacctgaccctgactatgaaaacctgcggcgctcagcgggg cgctggggcgaggctgaggggggcaaagaaggaaattccaaggagggggcgcccgggggg aatgcccaggctggggtggaggcccagcccgtcagagtggagaacgagaaagatgctacc acagagaagaacaagaagagagggttcttattcaaggccaagaaggtcgccatgatgacc cagccaccagccactcccactctgccccgactccctcgagaggttgtgccggctgacaac cgtgatgaccctgagatcatcctcagtaccaccacgtactattactctgtgagggtcttc gctggccaggagcccagctgcgtgtgggtaggctgggtcacccctgactaccatcagcat gacatgaacttcgagctcagcaaggtccgggcagtgacggtgaccatgggggacgaacaa ggcaacgtccacagcagcctcaagtgcagcaactgctacatggtgtggggcggggacttc gtgagctccgggcagcagggccggatcagccacacagaccttgtcattggctgcctggtg gacttggccactggtctgatgacctttaccgccaatggcaaagagagcaacacctttttc caggtggagcccaacacgaagctgtttcctgctgtctttgtcctgcccacccaccagaac gtcatccagtttgagttggggaagcagaagaacatcatgccgctgtcggctgccatgttt ctgagtgagcgtaagaacccggccccgcagtgcccgcctcggctagaggtgcagatgctg atgcccgtctcgtggagccgtatgcccaaccacttcctgcaggtggagacacgacgtgcg ggcgagcggttgggctgggccgtgcagtgccaggagccgctgaccatgatggctttgcac atccctgaggagaacagatccatggacatcctggagctatcggagcgcctggacctgcag cggttccactcccacaccctccgcctctaccgcgccgtgtgcgcgctgggcaacaaccgt gtggcgcatgctctgtgcagccacgtggaccaggcgcagctgctgcatgcgctggaggac gcgcacctgccggggccgctgcgggctggttactacgacctcctcatcagcatccacctc gaaagcgcctgccgcagccgccgctccatgctctccgagtacatcgtgcccctcacggag gagacgcgcgccatcactctcttcccaccggaaagaagcgcggaagacggcccccggcgc cacgggctgccgggcgttggcgtcaccacctcgctgcggcctccacaccatttctcagcc ccctgtttcgtggccgccctgccggctgccggggtggcggaagctccggcccgcctcagc cccagcatccctctggaggccctacgggataaagcactgagaatgctgggggaggctgtg cgagatggtgggcagcacgcacgtgaccctgtcgggggctctgtggagttccagttcgtg cccgtgctcaagctcgtgtccaccctgttggtgatgggcatctttgccgatgaggacgtg aaacagatcttgaagatgattgaacctgaagtattcactgaggaagaagaggaagaggaa gaggaggaagaagaagaagaagatgaagaggagaaggaggaggatgaagaggaagaggca caggagaaagaagatgaggaaaaagaggaagaggagacagcagaaggggagaaagaagaa ggcttggaggaagggctgctccagatgaagttgccagaatccgtgaagttacagatgtgc cacctgctggagtatttctgtgaccaagagctacagcaccgggtggaatccctagcagcc tttgcggagcgctatgtggacaagctccaggccaaccagcgggaccgctatggcctcctc atgaaagccttcaccatgtctgctgctgagactgcgagacgtactcgcgagttccgctcc ccaccccaggagcagataaacatgctgttgcacttcaaagatggtgaggatgaggaagag tgtcctctccctgaagaggtccgacaggatttgctcgaatttcatcaagacttgctggca cactgtggaattcagctggagggggaggaggaggaaccagaggaagaggccaccctgggc agccgactgatgagcctgttggagaaagtacggctggtgaagaagaaggaggagaaaccc gaggaggaaccaccagctgaggagagcaaaccccagtcactgcaggagctggtgtcccac acagtggtgcgctgggctcaagaggacttcgtgcagagccctgagctcgttcgggccatg ttcagcctcctgcaccggcagtacgatgggctcggggagctgctgcgtgccctgccccgg gcgtacaccatctccccatcatccgtggaagacaccatgagcttgcttgagtgcctcggc cagatccggtccctgcttatcgtgcagatgggtccccaggaggaaaacctcatgatccag agcattgggaacatcatgaacaacaaagtcttctaccaacacccgaacctgatgcgggcc ctgggcatgcatgagacggtcatggaagtcatggtgaatgtcctcgggggtggtggcgaa tccaaggagatccgcttccctaagatggtgacaagttgctgccgcttcctctgttatttc tgtcgcatcagccggcagaaccaacgctccatgttcgaccacctgagctacctgctggag aacagtggcatcggtctaggcatgcagggctccacgcctctggatgtagcagctgcctcc gtcatcgacaacaacgagctggccttggcattgcaagagcaggacctggagaaggtggtg tcctatctggcgggttgtggccttcagagctgccccatgctcctggccaaagggtacccg gacatcggctggaacccgtgtggcggggagcgctacctggactttctacgcttcgctgtc ttcgtcaacggcgagagcgtggaggagaacgccaacgtggtggtgcggctgctcatccgc aagcccgagtgcttcgggcccgccctgcggggtgagggtggctccgggctgctggctgcc atcgaagaagccattcgcatctctgaggacccagcgcgtgacggcccaggtgtccgcagg gaccggcggcgtgagcacttcggcgaggagcccccagaggagaaccgggtacacctggga catgccatcatgtccttctacgctgccttgattgacctgctgggacgctgtgcgccagag atgcacctaatccaagccggcaagggagaggccctgcggatccgcgccatcctgcgctcc ctcgtgccgctggacgaccttgtgggcatcatcagcctcccactgcagatccccaccctg ggcaaagatggggctctggtgcagccgaagatgtcagcctccttcgtgccagaccacaag gcatccatggtgctcttcctggaccgcgtgtatggcatcgagaaccaggacttcttgctg catgtgctggacgtgggattcctgcctgacatgcgggcagctgcttcactggacacggcc actttcagcacgacggagatggcgctggcgctgaaccgctacctgtgcctggcggtgctg ccgctcatcaccaagtgcgcgccgctgttcgcggggacggagcaccgcgccatcatggtg gactccatgctgcacacggtgtaccgcctgtcccgcggccgctcgctcaccaaggcgcag cgcgacgtcatcgaggactgtctcatggcgctctgcaggtacatccggccgtccatgctg cagcacctgctgcggcgcctggtgttcgatgtgcccatcctgaacgagttcgccaagatg ccgctcaagctcctcaccaaccactatgagcgctgctggaagtattactgcctccccacg ggctgggctaacttcggggtcacctccgaggaagagctgcacctcactcgcaaactcttc tggggcatctttgactcgctggcacataagaagtatgatgcagagctgtaccgcatggct atgccttgtctgtgcgccatcgcaggggccctgccccctgactacgtggacgcctcatac tcatccaaggccgagaaaaaggccacagtggacgctgaaggcaacttcgatcctcggcct gtggagaccctcaatgtgatcatcccagagaagctggactccttcattaacaagtttgcg gagtacacgcatgagaagtgggccttcgacaagattcagaacaattggtcctatggggag aacatagatgaggaactgaagacccatcccatgctgaggccctataagaccttttcagag aaggacaaagagatttaccgctggcccatcaaggagtccttgaaggccatgattgcctgg gaatggacgatagagaaggccagggagggggaagaggagaagacggagaagaagaaaacg cggaagatatcccaaagtgcccagacttatgatccgcgagaaggctacagcccccagccc cccgacctcagcggagttaccctgtcccgggagctgcaggccatggcggaacagctggcg gagaattaccacaacacgtgggggcggaagaagaagcaggagctggaggccaagggtggt ggtacccaccctctgctggtcccctatgacacactcacagccaaggagaaggcacgagat cgagagaaagcccaggagcttctaaagttcctgcagatgaacggctatgctgtcaccaga ggccttaaggacatggagttggacacgtcttccattgagaaacggtttgcttttggcttc ctgcagcagttgctgcgctggatggacatctcccaggaatttatcgcccatctggaggct gtggtcagcagtggacgagtggaaaagtccccacatgaacaggagattaagttctttgcc aagatcctgctccctttgatcaaccagtacttcaccaaccactgcctctatttcctgtcc acaccggccaaagtgctgggcagtggtggccatgcctccaacaaggagaaggaaatgatc accagcctcttctgcaagcttgccgctcttgtccgtcaccgagtttctctcttcgggaca gatgctccggctgtggtcaactgccttcacatcctggcccgctccctggatgccaggacg gtgatgaagtcgggccctgagatcgtgaaggctggcctccgctccttctttgagagtgcg tcagaggacatcgagaagatggtggagaacctgcgcctgggcaaggtgtcccaggcacgt acacaggtgaagggcgtgggccagaacctcacctacaccaccgtggccctgctgcccgtc ctcaccacgctcttccagcacatcgcccagcaccagttcggagacgacgtcatcctggat gatgtccaggtctcttgctaccgaacgctgtgcagtatctactctctgggaaccaccaag aacacttacgtggaaaagctgcggccagccctgggggagtgcctggcccgtctggcagca gctatgccggtggcgttcctggagcctcagctgaacgagtataatgcctgctcagtgtac actaccaagtctccccgggagcgggccatcctggggctccccaacagcgtggaggagatg tgtcctgacatcccagtgctggagcggctcatggcagacatcggggtgctggccgagtcg ggggcccgctacacggagatgccacacgtcatcgagatcacgctgcccatgctgtgcagc tacctgccccgctggtgggagcgtgggcccgaggcgccgccccctgccctgcccgcaggg gcccccccaccctgcacggcagtcacctctgaccacctcaactccctgctggggaacatc ctgcgcatcatcgtcaacaacctgggcattgacgaggcatcgtggatgaagcggctggcc gtgtttgcccagcccattgtgagccgggcccggcctgagcttctgcattcccacttcatc cccaccatcgggcgcttgcgcaagcgggcagggaaggtggtggccgaggaggagcagctg cgcctggaggccaaggccgaagcggaagagggcgagctcctggtgcgggacgagttctct gtgctctgccgggacctgtacgccctctacccactgctcatccgctatgtggacaacaac agggcgcactggctgacggagcccaatcccagcgccgaggagctgttcaggatggtgggc gagatcttcatctactggtccaagtcccacaactttaagcgcgaagagcagaactttgtg gtccagaatgagatcaacaacatgtcatttctgactgctgacaacaagagcaaaatggcc aaggcgggagatgtacagtcaggtggctcagaccaggaacgcaccaagaagaagcgccga ggggaccggtactctgtgcagacatccctgattgtcgccacgctcaagaagatgctgccc atcggcctgaatatgtgtgcgcccacggaccaggaactcatcacgcaggccaagaaccgc tatgccctgaaagacacagacgaggaggtacgggaatatctgcaaaacaaccttcacctt cagggaaaggtcgaaggctccccttctttgcgctggcagatggccctgtaccgtggtgtc ccgggccgtgaggaggacgccgacgaccccgagaaaatcgtgcgcagggttcaggaagtg tctgcggtgctctaccacctggagcagatcgagcacccttacaaatccaagaaggccgtg tggcacaagctcttgtccaagcagcgccggagggcagtggttgcctgtttccgcatgacc cccctgtacaacctgcccacgcaccgggcctgtaacatgttcctggagagctacaaggcc gcgtggatcctgactgaagaccacagttttgaggaccgcatgatcgatgacctttcaaaa gctggggaacaggaggaggaggaggaggaggtggaggagaagaagccggaccccctacat cagctggtccttcacttcagccgcaccgccctgactgagaagagcaaactggatgaggat tacctgtatatggcgtatgccgacatcatggcaaagagctgccacctggaggagggaggg gagaatggcgaagcagatgaggaggaagtggaggtgtcctttgaggagaaagagatggag aaacagaggctgctgtaccagcaggcgcggctgcacaacaggggagccgccgagatggtg ctgcagatgatcagtgcctgcaaaggagagacaggcgccatggtatcctccaccctgaag ctgggcatctccatcctaaatggaggcaatgcagatgtgcagcagaaaatgctggattat ctgaaggacaagaaggaagtgggcttcttccagagtatccaggcgctgatgcaaacatgc agcgtcctggatctcaatgccttcgagagacagaacaaggcagaggggctgggcatggtg aacgaggatggaactgtcatcaatcgccagaacggagagaaggtcatggcagatgacgaa ttcacccaagacctgttccgattcctacaactgctctgtgaggggcacaacaatgatttc cagaactacctacggacacaaacggggaacacgaccactattaacatcatcatctgcacg gtggactacctcctgaggctgcaggaatccatcagcgacttctactggtactactctggc aaggatgtcattgaggagcagggcaagaggaacttttccaaggccatgtcggtcgctaaa caggtgttcaacagcctcaccgagtacatacagggcccctgcaccgggaaccagcagagc ctggcacatagccgcctctgggatgctgtggtgggattcctgcacgtgtttgcccacatg atgatgaagctcgctcaggactccagccagatcgagctgctgaaggagctgctagatctc cagaaggacatggtggtgatgttgctgtcgctactagaagggaatgtggtgaacggcatg attgcccggcagatggtggacatgcttgtggaatcctcatccaacgtggagatgatcctc aagttcttcgacatgttcctgaaactcaaggacatcgtgggctcagaggccttccaggac tatgttaccgatccccgtggcctcatctccaagaaggacttccagaaggctatggacagc cagaagcagttcactggcccagaaatccagttcctgctttcctgctccgaagccgatgag aacgagatgatcaactgtgaggagttcgccaaccgcttccaggagcccgcccgcgacatc ggcttcaacgtggcggtgctgctgaccaacctgtcggagcacgtgccccacgacccacgc ctgcgcaccttcctggagctggcggagagcatccttgagtacttccggccctacctgggc cgcatcgagattatgggcgcctcgcgccgcatcgagcgcatctactttgagatctcagag accaaccgcatgcagtgggagatgccccaggtcaaggagtccaagcgccagttcatcttc gacgtggtgaacgagggcggcgagtccgagaagatggagctcttcgtgagcttctgcgag gacaccatcttcgagatgcagatcgccgcgcagatctccgagcccgagggcgagccggag gcggacgaagacgacggcgcggccgaggcgggcgcggagggcgcggaggagggcgcggcg ggacccgagggcgcggcggggcaggcggcggcgggcgtgacggcgcgcgcggcggcggcg gcggcggcccgggcgctgcgcggcctcagctaccgcagcctgcggcggcgcgtacggcga ctgcggcggctcacggcgcgcgaggcggccgcggcggtggcttcgctgctctgggcggcg gtgacgcgcgcggcgggcgcgggcgcgggcgcggcggctggcgcgctgcgcctgctctgg cgctcgctcttcggcggcggcctcgtggagggcgccaagaaggtgacggtgaccgagctc ctggccggcatgcccgaccccacgggcgacgaggtgcacggcgagcagacagccgggccc ggcggcgacgcggacggcgagggcgcgggcgagggcgcgggcgacgaggcggagggcgcg ggcgacgaggaggtggcggcgcaagaggccggcccgggaggcgcagacggggccgtggcc gtggcggacgggggccccttccggcccgaaggggcgggcggcctcggggacatgggtgac acgacgccggcggagccgcccacgcccgagggctcccccatcatcaagaggaagctgggg gtggatggagaggaagaggagctgcctccagaacccgagccagagcccgaacccgagcct gagaaagccgatgctgagaatggggagaaggaagaagtccctgaacccccaccagagccc cccaagaagacagcacctcctccaccccttccaaagaaggaggaggctggaggtgggggc ttggaattctggggagaactggaagtacagagggtgaagttcttgaactacctctcccgg aacttctacaccctgcgattccttgcgctcttcttggcctttgccatcaacttcatcttg ctgttttataaggtctcagactctccgccaggggaggacgacgtggagggctcagcagct ggggacttgtcaggtgcagggtctggtggcggctctggctggggctcgggggctggcgag gaagcggagggtgatgaggacgagaacatggtgtactacttcctggaggagagcaccggc tacatggagcccgccttgcgctgtctgagcctgctccatacgctggtggccttcctctgc atcattggctacaactgcctcaaggtgcccctggtgatctttaaacgggaaaaggagctg gcccgaaagctggagtttgacggcctctacatcacagagcagcccgaggatgacgacgtg aagggccagtgggaccggctggtgctcaacacaccgtctttccccagcaattactgggat aagtttgtcaagcggaaggtcctggacaagcatggggacatctacgggcgggagaggatc gctgagctgctgggcatggatctggccacactggagatcacagcccacaacgagcgaaag cctgaaccaccaccaggactgctcacctggctcatgtccattgatgtcaagtaccagatc tggaagtttggggtcatcttcacagacaattctttcctatatctgggctggtacatggtg atgtccctcctgggacactacaacaacttcttcttcgctgcccacctcctggacattgcc atgggggtcaagacgctgcgaaccatcctctcctccgtcacccataatggaaagcagctg gtgatgaccgtgggcctcctggcggtggttgtctacctctacaccgtggtggccttcaac ttcttccgcaagttctacaacaagagtgaggatgaggacgagcctgacatgaagtgtgac gatatgatgacgtgttacctgtttcacatgtacgtgggtgtccgagccggtgggggcatc ggggatgagattgaggatccagcaggcgatgaatatgagctgtaccgagtggtcttcgat atcaccttcttcttctttgtcatcgtcatcctgctggccatcatccagggtctgatcatt gacgctttcggcgagctccgagaccaacaagagcaagtgaaggaagatatggagaccaag tgcttcatctgcgggatcggcagcgattactttgatacgacaccgcacgggtttgagacc cacacgctagaggagcacaacctggccaattacatgtttttcctgatgtatctgataaat aaggacgagacggaacacacgggccaggagtcttatgtctggaagatgtaccaagagaga tgttgggatttcttcccagctggcgattgtttccgcaagcagtatgaggaccagcttagc tga

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