KEGG   Lutra lutra (Eurasian river otter): 125093458
Entry
125093458         CDS       T08100                                 
Name
(RefSeq) fibroblast growth factor receptor 3 isoform X1
  KO
K05094  fibroblast growth factor receptor 3 [EC:2.7.10.1]
Organism
llv  Lutra lutra (Eurasian river otter)
Pathway
llv01521  EGFR tyrosine kinase inhibitor resistance
llv04010  MAPK signaling pathway
llv04014  Ras signaling pathway
llv04015  Rap1 signaling pathway
llv04020  Calcium signaling pathway
llv04144  Endocytosis
llv04151  PI3K-Akt signaling pathway
llv04550  Signaling pathways regulating pluripotency of stem cells
llv04810  Regulation of actin cytoskeleton
llv05200  Pathways in cancer
llv05206  MicroRNAs in cancer
llv05219  Bladder cancer
llv05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:llv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125093458
   04014 Ras signaling pathway
    125093458
   04015 Rap1 signaling pathway
    125093458
   04020 Calcium signaling pathway
    125093458
   04151 PI3K-Akt signaling pathway
    125093458
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    125093458
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    125093458
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125093458
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125093458
   05206 MicroRNAs in cancer
    125093458
   05230 Central carbon metabolism in cancer
    125093458
  09162 Cancer: specific types
   05219 Bladder cancer
    125093458
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125093458
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:llv01001]
    125093458
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:llv04090]
    125093458
Enzymes [BR:llv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     125093458
Protein kinases [BR:llv01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   125093458
CD molecules [BR:llv04090]
 Proteins
  125093458
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase I-set Ig_3 ig Ig_2 V-set FGFR3_TM C2-set_2 Pkinase_fungal ABC1 V-set_CD47
Other DBs
NCBI-GeneID: 125093458
NCBI-ProteinID: XP_047574571
LinkDB
Position
2:141484955..141501078
AA seq 807 aa
MGAPARALAICVVLAVMTGAASMPRGMEPRVLRRAAEALGPEPGQQEQLVFGSGDTVELS
CHAPAGGPTGPSVWVKDGVGLVPSDRVLLGPQRLQVLNASHEDSGSYSCRQRLTHRVLSH
FSVRVMDAPSSGDDEDGEDEAEDTAGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT
PSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVQNKFGSIQQTYTL
DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT
PYVTVLKSWISESVEADARLRLANVSERDGGEYLCRASNFIGVAEKAFWLRVHGPQAAEE
ELVEAGEAGSVYAGVLSYGVGFLLFILVVAAVTLCRLRTPPKKGLGSPAVHKVSRFPLKR
QVTVSLESNSSMNSNTPLVRIARLSSGEGPALANVSELELPADPKWELSRARLTLGKPLG
EGCFGQVVMAEAIGIDKDRAARPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGRHKNII
NLLGACTQGGPLYVLVEYAAKGNLREYLRARRPPGLDYSFDTCGPPGEQLTCKDLVSCAY
QVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVK
WMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANC
THDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPS
SSSSGDDSVFAHDLLPPAPSSSGGLRT
NT seq 2424 nt   +upstreamnt  +downstreamnt
atgggcgccccggctcgcgccctcgcgatctgcgtggtgctggcggtcatgaccggcgcc
gcctcgatgccccggggcatggagccgcgcgtcttgcggagagcggcagaggccctgggg
cctgagcccggccagcaggaacagctggtctttggcagcggggacaccgtggagctgagc
tgtcatgcgcctgctggtggtcccacagggcccagcgtctgggtcaaggatggcgtgggc
ctggtgccttcagaccgcgtcctgctggggcctcagcggctgcaggtgctcaacgcctct
cacgaggactcagggtcctacagctgccggcagcggctcacgcaccgtgtgctctcccac
ttcagtgtgcgagtgatggatgctccgtcctctggagatgatgaagatggggaggacgag
gctgaggatacagcaggggctccttattggacgcggcccgagcggatggacaagaagctg
ctagcggtgccagccgccaacactgtgcgcttccgctgcccggccgccggcaatcccacg
ccatccatctcctggctgaagaacggcaaggagttccgaggcgagcaccgcatcgggggc
atcaagctacgacaccagcagtggagcctggtcatggagagcgtggtgccctcggaccgc
gggaactatacgtgtgttgtgcagaacaagttcggcagcatccagcagacctacaccctg
gacgtgctggagcgttcgccgcaccggcccatcctgcaggccgggctgcctgccaaccag
acggctgtgctgggcagcgacgtggagttccactgcaaggtgtacagtgacgcgcagccc
cacatccagtggctcaagcacgtggaggtgaacggcagcaaagttggtcccgacggcacc
ccgtatgtcaccgtgctcaagtcctggatcagtgagagtgtggaggccgacgcacgcctc
cgcctggccaatgtgtccgagcgtgatgggggcgagtacctctgtcgagcctccaatttc
ataggcgtggctgagaaggccttttggctgcgtgttcacgggccccaagcagctgaggag
gagctggtggaggctggtgaggctggcagcgtgtacgcgggcgtcctcagctacggggtg
ggcttcctcctcttcatcctggtggtggcagccgtcactctctgccgcctgcgcacgccc
ccgaagaagggcctgggctcacccgccgtgcacaaggtctcccgcttcccactcaagcga
caggtaacagtgtccttggagtccaactcgtccatgaactccaatacacccctggtgcgc
atcgccaggctgtcctcaggggaaggccccgcgctggccaatgtctccgagctggagttg
cctgctgaccccaagtgggagctgtccagggcccggctgaccctaggcaagccacttggg
gagggatgcttcggccaggtggtcatggcggaggccattggcatcgacaaggacagggct
gcccggcccgtcactgtggcagtgaagatgctcaaagatgacgccacagataaggacctg
tcggatctggtgtctgagatggagatgatgaagatgattggccgccacaagaacatcatc
aacctgctgggggcctgcacccagggtgggcccctgtacgtgctagtggagtacgcggcc
aagggtaacctgcgggagtacctgcgggcacggcggcccccaggcctggactactccttc
gacacctgtgggccgcccggggagcagctcacctgcaaggacctggtgtcctgcgcctac
caggtggcccggggcatggagtacctggcctcccagaagtgcatccacagggacctggcc
gcccgcaatgtgctggtgaccgaggacaatgtaatgaagatagcagacttcggcctggcc
cgtgatgtgcacaacctggactactacaagaagaccaccaacggccggctgcctgtgaag
tggatggcacctgaggccttgtttgaccgggtctacacccaccagagtgacgtctggtcc
tttggggtccttctctgggagatcttcaccctggggggctcaccgtaccccggcatcccc
gtggaggaactcttcaagctgttgaaggagggtcaccgcatggacaagccggccaactgc
acacatgacctgtacatgattatgcgggaatgctggcatgctgtgccctcccagaggccc
accttcaagcagttggtggaggacctggaccgtatccttactgtgacgtccacagatgag
tacttggacctgtctgtgccttttgagcagtattcaccaggcggccaggacaccccgagc
tccagctcctcgggggacgactctgtgtttgctcacgacctgctgcctccggcccccagc
agcagcgggggcctgcggacgtga

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