Lutra lutra (Eurasian river otter): 125095145 Help Entry 125095145         CDS       T08100                                  Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism llv  Lutra lutra (Eurasian river otter) Pathway llv04022   cGMP-PKG signaling pathway llv04068   FoxO signaling pathway llv04081   Hormone signaling llv04140   Autophagy - animal llv04150   mTOR signaling pathway llv04151   PI3K-Akt signaling pathway llv04152   AMPK signaling pathway llv04211   Longevity regulating pathway llv04213   Longevity regulating pathway - multiple species llv04722   Neurotrophin signaling pathway llv04910   Insulin signaling pathway llv04920   Adipocytokine signaling pathway llv04923   Regulation of lipolysis in adipocytes llv04930   Type II diabetes mellitus llv04931   Insulin resistance llv04932   Non-alcoholic fatty liver disease llv04935   Growth hormone synthesis, secretion and action llv04960   Aldosterone-regulated sodium reabsorption llv05010   Alzheimer disease llv05206   MicroRNAs in cancer llv05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:llv00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     125095145    04022 cGMP-PKG signaling pathway     125095145    04151 PI3K-Akt signaling pathway     125095145    04152 AMPK signaling pathway     125095145    04150 mTOR signaling pathway     125095145   09133 Signaling molecules and interaction    04081 Hormone signaling     125095145  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     125095145  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     125095145    04923 Regulation of lipolysis in adipocytes     125095145    04920 Adipocytokine signaling pathway     125095145    04935 Growth hormone synthesis, secretion and action     125095145   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     125095145   09156 Nervous system    04722 Neurotrophin signaling pathway     125095145   09149 Aging    04211 Longevity regulating pathway     125095145    04213 Longevity regulating pathway - multiple species     125095145  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     125095145   09164 Neurodegenerative disease    05010 Alzheimer disease     125095145   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     125095145   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     125095145    04932 Non-alcoholic fatty liver disease     125095145    04931 Insulin resistance     125095145 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  125095145 NCBI-ProteinID:  XP_047577110 LinkDB All DBs Position 3:complement(36039704..36098706) Genome browser AA seq 1235 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLAAPN GHYILPRGGNGHRYIPGTGLGTSPALAGDEAASATDLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLDRRGGHHR PDASTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPS GYMMMSPSGSCSPDIGGGPSNNTGAAPSGGSYGKLWTNGVGGHHGSALPHPKLPGESGSG KLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEES ARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCGVRPDPGLPHIHHQVLQPHLPR KVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQPSLLHPPEPKSPGEYVNIEFGSD QPGYLSGPVASRSSPSVRCPSQLQPAPREEETGTEEYMNMDLGPGRRATWQESTGVQPGR VGPAPPGAATMCRPTRALPSSRGDYMTMQMGCPGQSYVDTSPVAPISYADMRTGVVEEAS IPGATAAAPSSSAASASPSTAPEKAGELVARSSLLGAPQGPGAMSAFTRVNLSPNRNQSA KVIRADPQGCRRRHSSETFSSTPSATRAGNMVPFGGGAAVGGSGGGSSSTEDMKRHSSAS FENVWLRPGDLGGAAKEPAPVCGAAGGLENGLNYIDLDLVKDFKHRPQERPPQPQPPPPP HQPPGNSESSSTSRSSEDLSAYASISFQKQPEDLQ NT seq 3708 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctcccgagaccgacggcttctcggatgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgtttcaacatcaacaagcgggccgactccaagaac aagcacctggtggccctttacacccgggacgagcactttgccatcgcggcggacagcgag gcggagcaggacagctggtaccaggcccttctgcagctgcacaaccgggccaagggccac cacgacggggcggcagcccccggggcaggaggaggtgggggcagctgcagcggcagctct ggcctcggggaggctggggaggacttgagttacggggacgtgcccccaggacctgcgttc aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt ggtatctaccgtctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcggcggctgtggtgctgcagctgatgaacatcagacgctgcggccactcagagaacttc ttcttcatcgaggtgggccgttccgcagtgacgggacctggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagacaattctggaggccatgagggccatg agcgatgagttccgtcctcgaagtaagagccagtcctcctccaactgctccaaccccatc agcgtccccctgcgcaggcaccatctcaacaaccccccgcccagccaggtggggctgacg cgccgctctcgcaccgagagcatcaccgccacctctccggccagcatggtgggcggcaag cagggctccttccgtgtgcgcgcgtccagtgatggcgaaggcaccatgtcccggccggcc tcggtggacggcagccccgtgagtcctagcaccaacaggacccacgcccaccggcatcgc ggcagctcccggctacaccctcctctcaaccacagccgctccatccccatgccttcctct cgctgctcaccttctgccaccagcccggtcagtctgtcgtccagcagcaccagtggccac ggctccacctcggactgtcttttcccacggaggtctagtgcttctgtgtcgggatccccc agcgatggcggcttcatctcctcggatgagtatggctccagcccttgcgatttccgaagt tccttccgcagtgtcaccccggattccctgggccacaccccaccagcccgcggcgaggag gagctgagcaactacatctgcatggggggcaaagggtcctccacccttgccgcccccaat ggtcactacattttgcctcggggtggcaacggtcaccgctacatcccaggaactggtttg ggcacgagcccagccctggctggggatgaagccgccagcgctacagatctggataatcgg ttccgaaagcggactcactctgcgggcacgtcccctaccatttcccaccagaagacccca tcccagtcctctgtggcttccattgaggaatacacggagatgatgcctgcctacccacca ggaggtggcagtggaggccgactgcctggctaccgacactctgccttcgtgcccacccac tcctacccggaggagggtctggaaatgcaccctttggacaggcgtgggggccaccaccgc ccagacgcctccactctccacactgatgatggctacatgcccatgtccccaggagtggcg ccagtgcccagcagccgaaagggcagtggggactacatgcccatgagccccaagagcgtg tctgcaccccagcagatcatcaacccaatcagacgccatccccagcgagtggaccccagt ggctacatgatgatgtccccgagtggcagctgctcccccgacattggaggtgggcccagc aataatactggcgctgccccttctgggggcagctatggcaagctgtggacaaatggggtc ggggggcaccatggttctgccctgccgcatcccaagctgcctggggagagtggcagcggc aagctcttgtcttgtactggtgactacatgaacatgtcgccagtgggggactccaacacc agcagcccctccgactgctactatggcccggaagacccccagcacaagccagttctctcc tactactcattgccaaggtcctttaagcacacccagcgccctggggagctggaggagagt gctcggcaccaacaccttcgcctttcctccagctctggtcgccttctctatgctgcagcg gcagaagattcctcctcctccaccagcagcgacagcctgggagggggatactgtggggtg aggccagatcctggcctcccacatatccaccatcaggtcctgcagcctcatctgcctcga aaggtggacacagctgcccagaccaacagccgcctggctcggcccacgaggctgtcattg ggggatcccaaggccagcaccttacctcgggtccgagagcagcagcaacagccatccctg ctgcaccctccagagcccaagagcccaggggaatatgtgaacattgaatttgggagtgat cagccgggttacttgtctggtcctgtggcttcccgcagctcgccttctgtcaggtgtcca tcccagctccagccagctccccgagaggaagagactggcacggaggaatacatgaacatg gacctggggccgggccggagggcgacctggcaggagagcactggggtccagccaggcaga gtgggccctgcacctcctggagctgctaccatgtgccggcctacccgggcactgcccagc agccggggggactacatgaccatgcagatgggttgtcccgggcagagctatgtggacacc tcaccagttgcccccatcagctatgctgacatgaggacaggcgttgtggaggaggccagc attccaggggccacagcagcggctccctcatcctctgcagcctctgcttccccttccact gcgcctgagaaagcaggggagctggtggctcgctcttccctgctgggagccccacaggga cctggggccatgagcgccttcacccgggtcaacctcagtcccaaccggaaccagagtgcc aaagtgatccgtgcggaccctcaagggtgcaggaggaggcatagttctgagaccttctcc tccacacctagtgccacccgagcgggcaacatggtgccctttggagggggggcagctgta gggggcagcggtggtggcagcagcagcacggaggatatgaaacgccacagttctgcttcc tttgagaatgtgtggctgaggcctggggacctcgggggagctgccaaggagccggcccca gtgtgtggggctgctgggggtttggagaatgggcttaactacatagacctggatctggtc aaggacttcaaacatcgacctcaggagcgcccccctcaaccgcagccgcccccgccccct catcagcctccgggcaacagtgagagcagctcaaccagccgctccagtgaggatttaagc gcctatgccagcatcagtttccagaagcagccagaggacctccagtag

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