Lutra lutra (Eurasian river otter): 125099871 Help Entry 125099871         CDS       T08100                                  Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism llv  Lutra lutra (Eurasian river otter) Pathway llv00230   Purine metabolism llv01100   Metabolic pathways llv01522   Endocrine resistance llv04015   Rap1 signaling pathway llv04020   Calcium signaling pathway llv04022   cGMP-PKG signaling pathway llv04024   cAMP signaling pathway llv04062   Chemokine signaling pathway llv04072   Phospholipase D signaling pathway llv04081   Hormone signaling llv04082   Neuroactive ligand signaling llv04114   Oocyte meiosis llv04211   Longevity regulating pathway llv04213   Longevity regulating pathway - multiple species llv04261   Adrenergic signaling in cardiomyocytes llv04270   Vascular smooth muscle contraction llv04371   Apelin signaling pathway llv04540   Gap junction llv04611   Platelet activation llv04713   Circadian entrainment llv04714   Thermogenesis llv04723   Retrograde endocannabinoid signaling llv04724   Glutamatergic synapse llv04725   Cholinergic synapse llv04727   GABAergic synapse llv04750   Inflammatory mediator regulation of TRP channels llv04911   Insulin secretion llv04912   GnRH signaling pathway llv04913   Ovarian steroidogenesis llv04914   Progesterone-mediated oocyte maturation llv04915   Estrogen signaling pathway llv04916   Melanogenesis llv04918   Thyroid hormone synthesis llv04921   Oxytocin signaling pathway llv04922   Glucagon signaling pathway llv04923   Regulation of lipolysis in adipocytes llv04925   Aldosterone synthesis and secretion llv04926   Relaxin signaling pathway llv04927   Cortisol synthesis and secretion llv04928   Parathyroid hormone synthesis, secretion and action llv04934   Cushing syndrome llv04935   Growth hormone synthesis, secretion and action llv04970   Salivary secretion llv04971   Gastric acid secretion llv04972   Pancreatic secretion llv04976   Bile secretion llv05032   Morphine addiction llv05163   Human cytomegalovirus infection llv05166   Human T-cell leukemia virus 1 infection llv05200   Pathways in cancer llv05207   Chemical carcinogenesis - receptor activation llv05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:llv00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     125099871  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     125099871    04371 Apelin signaling pathway     125099871    04020 Calcium signaling pathway     125099871    04072 Phospholipase D signaling pathway     125099871    04024 cAMP signaling pathway     125099871    04022 cGMP-PKG signaling pathway     125099871   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     125099871    04081 Hormone signaling     125099871  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     125099871   09144 Cellular community - eukaryotes    04540 Gap junction     125099871  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     125099871    04062 Chemokine signaling pathway     125099871   09152 Endocrine system    04911 Insulin secretion     125099871    04922 Glucagon signaling pathway     125099871    04923 Regulation of lipolysis in adipocytes     125099871    04912 GnRH signaling pathway     125099871    04913 Ovarian steroidogenesis     125099871    04915 Estrogen signaling pathway     125099871    04914 Progesterone-mediated oocyte maturation     125099871    04921 Oxytocin signaling pathway     125099871    04926 Relaxin signaling pathway     125099871    04935 Growth hormone synthesis, secretion and action     125099871    04918 Thyroid hormone synthesis     125099871    04928 Parathyroid hormone synthesis, secretion and action     125099871    04916 Melanogenesis     125099871    04925 Aldosterone synthesis and secretion     125099871    04927 Cortisol synthesis and secretion     125099871   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     125099871    04270 Vascular smooth muscle contraction     125099871   09154 Digestive system    04970 Salivary secretion     125099871    04971 Gastric acid secretion     125099871    04972 Pancreatic secretion     125099871    04976 Bile secretion     125099871   09156 Nervous system    04724 Glutamatergic synapse     125099871    04727 GABAergic synapse     125099871    04725 Cholinergic synapse     125099871    04723 Retrograde endocannabinoid signaling     125099871   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     125099871   09149 Aging    04211 Longevity regulating pathway     125099871    04213 Longevity regulating pathway - multiple species     125099871   09159 Environmental adaptation    04713 Circadian entrainment     125099871    04714 Thermogenesis     125099871  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     125099871    05207 Chemical carcinogenesis - receptor activation     125099871   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     125099871    05163 Human cytomegalovirus infection     125099871   09165 Substance dependence    05032 Morphine addiction     125099871   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     125099871   09167 Endocrine and metabolic disease    04934 Cushing syndrome     125099871   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     125099871 Enzymes [BR:llv01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      125099871 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  125099871 NCBI-ProteinID:  XP_047585416 LinkDB All DBs Position 5:5557181..5979341 Genome browser AA seq 1093 aa AA seqDB search MWREAMRRRRYLRDRAEAAAAAAGGGDGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMGA CLALLAVFFALRLEVEDHVAFLITVPTALAIFFAIFILVCIESVFQKLLRLFSLVIWLCL VAMGYLFMCFAGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCL SATPGAKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEK RQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIV GFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKN CVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHME AGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPHLFR PRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNR TLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKILEKEYRATALP AFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLVLAFTLFICFAGQLLQCSKKA SASLLWLLKSSGIIADRPWPRVSLTVLTTAIILTMAVFNMFFLSDPEETILPTANTSNTS LSALSNQAAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVAYNTILL HTHAHVLDDYSQVLFERPGIWKDLKTMGSVSLFIFFVTLLVLGRQSEYYCRLDFLWKNKF NKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEDLYHQSYDCVCVMFASIPDFKE FYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE HTQEPERQYMHIGTMVEFAFALVAKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQY DIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGELKTYFVNT EMSRSLSQSNLAS NT seq 3282 nt NT seq  +upstreamnt  +downstreamnt atgtggcgggaggcgatgcggcgccgccgctacctgcgggaccgcgccgaggcggcggcg gcggcggcgggcggcggcgacgggctgcagcggtcccgggactggctctatgagtcctac tactgcatgagccagcagcacccgctcatcgtcttcctgctgctcatcgtcatgggcgcc tgcctcgccctactcgccgtcttcttcgcgctccggctggaagttgaagaccacgtggca tttttaataacggtcccgacagccctggcgattttcttcgcgatcttcatcctcgtctgc atcgagtccgtgtttcagaagctgctccgtcttttctctctggtgatatggctgtgcctc gtggccatggggtacctgttcatgtgctttgcaggcaccgtctctccctgggaccaggta tcattcttcctcttcatcatcttcgtggtgtacaccatgctgcccttcaacatgagagat gccatcatcgccagtgtgctcacctcctcctcccacaccatcgtgctgagcgtctgcctc tctgcgaccccgggggccaaggagcacctggtctggcagatcctggccaacgtgatcatt ttcatctgtgggaacctggcaggcgcgtaccacaaacatctcatggagctcgccctgcag cagacctaccaggacacgtgcaactgtatcaagtctcgaatcaagctggaatttgaaaag cggcagcaggagcggctgctgctctccctgctgcccgcgcacatagccatggagatgaaa gccgagatcatccagaggctgcagggccccaaagccggccaaatggaaaacacgaacaac tttcacaacctgtatgtcaagcgacacaccaacgtgagcatcctgtacgcggacatcgtt ggcttcacccggctggccagtgactgctctccgggagaactcgtccacatgctgaacgag ctctttggaaagttcgaccaaattgcaaaggagaatgaatgcatgagaataaagattttg ggagactgctactactgcgtgtccggactccccatatctctcccgaaccatgccaagaac tgtgtgaaaatggggctggacatgtgtgaagccataaagaaagtgagggacgccactgga gtggatatcaacatgcgcgtgggagtgcattctggcaatgtcctctgcggggtgattggt ctgcagaagtggcagtatgacgtgtggtcacatgatgttaccttggccaatcacatggaa gccggaggggtccctggacgtgttcacatttcttccgtcactttggagcacttgaacggc gcttataaagtggaggaaggagacggtgacatcagagacccatatttaaaacagcaccta gtgaaaacctactttgtaatcaaccccaagggagagcgaaggagtcctcacctcttcaga cctcgccacaccctcgatggagccaagatgagggcctccgtgcgcatgacccggtacctg gagtcctggggagcagccaagcccttcgcacacctgcatcaccgagacagcatgaccaca gagaacggcaagatcagcaccacggatgtgccaatgggtcagcataattttcagaatcgc accttgagaaccaagtcccaaaagaagagatttgaagaagaattaaatgaaaggatgatt caagcaattgatggaattaatgcccaaaagcagtggctgaagtctgaagacattcagagg atctcgctcctattctacaataaaatactagagaaagaataccgagccaccgccctgcca gcgtttaagtactacgtgacctgcgcgtgtctcattttcttctgcatcttcattgtgcag atcctagtattaccaaaaacgtctgtcctggggatctccttcggagctgcatttctcgtg ctcgccttcaccctcttcatctgctttgctggacagcttttgcaatgcagcaagaaagcc tcggcctctctcctgtggctgttgaagtcgtcgggcatcatcgcggaccggccctggccg cgcgtctccctcaccgtcctcaccacggccatcattctgaccatggccgtgttcaacatg tttttcctgagtgacccagaggaaacaattcttccaactgccaatacatccaacacaagt ctttccgccttaagtaatcaggcagcaattctgcgggcacaaaatctgtttttcctcccg tacttcatctacagctgcatcctgggactgatttcctgctcggtcttcctgagggtcaac tacgagctgaagatgttgatcatgatggtggcgttggtggcctacaacaccatccttctg cacactcacgcccacgtcctggacgactacagccaggtcttattcgagagaccaggcatt tggaaagacctgaagaccatgggctcagtgtctctctttatattcttcgtcacactgctc gttctgggtagacagagtgaatattactgtaggttagacttcttatggaagaacaagttc aacaaagagcgggaggagatagaaaccatggagaacctgaaccgcgtgctgctggagaac gtgctgcccgcccacgtggcggagcatttcctggcccggagcctgaagaacgaggactta taccaccagtcctatgactgtgtctgtgtcatgtttgcctctattccggatttcaaagaa ttctacacggaatcagatgtgaacaaggagggcttggaatgccttcggctcctgaatgag atcatcgccgacttcgatgatctgctgtccaagccgaaattcagtggagttgaaaagatc aagaccattggcagcacgtacatggcggcaacgggtctgagcgccgtgcccagccaggag cacacccaggagcccgagcggcagtacatgcacatcggcaccatggtggagttcgccttc gcgctggtggcgaagctggacgccatcaacaagcactccttcaacgacttcaagctgcgc gtcggtattaaccacggacctgtgatagcgggtgtcattggagctcagaagccgcagtat gatatctggggcaacactgtaaatgtggccagcaggatggacagcaccggcgtgctggac aaaatacaggtcaccgaggagacaagcctcatcctccagaccctggggtacacatgcacc tgcagaggaataatcaacgtgaaaggcaagggggagctgaagacatactttgtaaacaca gaaatgtcaaggtccctttcccagagcaacctggcatcctga

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