KEGG   Leishmania major: LMJF_07_0090
Entry
LMJF_07_0090      CDS       T01014                                 
Name
(RefSeq) putative methionine synthase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
lma  Leishmania major
Pathway
lma00270  Cysteine and methionine metabolism
lma00450  Selenocompound metabolism
lma00670  One carbon pool by folate
lma01100  Metabolic pathways
lma01110  Biosynthesis of secondary metabolites
lma01230  Biosynthesis of amino acids
lma04980  Cobalamin transport and metabolism
lma04981  Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:lma00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    LMJF_07_0090
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    LMJF_07_0090
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    LMJF_07_0090
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    LMJF_07_0090
   04980 Cobalamin transport and metabolism
    LMJF_07_0090
Enzymes [BR:lma01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     LMJF_07_0090
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-GeneID: 5649165
NCBI-ProteinID: XP_001680913
UniProt: Q4QIT5
LinkDB
Position
7:28603..32361
AA seq 1252 aa
MSAMRGERSPVFEELEELFQKRILVLDGGMGTMLQRYKLEETDFRGEEFKNATKDLKGNN
DLLCLTQPAKVRDVHYKYAIAGADVVETNTFNSQAVSQSDYETQHLVRRINLAAAKICRD
AAEQASRETGRRIFVAGVLGPLNRTASISPSVERPDYRNITYDEIVAAYTEQATALLDGG
VDVLLIETIFDSLNAKAALFAVNTLFEDKGYTRLPIMVSGTITDLSGRTLSGQTVDAFYS
SMRHGNIISIGLNCALGCREMRPYVERLAEISEGYVTCHPNAGLPNAMGEYDELPEDMAR
DIRDFAANGWVNLVGGCCGTTPDHIRAIATAVKGIPPRPRGHSSETMVISGLEALHFTHH
IGFCNIGERCNISGSLKFKRLVKEGKWEECLAVARQQVEEGAMVLDVNMDDGLIDGVTAM
TRFLNMIASDPEVARVPVMIDSSKFHVIEAGLKCTQGTPIVNSISLKVGEEEFLRQARLI
RRYGAAVVVMAFDENGQAADDANKTRICKRAYDMLVADGFPPENIVFDPNVLTICTGMEE
HNNYAIDFMNAATWIKANLPRAKVSGGISNLSFSFRGFEAIRMAMHSAFLKKMIADGSLD
MAIVNAGALPVYTDIEPDLLQLVEDAIYNRTPHSSERILEYAERLKAEKASGGGAEEAKV
SKVDEWRNASVEERLSHALIKGIVEFIEDDVEEARTCGKYERPLHIIEGPLMGGMGKVGE
LFGSGKMFLPQVIKSARVMKKAVAVLVPYMEAEKAALMADTNGASTSRAKRVLMATVKGD
VHDIGKNIVGVVLGCNSYEVLDLGVMVSCEKILAAAREHDVDVIGLSGLITPSLDEMVHV
AKEMKRMGFNIPLMVGGATTSKQHTAVKIQPHYNKTVHVLDASKAVVTVSNMLGSSEEEF
WEEVHETYQEIAEDYLANLKDRVYKPLAFCRENALKIDFVEHPPAPRPRKLGTITISDYS
VEMIATRIDWNPFFSVWQVRGTYPNRGFPKLFNCPTVGAEAKRLFDDAQEMLKDIIATRS
FRAKAVVTLMPVNSVGDDIEVYKDDTRNEKIATFFGLRQQSEKERGEPYLCISDFIAPKG
VAPDYLGSLVVGIFGADKMSEQYEKDNDSYRSIMIKALADRFAEAFTEEVHRIIRTDLWG
YAEKETAKTADLIQMQYQGIRPAPGYPSQPDHTEMDTMWRIGEVEERTGVKLSESYAMIP
AASVSALVFAHAQSKYFAVGKIQKDQVKDYAERKGWNLDRAESQLSSSLAYN
NT seq 3759 nt   +upstreamnt  +downstreamnt
atgtcagccatgcgtggcgaacgaagccccgtcttcgaggagctggaggagctcttccag
aaacgcattctcgtgctggacggtggcatgggcactatgctgcagcgctacaagctcgag
gaaacagacttccgcggcgaggagtttaagaatgccacaaaggatctcaagggcaacaac
gacctgctctgtctcacgcagccggcgaaggtgcgggatgtgcactacaagtatgccatc
gccggcgccgacgtcgtggagacgaacacgttcaactcgcaggcggtgagtcagtccgac
tacgagacacagcaccttgttcgtcgcatcaacctcgccgctgcgaaaatctgccgtgac
gcggcggagcaagccagccgcgagacggggcgacgcatcttcgtcgccggtgtgctgggc
ccgctgaaccgaacagcttccatctcgccatccgtcgagcgccccgactaccgcaacatc
acatatgacgaaattgtagccgcttacacggagcaggcgacggccctgctggacggaggc
gtagatgtgctgctgatcgagacaatcttcgactccctcaacgccaaggcggccctcttc
gcggtgaacacactcttcgaggataagggctacacacgccttccgatcatggtgagcggc
accattacagacctgtccggtcgcactctcagcggccagacagtggacgccttctactcg
tcgatgcggcacggcaacattatctcgatcggtctcaactgtgccctgggttgtcgcgaa
atgcgcccgtacgtcgaacgccttgcagagatcagcgagggctacgtgacgtgccacccc
aacgcggggctgccgaacgcgatgggtgaatacgacgagctgccggaggacatggcccgt
gacatccgcgactttgcagcgaacgggtgggtcaacctcgtcggcggctgctgtggtaca
accccggatcacatccgtgccattgccacggccgtgaagggcatcccgccgcgtccgagg
gggcactcgagtgagacaatggtcatcagcgggctcgaggcgctgcacttcacccaccac
atcggcttctgcaacatcggagagcgctgcaacatcagcggctcgctaaagtttaagcgc
ctcgtcaaggaggggaagtgggaggagtgcctggcggtggcccgccagcaggtcgaggag
ggggccatggtgttggacgtgaacatggacgatggcctcatcgacggtgtaaccgccatg
acgcgcttcctgaacatgattgcctccgacccggaggtagcgcgagtgccggtcatgatc
gactcgtccaagttccatgtcatcgaggcgggtttgaagtgcacccaaggaacgccgatc
gtcaactcgatctcgctgaaggttggtgaggaggagttcctgcgccaggctcgcctgatc
cggcgttatggtgccgccgtggtggtgatggcctttgacgaaaatggtcaggcggcggac
gatgccaacaagacccgcatctgtaagcgcgcgtacgacatgctggtggcggacggcttc
ccaccggagaacatcgtcttcgacccgaacgtgctgacgatctgcaccggcatggaggag
cacaacaactacgccatagacttcatgaatgcggcgacgtggatcaaggcaaatctgccc
cgcgccaaggtgagcggcggaatctcgaacctcagcttttccttccgcggcttcgaggcc
attcgcatggcgatgcactccgccttcttgaagaaaatgatcgccgatggaagtctcgac
atggcgatcgtgaacgcgggtgctctgccggtgtacaccgacatcgagccggatctgctg
cagctggtcgaggatgccatctacaaccgcaccccccactcctcggagcgcattctcgag
tacgcagagcgactcaaggcggagaaggcgtccggcggtggcgcggaggaggcgaaggtg
tctaaggtggatgaatggcgcaacgcctcggtggaggagcgtctctcgcacgccttgatc
aagggcatcgtcgagttcatcgaggatgacgtggaggaggcgcgaacgtgtggcaagtac
gagcggccgctgcacatcatcgagggtccactgatgggtggcatggggaaggttggcgag
ctgttcggcagtggcaagatgttcctaccccaggtaatcaagtcggcacgtgtcatgaag
aaggcggtggcggtgctggtgccatacatggaggctgagaaggcggctcttatggcggat
acgaacggcgcgtcgacctcgcgagcgaaacgggtgctcatggcgaccgtaaagggcgac
gtgcacgatatcggcaagaacatcgttggcgtcgtcctgggttgcaacagctacgaggtg
ttagacctcggcgtgatggtctcgtgtgaaaagatcttggcggctgcgagggagcacgac
gtagacgtcatcgggctctccggcctcatcacgccctcgctggatgagatggtgcacgtg
gcgaaggagatgaagaggatgggcttcaatatcccgctgatggttggtggggcaacaacg
tcgaagcagcacacggcggttaagattcagccgcactacaacaagacggtgcacgtgctg
gacgccagcaaggccgtggtcacggtatctaacatgctcgggagcagcgaggaggagttc
tgggaggaggtgcacgagacctaccaagagatcgcggaggactacctggcgaacctgaag
gaccgcgtctacaagcccctcgccttctgccgtgagaacgcgctgaagattgacttcgtc
gagcacccgccggcgccgcggccgaggaagctcggcaccatcaccatcagcgactactcg
gtcgagatgatcgccacacgtatcgactggaacccgtttttctccgtgtggcaggtgcgc
ggcacataccccaaccgtggctttccgaagctcttcaactgccccaccgtcggcgcggag
gcgaagcggctgttcgacgacgcgcaggagatgctgaaggacatcattgccacacgtagc
ttccgcgccaaggctgttgtcacactgatgcccgtgaacagcgtcggcgacgacatcgag
gtgtacaaggatgacacacgtaacgagaagatcgccaccttctttgggctgcgccagcaa
tcggagaaagagcgaggcgagccgtacctgtgcatctccgacttcatcgccccgaaaggg
gtggcgccagactacctcggcagtctcgttgttggcatctttggagcggacaagatgagc
gagcagtacgagaaagacaacgacagctaccgctccatcatgatcaaggccctggcagac
cgctttgccgaggccttcacggaggaggtacaccgcatcattcgcacagacctgtgggga
tacgcggagaaggagacagccaagacggccgacctgatccagatgcagtaccaaggtatt
cgacccgcccctgggtacccctcgcagccggaccacacggagatggacacgatgtggcgc
atcggcgaggtggaggagcgcacgggtgtaaagctgtctgagtcgtacgcgatgataccg
gcggcatctgtgagcgcactcgtctttgcgcatgcacagtccaagtactttgcagtgggc
aagatccagaaggaccaagtaaaggactacgccgagcgcaagggctggaatctagaccgg
gccgagagtcagctcagctcgtccttggcctacaactga

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