KEGG   Leishmania major: LMJF_11_1100
Entry
LMJF_11_1100      CDS       T01014                                 
Name
(RefSeq) putative lanosterol 14-alpha-demethylase
  KO
K05917  sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]
Organism
lma  Leishmania major
Pathway
lma00100  Steroid biosynthesis
lma01100  Metabolic pathways
lma01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:lma00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    LMJF_11_1100
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:lma00199]
    LMJF_11_1100
Enzymes [BR:lma01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.154  sterol 14alpha-demethylase
     LMJF_11_1100
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.36  sterol 14alpha-demethylase (ferredoxin)
     LMJF_11_1100
Cytochrome P450 [BR:lma00199]
 Cytochrome P450, animal type
  CYP51 family
   LMJF_11_1100
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 5649863
NCBI-ProteinID: XP_001681578
UniProt: Q4QGX0
LinkDB
Position
11:464294..465733
AA seq 479 aa
MIGEFFLLLTAGLALYGWYFCKSFNTTRPTDPPVVHGAMPFVGHIIQFGKDPLDFMLNAK
KKYGGVFTMNICGNRVTVVGDVHQHNKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYP
RMREQLNFLAEELTVAKFQNFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQ
CLFGEDLRKRLDARQFAQLLAKMESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILS
EIIIAREKEEAQKDSNTSDLLASLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTT
WSLLHLMDPRNKRHLAKLHQEIDEFPAQLNYDNVMEEMPFAEQCARESIRRDPPLIMLMR
KVLKPVQVGKCVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMKLVDGAFCGFGAGVH
KCIGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTASQCRVKYIRKKAAA
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgatcggcgagttcttccttctcctgaccgccggcctggcactgtacggctggtacttc
tgcaagtccttcaacacgacccgccccaccgatccgccggtcgttcacggcgcgatgcct
tttgtgggtcacatcatccagttcggcaaggatccgctggacttcatgctgaacgcgaag
aagaagtacggcggcgtattcaccatgaacatctgcggcaaccgcgtcaccgtcgttggc
gacgttcaccagcacaacaagttcttcaccccgcgtaacgagattctctccccgcgtgag
gtctacagcttcatggtgcccgtctttggcgagggcgtcgcctacgccgcgccatacccg
cgcatgcgcgagcagctcaacttcctggccgaggagctgactgtggccaagtttcagaac
ttcgctccgtcgatccagcacgaggtgcgcaagtttatgaaggcgaactggaacaaggac
gaaggcgagatcaacatcctcgacgactgcagcgccatgatcatcaacaccgcttgccag
tgcctcttcggcgaagacctgcgcaagcgcctggacgcgcgccagttcgcacagctgctg
gccaagatggagagctgcctcatccccgccgctgtcttcctaccgtggattctgaagctg
ccgctgccgcagtcctaccgctgccgcgacgcccgcgctgagctgcaggacatcctcagc
gagatcataatcgctcgcgagaaggaggaggcacagaaagacagcaacacgtcggatctg
ctcgccagtctgctcggcgccgtgtaccgcgatggcacccgcatgtctcagcacgaggtg
tgcggaatgatcgttgccgccatgtttgctggccagcacacgtccactatcaccaccacc
tggtccctgctgcatctgatggatccacgcaacaagaggcacctcgcgaagctgcatcag
gagatcgacgagttcccggcgcagttgaactacgacaacgtcatggaggagatgccgttc
gcggagcagtgcgcgcgcgagtcgatccgccgtgacccgccgctcattatgctcatgcgc
aaggtgctgaagccagtccaggtgggcaagtgcgtcgtgccggagggtgacatcatcgcc
tgctcgccgctcctctcgcaccaggatgaggaggcgttcccaaatccgcgtgagtggaat
ccggagcgcaacatgaagctcgtcgacggcgccttctgcggcttcggtgctggcgtgcac
aagtgcatcggcgagaagtttggcctccttcaggtcaagacggtgctggcgacggtcttg
cgcgactacgactttgagctcctcggcccactaccggagccgaactaccacaccatggtg
gtgggcccgacagccagccagtgccgcgtgaagtacatcaggaagaaggcggctgcttag

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