KEGG   PATHWAY: lml03060
Entry
lml03060                    Pathway                                
Name
Protein export - Listeria monocytogenes L99 (serotype 4a)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
lml03060  Protein export
lml03060

Other DBs
GO: 0043952 0043953
Organism
Listeria monocytogenes L99 (serotype 4a) [GN:lml]
Gene
lmo4a_0261  secE; preprotein translocase, SecE subunit [KO:K03073]
lmo4a_0598  secA2; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
lmo4a_1323  sipX; Signal peptidase I [KO:K03100] [EC:3.4.21.89]
lmo4a_1324  sipY; Signal peptidase I [KO:K03100] [EC:3.4.21.89]
lmo4a_1325  sipZ; Signal peptidase I [KO:K03100] [EC:3.4.21.89]
lmo4a_1436  oxaA2; inner membrane protein oxaA2 precursor [KO:K03217]
lmo4a_1583  secDF; protein-export membrane protein SecDF [KO:K12257]
lmo4a_1585  yajC; preprotein translocase subunit [KO:K03210]
lmo4a_1858  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
lmo4a_1860  ftsY; cell division ABC transporter, substrate-binding protein [KO:K03110]
lmo4a_1901  lspA; Lipoprotein signal peptidase [KO:K03101] [EC:3.4.23.36]
lmo4a_2454  secG; preprotein translocase, SecG subunit [KO:K03075]
lmo4a_2512  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
lmo4a_2676  secY; preprotein translocase, SecY subunit [KO:K03076]
lmo4a_2920  oxaA1; membrane protein oxaA 1 precursor [KO:K03217]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   

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