KEGG   PATHWAY: lpl02060
Entry
lpl02060                    Pathway                                
Name
Phosphotransferase system (PTS) - Lactiplantibacillus plantarum WCFS1
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
Pathway map
lpl02060  Phosphotransferase system (PTS)
lpl02060

Other DBs
GO: 0009401
TC: 4.A
Organism
Lactiplantibacillus plantarum WCFS1 [GN:lpl]
Gene
lp_0185  pts1BCA; PTS system, oligosucrose-specific EIIBCA component [KO:K02810] [EC:2.7.1.211]
lp_0230  pts2CB; PTS system, mannitol-specific EIICB component [KO:K02800] [EC:2.7.1.197]
lp_0232  pts2A; PTS system, mannitol-specific EIIA component [KO:K02798] [EC:2.7.1.197]
lp_0247  pts3C; PTS system, cellobiose-specific EIIC component [KO:K02761]
lp_0264  pts4ABC; PTS system, trehalose-specific IIBC component [KO:K02757] [EC:2.7.1.-]
lp_0265  pts5ABC; PTS system, trehalose-specific IIBC component [KO:K02757] [EC:2.7.1.-]
lp_0286  pts6C; PTS system, cellobiose-specific EIIC component [KO:K02761]
lp_0436  pts7C; PTS system, cellobiose-specific EIIC component [KO:K02761]
lp_0439  pts8C; PTS system, cellobiose-specific EIIC component [KO:K02761]
lp_0575  pts9AB; PTS system, mannose-specific EIIAB component [KO:K02794] [EC:2.7.1.191]
lp_0576  pts9C; PTS system, mannose-specific EIIC component [KO:K02795]
lp_0577  pts9D; PTS system, mannose-specific EIID component [KO:K02796]
lp_0586  pts10A; PTS system, mannose-specific EIIAcomponent [KO:K02793] [EC:2.7.1.191]
lp_0587  pts10B; PTS system, mannose-specific EIIB component [KO:K02769] [EC:2.7.1.202]
lp_0884  pts11A; PTS system, EIIA component [KO:K02777] [EC:2.7.1.-]
lp_0886  pts11BC; PTS system, beta-glucosides-specific EIIBC component [KO:K02757] [EC:2.7.1.-]
lp_0905  pts12BCA; PTS system, beta-glucosides-specific EIIBCA component [KO:K02757] [EC:2.7.1.-]
lp_0934  [KO:K02759] [EC:2.7.1.196 2.7.1.205]
lp_1155  pts13C; PTS system, cellobiose-specific EIIC component [KO:K02761]
lp_1164  pts14C; PTS system, cellobiose-specific EIIC component [KO:K02761]
lp_1273  ptsH; phosphocarrier protein Hpr [KO:K02784]
lp_1274  ptsI; phosphoenolpyruvate-protein phosphotransferase [KO:K08483] [EC:2.7.3.9]
lp_1398  pts15A; PTS system, beta-glucosides-specific EIIA component [KO:K02759] [EC:2.7.1.196 2.7.1.205]
lp_1399  pts15B; PTS system, beta-glucosides-specific EIIB component [KO:K02760] [EC:2.7.1.196 2.7.1.205]
lp_1400  pts15C; PTS system, beta-glucosides-specific EIIC component [KO:K02761]
lp_2096  fruK; 1-phosphofructokinase [KO:K00882] [EC:2.7.1.56]
lp_2097  fruA; PTS system, fructose-specific EIIABC component [KO:K02770] [EC:2.7.1.202]
lp_2218  pts17A; PTS system, glucitol/sorbitol-specific EIIA component [KO:K02781] [EC:2.7.1.198]
lp_2531  pts18CBA; PTS system, N-acetylglucosamine and glucose-specific EIICBA component [KO:K02804] [EC:2.7.1.193]
lp_2647  pts19A; PTS system,N-acetylglucosamine/galactosamine-specific EIIA component [KO:K02744] [EC:2.7.1.-]
lp_2648  pts19D; PTS system, N-acetylglucosamine-specific EIID component [KO:K10986]
lp_2649  pts19C; PTS system, N-acetylglucosamine-specific EIIC component [KO:K10985]
lp_2650  pts19B; PTS system, N-acetylglucosamine-specific EIIB component [KO:K10984] [EC:2.7.1.-]
lp_2780  pts20A; PTS system, cellobiose-specific EIIA component [KO:K02759] [EC:2.7.1.196 2.7.1.205]
lp_2781  pts20B; PTS system, cellobiose-specific EIIB component [KO:K02760] [EC:2.7.1.196 2.7.1.205]
lp_2969  pts22CBA; PTS system N-acetylglucosamine-specific EIICBA component [KO:K02804] [EC:2.7.1.193]
lp_3008  pts23A; PTS system, cellobiose-specific EIIA component [KO:K02777] [EC:2.7.1.-]
lp_3009  pts23B; PTS system, cellobiose-specific EIIB component [KO:K02760] [EC:2.7.1.196 2.7.1.205]
lp_3010  pts23C; PTS system, cellobiose-specific EIIC component [KO:K02761]
lp_3133  pts24BCA; PTS system, beta-glucosides-specific EIIBCA component [KO:K02757] [EC:2.7.1.-]
lp_3137  pts25B; PTS system, EIIB component [KO:K02822] [EC:2.7.1.194]
lp_3219  pts26BCA; PTS system, sucrose-specific EIIBCA component [KO:K02810] [EC:2.7.1.211]
lp_3229  pts27BCA; PTS system, beta-glucosides-specific EIIBCA component [KO:K02757] [EC:2.7.1.-]
lp_3240  pts28ABC; PTS system, beta-glucosides-specific EIIABC component [KO:K02757] [EC:2.7.1.-]
lp_3507  pts29C; PTS system, cellobiose-specific EIIC component [KO:K02761]
lp_3513  pts30BCA; PTS system, beta-glucosides-specific EIIBCA component [KO:K02757] [EC:2.7.1.-]
lp_3520  pts32A; PTS system glucose-specific EIICBA component [KO:K02777] [EC:2.7.1.-]
lp_3522  pts32BC; PTS system sucrose-specific EIIBC component [KO:K02810] [EC:2.7.1.211]
lp_3527  pts33BCA; PTS system beta-glucoside-specific EIIBCA component [KO:K02757] [EC:2.7.1.-]
lp_3540  [KO:K03475]
lp_3541  pts34B; PTS system, lactose/cellobiose-specific EIIB component [KO:K02822] [EC:2.7.1.194]
lp_3542  pts34A; PTS system, mannitol-specific EIIA component [KO:K02821] [EC:2.7.1.194]
lp_3546  pts35C; PTS system, galactitol-specific EIIC component [KO:K02775]
lp_3547  pts35B; PTS system, galactitol-specific EIIB component [KO:K02774] [EC:2.7.1.200]
lp_3548  pts35A; PTS system, galactitol-specific EIIA component [KO:K02773] [EC:2.7.1.200]
lp_3599  pts36A; PTS system, galactitol-specific EIIA component [KO:K02773] [EC:2.7.1.200]
lp_3600  pts36B; PTS system, galactitol-specific EIIB component [KO:K02774] [EC:2.7.1.200]
lp_3601  pts36C; PTS system, galactitol-specific EIIC component [KO:K02775]
lp_3618  pts37A; PTS system, glucitol/sorbitol-specific EIIA component [KO:K02781] [EC:2.7.1.198]
lp_3619  pts37BC; PTS system, glucitol/sorbitol-specific EIIB component and second of two IIC components [KO:K02782] [EC:2.7.1.198]
lp_3620  pts37C; PTS system, glucitol/sorbitol-specific EIIC component [KO:K02783]
lp_3652  pts38A; PTS system, glucitol/sorbitol-specific EIIA component [KO:K02781] [EC:2.7.1.198]
lp_3653  pts38BC; PTS system, glucitol/sorbitol-specific EIIB component and second of two IIC components [KO:K02782] [EC:2.7.1.198]
lp_3654  pts38C; PTS system, glucitol/sorbitol-specific EIIC component [KO:K02783]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00354  D-Fructose 1,6-bisphosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Reference
PMID:11361076
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
PMID:15060041
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S
Reference
PMID:12603740
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x
Reference
PMID:14645248
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
Reference
PMID:15608210
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108
Reference
PMID:18156259
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07
Reference
PMID:10931310
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x
Reference
PMID:11361063
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
PMID:16233138
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X
Related
pathway
lpl00051  Fructose and mannose metabolism
KO pathway
ko02060   

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