Lacticaseibacillus rhamnosus GG: LRHM_1159
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Entry
LRHM_1159 CDS
T02100
Name
(GenBank) glutamate-cysteine ligase/glutathione synthetase
KO
K28983
glutamate---cysteine ligase / glutathione synthase [EC:
6.3.2.2
6.3.2.3
]
Organism
lrg
Lacticaseibacillus rhamnosus GG
Pathway
lrg00480
Glutathione metabolism
lrg01100
Metabolic pathways
lrg01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
lrg00001
]
09100 Metabolism
09106 Metabolism of other amino acids
00480 Glutathione metabolism
LRHM_1159
Enzymes [BR:
lrg01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
LRHM_1159
6.3.2.3 glutathione synthase
LRHM_1159
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Paralog
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Motif
Pfam:
ATP-grasp_6
GARS_A
DUF348
Glu_cys_ligase
Motif
Other DBs
NCBI-ProteinID:
BAI41686
UniProt:
A0A7S7FNS0
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Position
1200399..1202360
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AA seq
653 aa
AA seq
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MNHYWQLIQKEHLFGLAAQTRMGVIRTVKPILPAETNLPQWPQRSRHALVQPLSASVLQI
VTPLLDDFPAVIDQLRAGLSRIWAALPEAGHLSAFTAEKVNQQTVRIVLPETLFERLYTA
ENFQGHGPEYVAYRNEVYQLVADGLTRQLPLLTYLFSASPANGHRAFLPSPDQERQLVQK
VTDPDHLDRILALDVLVELDPYAASGITTQMLTFLRDSCWFALSQPAIPVAAASEVRRHA
VMQARTIAQMAPDAKVAELPAMLDAMATWLNHVGIDVQQKQAFELMQTRLVKPETSLASQ
VLATFHDQTAADASLSRQAQADLTSTNELPGMTDLSENTQALLQAAMDGGYQFTILDRQQ
NLVQIATDTQTQVIADGVVTKYKPANAMIVATHRHTAKQLLAAAGIPVARGAKFTKWPDA
KAAFEHSFAHKSIVVKPEARSQGEAVEQFSIPPTEKQFDRAFHEANRHHGVLIEMMARGT
TYHFTIIGQQVLSVLETAAANVVGDGRKAIKELIALKNGHRATSRQLQLDASARRQLKAQ
ALTPETVLQRGQQVFLTTAAHPQTGGDLYDVTDEIDDSYKQLALKAAATLDLPVAAVDIV
IDNLYAPYDPEADGQANVISVNPVPDLAAPLHPDMGESRALAPALLNWLFAVR
NT seq
1962 nt
NT seq
+upstream
nt +downstream
nt
gtgaatcattattggcaactgattcaaaaagaacatttgtttggtttggccgcccagacg
cgaatgggtgtgattcgaactgtcaaacccattctgccggcagaaaccaacttaccgcag
tggccgcaacgtagccgccatgctttggttcagccactttctgcttcagtgttgcaaatc
gtaaccccattactagacgattttcctgccgttattgaccagttacgggctgggctaagt
cgaatttgggcggcattaccggaagcagggcacttatcggcttttaccgcggaaaaagtg
aaccagcaaacggtccggatagttttaccggaaacactatttgaacggttgtacacagca
gagaattttcagggccatggtccggaatatgttgcctatcgtaatgaagtttatcagttg
gtagcagacgggttaacgcggcagttgccattgttgacttacttgttttctgcttctcca
gctaacggtcaccgcgcatttttgccgtcaccggatcaggaacggcaactggttcaaaaa
gtgacggatccagaccacttggatcgaattcttgcgctggacgttttggtggagcttgat
ccgtacgctgctagcgggatcacgacccaaatgctgacattcttgcgtgatagctgctgg
tttgcgctaagtcaaccggccattccggttgcagcggcaagtgaagtacgccggcatgct
gtcatgcaggcgcggacaattgcccagatggcacctgatgccaaagtcgccgagctgccg
gcaatgctggatgcgatggcgacatggttaaatcatgttggcattgatgtgcaacaaaaa
caagcttttgaattgatgcagacgcgattagtgaagccggaaacgagccttgccagtcaa
gttcttgcaacgtttcatgaccaaacagctgcggatgcgtcattgagtcggcaagcacag
gcggacttaaccagtaccaatgagttgccggggatgacagatttatcggaaaacacccag
gcattgttacaagctgctatggatggggggtatcagttcacgatactggatcggcaacag
aacctggtgcaaattgccacggatacccagacacaagtcattgcagacggcgttgttacc
aagtataagccagccaatgccatgatcgttgccactcatcggcacacagccaaacagttg
ctggccgcagcaggaataccagttgcacgtggggctaagtttactaaatggccggatgcc
aaagcagcttttgagcacagctttgcgcataaaagtattgtggtgaaacccgaggcacgc
agccaaggcgaagcggttgagcagttttcgataccaccgactgaaaagcagtttgaccga
gcctttcatgaagccaatcgccatcatggggtgctcattgaaatgatggcacgcggcacg
acctaccattttaccatcatcgggcaacaagtgctcagcgtcttggaaaccgcagcagct
aatgttgtaggcgatgggcgcaaagccattaaggaattgatcgccttgaaaaatggtcac
cgcgcgacttcccggcaattgcagcttgatgctagcgcgcgccgtcagttaaaggcacaa
gcgttgacacctgagactgtgcttcaacgcgggcagcaggttttcttaaccactgccgcg
catccgcaaaccggtggcgatttgtatgacgtgacggacgagattgatgacagttacaag
caactggcgctaaaagctgccgccacacttgatttgccggtagcagctgtcgacattgtg
attgataatctgtatgcaccatatgatccggaggcagatgggcaggcgaacgtaattagt
gtcaatccggtaccggatctcgctgcgcctttgcatccggacatgggcgaatcacgcgca
cttgccccggcattgctaaactggctgtttgctgtgagataa
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