KEGG   Lynx rufus (bobcat): 124514119
Entry
124514119         CDS       T08475                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
lruf  Lynx rufus (bobcat)
Pathway
lruf00140  Steroid hormone biosynthesis
lruf01100  Metabolic pathways
lruf04913  Ovarian steroidogenesis
lruf04925  Aldosterone synthesis and secretion
lruf04927  Cortisol synthesis and secretion
lruf04934  Cushing syndrome
Module
lruf_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
lruf_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
lruf_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
lruf_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:lruf00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    124514119
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    124514119
   04925 Aldosterone synthesis and secretion
    124514119
   04927 Cortisol synthesis and secretion
    124514119
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    124514119
Enzymes [BR:lruf01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     124514119
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     124514119
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA RmlD_sub_bind KR Sacchrp_dh_NADP adh_short DapB_N
Other DBs
NCBI-GeneID: 124514119
NCBI-ProteinID: XP_046938133
LinkDB
Position
Unknown
AA seq 373 aa
MAGWICLVTGAAGFLGQRIVRLLVEEKDLQEIRALDKVFSPELREEFSKLQSKIKLTILE
GDILDEQCLKKACQDTSVIIHTACIIDFMDVVHRETIMNVNLKGTQLLLEACVQASVPNF
IYTSTIEVAGPNSYREIIQNGHEDEHLESTWSSSYPCSKKLAEKAVLAANGWALKNGGTL
HTCALRPMYIYGEGSIFLYNHIYKALKNNGIIKQSSKFSIVNPVYVGNVAWAHILASRAL
QDPKKAPRVGGQFYYISDDTPHQSYDNLNYSLSKEWGFSLESRMSLPLFLEYWLAFLLEI
VSFLLSPIYKYQPPFNRHLVTLLNSVFTFSYKKAQRDLGYEPVFSWEEAKQKTMEWIGSI
VKEHKKSLKTKTH
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggctgggtggatctgccttgtgacaggggcagcagggtttctgggtcagagaatcgtg
cgtttgttggtggaggagaaggacctacaggagatccgggcactggacaaagtcttcagc
ccagaattgcgggaggaattttctaagctccagagcaagatcaagctgaccattctggaa
ggagacattctggatgaacagtgcttgaagaaggcctgccaggacacctcagtcatcatc
cacaccgcctgtatcattgacttcatggatgttgttcaccgagaaaccatcatgaatgtc
aatctgaagggtacccagctccttttggaagcctgtgtccaggcgagtgtgccaaacttc
atctataccagcaccatagaggtggctgggcccaactcctacagggagatcatccagaac
ggccacgaagacgaacatctcgaatccacatggtcctcttcgtatccatgcagcaaaaaa
cttgcggagaaagctgtgctggctgctaatgggtgggctcttaaaaatggtggcaccttg
cacacttgtgccttaaggcccatgtatatctacggggaaggaagcatattcctttataac
catatatacaaggccctgaagaacaatgggatcatcaaacagagcagcaaattctccata
gtcaaccctgtctatgtaggcaacgtggcctgggctcacattctggcctcgagggcccta
caggaccccaagaaggcccccagagttggaggacagttctattatatctcagatgacaca
cctcaccaaagctatgataacctcaattacagtttgagcaaagaatggggcttctccctt
gagtccagaatgagccttcctctatttctggagtactggcttgccttcctgctggaaata
gtgagcttcctactcagtccaatttacaaataccaacccccctttaaccgccacctggtg
acattgttaaatagcgtgtttaccttctcctataagaaagctcagcgggacctggggtat
gagccagtcttcagctgggaggaagcaaagcaaaagaccatggagtggattggctccata
gtgaaagagcacaagaagtccctaaaaacaaagactcactga

DBGET integrated database retrieval system