KEGG   Lipotes vexillifer (Yangtze River dolphin): 103083960
Entry
103083960         CDS       T03090                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
lve  Lipotes vexillifer (Yangtze River dolphin)
Pathway
lve01521  EGFR tyrosine kinase inhibitor resistance
lve01522  Endocrine resistance
lve01524  Platinum drug resistance
lve04012  ErbB signaling pathway
lve04014  Ras signaling pathway
lve04015  Rap1 signaling pathway
lve04024  cAMP signaling pathway
lve04062  Chemokine signaling pathway
lve04066  HIF-1 signaling pathway
lve04068  FoxO signaling pathway
lve04070  Phosphatidylinositol signaling system
lve04071  Sphingolipid signaling pathway
lve04072  Phospholipase D signaling pathway
lve04081  Hormone signaling
lve04140  Autophagy - animal
lve04145  Phagocytosis
lve04150  mTOR signaling pathway
lve04151  PI3K-Akt signaling pathway
lve04152  AMPK signaling pathway
lve04210  Apoptosis
lve04211  Longevity regulating pathway
lve04213  Longevity regulating pathway - multiple species
lve04218  Cellular senescence
lve04360  Axon guidance
lve04370  VEGF signaling pathway
lve04380  Osteoclast differentiation
lve04510  Focal adhesion
lve04517  IgSF CAM signaling
lve04518  Integrin signaling
lve04550  Signaling pathways regulating pluripotency of stem cells
lve04611  Platelet activation
lve04613  Neutrophil extracellular trap formation
lve04620  Toll-like receptor signaling pathway
lve04625  C-type lectin receptor signaling pathway
lve04630  JAK-STAT signaling pathway
lve04650  Natural killer cell mediated cytotoxicity
lve04660  T cell receptor signaling pathway
lve04662  B cell receptor signaling pathway
lve04664  Fc epsilon RI signaling pathway
lve04666  Fc gamma R-mediated phagosome formation
lve04668  TNF signaling pathway
lve04670  Leukocyte transendothelial migration
lve04722  Neurotrophin signaling pathway
lve04725  Cholinergic synapse
lve04750  Inflammatory mediator regulation of TRP channels
lve04810  Regulation of actin cytoskeleton
lve04910  Insulin signaling pathway
lve04914  Progesterone-mediated oocyte maturation
lve04915  Estrogen signaling pathway
lve04917  Prolactin signaling pathway
lve04919  Thyroid hormone signaling pathway
lve04923  Regulation of lipolysis in adipocytes
lve04926  Relaxin signaling pathway
lve04929  GnRH secretion
lve04930  Type II diabetes mellitus
lve04931  Insulin resistance
lve04932  Non-alcoholic fatty liver disease
lve04933  AGE-RAGE signaling pathway in diabetic complications
lve04935  Growth hormone synthesis, secretion and action
lve04960  Aldosterone-regulated sodium reabsorption
lve04973  Carbohydrate digestion and absorption
lve05010  Alzheimer disease
lve05017  Spinocerebellar ataxia
lve05020  Prion disease
lve05100  Bacterial invasion of epithelial cells
lve05135  Yersinia infection
lve05142  Chagas disease
lve05146  Amoebiasis
lve05160  Hepatitis C
lve05161  Hepatitis B
lve05162  Measles
lve05163  Human cytomegalovirus infection
lve05164  Influenza A
lve05165  Human papillomavirus infection
lve05166  Human T-cell leukemia virus 1 infection
lve05167  Kaposi sarcoma-associated herpesvirus infection
lve05168  Herpes simplex virus 1 infection
lve05169  Epstein-Barr virus infection
lve05170  Human immunodeficiency virus 1 infection
lve05171  Coronavirus disease
lve05200  Pathways in cancer
lve05203  Viral carcinogenesis
lve05205  Proteoglycans in cancer
lve05206  MicroRNAs in cancer
lve05207  Chemical carcinogenesis - receptor activation
lve05208  Chemical carcinogenesis - reactive oxygen species
lve05210  Colorectal cancer
lve05211  Renal cell carcinoma
lve05212  Pancreatic cancer
lve05213  Endometrial cancer
lve05214  Glioma
lve05215  Prostate cancer
lve05218  Melanoma
lve05220  Chronic myeloid leukemia
lve05221  Acute myeloid leukemia
lve05222  Small cell lung cancer
lve05223  Non-small cell lung cancer
lve05224  Breast cancer
lve05225  Hepatocellular carcinoma
lve05226  Gastric cancer
lve05230  Central carbon metabolism in cancer
lve05231  Choline metabolism in cancer
lve05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lve05415  Diabetic cardiomyopathy
lve05417  Lipid and atherosclerosis
lve05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lve00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103083960 (PIK3R2)
   04014 Ras signaling pathway
    103083960 (PIK3R2)
   04015 Rap1 signaling pathway
    103083960 (PIK3R2)
   04370 VEGF signaling pathway
    103083960 (PIK3R2)
   04630 JAK-STAT signaling pathway
    103083960 (PIK3R2)
   04668 TNF signaling pathway
    103083960 (PIK3R2)
   04066 HIF-1 signaling pathway
    103083960 (PIK3R2)
   04068 FoxO signaling pathway
    103083960 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    103083960 (PIK3R2)
   04072 Phospholipase D signaling pathway
    103083960 (PIK3R2)
   04071 Sphingolipid signaling pathway
    103083960 (PIK3R2)
   04024 cAMP signaling pathway
    103083960 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    103083960 (PIK3R2)
   04152 AMPK signaling pathway
    103083960 (PIK3R2)
   04150 mTOR signaling pathway
    103083960 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103083960 (PIK3R2)
   04517 IgSF CAM signaling
    103083960 (PIK3R2)
   04518 Integrin signaling
    103083960 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    103083960 (PIK3R2)
   04140 Autophagy - animal
    103083960 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    103083960 (PIK3R2)
   04218 Cellular senescence
    103083960 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103083960 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    103083960 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103083960 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103083960 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    103083960 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    103083960 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    103083960 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    103083960 (PIK3R2)
   04660 T cell receptor signaling pathway
    103083960 (PIK3R2)
   04662 B cell receptor signaling pathway
    103083960 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    103083960 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    103083960 (PIK3R2)
   04670 Leukocyte transendothelial migration
    103083960 (PIK3R2)
   04062 Chemokine signaling pathway
    103083960 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103083960 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    103083960 (PIK3R2)
   04929 GnRH secretion
    103083960 (PIK3R2)
   04915 Estrogen signaling pathway
    103083960 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    103083960 (PIK3R2)
   04917 Prolactin signaling pathway
    103083960 (PIK3R2)
   04926 Relaxin signaling pathway
    103083960 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    103083960 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    103083960 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    103083960 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103083960 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    103083960 (PIK3R2)
   04722 Neurotrophin signaling pathway
    103083960 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103083960 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    103083960 (PIK3R2)
   04380 Osteoclast differentiation
    103083960 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    103083960 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    103083960 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103083960 (PIK3R2)
   05206 MicroRNAs in cancer
    103083960 (PIK3R2)
   05205 Proteoglycans in cancer
    103083960 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    103083960 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    103083960 (PIK3R2)
   05203 Viral carcinogenesis
    103083960 (PIK3R2)
   05230 Central carbon metabolism in cancer
    103083960 (PIK3R2)
   05231 Choline metabolism in cancer
    103083960 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103083960 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103083960 (PIK3R2)
   05212 Pancreatic cancer
    103083960 (PIK3R2)
   05225 Hepatocellular carcinoma
    103083960 (PIK3R2)
   05226 Gastric cancer
    103083960 (PIK3R2)
   05214 Glioma
    103083960 (PIK3R2)
   05221 Acute myeloid leukemia
    103083960 (PIK3R2)
   05220 Chronic myeloid leukemia
    103083960 (PIK3R2)
   05218 Melanoma
    103083960 (PIK3R2)
   05211 Renal cell carcinoma
    103083960 (PIK3R2)
   05215 Prostate cancer
    103083960 (PIK3R2)
   05213 Endometrial cancer
    103083960 (PIK3R2)
   05224 Breast cancer
    103083960 (PIK3R2)
   05222 Small cell lung cancer
    103083960 (PIK3R2)
   05223 Non-small cell lung cancer
    103083960 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103083960 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    103083960 (PIK3R2)
   05161 Hepatitis B
    103083960 (PIK3R2)
   05160 Hepatitis C
    103083960 (PIK3R2)
   05171 Coronavirus disease
    103083960 (PIK3R2)
   05164 Influenza A
    103083960 (PIK3R2)
   05162 Measles
    103083960 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    103083960 (PIK3R2)
   05163 Human cytomegalovirus infection
    103083960 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103083960 (PIK3R2)
   05169 Epstein-Barr virus infection
    103083960 (PIK3R2)
   05165 Human papillomavirus infection
    103083960 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    103083960 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    103083960 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103083960 (PIK3R2)
   05142 Chagas disease
    103083960 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103083960 (PIK3R2)
   05017 Spinocerebellar ataxia
    103083960 (PIK3R2)
   05020 Prion disease
    103083960 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103083960 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    103083960 (PIK3R2)
   05415 Diabetic cardiomyopathy
    103083960 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103083960 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    103083960 (PIK3R2)
   04931 Insulin resistance
    103083960 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103083960 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103083960 (PIK3R2)
   01524 Platinum drug resistance
    103083960 (PIK3R2)
   01522 Endocrine resistance
    103083960 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lve04131]
    103083960 (PIK3R2)
Membrane trafficking [BR:lve04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    103083960 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9 ATG11
Other DBs
NCBI-GeneID: 103083960
NCBI-ProteinID: XP_007461102
UniProt: A0A340XLU5
LinkDB
Position
Unknown
AA seq 724 aa
MAGAEGFQYRALYPFCRERPEDLELLPGDVLVVSRAALQALGVAEGSERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVTLARPGPRPRGPRPLPARPRDGPPEPGLTLPDLSEQFSP
PDVAPPILVKLVEAIERTGLDSYRPEAPAARTDWSLNDMEQWDAAALTDGVKGFLLALPA
PLVTPEAASEAHRALREAAGPVGPVLEPPTLPLHSVLTLRFLLQHLGRVARRAPALGPAV
RALSAAFGPLLLRAPSPSPPPGGAPDGTEATPDFPALLVEKLLQEHLEEQEITPPALPPK
PPKAKPAPTGLANGGNPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEY
TLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLLYPV
SKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFN
ETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLXXXXRLKSRIAEIHESRTKLEQ
ELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQ
YSLMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGD
TKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPP
PATR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atggctggtgccgagggcttccaataccgtgcgttgtacccgttctgccgggagcggccg
gaggacctggagctgctgccgggcgacgtgctggtggtgagcagggcagccctgcaggcg
ctgggcgtggccgagggcagcgagcgctgcccacagagcgtgggctggatgcctggcctc
aatgagcgaacacggcagcgcggcgacttccctggcacctatgttgagttcctagggcct
gtgaccctggcccggcctgggcctcgcccacgtggcccacgcccactgcctgccaggccc
cgagatgggccccctgagccaggcctcacactccctgacctatccgagcagttctccccg
cctgatgtggctccccctatcctggtgaaacttgtggaggccattgagcggacagggcta
gacagctacaggcctgaggcacctgccgcgcgcacagactggtcgctgaacgatatggag
cagtgggacgctgcagccctaacagatggcgtgaagggcttcctgctggcgctgcccgca
ccccttgtgacacccgaggccgcgtctgaggcacacagagccctgcgggaggccgcgggg
cccgtggggccggtgctggagcccccgacgctgccgctgcacagcgtgctcacactgcgc
ttcctgctccagcacctgggccgggtggcccggcgcgccccagccctgggcccagctgtg
cgtgccctgagcgccgcctttgggccgctgctgctgcgggcgccgtcgccttcgccgccg
ccagggggcgcgcccgacgggactgaggccacccccgacttccctgcgctactagtggag
aagttgcttcaggaacatctggaggaacaggagattacacccccagcactgccgccaaaa
ccccccaaggcaaagccagcccccacaggcctggccaatgggggcaacccgccctccctg
caggatgctgagtggtactggggtgacatctccagggaggaggtaaatgagaaactgcgg
gacacacctgatggcacctttctggtccgagatgcatctagcaagatccagggggagtac
acgctgaccctcaggaaaggtgggaacaacaagctgatcaaggtcttccaccgagacggg
cactacggcttttcggagccactcaccttctgctctgttgtggacctcatcacccactac
cgccacgagtcgctggctcagtacaacgccaagctggacacgcggctcctctacccggtg
tccaagtaccagcaggaccagatcgtcaaggaggacagtgtggaagcagtgggcgcccag
ctcaaggtctaccaccagcagtaccaggacaagagccgcgagtatgaccagctctacgag
gagtacacacgcacttcccaggaactgcagatgaagcgcacagccattgaggccttcaat
gagactatcaagatctttgaagagcagggccagacacaggagaagtgcagcaaggaatat
ctggagcgcttccggcgtgagggcaatgagaaagagatgcagaggatcctgctgannnnn
nnnnngcgactgaagtctcgcattgctgagatccacgagagccgcacaaagctggaacag
gagctgcgggcacaggcctccgacaaccgagagattgacaagcgcatgaacagcctcaag
ccagacctcatgcagctgcgcaagatcagagaccagtacctcgtgtggctcactcagaaa
ggtgcccggcagaagaaaatcaatgaatggttggggatcaagaatgagactgaggaccag
tactcactgatggaggatgaagatgatctgccccaccacgaggaacgcacatggtatgta
ggcaagatcaaccgcacccaagctgaggaaatgctgagtggcaagcgagatggcaccttc
ctcatccgtgaaagcagccagcggggctgctatgcctgttctgtagtggtggacggcgac
accaaacactgcgtcatctaccgcacagccacgggctttggcttcgcagaaccgtacaac
ttgtatgggtcgctgaaggagctggtgctgcactaccagcacgcctcgctggtgcagcac
aacgacgcgctcaccgtcacacttgcccatcctgtgcgcgccccgggccccgggccccca
cctgccacccgctga

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