KEGG   Leptonychotes weddellii (Weddell seal): 102728383
Entry
102728383         CDS       T08708                                 
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
lww  Leptonychotes weddellii (Weddell seal)
Pathway
lww01521  EGFR tyrosine kinase inhibitor resistance
lww01522  Endocrine resistance
lww01524  Platinum drug resistance
lww04012  ErbB signaling pathway
lww04014  Ras signaling pathway
lww04015  Rap1 signaling pathway
lww04024  cAMP signaling pathway
lww04062  Chemokine signaling pathway
lww04066  HIF-1 signaling pathway
lww04068  FoxO signaling pathway
lww04070  Phosphatidylinositol signaling system
lww04071  Sphingolipid signaling pathway
lww04072  Phospholipase D signaling pathway
lww04081  Hormone signaling
lww04140  Autophagy - animal
lww04150  mTOR signaling pathway
lww04151  PI3K-Akt signaling pathway
lww04152  AMPK signaling pathway
lww04210  Apoptosis
lww04211  Longevity regulating pathway
lww04213  Longevity regulating pathway - multiple species
lww04218  Cellular senescence
lww04360  Axon guidance
lww04370  VEGF signaling pathway
lww04380  Osteoclast differentiation
lww04510  Focal adhesion
lww04517  IgSF CAM signaling
lww04518  Integrin signaling
lww04550  Signaling pathways regulating pluripotency of stem cells
lww04611  Platelet activation
lww04613  Neutrophil extracellular trap formation
lww04620  Toll-like receptor signaling pathway
lww04625  C-type lectin receptor signaling pathway
lww04630  JAK-STAT signaling pathway
lww04650  Natural killer cell mediated cytotoxicity
lww04660  T cell receptor signaling pathway
lww04662  B cell receptor signaling pathway
lww04664  Fc epsilon RI signaling pathway
lww04666  Fc gamma R-mediated phagocytosis
lww04668  TNF signaling pathway
lww04670  Leukocyte transendothelial migration
lww04722  Neurotrophin signaling pathway
lww04725  Cholinergic synapse
lww04750  Inflammatory mediator regulation of TRP channels
lww04810  Regulation of actin cytoskeleton
lww04910  Insulin signaling pathway
lww04914  Progesterone-mediated oocyte maturation
lww04915  Estrogen signaling pathway
lww04917  Prolactin signaling pathway
lww04919  Thyroid hormone signaling pathway
lww04923  Regulation of lipolysis in adipocytes
lww04926  Relaxin signaling pathway
lww04929  GnRH secretion
lww04930  Type II diabetes mellitus
lww04931  Insulin resistance
lww04932  Non-alcoholic fatty liver disease
lww04933  AGE-RAGE signaling pathway in diabetic complications
lww04935  Growth hormone synthesis, secretion and action
lww04960  Aldosterone-regulated sodium reabsorption
lww04973  Carbohydrate digestion and absorption
lww05010  Alzheimer disease
lww05017  Spinocerebellar ataxia
lww05020  Prion disease
lww05100  Bacterial invasion of epithelial cells
lww05135  Yersinia infection
lww05142  Chagas disease
lww05146  Amoebiasis
lww05160  Hepatitis C
lww05161  Hepatitis B
lww05162  Measles
lww05163  Human cytomegalovirus infection
lww05164  Influenza A
lww05165  Human papillomavirus infection
lww05166  Human T-cell leukemia virus 1 infection
lww05167  Kaposi sarcoma-associated herpesvirus infection
lww05168  Herpes simplex virus 1 infection
lww05169  Epstein-Barr virus infection
lww05170  Human immunodeficiency virus 1 infection
lww05171  Coronavirus disease - COVID-19
lww05200  Pathways in cancer
lww05203  Viral carcinogenesis
lww05205  Proteoglycans in cancer
lww05206  MicroRNAs in cancer
lww05207  Chemical carcinogenesis - receptor activation
lww05208  Chemical carcinogenesis - reactive oxygen species
lww05210  Colorectal cancer
lww05211  Renal cell carcinoma
lww05212  Pancreatic cancer
lww05213  Endometrial cancer
lww05214  Glioma
lww05215  Prostate cancer
lww05218  Melanoma
lww05220  Chronic myeloid leukemia
lww05221  Acute myeloid leukemia
lww05222  Small cell lung cancer
lww05223  Non-small cell lung cancer
lww05224  Breast cancer
lww05225  Hepatocellular carcinoma
lww05226  Gastric cancer
lww05230  Central carbon metabolism in cancer
lww05231  Choline metabolism in cancer
lww05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lww05415  Diabetic cardiomyopathy
lww05417  Lipid and atherosclerosis
lww05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lww00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102728383
   04014 Ras signaling pathway
    102728383
   04015 Rap1 signaling pathway
    102728383
   04370 VEGF signaling pathway
    102728383
   04630 JAK-STAT signaling pathway
    102728383
   04668 TNF signaling pathway
    102728383
   04066 HIF-1 signaling pathway
    102728383
   04068 FoxO signaling pathway
    102728383
   04070 Phosphatidylinositol signaling system
    102728383
   04072 Phospholipase D signaling pathway
    102728383
   04071 Sphingolipid signaling pathway
    102728383
   04024 cAMP signaling pathway
    102728383
   04151 PI3K-Akt signaling pathway
    102728383
   04152 AMPK signaling pathway
    102728383
   04150 mTOR signaling pathway
    102728383
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102728383
   04517 IgSF CAM signaling
    102728383
   04518 Integrin signaling
    102728383
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102728383
  09143 Cell growth and death
   04210 Apoptosis
    102728383
   04218 Cellular senescence
    102728383
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102728383
   04550 Signaling pathways regulating pluripotency of stem cells
    102728383
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102728383
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102728383
   04613 Neutrophil extracellular trap formation
    102728383
   04620 Toll-like receptor signaling pathway
    102728383
   04625 C-type lectin receptor signaling pathway
    102728383
   04650 Natural killer cell mediated cytotoxicity
    102728383
   04660 T cell receptor signaling pathway
    102728383
   04662 B cell receptor signaling pathway
    102728383
   04664 Fc epsilon RI signaling pathway
    102728383
   04666 Fc gamma R-mediated phagocytosis
    102728383
   04670 Leukocyte transendothelial migration
    102728383
   04062 Chemokine signaling pathway
    102728383
  09152 Endocrine system
   04910 Insulin signaling pathway
    102728383
   04923 Regulation of lipolysis in adipocytes
    102728383
   04929 GnRH secretion
    102728383
   04915 Estrogen signaling pathway
    102728383
   04914 Progesterone-mediated oocyte maturation
    102728383
   04917 Prolactin signaling pathway
    102728383
   04926 Relaxin signaling pathway
    102728383
   04935 Growth hormone synthesis, secretion and action
    102728383
   04919 Thyroid hormone signaling pathway
    102728383
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102728383
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102728383
  09156 Nervous system
   04725 Cholinergic synapse
    102728383
   04722 Neurotrophin signaling pathway
    102728383
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102728383
  09158 Development and regeneration
   04360 Axon guidance
    102728383
   04380 Osteoclast differentiation
    102728383
  09149 Aging
   04211 Longevity regulating pathway
    102728383
   04213 Longevity regulating pathway - multiple species
    102728383
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102728383
   05206 MicroRNAs in cancer
    102728383
   05205 Proteoglycans in cancer
    102728383
   05207 Chemical carcinogenesis - receptor activation
    102728383
   05208 Chemical carcinogenesis - reactive oxygen species
    102728383
   05203 Viral carcinogenesis
    102728383
   05230 Central carbon metabolism in cancer
    102728383
   05231 Choline metabolism in cancer
    102728383
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102728383
  09162 Cancer: specific types
   05210 Colorectal cancer
    102728383
   05212 Pancreatic cancer
    102728383
   05225 Hepatocellular carcinoma
    102728383
   05226 Gastric cancer
    102728383
   05214 Glioma
    102728383
   05221 Acute myeloid leukemia
    102728383
   05220 Chronic myeloid leukemia
    102728383
   05218 Melanoma
    102728383
   05211 Renal cell carcinoma
    102728383
   05215 Prostate cancer
    102728383
   05213 Endometrial cancer
    102728383
   05224 Breast cancer
    102728383
   05222 Small cell lung cancer
    102728383
   05223 Non-small cell lung cancer
    102728383
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102728383
   05170 Human immunodeficiency virus 1 infection
    102728383
   05161 Hepatitis B
    102728383
   05160 Hepatitis C
    102728383
   05171 Coronavirus disease - COVID-19
    102728383
   05164 Influenza A
    102728383
   05162 Measles
    102728383
   05168 Herpes simplex virus 1 infection
    102728383
   05163 Human cytomegalovirus infection
    102728383
   05167 Kaposi sarcoma-associated herpesvirus infection
    102728383
   05169 Epstein-Barr virus infection
    102728383
   05165 Human papillomavirus infection
    102728383
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102728383
   05100 Bacterial invasion of epithelial cells
    102728383
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102728383
   05142 Chagas disease
    102728383
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102728383
   05017 Spinocerebellar ataxia
    102728383
   05020 Prion disease
    102728383
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102728383
   05418 Fluid shear stress and atherosclerosis
    102728383
   05415 Diabetic cardiomyopathy
    102728383
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102728383
   04932 Non-alcoholic fatty liver disease
    102728383
   04931 Insulin resistance
    102728383
   04933 AGE-RAGE signaling pathway in diabetic complications
    102728383
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102728383
   01524 Platinum drug resistance
    102728383
   01522 Endocrine resistance
    102728383
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lww04131]
    102728383
Membrane trafficking [BR:lww04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102728383
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Transcrip_act Exonuc_VII_L
Other DBs
NCBI-GeneID: 102728383
NCBI-ProteinID: XP_006729081
UniProt: A0A2U3XCA0
LinkDB
Position
Unknown
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVTNGMKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFV
EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcagccgttacaaatggaatgaaggacagttctgtttctctt
caggatgcagaatggtactggggggatatttcaagggaggaggtaaatgacaaattacgg
gatatgccagatggtacgttcttggtcagagatgcctcaacaaaaatgcagggggattac
actttgactttgcggaagggaggcaataataagttaataaagatctatcatcgagatggt
aaatacggcttttctgatcctctgacatttaattctgtggtggagctcattaaccactat
catcatgaatctcttgctcagtacaatcccaaacttgatgtgaagctaatgtacccagtg
tccagataccaacaggatcagttggtaaaagaagacaacattgatgcagttggtaaaaaa
ctgcaagagtaccactctcagtatcaggaaaagagtaaagagtatgacaggctatatgag
gaatataccagaacatcccaggaaatacagatgaagaggactgcaattgaagcttttaat
gaaacaattaaaatatttgaagagcagtgtcacacacaagaacaacatagcaaagaatat
attgagcgatttcgcagagaggggaatgaaaaggaaattgaacgaattatgatgaattat
gacaaattgaaatcacgtctgggtgagattcatgatagcaaaatgcgtctagagcaggat
ttgaagaaacaagctttggacaaccgggaaatagataaaaaaatgaacagtatcaaacct
gacctgatccagctgcgcaagatccgagatcagcaccttgtatggctcaatcacaaagga
gtgagacagaagcgcctaaatgcctggctgggaatcaagaatgaggatgctgatgagacc
tattttatcaatgaggaagatgaaaacctgccccattatgatgagaaaacctggtttgtt
gaggatatcaatcgagtacaagcagaggacttgctttatgggaaacctgatggtgcattt
ttaattcgtgagagtagcaagaaaggatgttatgcttgctctgtggttgccgatggggaa
gtgaagcactgtgtgatctacagcactgctcggggctatggctttgcagagccctacaac
ctgtacagctccctgaaggagctggtgctccattaccagcagacatccctcgttcagcac
aacgactccctcaacgtcaggcttgcctaccctgtccacgcacagatgccctcactctgc
agataa

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