Leptonychotes weddellii (Weddell seal): 102728925 Help Entry 102728925         CDS       T08708                                  Symbol LCK Name (RefSeq) tyrosine-protein kinase Lck   KO K05856   lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] Organism lww  Leptonychotes weddellii (Weddell seal) Pathway lww04064   NF-kappa B signaling pathway lww04380   Osteoclast differentiation lww04650   Natural killer cell mediated cytotoxicity lww04658   Th1 and Th2 cell differentiation lww04659   Th17 cell differentiation lww04660   T cell receptor signaling pathway lww05135   Yersinia infection lww05166   Human T-cell leukemia virus 1 infection lww05235   PD-L1 expression and PD-1 checkpoint pathway in cancer lww05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:lww00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     102728925 (LCK)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     102728925 (LCK)    04660 T cell receptor signaling pathway     102728925 (LCK)    04658 Th1 and Th2 cell differentiation     102728925 (LCK)    04659 Th17 cell differentiation     102728925 (LCK)   09158 Development and regeneration    04380 Osteoclast differentiation     102728925 (LCK)  09160 Human Diseases   09161 Cancer: overview    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102728925 (LCK)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102728925 (LCK)   09171 Infectious disease: bacterial    05135 Yersinia infection     102728925 (LCK)   09163 Immune disease    05340 Primary immunodeficiency     102728925 (LCK)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:lww01001]     102728925 (LCK)   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:lww03036]     102728925 (LCK) Enzymes [BR:lww01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102728925 (LCK) Protein kinases [BR:lww01001]  Non-receptor tyrosine kinases   SRC family    102728925 (LCK) Chromosome and associated proteins [BR:lww03036]  Eukaryotic type   Centrosome formation proteins    Kinases and associated factors     102728925 (LCK) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_2 SH3_9 ABC1 SH2_1 Haspin_kinase SH3_16 Motif Other DBs NCBI-GeneID:  102728925 NCBI-ProteinID:  XP_006734226 UniProt:  A0A2U3XRY1 LinkDB All DBs Position Unknown AA seq 509 aa AA seqDB search MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLPIWNGSEVRDPLVTYEGCNPPASP LQDNLVIALHNYEPSHDGDLGFEKGEQLRILEQNGEWWKAQSLTTGQEGFIPFNFVAKAN SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH YKIRNLDKGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEI PRETLKLVERLGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL VRLYAVVTQEPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNY IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER PEERPTFDYLRSVLEDFFTATEGQYQPQP NT seq 1530 nt NT seq  +upstreamnt  +downstreamnt atgggctgtagctgcagctcaaaccctgaagatgactggatggaaaacatcgatgtatgt gagaactgccattaccccatagtcccactggacggcaaggccacgctgcccatctggaat ggctctgaggtgcgggatccactggttacctacgaaggctgcaaccccccagcctcaccg ttgcaagataacctggttatcgctctgcacaactatgagccctctcacgatggagacttg ggcttcgagaagggtgaacagctccgtatcctggagcagaacggcgagtggtggaaggcg cagtccctgaccaccggccaggaaggtttcatccccttcaacttcgtggccaaagcgaac agcctggagcctgaaccctggttcttcaagaacctgagccgcaaggacgctgagcggcag ctcctggcgcccgggaacacgcacggctccttcctgatccgggagagcgagagcaccgcc ggatcgttctcactgtccgtgcgggacttcgaccagaaccagggagaggtggtgaaacat tacaaaatccgtaacctggacaaaggcggcttctacatctccccccgcatcacttttcct ggcctgcacgagctggtccgccattacaccaatgcttcggacgggctgtgcacgcggttg agtcgcccctgccagacccagaagccccagaagccttggtgggaggacgagtgggagatt cccagggagacgctgaagctggtggagcggctgggggctggccagttcggggaggtgtgg atggggtactacaacgagcacacaaaggtggcagtgaagagcctgaagcagggcagcatg tcccccgacgccttcctggccgaggccaacctcatgaagcagctgcaacaccagagactg gtccggctctacgcggtggtcacccaggagcccatctacatcatcacggaatacatggag aacgggagcctggtggatttcctcaagacccccccaggcatcaagctgaccatcaacaaa ctcttggacatggcagcccaaattgcagagggcatggcattcattgaagagcggaattat atccatcgtgacctgagagctgccaacatcctggtatctgacactctgagctgcaagatt gcagactttggcctagcacgcctcatcgaggacaacgagtacacagccagggagggagcc aagtttcccattaagtggacagcaccagaagccattaactacgggacattcaccatcaag tcggacgtgtggtcttttgggatcctgctgacggagattgtcacccacggccgcatccct tacccagggatgaccaatcctgaggtgattcagaacctggagcgaggctaccgcatggtg cgacctgacaactgtcccgaggagctgtaccacctcatgatgctgtgctggaaggagcgc ccagaggaacggcccacctttgactacctgcgcagtgtgctggaggacttcttcacggcc acggagggccagtaccagccccagccctga

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