Methylotuvimicrobium alcaliphilum: MEALZ_0523
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Entry
MEALZ_0523 CDS
T01649
Symbol
metH
Name
(GenBank) Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS)
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
mah
Methylotuvimicrobium alcaliphilum
Pathway
mah00270
Cysteine and methionine metabolism
mah00450
Selenocompound metabolism
mah00670
One carbon pool by folate
mah01100
Metabolic pathways
mah01110
Biosynthesis of secondary metabolites
mah01230
Biosynthesis of amino acids
mah04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
mah00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
MEALZ_0523 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
MEALZ_0523 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
MEALZ_0523 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
MEALZ_0523 (metH)
04980 Cobalamin transport and metabolism
MEALZ_0523 (metH)
Enzymes [BR:
mah01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
MEALZ_0523 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
MtrH
Motif
Other DBs
NCBI-ProteinID:
CCE22221
UniProt:
G4SZ71
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All DBs
Position
577680..581351
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AA seq
1223 aa
AA seq
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MSKLENFKKRLSQSILFLDGAMGTMIQSYKLEEKDYRGKRFSDWTVDLKGNNDLLSLTQP
DIIKAIHCAYLDVGCDIIETNTFNATQIAMADYQMESLAYEINLESARIARQAADEYSQK
TPEKPRFVAGILGPTNRTASMSPDVNDPGFRNIDFDTLVDAYTEAMRGLIDGGVDIILIE
TVFDTLNAKAAIFAVDQYFEAIGYKLPVMISGTITDASGRTLSGQTVAAFWNSLSHIEPI
SFGFNCALGAKELRQHIEELSSIADTHVSAHPNAGLPNEFGEYDESPEDMALELADWAAN
GYLNIIGGCCGTSPEHIKAIVEAVKQYPPRVVPVIEKQCRLAGLEPMNIGSDSLFVNVGE
RTNVTGSAKFKRLVVEGDFETALEVAKDQVENGAQIIDINMDEGMLESKEAMVRFLSLIA
AEPDIAKVPIMLDSSKWDIIEAGLKCIQGKGIVNSISLKEGEEAFIQHAKLIRRYGAAAI
VMAFDEQGQADTRDRKVEICSRAYRILTEQLNFPAEDIIFDPNIFAIATGIDEHNNYGMD
FIEATREIKRTLPHALISGGVSNVSFSFRGNNPVREAIHAVFLYHAIKAGMDMGIVNAGQ
LAIYEDIPLELRDAVEDVVLNRNDHATERLLELAEKYRGDGSTAAKPEELEWRSWPVTKR
LEHALVKGIADFIDEDTEQARQEAEKPLHVIEGALMDGMNVVGDLFGAGKMFLPQVVKSA
RVMKKAVAYLMPFMEAEQDGEMQTNGKILMATVKGDVHDIGKNIVGVVLQCNNFQVIDLG
VMVPAEKILQTARDEKVDIIGLSGLITPSLDEMVHMAKEMERQGFDIPLMIGGATTSRAH
TAVKIEPNYHGPVVYVADASRSVGVASHLVSDDSKEAFTQKIKEEYKEVRERHQGRKAKT
KQHSIEQARRNKFNWTDFEPVKPTFLGNKVIDRFPLDTLVWYIDWTPFFHTWELAGKYPN
IFEDRVVGEEARKLFDDAQVMLKKIINEEWLQARAVIGFYPANSDGDDIILYKDDSRLEK
REILHHLRQQSVKAPGRPNYCLSDFIAPIDSGKIDYLGGFAVTTGIGIEAKLEEFEKDHD
DYSSIMLKALADRLAEAFAEYMHEAVRKDFWGYAKDEQYRNDELISESYQGIRPAPGYPA
CPDHTEKSKLFELLNVTATTGIELTESYAMYPASAVSGWYFSHPEAQYFNVGKIDHDQLE
DYARRKGIAKEVAERWLSAHLHH
NT seq
3672 nt
NT seq
+upstream
nt +downstream
nt
atgagtaaattagaaaactttaaaaaaagattgtcccaaagtatcttgtttttagatggc
gctatgggcacgatgattcaaagctacaaattggaagaaaaagattatcggggcaagcgt
ttttcggattggactgtcgatctaaaaggtaacaatgatctgttgtctttgactcagccg
gatattattaaagcgattcattgcgcttatctcgatgtcggttgcgatattatcgagacg
aatacctttaacgcgactcaaattgcgatggccgattatcaaatggaatcattggcctat
gagattaatttggaatcggcgcggatagctagacaagctgctgatgaatatagtcaaaaa
acacctgaaaagccgcgcttcgttgccggtattttagggccgacaaaccggacggcgtcg
atgtcgcccgatgttaacgatcccggttttcgtaacatcgatttcgatactttggtcgat
gcttataccgaagcgatgcgcggcttaatcgacggcggtgtcgatattattttgatcgaa
acggtattcgatacgctcaatgccaaggcggctattttcgcggtcgatcaatatttcgag
gcgatcggttataaattgccggtcatgatttccggcacgattaccgatgcttcgggcaga
acgctgtcgggccaaaccgttgcggcgttttggaactcgctcagtcatatcgagccgatt
tcgttcggcttcaactgtgccttaggtgccaaagagctcaggcaacatatcgaggaatta
tcatcgatcgccgatacgcatgtgtcggctcatccgaatgccggtttgccgaacgagttc
ggcgaatatgacgaatctccggaagacatggccttggaattagccgattgggcggcgaac
ggttatttaaacatcattggtggctgctgcggtacgtcgcccgagcatatcaaagcgatt
gtcgaggcggtcaaacaatacccgccgagagtcgttcccgttattgaaaagcaatgccgc
ttggcaggccttgagccgatgaatattgggtcggattcgttgttcgtcaatgtcggcgaa
cgtaccaacgtgaccggttcggcaaaattcaagcgcttagttgttgaaggcgattttgaa
acggcattggaagtagccaaagatcaggtcgaaaacggcgcacaaattatcgacatcaat
atggatgaaggtatgttggagtcgaaagaagcgatggtgcgctttctcagcctgatcgcg
gccgaacccgatatcgccaaggtgccgatcatgcttgactcgtcgaaatgggatattatc
gaagccggattgaagtgcattcaaggcaagggcatcgtcaattctatctcgctgaaagaa
ggcgaggaagcctttatacagcatgccaagttgattcgtcgctatggtgcggctgcaatc
gtgatggctttcgacgaacaaggtcaagccgatacgcgtgatagaaaagtcgaaatctgc
agtcgtgcctatcgtattctgaccgagcaattgaattttccggccgaggacattattttc
gacccgaacatctttgcgattgcaaccggtatcgatgagcacaataactacggcatggat
tttatcgaggcgacccgcgaaatcaagcgaacgctacctcatgccttgatttcgggcggc
gtgtcgaacgtgtctttttcgttccgagggaacaatccggttcgcgaggcgatacatgcg
gtatttttgtatcatgcgattaaggccggcatggatatgggcatcgtcaatgccggccaa
ttggctatctatgaagacattccgttggaattgcgcgatgcggttgaggatgtcgtgctc
aatcgcaacgatcacgcgaccgaacgcttgcttgagttggccgaaaaatatcgcggcgac
ggcagtacggcagccaaacctgaagagctcgaatggcgaagttggccggttaccaaaaga
ctcgagcatgctctggttaaaggcatcgccgatttcatcgacgaagataccgagcaggcc
cggcaagaagccgaaaagccgttgcatgtgatcgaaggcgcgttgatggacggcatgaat
gtggtcggcgatttgttcggggccggcaaaatgtttttgccgcaagtcgtcaagtcggcg
cgggtcatgaaaaaagcggtcgcgtatttgatgccgttcatggaagccgagcaagacggc
gaaatgcagaccaacggcaaaatactgatggccaccgtcaaaggcgacgtgcacgatatc
ggcaagaatattgtcggcgtagtgctgcaatgcaataattttcaggtcatcgacttgggg
gtaatggtgccggccgaaaaaatcttgcagaccgcgcgcgatgaaaaagtcgatatcatc
ggtcttagcggcttgattacgccgtctctcgatgaaatggtacatatggccaaagaaatg
gaacgacaaggcttcgacattccgctgatgatcggcggcgcaacgacctcaagagcccat
actgcggtcaagatcgagcctaactatcatggtccggttgtttatgtcgccgatgcctcc
agaagcgtcggtgtggccagtcatttggtcagcgacgactccaaggaggcatttacccaa
aaaatcaaggaagaatacaaggaggttcgggaaaggcatcaggggcgtaaagccaaaacc
aagcaacatagcattgagcaggcgagacgcaataaattcaattggaccgatttcgagccg
gtcaagcccacctttttaggcaacaaagtcatcgatcgctttcctctcgatacgttggtt
tggtatatcgattggacgccgttcttccatacttgggagttggccggtaaatatcccaat
attttcgaagaccgagtcgtcggcgaagaagctagaaagctgttcgacgatgcgcaagtg
atgttgaaaaaaatcatcaacgaagaatggcttcaggctcgtgccgttatcgggttttac
ccggccaacagcgacggcgacgacatcattttatataaagacgattcgcggcttgaaaag
cgagaaattttgcatcatttgcggcagcaaagtgtcaaggcgccggggcggccgaattat
tgtttgtccgatttcatcgcgcctatcgatagcggcaagatcgattatttgggcggcttt
gcggtaacgaccggcatcggcatcgaagctaagctcgaagaattcgaaaaagaccatgac
gattacagttcgatcatgctcaaggccttggcagaccgattggcagaagccttcgccgag
tatatgcatgaagcggttaggaaggatttttggggatatgcaaaagacgaacaataccgt
aacgatgagttgatctccgaatcttatcaaggcataaggccggctccgggttatccggct
tgtccggatcataccgaaaagagcaaattgttcgagttgcttaatgtcactgcgacgacc
ggaatcgagttgaccgagagttacgcgatgtatccggcctcggcggtcagcggctggtat
ttttcgcatccggaggcgcagtatttcaatgtcggcaagatcgatcacgatcagctcgag
gactatgcgcgccgaaaaggcatcgcgaaggaagtagctgagcggtggttgtccgcgcat
ttgcatcactga
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