KEGG   PATHWAY: map00621
Entry
map00621                    Pathway                                
Name
Dioxin degradation
Description
Dioxins and dioxin-like compounds, including PCDDs, PCDFs and PCBs, are persistent organic pollutants (POPs) that are resistant to environmental degradation. However, POPs can be degraded by certain microorganisms with acquisition of a novel set of enzymes, such as biphenyl degradation by Paraburkholderia xenovorans LB400 involving four novel enzymes encoded in operon-like structures [MD:M00543]. DDT, another POP, and carbazol are also known to be degraded in similar pathways.
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
map00621  Dioxin degradation
map00621

Module
M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate [PATH:map00621]
M00544  Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate [PATH:map00621]
Other DBs
UMBBD: dpd dbf bph cbp car ddt
Reference
  Authors
Nojiri H, Omori T.
  Title
Molecular bases of aerobic bacterial degradation of dioxins: involvement of angular dioxygenation.
  Journal
Biosci Biotechnol Biochem 66:2001-16 (2002)
DOI:10.1271/bbb.66.2001
Reference
  Authors
Jin S, Zhu T, Xu X, Xu Y.
  Title
Biodegradation of dibenzofuran by Janibacter terrae strain XJ-1.
  Journal
Curr Microbiol 53:30-6 (2006)
DOI:10.1007/s00284-005-0180-1
Reference
  Authors
Nojiri H, Habe H, Omori T.
  Title
Bacterial degradation of aromatic compounds via angular dioxygenation.
  Journal
J Gen Appl Microbiol 47:279-305 (2001)
DOI:10.2323/jgam.47.279
Reference
  Authors
Kasuga K, Habe H, Chung JS, Yoshida T, Nojiri H, Yamane H, Omori T.
  Title
Isolation and characterization of the genes encoding a novel oxygenase component of angular dioxygenase from the gram-positive dibenzofuran-degrader Terrabacter sp. strain DBF63.
  Journal
Biochem Biophys Res Commun 283:195-204 (2001)
DOI:10.1006/bbrc.2001.4763
Reference
  Authors
Vezina J, Barriault D, Sylvestre M
  Title
Family shuffling of soil DNA to change the regiospecificity of Burkholderia xenovorans LB400 biphenyl dioxygenase.
  Journal
J Bacteriol 189:779-88 (2007)
DOI:10.1128/JB.01267-06
Reference
  Authors
Ouchiyama N, Miyachi S, Omori T
  Title
Cloning and nucleotide sequence of carbazole catabolic genes from Pseudomonas stutzeri strain OM1, isolated from activated sludge.
  Journal
J Gen Appl Microbiol 44:57-63 (1998)
DOI:10.2323/jgam.44.57
Reference
PMID:9244273
  Authors
Sato SI, Ouchiyama N, Kimura T, Nojiri H, Yamane H, Omori T
  Title
Cloning of genes involved in carbazole degradation of Pseudomonas sp. strain CA10: nucleotide sequences of genes and characterization of meta-cleavage enzymes and hydrolase.
  Journal
J Bacteriol 179:4841-9 (1997)
DOI:10.1128/JB.179.15.4841-4849.1997
Reference
  Authors
Nguyen PA, Trinh TH, Fukumitsu Y, Shimodaira J, Miyauchi K, Tokuda M, Kasai D, Masai E, Fukuda M
  Title
Gene cluster and regulation system for 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE) degradation in Janibacter sp.  TYM3221.
  Journal
J Biosci Bioeng 116:91-100 (2013)
DOI:10.1016/j.jbiosc.2013.01.007
Related
pathway
map00020  Citrate cycle (TCA cycle)
map00350  Tyrosine metabolism
map00362  Benzoate degradation
map00364  Fluorobenzoate degradation
map00620  Pyruvate metabolism
map00627  Aminobenzoate degradation
KO pathway
ko00621   
LinkDB

DBGET integrated database retrieval system