KEGG PATHWAY: map04011

KEGG

PATHWAY: map04011

Entry

map04011                    Pathway

Name

MAPK signaling pathway - yeast

Description

The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MAPKK/MEK), which is itself phosphorylated by a MEK kinase (MAPKKK/MEKK).

Class

Environmental Information Processing; Signal transduction

Pathway map

MAPK signaling pathway - yeast

Other DBs

GO:

Reference

Authors

Bardwell L

Title

A walk-through of the yeast mating pheromone response pathway.

Journal

Peptides 26:339-50 (2005)
DOI:10.1016/j.peptides.2004.10.002

Reference

Authors

Levin DE

Title

Cell wall integrity signaling in Saccharomyces cerevisiae.

Journal

Microbiol Mol Biol Rev 69:262-91 (2005)
DOI:10.1128/MMBR.69.2.262-291.2005

Reference

Authors

Levin DE

Title

Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.

Journal

Genetics 189:1145-75 (2011)
DOI:10.1534/genetics.111.128264

Reference

Authors

Hohmann S, Krantz M, Nordlander B

Title

Yeast osmoregulation.

Journal

Methods Enzymol 428:29-45 (2007)
DOI:10.1016/S0076-6879(07)28002-4

Reference

Authors

Saito H, Posas F

Title

Response to hyperosmotic stress.

Journal

Genetics 192:289-318 (2012)
DOI:10.1534/genetics.112.140863

Reference

Authors

Cullen PJ, Sprague GF Jr

Title

The regulation of filamentous growth in yeast.

Journal

Genetics 190:23-49 (2012)
DOI:10.1534/genetics.111.127456

Reference

Authors

Gustin MC, Albertyn J, Alexander M, Davenport K

Title

MAP kinase pathways in the yeast Saccharomyces cerevisiae.

Journal

Microbiol Mol Biol Rev 62:1264-300 (1998)

Reference

Authors

Chen RE, Thorner J

Title

Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.

Journal

Biochim Biophys Acta 1773:1311-40 (2007)
DOI:10.1016/j.bbamcr.2007.05.003

KO pathway

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