KEGG   PATHWAY: ko04011
Entry
ko04011                     Pathway                                
Name
MAPK signaling pathway - yeast
Description
The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MAPKK/MEK), which is itself phosphorylated by a MEK kinase (MAPKKK/MEKK).
Class
Environmental Information Processing; Signal transduction
Pathway map
ko04011  MAPK signaling pathway - yeast
ko04011

Other DBs
GO: 0000165
Orthology
K00006  GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]
K00706  E2.4.1.34; 1,3-beta-glucan synthase [EC:2.4.1.34]
K00888  PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K01383  BAR1; barrierpepsin [EC:3.4.23.35]
K02218  CSNK1, CKI; casein kinase 1 [EC:2.7.11.1]
K02220  CLB1; G2/mitotic-specific cyclin 1
K02515  HSL1; serine/threonine-protein kinase HSL1, negative regulator of Swe1 kinase [EC:2.7.11.-]
K02516  PRMT5, HSL7; type II protein arginine methyltransferase [EC:2.1.1.320]
K02555  MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]
K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K03085  SIC1; substrate and inhibitor of the cyclin-dependent protein kinase CDC28
K03114  SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]
K03781  katE, CAT, catB, srpA; catalase [EC:1.11.1.6]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04393  CDC42; cell division control protein 42
K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
K04441  P38; p38 MAP kinase [EC:2.7.11.24]
K04464  MAPK7; mitogen-activated protein kinase 7 [EC:2.7.11.24]
K04513  RHOA; Ras homolog gene family, member A
K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04563  CDC28, CDC2; cyclin-dependent kinase [EC:2.7.11.22]
K04627  STE3; pheromone a factor receptor
K06009  YPS1_2; yapsin 1/2 [EC:3.4.23.41]
K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K06630  YWHAE; 14-3-3 protein epsilon
K06648  SWI6; regulatory protein SWI6
K06649  SWI4; regulatory protein SWI4
K06650  CLN2; G1/S-specific cyclin CLN2
K06651  CLB5_6; S-phase entry cyclin 5/6
K06652  FAR1; cyclin-dependent kinase inhibitor FAR1
K06665  SSN6, CYC8; general transcriptional corepressor CYC8
K06666  TUP1; general transcriptional corepressor TUP1
K07973  GNG; guanine nucleotide-binding protein subunit gamma, fungi
K08294  MKK1_2; mitogen-activated protein kinase kinase [EC:2.7.12.2]
K09051  SKO1, ATF1, PCR1; ATF/CREB family transcription factor
K09265  RLM1; transcription factor RLM1
K09448  TEAD; transcriptional enhancer factor
K09468  MSN2_4; zinc finger protein MSN2/4
K10591  NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
K11213  STE2; pheromone alpha factor receptor
K11215  STE12; transcription factor STE12
K11226  STE7; mitogen-activated protein kinase kinase [EC:2.7.12.2]
K11227  PBS2; mitogen-activated protein kinase kinase [EC:2.7.12.2]
K11228  STE11; mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
K11229  BCK1; mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
K11230  SSK2; mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
K11231  SLN1; osomolarity two-component system, sensor histidine kinase SLN1 [EC:2.7.13.3]
K11232  YPD1; osomolarity two-component system, phosphorelay intermediate protein YPD1
K11233  SSK1; osomolarity two-component system, response regulator SSK1
K11234  MFAL; mating pheromone alpha-factor
K11235  MFA; mating pheromone A-factor
K11236  CDC24; cell division control protein 24
K11237  BEM1; bud emergence protein 1
K11238  BNI1; cytokinesis protein
K11239  STE5; pheromone-response scaffold protein
K11240  MSG5; tyrosine-protein phosphatase MSG5 [EC:3.1.3.48]
K11241  DIG1; down-regulator of invasive growth 1
K11242  DIG2; down-regulator of invasive growth 2
K11243  FUS1; nuclear fusion protein
K11244  WSC; cell wall integrity and stress response component
K11245  MID2, MTL1; mating pheromone-induced death protein 2
K11246  SHO1; SHO1 osmosensor
K12412  MCM1; pheromone receptor transcription factor
K12760  CLN1; G1/S-specific cyclin CLN1
K15174  PAF1; RNA polymerase II-associated factor 1
K17741  GRE2; NADPH-dependent methylglyoxal reductase [EC:1.1.1.283]
K17971  BNR1; BNI1-related protein 1
K19704  PTC1; protein phosphatase PTC1 [EC:3.1.3.16]
K19806  PTP2_3; tyrosine-protein phosphatase 2/3 [EC:3.1.3.48]
K19807  SMP1; transcription factor SMP1
K19812  SDP1; dual-specificity protein phosphatase SDP1 [EC:3.1.3.48]
K19815  HOT1; high-osmolarity-induced transcription protein 1
K19816  MSS11; transcription activator MSS11
K19833  CLA4; serine/threonine-protein kinase CLA4 [EC:2.7.11.1]
K19838  SST2; GTPase-activating protein SST2
K19839  RGA1_2; Rho-type GTPase-activating protein 1/2
K19840  BEM3; Rho-type GTPase-activating protein
K19841  STE50; protein STE50
K19842  ROM1_2; RHO1 GDP-GTP exchange protein 1/2
K19843  TUS1; Rho1 guanine nucleotide exchange factor TUS1
K19844  BEM2; GTPase-activating protein BEM2
K19845  SAC7; GTPase-activating protein SAC7
K19846  SPA2; protein SPA2
K19847  MLP1, KDX1; MPK-like protein 1
K19848  HKR1; signaling mucin HKR1
K19849  MSB2; signaling mucin MSB2
K19850  OPY2; protein OPY2
K19851  FLO11; flocculation protein FLO11
K19860  GPA1; guanine nucleotide-binding protein alpha-1 subunit
K23469  CLB2; G2/mitotic-specific cyclin 2
Reference
PMID:15690603
  Authors
Bardwell L
  Title
A walk-through of the yeast mating pheromone response pathway.
  Journal
Peptides 26:339-50 (2005)
DOI:10.1016/j.peptides.2004.10.002
Reference
PMID:15944456
  Authors
Levin DE
  Title
Cell wall integrity signaling in Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 69:262-91 (2005)
DOI:10.1128/MMBR.69.2.262-291.2005
Reference
PMID:22174182
  Authors
Levin DE
  Title
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
  Journal
Genetics 189:1145-75 (2011)
DOI:10.1534/genetics.111.128264
Reference
PMID:17875410
  Authors
Hohmann S, Krantz M, Nordlander B
  Title
Yeast osmoregulation.
  Journal
Methods Enzymol 428:29-45 (2007)
DOI:10.1016/S0076-6879(07)28002-4
Reference
PMID:23028184
  Authors
Saito H, Posas F
  Title
Response to hyperosmotic stress.
  Journal
Genetics 192:289-318 (2012)
DOI:10.1534/genetics.112.140863
Reference
PMID:22219507
  Authors
Cullen PJ, Sprague GF Jr
  Title
The regulation of filamentous growth in yeast.
  Journal
Genetics 190:23-49 (2012)
DOI:10.1534/genetics.111.127456
Reference
PMID:9841672
  Authors
Gustin MC, Albertyn J, Alexander M, Davenport K
  Title
MAP kinase pathways in the yeast Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 62:1264-300 (1998)
Reference
PMID:17604854
  Authors
Chen RE, Thorner J
  Title
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1773:1311-40 (2007)
DOI:10.1016/j.bbamcr.2007.05.003

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