Entry Name Ras signaling pathway
Description The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Reference Authors Karnoub AE, Weinberg RA
Title Ras oncogenes: split personalities.
Journal Reference Authors Malumbres M, Barbacid M
Title RAS oncogenes: the first 30 years.
Journal Reference Authors Cox AD, Der CJ
Title Ras history: The saga continues.
Journal Reference Authors Cox AD, Der CJ
Title Ras family signaling: therapeutic targeting.
Journal Reference Authors Rajalingam K, Schreck R, Rapp UR, Albert S
Title Ras oncogenes and their downstream targets.
Journal Reference Authors Schubbert S, Shannon K, Bollag G
Title Hyperactive Ras in developmental disorders and cancer.
Journal Reference Authors Poulogiannis G, Luo F, Arends MJ
Title RAS signalling in the colorectum in health and disease.
Journal Reference Authors Berndt N, Hamilton AD, Sebti SM
Title Targeting protein prenylation for cancer therapy.
Journal Reference Authors Overmeyer JH, Maltese WA
Title Death pathways triggered by activated Ras in cancer cells.
Journal Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:
10.2741/3814 Reference Authors Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
Title Cancer targets in the Ras pathway.
Journal Reference Authors Cox AD, Der CJ
Title The dark side of Ras: regulation of apoptosis.
Journal Reference Authors Braun BS, Shannon K
Title Targeting Ras in myeloid leukemias.
Journal Reference Authors Pino MS, Chung DC
Title The chromosomal instability pathway in colon cancer.
Journal Reference Authors Schrader JW, Schallhorn A, Grill B, Guo X
Title Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
Journal Reference Authors Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
Title Regulating the regulator: post-translational modification of RAS.
Journal Reference Authors Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
Title A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
Journal Reference Authors Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
Title RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
Journal Reference Authors Kortum RL, Rouquette-Jazdanian AK, Samelson LE
Title Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
Journal Reference Authors Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
Title A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
Journal Reference Authors Reuther GW, Der CJ
Title The Ras branch of small GTPases: Ras family members don't fall far from the tree.
Journal Reference Authors Fernandez-Medarde A, Santos E
Title The RasGrf family of mammalian guanine nucleotide exchange factors.
Journal Reference Authors Iwashita S, Song SY
Title RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
Journal Reference Authors Ory S, Morrison DK
Title Signal transduction: implications for Ras-dependent ERK signaling.
Journal Reference Authors Matheny SA, White MA
Title Signaling threshold regulation by the Ras effector IMP.
Journal Reference Authors Lemmon MA, Schlessinger J
Title Cell signaling by receptor tyrosine kinases.
Journal Reference Authors Skaper SD
Title The neurotrophin family of neurotrophic factors: an overview.
Journal Reference Authors Apken LH, Oeckinghaus A
Title The RAL signaling network: Cancer and beyond.
Journal Related map04660 T cell receptor signaling pathway
map04810 Regulation of actin cytoskeleton
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