Entry Name Phagocytosis
Description Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Other DBs Reference Authors Stuart LM, Ezekowitz RA
Title Phagocytosis: elegant complexity.
Journal Reference Authors Tjelle TE, Lovdal T, Berg T
Title Phagosome dynamics and function.
Journal Reference Authors Dupuy AG, Caron E
Title Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal Reference Authors Brumell JH, Grinstein S
Title Salmonella redirects phagosomal maturation.
Journal Reference Authors Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal Reference Authors Luzio JP, Pryor PR, Bright NA
Title Lysosomes: fusion and function.
Journal Reference Authors Sumimoto H
Title Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal Reference Authors Depierre M, Pompili C, Niedergang F
Title Phagocytosis at a glance.
Journal Reference Authors Lee HJ, Woo Y, Hahn TW, Jung YM, Jung YJ
Title Formation and Maturation of the Phagosome: A Key Mechanism in Innate Immunity against Intracellular Bacterial Infection.
Journal Reference Authors Heckmann BL, Green DR
Title LC3-associated phagocytosis at a glance.
Journal Reference Authors Yuan J, Zhang Q, Chen S, Yan M, Yue L
Title LC3-Associated Phagocytosis in Bacterial Infection.
Journal Reference Authors Pena-Martinez C, Rickman AD, Heckmann BL
Title Beyond autophagy: LC3-associated phagocytosis and endocytosis.
Journal Reference Authors Othman A, Sekheri M, Filep JG
Title Roles of neutrophil granule proteins in orchestrating inflammation and immunity.
Journal Reference Authors Rosales C
Title Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Journal Reference Authors Naish E, Wood AJ, Stewart AP, Routledge M, Morris AC, Chilvers ER, Lodge KM
Title The formation and function of the neutrophil phagosome.
Journal Reference Authors Skubitz KM
Title The role of CEACAMs in neutrophil function.
Journal Reference Authors Weiss G, Schaible UE
Title Macrophage defense mechanisms against intracellular bacteria.
Journal Reference Authors Cruz FM, Chan A, Rock KL
Title Pathways of MHC I cross-presentation of exogenous antigens.
Journal Related map04610 Complement and coagulation cascades
map04612 Antigen processing and presentation
map04613 Neutrophil extracellular trap formation
map04620 Toll-like receptor signaling pathway
map04666 Fc gamma R-mediated phagosome formation
KO pathway
