Entry Name Phagosome
Description Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K13505 vesicle-associated membrane protein 3
K08517 vesicle transport protein SEC22
K07887 Ras-related protein Rab-5A
K07888 Ras-related protein Rab-5B
K07889 Ras-related protein Rab-5C
K12478 early endosome antigen 1
K12182 hepatocyte growth factor-regulated tyrosine kinase substrate
K02147 V-type H+-transporting ATPase subunit B
K02148 V-type H+-transporting ATPase subunit C
K02149 V-type H+-transporting ATPase subunit D
K02150 V-type H+-transporting ATPase subunit E
K02151 V-type H+-transporting ATPase subunit F
K02152 V-type H+-transporting ATPase subunit G
K02153 V-type H+-transporting ATPase subunit e
K02154 V-type H+-transporting ATPase subunit a
K02146 V-type H+-transporting ATPase subunit d
K02144 V-type H+-transporting ATPase subunit H
K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit
K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit
K03662 V-type H+-transporting ATPase S1 subunit
K07897 Ras-related protein Rab-7A
K07898 Ras-related protein Rab-7B
K13883 Rab-interacting lysosomal protein
K10413 dynein cytoplasmic 1 heavy chain
K10414 dynein cytoplasmic 2 heavy chain
K10415 dynein cytoplasmic 1 intermediate chain
K10416 dynein cytoplasmic 1 light intermediate chain
K06528 lysosomal-associated membrane protein 1/2
K10089 cation-dependent mannose-6-phosphate receptor
K10956 protein transport protein SEC61 subunit alpha
K09481 protein transport protein SEC61 subunit beta
K07342 protein transport protein SEC61 subunit gamma and related proteins
K05653 ATP-binding cassette, subfamily B (MDR/TAP), member 2 [EC:7.4.2.14 ]
K05654 ATP-binding cassette, subfamily B (MDR/TAP), member 3 [EC:7.4.2.14 ]
K06498 high affinity immunoglobulin gamma Fc receptor I
K06472 low affinity immunoglobulin gamma Fc receptor II-a
K12560 low affinity immunoglobulin gamma Fc receptor II-b
K16824 low affinity immunoglobulin gamma Fc receptor II-c
K06463 low affinity immunoglobulin gamma Fc receptor III
K06856 immunoglobulin heavy chain
K10066 collectin sub-family member 11
K10062 collectin sub-family member 12
K10067 pulmonary surfactant-associated protein A
K10068 pulmonary surfactant-associated protein D
K04391 monocyte differentiation antigen CD14
K06560 mannose receptor, C type
K06563 C-type lectin domain family 4 member L/M
K10074 C-type lectin domain family 7 member A
K06558 macrophage scavenger receptor 1
K13884 macrophage receptor with collagenous structure
K08763 oxidised low-density lipoprotein receptor 1
K13885 scavenger receptor class B, member 1
K08009 cytochrome b-245, alpha polypeptide
K21421 NADPH oxidase 2 [EC:1.-.-.-]
K04392 Ras-related C3 botulinum toxin substrate 1
K08011 neutrophil cytosolic factor 1
K08010 neutrophil cytosolic factor 2
K08012 neutrophil cytosolic factor 4
Compound C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference Authors Stuart LM, Ezekowitz RA
Title Phagocytosis: elegant complexity.
Journal Reference Authors Tjelle TE, Lovdal T, Berg T
Title Phagosome dynamics and function.
Journal Reference Authors Dupuy AG, Caron E
Title Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal Reference Authors Brumell JH, Grinstein S
Title Salmonella redirects phagosomal maturation.
Journal Reference Authors Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal Reference Authors Luzio JP, Pryor PR, Bright NA
Title Lysosomes: fusion and function.
Journal Reference Authors Sumimoto H
Title Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal Related ko04610 Complement and coagulation cascades
ko04612 Antigen processing and presentation
ko04620 Toll-like receptor signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
LinkDB All DBs
