KEGG   PATHWAY: ko04145
Entry
ko04145                     Pathway                                
Name
Phagosome
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
ko04145  Phagosome
ko04145

Other DBs
GO: 0045335
Orthology
K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K01330  C1R; complement component 1, r subcomponent [EC:3.4.21.41]
K01365  CTSL; cathepsin L [EC:3.4.22.15]
K01368  CTSS; cathepsin S [EC:3.4.22.27]
K02144  ATPeV1H; V-type H+-transporting ATPase subunit H
K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A [EC:7.1.2.2]
K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
K02147  ATPeV1B, ATP6B; V-type H+-transporting ATPase subunit B
K02148  ATPeV1C, ATP6C; V-type H+-transporting ATPase subunit C
K02149  ATPeV1D, ATP6M; V-type H+-transporting ATPase subunit D
K02150  ATPeV1E, ATP6E; V-type H+-transporting ATPase subunit E
K02151  ATPeV1F, ATP6S14; V-type H+-transporting ATPase subunit F
K02152  ATPeV1G, ATP6G; V-type H+-transporting ATPase subunit G
K02153  ATPeV0E, ATP6H; V-type H+-transporting ATPase subunit e
K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
K02155  ATPeV0C, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit
K03661  ATPeV0B, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit
K03662  ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit
K03990  C3; complement component 3
K03991  MBL; mannose-binding lectin
K04391  CD14; monocyte differentiation antigen CD14
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04659  THBS2S; thrombospondin 2/3/4/5
K05653  ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2 [EC:7.4.2.14]
K05654  ABCB3, TAP2; ATP-binding cassette, subfamily B (MDR/TAP), member 3 [EC:7.4.2.14]
K05692  ACTB_G1; actin beta/gamma 1
K05719  ITGB1, CD29; integrin beta 1
K06259  CD36; CD36 antigen
K06461  ITGAM, CD11b; integrin alpha M
K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
K06464  ITGB2, CD18; integrin beta 2
K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
K06481  ITGA2, CD49b; integrin alpha 2
K06484  ITGA5, CD49e; integrin alpha 5
K06487  ITGAV, CD51; integrin alpha V
K06493  ITGB3, CD61; integrin beta 3
K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
K06503  TFRC, CD71; transferrin receptor
K06513  FCAR, CD89; CD89 antigen
K06528  LAMP1_2, CD107; lysosomal-associated membrane protein 1/2
K06558  MSR1, CD204; macrophage scavenger receptor 1
K06560  MRC, CD206, CD280; mannose receptor, C type
K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
K06588  ITGB5; integrin beta 5
K06751  MHC1; MHC class I antigen
K06752  MHC2; MHC class II antigen
K06856  IGH; immunoglobulin heavy chain
K07342  SEC61G, SSS1, secE; protein transport protein SEC61 subunit gamma and related proteins
K07374  TUBA; tubulin alpha
K07375  TUBB; tubulin beta
K07887  RAB5A; Ras-related protein Rab-5A
K07888  RAB5B; Ras-related protein Rab-5B
K07889  RAB5C; Ras-related protein Rab-5C
K07897  RAB7A; Ras-related protein Rab-7A
K07898  RAB7B; Ras-related protein Rab-7B
K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
K08010  NCF2, P67PHOX; neutrophil cytosolic factor 2
K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
K08012  NCF4, P40PHOX; neutrophil cytosolic factor 4
K08054  CANX; calnexin
K08057  CALR; calreticulin
K08488  STX7; syntaxin 7
K08492  STX18; syntaxin 18
K08517  SEC22; vesicle transport protein SEC22
K08763  OLR1; oxidised low-density lipoprotein receptor 1
K09481  SEC61B, SBH2; protein transport protein SEC61 subunit beta
K10062  COLEC12; collectin sub-family member 12
K10066  COLEC11; collectin sub-family member 11
K10067  SFTPA; pulmonary surfactant-associated protein A
K10068  SFTPD, SFTP4; pulmonary surfactant-associated protein D
K10074  CLEC7A, DECTIN1, CD369; C-type lectin domain family 7 member A
K10089  M6PR; cation-dependent mannose-6-phosphate receptor
K10159  TLR2, CD282; toll-like receptor 2
K10160  TLR4, CD284; toll-like receptor 4
K10169  TLR6, CD286; toll-like receptor 6
K10413  DYNC1H; dynein cytoplasmic 1 heavy chain
K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
K10415  DYNC1I, DNCI; dynein cytoplasmic 1 intermediate chain
K10416  DYNC1LI, DNCLI; dynein cytoplasmic 1 light intermediate chain
K10789  MPO; myeloperoxidase [EC:1.11.2.2]
K10956  SEC61A; protein transport protein SEC61 subunit alpha
K12182  HGS, HRS, VPS27; hepatocyte growth factor-regulated tyrosine kinase substrate
K12478  EEA1; early endosome antigen 1
K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
K13240  NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]
K13505  VAMP3; vesicle-associated membrane protein 3
K13813  STX12, STX13; syntaxin 12/13
K13882  CORO1A; coronin-1A
K13883  RILP; Rab-interacting lysosomal protein
K13884  MARCO; macrophage receptor with collagenous structure
K13885  SCARB1; scavenger receptor class B, member 1
K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
K16857  THBS1; thrombospondin 1
K21421  NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
ko04142  Lysosome
ko04144  Endocytosis
ko04610  Complement and coagulation cascades
ko04612  Antigen processing and presentation
ko04620  Toll-like receptor signaling pathway
ko04666  Fc gamma R-mediated phagocytosis

DBGET integrated database retrieval system