Entry Name Ferroptosis
Description Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Other DBs Reference Authors Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
Title Regulated necrosis: disease relevance and therapeutic opportunities.
Journal Reference Authors Yang WS, Stockwell BR
Title Ferroptosis: Death by Lipid Peroxidation.
Journal Reference Authors Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H
Title Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
Journal Reference Authors D'Herde K, Krysko DV
Title Ferroptosis: Oxidized PEs trigger death.
Journal Reference Authors Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S
Title Ferroptosis and cell death mechanisms in Parkinson's disease.
Journal Reference Authors Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y
Title Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Journal Reference Authors Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D
Title Ferroptosis: process and function.
Journal Reference Authors Murphy ME
Title Ironing out how p53 regulates ferroptosis.
Journal Reference Authors Muckenthaler MU, Rivella S, Hentze MW, Galy B
Title A Red Carpet for Iron Metabolism.
Journal Reference Authors Yu H, Guo P, Xie X, Wang Y, Chen G
Title Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.
Journal Reference Authors Wang SJ, Ou Y, Jiang L, Gu W
Title Ferroptosis: A missing puzzle piece in the p53 blueprint?
Journal Reference Authors Cao JY, Dixon SJ
Title Mechanisms of ferroptosis.
Journal Reference Authors Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW
Title Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
Journal Reference Authors Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ
Title The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis.
Journal Reference Authors Kwon MY, Park E, Lee SJ, Chung SW
Title Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.
Journal Reference Authors Reed JC, Pellecchia M
Title Ironing out cell death mechanisms.
Journal Related map00900 Terpenoid backbone biosynthesis
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