Entry Name Thermogenesis
Description Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class Organismal Systems; Environmental adaptationBRITE hierarchy
Pathway map Other DBs Reference Authors Inagaki T, Sakai J, Kajimura S
Title Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
Journal Reference Authors Harms M, Seale P
Title Brown and beige fat: development, function and therapeutic potential.
Journal Reference Authors Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
Title Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
Journal Reference Authors Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
Title Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
Journal Reference Authors van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
Title Regulation of brown fat by AMP-activated protein kinase.
Journal Reference Authors Kooijman S, van den Heuvel JK, Rensen PC
Title Neuronal Control of Brown Fat Activity.
Journal Reference Authors Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
Title Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
Journal Reference Authors Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
Title Regulation of adipocyte lipolysis.
Journal Reference Authors Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
Title The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
Journal Reference Authors Collins S, Yehuda-Shnaidman E, Wang H
Title Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
Journal Reference Authors Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
Title Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
Journal Reference Authors Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
Title ASK1 signalling regulates brown and beige adipocyte function.
Journal Reference Authors Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
Title JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Journal Reference Authors Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
Title Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
Journal Reference Authors Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
Title LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
Journal Reference Authors Villarroya F, Peyrou M, Giralt M
Title Transcriptional regulation of the uncoupling protein-1 gene.
Journal Reference Authors Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
Title p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
Journal Reference Authors Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
Title Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
Journal Reference Authors Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
Title Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Journal Reference Authors Klingenberg M
Title UCP1 - A sophisticated energy valve.
Journal Reference Authors Bertholet AM, Kirichok Y
Title UCP1: A transporter for H(+) and fatty acid anions.
Journal Reference Authors Betz MJ, Enerback S
Title Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
Journal Reference Authors Tseng YH, Cypess AM, Kahn CR
Title Cellular bioenergetics as a target for obesity therapy.
Journal Reference Authors Fenzl A, Kiefer FW
Title Brown adipose tissue and thermogenesis.
Journal Reference Authors Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
Title mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
Journal Reference Authors Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
Title FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
Journal Reference Authors Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
Title Natriuretic peptides in cardiometabolic regulation and disease.
Journal Reference Authors Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
Title The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
Journal Reference Authors McCoin CS, Knotts TA, Adams SH
Title Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
Journal Reference Authors Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
Title Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
Journal Related map04923 Regulation of lipolysis in adipocytes
KO pathway
