KEGG   PATHWAY: map04981
Entry
map04981                    Pathway                                
Name
Folate transport and metabolism
Class
Organismal Systems; Digestive system
Pathway map
map04981  Folate transport and metabolism
map04981

Reference
  Authors
Alam C, Kondo M, O'Connor DL, Bendayan R
  Title
Clinical Implications of Folate Transport in the Central Nervous System.
  Journal
Trends Pharmacol Sci 41:349-361 (2020)
DOI:10.1016/j.tips.2020.02.004
Reference
  Authors
Akiyama T, Kuki I, Kim K, Yamamoto N, Yamada Y, Igarashi K, Ishihara T, Hatano Y, Kobayashi K
  Title
Folic acid inhibits 5-methyltetrahydrofolate transport across the blood-cerebrospinal fluid barrier: Clinical biochemical data from two cases.
  Journal
JIMD Rep 63:529-535 (2022)
DOI:10.1002/jmd2.12321
Reference
  Authors
Visentin M, Diop-Bove N, Zhao R, Goldman ID
  Title
The intestinal absorption of folates.
  Journal
Annu Rev Physiol 76:251-74 (2014)
DOI:10.1146/annurev-physiol-020911-153251
Reference
  Authors
Ledowsky C, Mahimbo A, Scarf V, Steel A
  Title
Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid:  A Systematic Review.
  Journal
Nutrients 14:nu14132715 (2022)
DOI:10.3390/nu14132715
Reference
  Authors
Zarou MM, Vazquez A, Vignir Helgason G
  Title
Folate metabolism: a re-emerging therapeutic target in haematological cancers.
  Journal
Leukemia 35:1539-1551 (2021)
DOI:10.1038/s41375-021-01189-2
Reference
  Authors
Bekdash RA
  Title
Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection.
  Journal
Int J Mol Sci 24:ijms24032346 (2023)
DOI:10.3390/ijms24032346
Reference
  Authors
Steinfeld R, Grapp M, Kraetzner R, Dreha-Kulaczewski S, Helms G, Dechent P, Wevers R, Grosso S, Gartner J
  Title
Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.
  Journal
Am J Hum Genet 85:354-63 (2009)
DOI:10.1016/j.ajhg.2009.08.005
Reference
  Authors
Sternbach S, West N, Singhal NK, Clements R, Basu S, Tripathi A, Dutta R, Freeman EJ, McDonough J
  Title
The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation.
  Journal
PLoS One 16:e0250486 (2021)
DOI:10.1371/journal.pone.0250486
Reference
  Authors
Shulpekova Y, Nechaev V, Kardasheva S, Sedova A, Kurbatova A, Bueverova E, Kopylov A, Malsagova K, Dlamini JC, Ivashkin V
  Title
The Concept of Folic Acid in Health and Disease.
  Journal
Molecules 26:molecules26123731 (2021)
DOI:10.3390/molecules26123731
Reference
  Authors
Mafi S, Laroche-Raynaud C, Chazelas P, Lia AS, Derouault P, Sturtz F, Baaj Y, Froget R, Rio M, Benoist JF, Poumeaud F, Favreau F, Faye PA
  Title
Pharmacoresistant Epilepsy in Childhood: Think of the Cerebral Folate Deficiency, a Treatable Disease.
  Journal
Brain Sci 10:brainsci10110762 (2020)
DOI:10.3390/brainsci10110762
Related
pathway
map00240  Pyrimidine metabolism
map00670  One carbon pool by folate
map01523  Antifolate resistance
map04144  Endocytosis
map04725  Cholinergic synapse
KO pathway
ko04981   
LinkDB

DBGET integrated database retrieval system