PATHWAY: ko04981 Help
Entry Name Folate transport and metabolism
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map ko04981 Folate transport and metabolism
Orthology K00288 MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3 ]
K00544 BHMT; betaine-homocysteine S-methyltransferase [EC:2.1.1.5 ]
K00548 metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13 ]
K05043 SLCO1B; solute carrier organic anion transporter family, member 1B
K05665 ABCC1; ATP-binding cassette, subfamily C (CFTR/MRP), member 1 [EC:7.6.2.3 ]
K05666 ABCC2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2
K05667 ABCC3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3
K05668 ABCC5; ATP-binding cassette, subfamily C (CFTR/MRP), member 5
K05673 ABCC4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4
K05681 ABCG2, CD338; ATP-binding cassette, subfamily G (WHITE), member 2
K08203 SLC22A6, OAT1; MFS transporter, OCT family, solute carrier family 22 (organic anion transporter), member 6
K08205 SLC22A8, OAT3; MFS transporter, OCT family, solute carrier family 22 (organic anion transporter), member 8
K14352 SLCO2B; solute carrier organic anion transporter family, member 2B
K14592 FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1) [EC:3.4.17.21 ]
K14609 SLC19A1, RFC1; solute carrier family 19 (folate transporter), member 1
K14613 SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
K25004 MTHFR; methylenetetrahydrofolate reductase (NADPH)
Compound C00019 S-Adenosyl-L-methionine
C00021 S-Adenosyl-L-homocysteine
C00143 5,10-Methylenetetrahydrofolate
C00440 5-Methyltetrahydrofolate
C00445 5,10-Methenyltetrahydrofolate
Reference Authors Alam C, Kondo M, O'Connor DL, Bendayan R
Title Clinical Implications of Folate Transport in the Central Nervous System.
Journal Reference Authors Akiyama T, Kuki I, Kim K, Yamamoto N, Yamada Y, Igarashi K, Ishihara T, Hatano Y, Kobayashi K
Title Folic acid inhibits 5-methyltetrahydrofolate transport across the blood-cerebrospinal fluid barrier: Clinical biochemical data from two cases.
Journal Reference Authors Visentin M, Diop-Bove N, Zhao R, Goldman ID
Title The intestinal absorption of folates.
Journal Reference Authors Ledowsky C, Mahimbo A, Scarf V, Steel A
Title Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review.
Journal Reference Authors Zarou MM, Vazquez A, Vignir Helgason G
Title Folate metabolism: a re-emerging therapeutic target in haematological cancers.
Journal Reference Authors Bekdash RA
Title Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection.
Journal Reference Authors Steinfeld R, Grapp M, Kraetzner R, Dreha-Kulaczewski S, Helms G, Dechent P, Wevers R, Grosso S, Gartner J
Title Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.
Journal Reference Authors Sternbach S, West N, Singhal NK, Clements R, Basu S, Tripathi A, Dutta R, Freeman EJ, McDonough J
Title The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation.
Journal Reference Authors Shulpekova Y, Nechaev V, Kardasheva S, Sedova A, Kurbatova A, Bueverova E, Kopylov A, Malsagova K, Dlamini JC, Ivashkin V
Title The Concept of Folic Acid in Health and Disease.
Journal Reference Authors Mafi S, Laroche-Raynaud C, Chazelas P, Lia AS, Derouault P, Sturtz F, Baaj Y, Froget R, Rio M, Benoist JF, Poumeaud F, Favreau F, Faye PA
Title Pharmacoresistant Epilepsy in Childhood: Think of the Cerebral Folate Deficiency, a Treatable Disease.
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