KEGG   Mesocricetus auratus (golden hamster): 101822879
Entry
101822879         CDS       T08306                                 
Symbol
Map2k2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X1
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
maua  Mesocricetus auratus (golden hamster)
Pathway
maua01521  EGFR tyrosine kinase inhibitor resistance
maua01522  Endocrine resistance
maua04010  MAPK signaling pathway
maua04012  ErbB signaling pathway
maua04014  Ras signaling pathway
maua04015  Rap1 signaling pathway
maua04022  cGMP-PKG signaling pathway
maua04024  cAMP signaling pathway
maua04066  HIF-1 signaling pathway
maua04068  FoxO signaling pathway
maua04071  Sphingolipid signaling pathway
maua04072  Phospholipase D signaling pathway
maua04140  Autophagy - animal
maua04148  Efferocytosis
maua04150  mTOR signaling pathway
maua04151  PI3K-Akt signaling pathway
maua04210  Apoptosis
maua04218  Cellular senescence
maua04270  Vascular smooth muscle contraction
maua04370  VEGF signaling pathway
maua04371  Apelin signaling pathway
maua04540  Gap junction
maua04550  Signaling pathways regulating pluripotency of stem cells
maua04613  Neutrophil extracellular trap formation
maua04620  Toll-like receptor signaling pathway
maua04650  Natural killer cell mediated cytotoxicity
maua04660  T cell receptor signaling pathway
maua04662  B cell receptor signaling pathway
maua04664  Fc epsilon RI signaling pathway
maua04720  Long-term potentiation
maua04722  Neurotrophin signaling pathway
maua04730  Long-term depression
maua04810  Regulation of actin cytoskeleton
maua04910  Insulin signaling pathway
maua04912  GnRH signaling pathway
maua04915  Estrogen signaling pathway
maua04916  Melanogenesis
maua04917  Prolactin signaling pathway
maua04919  Thyroid hormone signaling pathway
maua04921  Oxytocin signaling pathway
maua04926  Relaxin signaling pathway
maua04929  GnRH secretion
maua04934  Cushing syndrome
maua04935  Growth hormone synthesis, secretion and action
maua05010  Alzheimer disease
maua05022  Pathways of neurodegeneration - multiple diseases
maua05132  Salmonella infection
maua05135  Yersinia infection
maua05160  Hepatitis C
maua05161  Hepatitis B
maua05163  Human cytomegalovirus infection
maua05164  Influenza A
maua05165  Human papillomavirus infection
maua05166  Human T-cell leukemia virus 1 infection
maua05167  Kaposi sarcoma-associated herpesvirus infection
maua05170  Human immunodeficiency virus 1 infection
maua05200  Pathways in cancer
maua05205  Proteoglycans in cancer
maua05206  MicroRNAs in cancer
maua05207  Chemical carcinogenesis - receptor activation
maua05208  Chemical carcinogenesis - reactive oxygen species
maua05210  Colorectal cancer
maua05211  Renal cell carcinoma
maua05213  Endometrial cancer
maua05214  Glioma
maua05215  Prostate cancer
maua05216  Thyroid cancer
maua05218  Melanoma
maua05219  Bladder cancer
maua05220  Chronic myeloid leukemia
maua05221  Acute myeloid leukemia
maua05223  Non-small cell lung cancer
maua05224  Breast cancer
maua05225  Hepatocellular carcinoma
maua05226  Gastric cancer
maua05230  Central carbon metabolism in cancer
maua05231  Choline metabolism in cancer
maua05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:maua00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101822879 (Map2k2)
   04012 ErbB signaling pathway
    101822879 (Map2k2)
   04014 Ras signaling pathway
    101822879 (Map2k2)
   04015 Rap1 signaling pathway
    101822879 (Map2k2)
   04370 VEGF signaling pathway
    101822879 (Map2k2)
   04371 Apelin signaling pathway
    101822879 (Map2k2)
   04066 HIF-1 signaling pathway
    101822879 (Map2k2)
   04068 FoxO signaling pathway
    101822879 (Map2k2)
   04072 Phospholipase D signaling pathway
    101822879 (Map2k2)
   04071 Sphingolipid signaling pathway
    101822879 (Map2k2)
   04024 cAMP signaling pathway
    101822879 (Map2k2)
   04022 cGMP-PKG signaling pathway
    101822879 (Map2k2)
   04151 PI3K-Akt signaling pathway
    101822879 (Map2k2)
   04150 mTOR signaling pathway
    101822879 (Map2k2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101822879 (Map2k2)
   04148 Efferocytosis
    101822879 (Map2k2)
  09143 Cell growth and death
   04210 Apoptosis
    101822879 (Map2k2)
   04218 Cellular senescence
    101822879 (Map2k2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101822879 (Map2k2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101822879 (Map2k2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101822879 (Map2k2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    101822879 (Map2k2)
   04620 Toll-like receptor signaling pathway
    101822879 (Map2k2)
   04650 Natural killer cell mediated cytotoxicity
    101822879 (Map2k2)
   04660 T cell receptor signaling pathway
    101822879 (Map2k2)
   04662 B cell receptor signaling pathway
    101822879 (Map2k2)
   04664 Fc epsilon RI signaling pathway
    101822879 (Map2k2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101822879 (Map2k2)
   04929 GnRH secretion
    101822879 (Map2k2)
   04912 GnRH signaling pathway
    101822879 (Map2k2)
   04915 Estrogen signaling pathway
    101822879 (Map2k2)
   04917 Prolactin signaling pathway
    101822879 (Map2k2)
   04921 Oxytocin signaling pathway
    101822879 (Map2k2)
   04926 Relaxin signaling pathway
    101822879 (Map2k2)
   04935 Growth hormone synthesis, secretion and action
    101822879 (Map2k2)
   04919 Thyroid hormone signaling pathway
    101822879 (Map2k2)
   04916 Melanogenesis
    101822879 (Map2k2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101822879 (Map2k2)
  09156 Nervous system
   04720 Long-term potentiation
    101822879 (Map2k2)
   04730 Long-term depression
    101822879 (Map2k2)
   04722 Neurotrophin signaling pathway
    101822879 (Map2k2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101822879 (Map2k2)
   05206 MicroRNAs in cancer
    101822879 (Map2k2)
   05205 Proteoglycans in cancer
    101822879 (Map2k2)
   05207 Chemical carcinogenesis - receptor activation
    101822879 (Map2k2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101822879 (Map2k2)
   05230 Central carbon metabolism in cancer
    101822879 (Map2k2)
   05231 Choline metabolism in cancer
    101822879 (Map2k2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101822879 (Map2k2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101822879 (Map2k2)
   05225 Hepatocellular carcinoma
    101822879 (Map2k2)
   05226 Gastric cancer
    101822879 (Map2k2)
   05214 Glioma
    101822879 (Map2k2)
   05216 Thyroid cancer
    101822879 (Map2k2)
   05221 Acute myeloid leukemia
    101822879 (Map2k2)
   05220 Chronic myeloid leukemia
    101822879 (Map2k2)
   05218 Melanoma
    101822879 (Map2k2)
   05211 Renal cell carcinoma
    101822879 (Map2k2)
   05219 Bladder cancer
    101822879 (Map2k2)
   05215 Prostate cancer
    101822879 (Map2k2)
   05213 Endometrial cancer
    101822879 (Map2k2)
   05224 Breast cancer
    101822879 (Map2k2)
   05223 Non-small cell lung cancer
    101822879 (Map2k2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101822879 (Map2k2)
   05170 Human immunodeficiency virus 1 infection
    101822879 (Map2k2)
   05161 Hepatitis B
    101822879 (Map2k2)
   05160 Hepatitis C
    101822879 (Map2k2)
   05164 Influenza A
    101822879 (Map2k2)
   05163 Human cytomegalovirus infection
    101822879 (Map2k2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101822879 (Map2k2)
   05165 Human papillomavirus infection
    101822879 (Map2k2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101822879 (Map2k2)
   05135 Yersinia infection
    101822879 (Map2k2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101822879 (Map2k2)
   05022 Pathways of neurodegeneration - multiple diseases
    101822879 (Map2k2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101822879 (Map2k2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101822879 (Map2k2)
   01522 Endocrine resistance
    101822879 (Map2k2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:maua01001]
    101822879 (Map2k2)
Enzymes [BR:maua01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     101822879 (Map2k2)
Protein kinases [BR:maua01001]
 Serine/threonine kinases: STE group
  STE7 family
   101822879 (Map2k2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 101822879
NCBI-ProteinID: XP_005083328
UniProt: A0A1U7R0S2
LinkDB
Position
Unknown
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEASLVDLQKKLEELDLDEQQRKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKAQHRPSGLIMARKLIHLEIKPAVRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADL
KMLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaggcgagcctggtggacctgcagaagaaa
ctagaggagctggacctggatgagcagcagaggaagcggctggaggccttcctcacccag
aaggccaaggttggggaactcaaggacgacgactttgagaggatctcagagctgggagct
ggcaatggtggtgtggttactaaggcccagcacaggccgtcgggcctcatcatggccaga
aagctgatccacctggagatcaaaccagccgtccgcaaccagatcatccgcgagctgcag
gtgctgcatgagtgcaactcgccctacattgtgggcttctacggggccttctacagtgac
ggcgagatcagcatctgcatggagcacatggacggtggctcactggaccaggtgctgaag
gaggccaagaggatccctgaggacatcctgggaaaggtcagcattgcggtgctccgaggc
ctggcatacctccgtgagaagcaccagatcatgcacagagatgtgaagccctccaacatc
ctggtgaactctcgtggtgagatcaagctgtgcgacttcggggtgagcggccagctgatt
gactccatggccaattccttcgtaggaacgcgctcctatatgtctccagagagactacag
ggcacgcattactctgtgcagtcagacatctggagcatgggcctgtcgttggtggagctg
gccatcgggaggtaccctatccccccacctgacgccaaggaactagaggccagctttggc
cggcctgtggtcgatggcgcagacggagagccccatagtgtctcaccgcggcccaggccg
cctggacgccccatcagcggtcatgggatggacagccgacccgccatggccatcttcgag
ctgctggactacatcgtgaatgagccacctcccaagctgcctagtggtgtgttcagctcg
gacttccaggagtttgtgaataaatgcctcattaagaacccagcagagcgagcggatctg
aagatgctgatgaaccacgccttcatcaagcgctccgagggggaggaggtggacttcgca
ggctggctgtgccgaaccctgcggctgaagcagcccagcacacccacgcgcactgcagtg
tga

DBGET integrated database retrieval system