KEGG   Mesocricetus auratus (golden hamster): 101829045
Entry
101829045         CDS       T08306                                 
Symbol
Pik3r2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta isoform X2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
maua  Mesocricetus auratus (golden hamster)
Pathway
maua01521  EGFR tyrosine kinase inhibitor resistance
maua01522  Endocrine resistance
maua01524  Platinum drug resistance
maua04012  ErbB signaling pathway
maua04014  Ras signaling pathway
maua04015  Rap1 signaling pathway
maua04024  cAMP signaling pathway
maua04062  Chemokine signaling pathway
maua04066  HIF-1 signaling pathway
maua04068  FoxO signaling pathway
maua04070  Phosphatidylinositol signaling system
maua04071  Sphingolipid signaling pathway
maua04072  Phospholipase D signaling pathway
maua04081  Hormone signaling
maua04140  Autophagy - animal
maua04145  Phagocytosis
maua04150  mTOR signaling pathway
maua04151  PI3K-Akt signaling pathway
maua04152  AMPK signaling pathway
maua04210  Apoptosis
maua04211  Longevity regulating pathway
maua04213  Longevity regulating pathway - multiple species
maua04218  Cellular senescence
maua04360  Axon guidance
maua04370  VEGF signaling pathway
maua04380  Osteoclast differentiation
maua04510  Focal adhesion
maua04517  IgSF CAM signaling
maua04518  Integrin signaling
maua04550  Signaling pathways regulating pluripotency of stem cells
maua04611  Platelet activation
maua04613  Neutrophil extracellular trap formation
maua04620  Toll-like receptor signaling pathway
maua04625  C-type lectin receptor signaling pathway
maua04630  JAK-STAT signaling pathway
maua04650  Natural killer cell mediated cytotoxicity
maua04660  T cell receptor signaling pathway
maua04662  B cell receptor signaling pathway
maua04664  Fc epsilon RI signaling pathway
maua04666  Fc gamma R-mediated phagosome formation
maua04668  TNF signaling pathway
maua04670  Leukocyte transendothelial migration
maua04722  Neurotrophin signaling pathway
maua04725  Cholinergic synapse
maua04750  Inflammatory mediator regulation of TRP channels
maua04810  Regulation of actin cytoskeleton
maua04910  Insulin signaling pathway
maua04914  Progesterone-mediated oocyte maturation
maua04915  Estrogen signaling pathway
maua04917  Prolactin signaling pathway
maua04919  Thyroid hormone signaling pathway
maua04923  Regulation of lipolysis in adipocytes
maua04926  Relaxin signaling pathway
maua04929  GnRH secretion
maua04930  Type II diabetes mellitus
maua04931  Insulin resistance
maua04932  Non-alcoholic fatty liver disease
maua04933  AGE-RAGE signaling pathway in diabetic complications
maua04935  Growth hormone synthesis, secretion and action
maua04960  Aldosterone-regulated sodium reabsorption
maua04973  Carbohydrate digestion and absorption
maua05010  Alzheimer disease
maua05017  Spinocerebellar ataxia
maua05020  Prion disease
maua05100  Bacterial invasion of epithelial cells
maua05135  Yersinia infection
maua05142  Chagas disease
maua05146  Amoebiasis
maua05160  Hepatitis C
maua05161  Hepatitis B
maua05162  Measles
maua05163  Human cytomegalovirus infection
maua05164  Influenza A
maua05165  Human papillomavirus infection
maua05166  Human T-cell leukemia virus 1 infection
maua05167  Kaposi sarcoma-associated herpesvirus infection
maua05168  Herpes simplex virus 1 infection
maua05169  Epstein-Barr virus infection
maua05170  Human immunodeficiency virus 1 infection
maua05171  Coronavirus disease
maua05200  Pathways in cancer
maua05203  Viral carcinogenesis
maua05205  Proteoglycans in cancer
maua05206  MicroRNAs in cancer
maua05207  Chemical carcinogenesis - receptor activation
maua05208  Chemical carcinogenesis - reactive oxygen species
maua05210  Colorectal cancer
maua05211  Renal cell carcinoma
maua05212  Pancreatic cancer
maua05213  Endometrial cancer
maua05214  Glioma
maua05215  Prostate cancer
maua05218  Melanoma
maua05220  Chronic myeloid leukemia
maua05221  Acute myeloid leukemia
maua05222  Small cell lung cancer
maua05223  Non-small cell lung cancer
maua05224  Breast cancer
maua05225  Hepatocellular carcinoma
maua05226  Gastric cancer
maua05230  Central carbon metabolism in cancer
maua05231  Choline metabolism in cancer
maua05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
maua05415  Diabetic cardiomyopathy
maua05417  Lipid and atherosclerosis
maua05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:maua00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101829045 (Pik3r2)
   04014 Ras signaling pathway
    101829045 (Pik3r2)
   04015 Rap1 signaling pathway
    101829045 (Pik3r2)
   04370 VEGF signaling pathway
    101829045 (Pik3r2)
   04630 JAK-STAT signaling pathway
    101829045 (Pik3r2)
   04668 TNF signaling pathway
    101829045 (Pik3r2)
   04066 HIF-1 signaling pathway
    101829045 (Pik3r2)
   04068 FoxO signaling pathway
    101829045 (Pik3r2)
   04070 Phosphatidylinositol signaling system
    101829045 (Pik3r2)
   04072 Phospholipase D signaling pathway
    101829045 (Pik3r2)
   04071 Sphingolipid signaling pathway
    101829045 (Pik3r2)
   04024 cAMP signaling pathway
    101829045 (Pik3r2)
   04151 PI3K-Akt signaling pathway
    101829045 (Pik3r2)
   04152 AMPK signaling pathway
    101829045 (Pik3r2)
   04150 mTOR signaling pathway
    101829045 (Pik3r2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101829045 (Pik3r2)
   04517 IgSF CAM signaling
    101829045 (Pik3r2)
   04518 Integrin signaling
    101829045 (Pik3r2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    101829045 (Pik3r2)
   04140 Autophagy - animal
    101829045 (Pik3r2)
  09143 Cell growth and death
   04210 Apoptosis
    101829045 (Pik3r2)
   04218 Cellular senescence
    101829045 (Pik3r2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101829045 (Pik3r2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101829045 (Pik3r2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101829045 (Pik3r2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101829045 (Pik3r2)
   04613 Neutrophil extracellular trap formation
    101829045 (Pik3r2)
   04620 Toll-like receptor signaling pathway
    101829045 (Pik3r2)
   04625 C-type lectin receptor signaling pathway
    101829045 (Pik3r2)
   04650 Natural killer cell mediated cytotoxicity
    101829045 (Pik3r2)
   04660 T cell receptor signaling pathway
    101829045 (Pik3r2)
   04662 B cell receptor signaling pathway
    101829045 (Pik3r2)
   04664 Fc epsilon RI signaling pathway
    101829045 (Pik3r2)
   04666 Fc gamma R-mediated phagosome formation
    101829045 (Pik3r2)
   04670 Leukocyte transendothelial migration
    101829045 (Pik3r2)
   04062 Chemokine signaling pathway
    101829045 (Pik3r2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101829045 (Pik3r2)
   04923 Regulation of lipolysis in adipocytes
    101829045 (Pik3r2)
   04929 GnRH secretion
    101829045 (Pik3r2)
   04915 Estrogen signaling pathway
    101829045 (Pik3r2)
   04914 Progesterone-mediated oocyte maturation
    101829045 (Pik3r2)
   04917 Prolactin signaling pathway
    101829045 (Pik3r2)
   04926 Relaxin signaling pathway
    101829045 (Pik3r2)
   04935 Growth hormone synthesis, secretion and action
    101829045 (Pik3r2)
   04919 Thyroid hormone signaling pathway
    101829045 (Pik3r2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101829045 (Pik3r2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101829045 (Pik3r2)
  09156 Nervous system
   04725 Cholinergic synapse
    101829045 (Pik3r2)
   04722 Neurotrophin signaling pathway
    101829045 (Pik3r2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101829045 (Pik3r2)
  09158 Development and regeneration
   04360 Axon guidance
    101829045 (Pik3r2)
   04380 Osteoclast differentiation
    101829045 (Pik3r2)
  09149 Aging
   04211 Longevity regulating pathway
    101829045 (Pik3r2)
   04213 Longevity regulating pathway - multiple species
    101829045 (Pik3r2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101829045 (Pik3r2)
   05206 MicroRNAs in cancer
    101829045 (Pik3r2)
   05205 Proteoglycans in cancer
    101829045 (Pik3r2)
   05207 Chemical carcinogenesis - receptor activation
    101829045 (Pik3r2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101829045 (Pik3r2)
   05203 Viral carcinogenesis
    101829045 (Pik3r2)
   05230 Central carbon metabolism in cancer
    101829045 (Pik3r2)
   05231 Choline metabolism in cancer
    101829045 (Pik3r2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101829045 (Pik3r2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101829045 (Pik3r2)
   05212 Pancreatic cancer
    101829045 (Pik3r2)
   05225 Hepatocellular carcinoma
    101829045 (Pik3r2)
   05226 Gastric cancer
    101829045 (Pik3r2)
   05214 Glioma
    101829045 (Pik3r2)
   05221 Acute myeloid leukemia
    101829045 (Pik3r2)
   05220 Chronic myeloid leukemia
    101829045 (Pik3r2)
   05218 Melanoma
    101829045 (Pik3r2)
   05211 Renal cell carcinoma
    101829045 (Pik3r2)
   05215 Prostate cancer
    101829045 (Pik3r2)
   05213 Endometrial cancer
    101829045 (Pik3r2)
   05224 Breast cancer
    101829045 (Pik3r2)
   05222 Small cell lung cancer
    101829045 (Pik3r2)
   05223 Non-small cell lung cancer
    101829045 (Pik3r2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101829045 (Pik3r2)
   05170 Human immunodeficiency virus 1 infection
    101829045 (Pik3r2)
   05161 Hepatitis B
    101829045 (Pik3r2)
   05160 Hepatitis C
    101829045 (Pik3r2)
   05171 Coronavirus disease
    101829045 (Pik3r2)
   05164 Influenza A
    101829045 (Pik3r2)
   05162 Measles
    101829045 (Pik3r2)
   05168 Herpes simplex virus 1 infection
    101829045 (Pik3r2)
   05163 Human cytomegalovirus infection
    101829045 (Pik3r2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101829045 (Pik3r2)
   05169 Epstein-Barr virus infection
    101829045 (Pik3r2)
   05165 Human papillomavirus infection
    101829045 (Pik3r2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101829045 (Pik3r2)
   05100 Bacterial invasion of epithelial cells
    101829045 (Pik3r2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101829045 (Pik3r2)
   05142 Chagas disease
    101829045 (Pik3r2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101829045 (Pik3r2)
   05017 Spinocerebellar ataxia
    101829045 (Pik3r2)
   05020 Prion disease
    101829045 (Pik3r2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101829045 (Pik3r2)
   05418 Fluid shear stress and atherosclerosis
    101829045 (Pik3r2)
   05415 Diabetic cardiomyopathy
    101829045 (Pik3r2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101829045 (Pik3r2)
   04932 Non-alcoholic fatty liver disease
    101829045 (Pik3r2)
   04931 Insulin resistance
    101829045 (Pik3r2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101829045 (Pik3r2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101829045 (Pik3r2)
   01524 Platinum drug resistance
    101829045 (Pik3r2)
   01522 Endocrine resistance
    101829045 (Pik3r2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:maua04131]
    101829045 (Pik3r2)
Membrane trafficking [BR:maua04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101829045 (Pik3r2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 Ribosomal_L22e ODF2_C SH3_1 SH3_9
Other DBs
NCBI-GeneID: 101829045
NCBI-ProteinID: XP_005086173
UniProt: A0A1U7R564
LinkDB
Position
Unknown
AA seq 722 aa
MAGSEGFQYRAVYPFRRERPEDLELLPGDLLVVSRVALQALGVADGGERCPHNVGWMPGF
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLDGPSDSGLALADLAEQFSP
PDPAPPLLVKLVAAVEQAGLDSDCYSRPELPAPRTDWSLSDLEQWDRTTLCDAVKGFLLA
LPTAVVTPEAAAEAHRALREAAGPVGPALEPPMLPLHQALTLRFLLQHLGRVARRAPVQA
TAVHSLASAFGPLLLRTAPPPGGDPDGSEPGPDFPVLLLERLLQEHVDEQDAAPPALPPK
PSKAKPASTALANGGNPPSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEY
TLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELICHYRHESLAQYNAKLDTRLLYPV
SKYQQDQVVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFN
ETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQD
LRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEWLGIKNETEDQY
SLMEDEDALPHHEERTWYVGKINRTQAEEMLSGRRDGTFLIRESSQRGCYACSVVVDGDT
KHCVIYRTATGFGFAEPYNLYASLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPA
AR
NT seq 2169 nt   +upstreamnt  +downstreamnt
atggcgggcagcgagggcttccagtacagggctgtgtacccgttccgccgggagcggccc
gaggacctggagctgctgcctggagacctgctggtggtgagccgggtggccctgcaggca
ctgggcgtggcagacggaggggagcgctgtccacacaacgtcggctggatgcccggcttc
aatgagcgcacccggcagcgaggggacttccctgggacatatgtggagttcctagggccc
gtggctctggctcgcccaggacctcgcccacgaggcccccgcccattgcccgccaggcct
ttggatgggccctccgactcaggcctggcgctggctgacctggcggagcagttctcccct
cctgaccctgccccgccccttctggtgaagttggtagcggccgttgagcaagcagggctg
gacagtgattgctacagtaggccggagctgcccgcaccccggacagactggtccctaagc
gacctggagcagtgggaccgcaccaccctttgcgatgctgttaagggcttcctgctggca
ttgcccacagccgtggtgacccctgaggctgcggcagaggcgcaccgggcactgcgggag
gctgcagggcccgtggggccagcgctggagcccccgatgctgccgctgcaccaggcactc
acgcttcggttcctgctgcagcacctgggccgtgtggcccgcagagcacccgtgcaggcc
accgctgtccactcgctggccagcgccttcgggccgctcctcctgcgcactgcacctccg
ccggggggtgaccctgatgggagcgagcctgggccggacttcccagtgctgctgttggag
cggctgctgcaggaacacgtggatgagcaggacgccgcccccccagcactgccacccaag
ccctctaaggcaaagccggcctccacggcgctggccaatggagggaacccgccctcgctt
caggatgccgagtggtactggggggatatctccagggaagaggtgaacgagaggctccgg
gacacgcccgatggcacattcttggtccgagatgcatccagcaagatccaaggagagtac
acactcaccctcaggaaaggcgggaacaacaagctgatcaaagtcttccaccgggatggc
cactacggcttttcggagccgctcaccttctgctccgtggtggagctcatctgccactac
cgccacgagtcgctggcccagtacaacgccaagctggacacgcgcctgctctaccctgtg
tccaagtaccagcaggaccaggtggtgaaggaggacagcgtggaggctgtgggcgcccag
ctcaaggtgtaccaccagcagtaccaggacaagagccgcgagtacgaccagctgtacgag
gagtacacacggacatctcaggagcttcagatgaagcgcacggccatagaggccttcaat
gagaccatcaagatcttcgaggagcagggccagacgcaggagaagtgcagcaaggagtat
ttggagcgcttccggcgggagggcaacgagaaggagatgcagaggatcttgctcaactct
gagcggctcaagtcccgcatcgcggagatccatgagagccgcacgaagctggaacaggac
ctgcgggcgcaggcctcggacaaccgcgagatcgacaagcgcatgaacagcctcaagccc
gacctcatgcagctgcgcaagatccgggaccagtatctcgtgtggctcacccagaaaggt
gcccggcagaggaagatcaacgagtggctgggaataaagaacgagactgaggaccagtac
tccctgatggaggatgaggacgccctcccccaccacgaggagcgcacgtggtacgtgggc
aagatcaaccgcacacaggcagaagagatgctgagtggcagacgggacgggaccttcctc
atccgggagagcagccagcgaggctgttacgcatgctccgtggtggtggacggcgacacc
aagcactgtgtcatctaccgcacggccacaggcttcggcttcgcggagccctacaacctg
tacgcgtcgctcaaggagctggtactgcattaccagcacgcctcgctcgtgcagcacaac
gacgcgctcaccgtcaccctggcgcaccctgtgcgtgcccctgggcccgggccgcccgcc
gcccgctga

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