KEGG   Mesocricetus auratus (golden hamster): 121138738
Entry
121138738         CDS       T08306                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
maua  Mesocricetus auratus (golden hamster)
Pathway
maua00140  Steroid hormone biosynthesis
maua01100  Metabolic pathways
maua04913  Ovarian steroidogenesis
maua04925  Aldosterone synthesis and secretion
maua04927  Cortisol synthesis and secretion
maua04934  Cushing syndrome
Module
maua_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
maua_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
maua_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:maua00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    121138738
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    121138738
   04925 Aldosterone synthesis and secretion
    121138738
   04927 Cortisol synthesis and secretion
    121138738
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    121138738
Enzymes [BR:maua01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     121138738
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     121138738
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA RmlD_sub_bind KR Ldh_1_N Sacchrp_dh_NADP Cytochrom_B558a
Other DBs
NCBI-GeneID: 121138738
NCBI-ProteinID: XP_040597293
LinkDB
Position
Unknown
AA seq 373 aa
MPGWSCLVTGAGGFLGQRIIHLLVQEKDLEEVRLLDKVFRPETREEFFKLQTKTKVTVLE
GDILDAQCLRRACQGISVVIHTAAAIDVWGIIPRQTIIDINVKGTLNLLEACVQASVPAF
IYTSSIDVAGPNSYKEIVLNGHEEQQHESTWSDPYPYSKMMAEKAVLAANGSSLKNGGTL
HTCALRPMYIYGEKSSILSGIMIRAIKNNGILKVTGKFSTVNPVYVSNAAWAHILAARGL
QDPKKSPNIQGQFYYISDDTPHQSYDDLNNTLSKKWGLRPDSSWRPPVALLYWLGFLLEL
VNFLLRPVYNYQPPFTRYLVTISNTVFTFSYKKAQRDLGYEPLVGWEEARENTSEWIGSL
VEQHKGTLNTKAQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctggatggagctgcttggtgacaggggctggagggtttctggggcaaaggattatc
cacttgctggtacaggagaaggatctggaagaggtcagactcctggacaaggtgttcaga
ccagaaaccagggaggaattcttcaagctgcagacaaagaccaaggtgacagtgctggag
ggtgacattctggatgcccagtgcctgaggagagcctgccagggcatctccgttgtcatc
cacactgctgccgccattgacgtctggggtatcattcccagacagaccatcatagatatc
aatgtgaaaggtaccctgaacctgttggaggcctgtgtccaggctagtgtgccagccttc
atctacaccagctcaattgatgttgcggggcccaactcctacaaggaaatcgtcctaaat
ggccatgaggaacaacagcatgaaagcacatggtctgatccatacccatacagcaaaatg
atggctgagaaggcagtgctggcagccaatgggtcctccctgaaaaatggtggcactttg
catacttgtgccttaaggcctatgtacatctatggggaaaaaagctcaatactttcaggg
ataatgattagggccatcaaaaataatggtattctgaaagttactggaaagttctccaca
gtcaacccagtgtatgtgagtaatgcagcctgggcacacattctggctgccaggggtctg
caagaccccaagaagtcaccaaacatccaagggcagttctactacatctcagatgacacc
cctcaccaaagctatgatgacttaaataacaccctgagcaagaaatggggcctccgccct
gattccagttggagacctcctgtggccctgctgtactggcttggcttcctgctggaattg
gtgaacttcctgctgcgtccggtctacaactaccagcctcccttcacccgatacttggtc
acaatctcaaatactgtgttcaccttctcctacaagaaagctcagcgagatctgggctat
gagccccttgtcggctgggaggaagccagggagaacacttcagagtggatcgggtcactg
gtggagcagcacaagggaacactgaacacaaaggctcagtga

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