KEGG   Moschus berezovskii (Chinese forest musk deer): 129558523
Entry
129558523         CDS       T09065                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
mbez  Moschus berezovskii (Chinese forest musk deer)
Pathway
mbez01521  EGFR tyrosine kinase inhibitor resistance
mbez01522  Endocrine resistance
mbez04010  MAPK signaling pathway
mbez04012  ErbB signaling pathway
mbez04014  Ras signaling pathway
mbez04015  Rap1 signaling pathway
mbez04022  cGMP-PKG signaling pathway
mbez04024  cAMP signaling pathway
mbez04066  HIF-1 signaling pathway
mbez04068  FoxO signaling pathway
mbez04071  Sphingolipid signaling pathway
mbez04072  Phospholipase D signaling pathway
mbez04140  Autophagy - animal
mbez04148  Efferocytosis
mbez04150  mTOR signaling pathway
mbez04151  PI3K-Akt signaling pathway
mbez04210  Apoptosis
mbez04218  Cellular senescence
mbez04270  Vascular smooth muscle contraction
mbez04370  VEGF signaling pathway
mbez04371  Apelin signaling pathway
mbez04540  Gap junction
mbez04550  Signaling pathways regulating pluripotency of stem cells
mbez04613  Neutrophil extracellular trap formation
mbez04620  Toll-like receptor signaling pathway
mbez04650  Natural killer cell mediated cytotoxicity
mbez04660  T cell receptor signaling pathway
mbez04662  B cell receptor signaling pathway
mbez04664  Fc epsilon RI signaling pathway
mbez04720  Long-term potentiation
mbez04722  Neurotrophin signaling pathway
mbez04730  Long-term depression
mbez04810  Regulation of actin cytoskeleton
mbez04910  Insulin signaling pathway
mbez04912  GnRH signaling pathway
mbez04915  Estrogen signaling pathway
mbez04916  Melanogenesis
mbez04917  Prolactin signaling pathway
mbez04919  Thyroid hormone signaling pathway
mbez04921  Oxytocin signaling pathway
mbez04926  Relaxin signaling pathway
mbez04929  GnRH secretion
mbez04934  Cushing syndrome
mbez04935  Growth hormone synthesis, secretion and action
mbez05010  Alzheimer disease
mbez05022  Pathways of neurodegeneration - multiple diseases
mbez05132  Salmonella infection
mbez05135  Yersinia infection
mbez05160  Hepatitis C
mbez05161  Hepatitis B
mbez05163  Human cytomegalovirus infection
mbez05164  Influenza A
mbez05165  Human papillomavirus infection
mbez05166  Human T-cell leukemia virus 1 infection
mbez05167  Kaposi sarcoma-associated herpesvirus infection
mbez05170  Human immunodeficiency virus 1 infection
mbez05200  Pathways in cancer
mbez05205  Proteoglycans in cancer
mbez05206  MicroRNAs in cancer
mbez05207  Chemical carcinogenesis - receptor activation
mbez05208  Chemical carcinogenesis - reactive oxygen species
mbez05210  Colorectal cancer
mbez05211  Renal cell carcinoma
mbez05213  Endometrial cancer
mbez05214  Glioma
mbez05215  Prostate cancer
mbez05216  Thyroid cancer
mbez05218  Melanoma
mbez05219  Bladder cancer
mbez05220  Chronic myeloid leukemia
mbez05221  Acute myeloid leukemia
mbez05223  Non-small cell lung cancer
mbez05224  Breast cancer
mbez05225  Hepatocellular carcinoma
mbez05226  Gastric cancer
mbez05230  Central carbon metabolism in cancer
mbez05231  Choline metabolism in cancer
mbez05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mbez00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129558523 (MAP2K2)
   04012 ErbB signaling pathway
    129558523 (MAP2K2)
   04014 Ras signaling pathway
    129558523 (MAP2K2)
   04015 Rap1 signaling pathway
    129558523 (MAP2K2)
   04370 VEGF signaling pathway
    129558523 (MAP2K2)
   04371 Apelin signaling pathway
    129558523 (MAP2K2)
   04066 HIF-1 signaling pathway
    129558523 (MAP2K2)
   04068 FoxO signaling pathway
    129558523 (MAP2K2)
   04072 Phospholipase D signaling pathway
    129558523 (MAP2K2)
   04071 Sphingolipid signaling pathway
    129558523 (MAP2K2)
   04024 cAMP signaling pathway
    129558523 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    129558523 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    129558523 (MAP2K2)
   04150 mTOR signaling pathway
    129558523 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    129558523 (MAP2K2)
   04148 Efferocytosis
    129558523 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    129558523 (MAP2K2)
   04218 Cellular senescence
    129558523 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    129558523 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    129558523 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129558523 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    129558523 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    129558523 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    129558523 (MAP2K2)
   04660 T cell receptor signaling pathway
    129558523 (MAP2K2)
   04662 B cell receptor signaling pathway
    129558523 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    129558523 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129558523 (MAP2K2)
   04929 GnRH secretion
    129558523 (MAP2K2)
   04912 GnRH signaling pathway
    129558523 (MAP2K2)
   04915 Estrogen signaling pathway
    129558523 (MAP2K2)
   04917 Prolactin signaling pathway
    129558523 (MAP2K2)
   04921 Oxytocin signaling pathway
    129558523 (MAP2K2)
   04926 Relaxin signaling pathway
    129558523 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    129558523 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    129558523 (MAP2K2)
   04916 Melanogenesis
    129558523 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    129558523 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    129558523 (MAP2K2)
   04730 Long-term depression
    129558523 (MAP2K2)
   04722 Neurotrophin signaling pathway
    129558523 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129558523 (MAP2K2)
   05206 MicroRNAs in cancer
    129558523 (MAP2K2)
   05205 Proteoglycans in cancer
    129558523 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    129558523 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    129558523 (MAP2K2)
   05230 Central carbon metabolism in cancer
    129558523 (MAP2K2)
   05231 Choline metabolism in cancer
    129558523 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129558523 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129558523 (MAP2K2)
   05225 Hepatocellular carcinoma
    129558523 (MAP2K2)
   05226 Gastric cancer
    129558523 (MAP2K2)
   05214 Glioma
    129558523 (MAP2K2)
   05216 Thyroid cancer
    129558523 (MAP2K2)
   05221 Acute myeloid leukemia
    129558523 (MAP2K2)
   05220 Chronic myeloid leukemia
    129558523 (MAP2K2)
   05218 Melanoma
    129558523 (MAP2K2)
   05211 Renal cell carcinoma
    129558523 (MAP2K2)
   05219 Bladder cancer
    129558523 (MAP2K2)
   05215 Prostate cancer
    129558523 (MAP2K2)
   05213 Endometrial cancer
    129558523 (MAP2K2)
   05224 Breast cancer
    129558523 (MAP2K2)
   05223 Non-small cell lung cancer
    129558523 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129558523 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    129558523 (MAP2K2)
   05161 Hepatitis B
    129558523 (MAP2K2)
   05160 Hepatitis C
    129558523 (MAP2K2)
   05164 Influenza A
    129558523 (MAP2K2)
   05163 Human cytomegalovirus infection
    129558523 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129558523 (MAP2K2)
   05165 Human papillomavirus infection
    129558523 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129558523 (MAP2K2)
   05135 Yersinia infection
    129558523 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129558523 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    129558523 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    129558523 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129558523 (MAP2K2)
   01522 Endocrine resistance
    129558523 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mbez01001]
    129558523 (MAP2K2)
Enzymes [BR:mbez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     129558523 (MAP2K2)
Protein kinases [BR:mbez01001]
 Serine/threonine kinases: STE group
  STE7 family
   129558523 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Kdo Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 129558523
NCBI-ProteinID: XP_055285702
LinkDB
Position
Unknown
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEAHLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPPSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcacacctggtggacctccagaagaag
ctagaggagctagagctcgacgagcagcagaagaagcggctggaagccttccttacccag
aaggccaaggtcggcgagctcaaggatgatgactttgaacggatctccgaactgggagcc
ggcaatggcggagtggtcaccaaggtccagcacagaccttcgggcctcatcatggccaga
aagctgatccacctggagatcaagccggccatccggaaccagatcatccgagagctacag
gtgctgcatgagtgcaactccccgtacattgtgggcttctatggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggatggcggctccttggaccaggtgttgaaa
gaagccaagagaatccccgaagagatcctgggcaaggtcagcatcgcggttctgcggggc
ctggcatacctccgggagaagcaccagatcatgcaccgagacgtgaagccgtccaacatc
ctcgtcaactcccgaggggagatcaagctgtgtgacttcggggtgagcggccagctcatt
gactccatggccaactccttcgtggggacgcggtcctacatgtctccggagcggctacaa
ggtacccactattcggtgcagtcagacatctggagcatgggcctatccctggtggaactg
tccatcggaaggtaccccatccccccgccagacgccaaggagctggaggccatattcggc
cggcccatggttgatggcgcggaaggagaacctcccagcatctcgccacggccgaggccc
cctggacgccccatcagcggtcacgggatggacagccggccagccatggcgatctttgag
ctgctggactacatcgtgaacgagcctcctcccaagctgcccaatggcgtattcacccag
gacttccaggagtttgtaaataaatgcctaattaagaacccagctgagcgagcggacctg
aagatgcttatgaaccacaccttcatcaagcggtccgaggtggaagaagtggattttgct
ggctggttgtgtaaaacactgcggctaaaccagcccagcacacccacacgcaccgctgtg
tga

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