Entry |
|
Symbol |
Plcb2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
|
KO |
|
Organism |
mcal Mus caroli (Ryukyu mouse)
|
Pathway |
mcal04070 | Phosphatidylinositol signaling system |
mcal04261 | Adrenergic signaling in cardiomyocytes |
mcal04613 | Neutrophil extracellular trap formation |
mcal04621 | NOD-like receptor signaling pathway |
mcal04723 | Retrograde endocannabinoid signaling |
mcal04750 | Inflammatory mediator regulation of TRP channels |
mcal04925 | Aldosterone synthesis and secretion |
mcal04928 | Parathyroid hormone synthesis, secretion and action |
mcal04933 | AGE-RAGE signaling pathway in diabetic complications |
mcal04935 | Growth hormone synthesis, secretion and action |
mcal04961 | Endocrine and other factor-regulated calcium reabsorption |
mcal04973 | Carbohydrate digestion and absorption |
mcal05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
mcal_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mcal00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
110286326 (Plcb2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
110286326 (Plcb2)
04310 Wnt signaling pathway
110286326 (Plcb2)
04371 Apelin signaling pathway
110286326 (Plcb2)
04020 Calcium signaling pathway
110286326 (Plcb2)
04070 Phosphatidylinositol signaling system
110286326 (Plcb2)
04072 Phospholipase D signaling pathway
110286326 (Plcb2)
04071 Sphingolipid signaling pathway
110286326 (Plcb2)
04022 cGMP-PKG signaling pathway
110286326 (Plcb2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
110286326 (Plcb2)
04081 Hormone signaling
110286326 (Plcb2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
110286326 (Plcb2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
110286326 (Plcb2)
04613 Neutrophil extracellular trap formation
110286326 (Plcb2)
04621 NOD-like receptor signaling pathway
110286326 (Plcb2)
04062 Chemokine signaling pathway
110286326 (Plcb2)
09152 Endocrine system
04911 Insulin secretion
110286326 (Plcb2)
04922 Glucagon signaling pathway
110286326 (Plcb2)
04929 GnRH secretion
110286326 (Plcb2)
04912 GnRH signaling pathway
110286326 (Plcb2)
04915 Estrogen signaling pathway
110286326 (Plcb2)
04921 Oxytocin signaling pathway
110286326 (Plcb2)
04926 Relaxin signaling pathway
110286326 (Plcb2)
04935 Growth hormone synthesis, secretion and action
110286326 (Plcb2)
04918 Thyroid hormone synthesis
110286326 (Plcb2)
04919 Thyroid hormone signaling pathway
110286326 (Plcb2)
04928 Parathyroid hormone synthesis, secretion and action
110286326 (Plcb2)
04916 Melanogenesis
110286326 (Plcb2)
04924 Renin secretion
110286326 (Plcb2)
04925 Aldosterone synthesis and secretion
110286326 (Plcb2)
04927 Cortisol synthesis and secretion
110286326 (Plcb2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
110286326 (Plcb2)
04270 Vascular smooth muscle contraction
110286326 (Plcb2)
09154 Digestive system
04970 Salivary secretion
110286326 (Plcb2)
04971 Gastric acid secretion
110286326 (Plcb2)
04972 Pancreatic secretion
110286326 (Plcb2)
04973 Carbohydrate digestion and absorption
110286326 (Plcb2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
110286326 (Plcb2)
09156 Nervous system
04724 Glutamatergic synapse
110286326 (Plcb2)
04725 Cholinergic synapse
110286326 (Plcb2)
04728 Dopaminergic synapse
110286326 (Plcb2)
04726 Serotonergic synapse
110286326 (Plcb2)
04720 Long-term potentiation
110286326 (Plcb2)
04730 Long-term depression
110286326 (Plcb2)
04723 Retrograde endocannabinoid signaling
110286326 (Plcb2)
09157 Sensory system
04742 Taste transduction
110286326 (Plcb2)
04750 Inflammatory mediator regulation of TRP channels
110286326 (Plcb2)
09159 Environmental adaptation
04713 Circadian entrainment
110286326 (Plcb2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
110286326 (Plcb2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
110286326 (Plcb2)
09174 Infectious disease: parasitic
05146 Amoebiasis
110286326 (Plcb2)
05142 Chagas disease
110286326 (Plcb2)
05143 African trypanosomiasis
110286326 (Plcb2)
09164 Neurodegenerative disease
05010 Alzheimer disease
110286326 (Plcb2)
05016 Huntington disease
110286326 (Plcb2)
05017 Spinocerebellar ataxia
110286326 (Plcb2)
05022 Pathways of neurodegeneration - multiple diseases
110286326 (Plcb2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
110286326 (Plcb2)
05415 Diabetic cardiomyopathy
110286326 (Plcb2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
110286326 (Plcb2)
04934 Cushing syndrome
110286326 (Plcb2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mcal04131]
110286326 (Plcb2)
Enzymes [BR:mcal01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
110286326 (Plcb2)
Membrane trafficking [BR:mcal04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
110286326 (Plcb2)
Endocytosis
Macropinocytosis
Phospholipase C
110286326 (Plcb2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
2:complement(111526725..111547729)
|
AA seq |
1181 aa
MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTNQNQEMEFLD
VTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNNFLLKTLTVVSGPDMVDLTFYNFVSYKE
NVGKDWAEDVLALAKHPMTANAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPAQPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASSSKKPGGV
AEGSLPSSVPVEEDTGWTAEDRTEVEEEELVEEEEEEESGSLDEEEIKKMQSDEGTAGLE
VTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKACELLSKASMQFVDYNKRQ
MSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHE
FMRRRDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYR
TKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHH
LCLRSESNMPLTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKEMTGS
LPEKLFSGTPVASQSNGAPVSAGNGSAAPGTKATGDEATKEVTEPQTASLEELQELKGVV
KLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTPAAGSKLRPGKGSRKKRTLPCEE
TVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAKEK
QAAELKTFKETSEIDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVV
QAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRA
YFKVCFPAEAEDKPERFCEASEESCPQEPLVSKADIQESRL |
NT seq |
3546 nt +upstreamnt +downstreamnt
atgtctttgctcaaccctgtcctgttgccccctaacgtgaaggcatatctgagccaaggg
gagcgcttcatcaagtgggacgatgaaacttcaatagcctctcctgttatcctccgtgtg
gatcccaagggctattacttatactggacaaatcaaaatcaggagatggagttcctggat
gtcacgagcatccgagatactcgctttgggaagtttgcaaagatacccaagagccagaaa
ctccgggaggtcttcaacatggacttcccagacaacaacttcctgctgaaaacactcaca
gtggtatccggccctgacatggtggacctcaccttctacaactttgtctcttacaaggag
aacgtaggcaaggactgggctgaggacgtgctagctctcgccaaacaccccatgacagcc
aatgctcctcgaagcacattcctggacaagatcctggtgaagcttaagatgcagctcaac
cctgaagggaagattcctgtgaagaattttttccagatgtttcctgctgatcgcaaacgg
gtggaagctgccctcggtgcttgtcaccttgcaaaaggcaaaaatgatgctatcaaccca
gaggacttcccagaatccgtgtacaagagcttcctcatgagcctctgtcctcggccagaa
atcgacgagatcttcacttcctaccacgctaaagctaagccctacatgaccaaggagcac
ctgaccaaattcatcaatcagaagcagcgagaccctcgactcaactctttgctgttccca
ccggcccagcctgagcaagttcaagtgctcattgacaaatacgaacccagcggcatcaat
gtgcagaggggccagctgtcgccagaggggatggtctggtttctctgtggaccagagaac
agtgtgctggcccacgatacactgctgatccaccaagacatgacacaaccactgaatcac
tatttcatcaactcctcacacaacacctacctgacagccggccagttctcaggcctttcc
tcggctgagatgtaccgccaggtgctgctgtctggctgccgttgtgtagagttagactgt
tggaagggcaagccccccgatgaagagcccattatcacccacggcttcaccatgaccaca
gatatcttgttcaaggaagcaatcgaagccattgcagaaagtgcctttaagacctccccg
tatcctgtcatcctgtcatttgaaaaccatgtagactcaccccgccaacaggctaagatg
gctgagtactgcaggaccatgtttggagagaccttgctcacagatcccctggaaaatttt
cctctgaaacctggcatccctctgcccagccccgaggacctccggggcaagatcctcatt
aagaataagaagaaccagttttctgggccagcatcctccagcaagaagcctggtggggtg
gctgagggcagcctcccgtctagtgtccctgtagaagaggacacggggtggactgctgag
gaccggactgaggtggaggaggaggagttggtggaagaggaggaagaggaggagtcagga
agcctggatgaagaagaaattaagaagatgcagtcggatgagggcacagcaggcctggag
gtgacagcttatgaggaaatgtccagccttgtcaattatatccagcccaccaagtttatc
tccttcgagttctctgcacagaagaacagaagttacgttgtctcttccttcacggagctc
aaggcctgcgagctgctctccaaggcctccatgcagtttgtggactataataaacgccag
atgagtcgtgtgtaccccaagggcacacgcatggactcttccaactacatgccccagatg
ttctggaatgctggatgtcagatggttgccctcaatttccagacaatggacctgcccatg
cagcagaacatggcactgtttgagttcaacgggcagagtggctacctcctaaagcatgag
ttcatgcgcagacgggacaagcagttcaaccccttctcagtggaccgcattgatgtggtg
gtagccaccaccctttccattacggtcatctctgggcagttcctgtcagagcgcagtgta
cgcacctatgtggaagtggaactgtttggcctcccaggggaccccaagaggcgatatcga
accaagctgtcacctactgctaactccatcaatcctgtctggaaagaggaaccctttatc
tttgagaagatcttgatgcctgagctggcctccctcaggatagctgtgatggaagaaggc
agcaaatttcttggacaccgcatcatccccatcaatgccttacattctggataccaccat
ctgtgcctgcgcagtgagagcaacatgccccttaccatgccagctctctttgtcttcctg
gagatgaaggactacatacctgacacgtgggcagatcttacggtggcccttgccaacccc
atcaagtacttcaatgcccaggataagaagtccgtgaagctcaaagaaatgacaggaagt
ctgcccgagaaactcttctctgggacacctgttgccagtcagtccaatggggcgccagtc
tcagcaggcaatgggtcagcagcgcctgggaccaaggccacgggggacgaagctacgaaa
gaagtgacagagccacagaccgccagcttggaagagttgcaggaactgaagggcgtggtg
aagctgcagcgaagacatgagaaggagcttcgagagctggagcgccgtggagcccggcgc
tgggaggaactgctgcagcgtggcgccgcacagctggcggagctccagaccccggcagca
ggcagcaaactccgcccgggcaagggctcccgcaagaagaggaccctgccctgtgaggag
accgtcgtggcgcctagcgagccccacgaccgggcggacccgcgcgtgcaggagctgaag
gacaggctggagcaggagctgcagcagcaaggcgaggagcagtaccgctctgtcctcaag
cgcaaggagcagcatgtgactgagcaaatcgccaagatgatggagctggccaaagagaaa
caggctgctgaactcaagaccttcaaggaaacctcagaaattgataccaaagaaatgaag
aaaaagctggaggccaagaggctggaacggatccaagccatgaccaaggtcaccacagac
aaggtggcccaggagaggctcaagagagaaattaacaactcccacatccaggaagtggtc
caggctgtcaagcagatgacagagaccctggagcgtcaccaagagaagctggaagagagg
cagacagcctgcctggagcagatccaggcaatggaaaagcagttccaggagaaggcgcta
gcagagtatgaggccaagatgaagggcctggaggctgaagtaaaggagtcggtgcgggcc
tacttcaaggtctgcttccccgctgaagcagaagacaagcctgagaggttctgtgaggcc
tctgaggagtcgtgtccacaggaaccacttgtgagcaaggcagacatccaggagagccgc
ctctga |