Mus caroli (Ryukyu mouse): 110294193 Help Entry 110294193         CDS       T05910                                  Symbol Pclo Name (RefSeq) protein piccolo   KO K16882   protein piccolo Organism mcal  Mus caroli (Ryukyu mouse) Pathway mcal04911   Insulin secretion Brite KEGG Orthology (KO) [BR:mcal00001]  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     110294193 (Pclo)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mcal04131]     110294193 (Pclo) Membrane trafficking [BR:mcal04131]  Exocytosis   Calcium ion-dependent exocytosis    Others     110294193 (Pclo) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  zf-piccolo C2 PDZ FYVE_2 Motif Other DBs NCBI-GeneID:  110294193 NCBI-ProteinID:  XP_029333121 Ensembl:  MGP_CAROLIEiJ_G0026970 UniProt:  A0A6P7R6B4 LinkDB All DBs Position 5:9834322..10162593 Genome browser AA seq 5097 aa AA seqDB search MGNEASLEGEGLPEGLAAAAGGAGGSGSALHPGIPAGMEADLSQLSEEERRQIAAVMSRA QGLPKGSVPAAAAESPSMHRKQELDSSQAPQQPGKPPDPGRPTQPGLSKSRTTDTFRSEQ KLPGRSPSTISLKESKSRTDFKEEYKSSMMPGFFSDVNPLSAVSSVVNKFNPFDLISDSE AVQEETTKKQKVAQKDQGKSEGVTKPPLQQPSPKLIPKQQGPVKEAIQQDIPPKSVSSQQ AEKIKPQAPGTAKPSQQSPAQTPAQQASPAKPAAQQPGPAKATVQQPGPAKSPAQPAGTG KSPAQPPVTAKPPAQQAGLEKTSLQQPGPKSLAQTPGQGKFPPGPAKSPAQQPGTAKLPA QQPGPQTAAKVPGPTKTPAQPSGPGKTPAQQPGPTKPSPQQPIPAKPQPQQPVATKPQPQ QPAPAKPQPQHPTPAKPQPQHPTPAKPQPQQPAPAKPQPQHPTPAKPQPQQPTPAKPQPQ QPAPAKPQPQQPAPAKPQPQQPTPAKPQPQQPTPAKPQPQQPGLAKPSAQQPTKSISQTV TGRPLQPPPTSAAQTPAQGLSKTICPLCNTTELLLHTPEKANFNTCTECQSTVCSLCGFN PNPHLTEIKEWLCLNCQMQRALGGELAAIPSSPQPTPKAASVQPTTASKSPVPSQQASPK KDPPSKQDSPKKPPESKKPPPLVKQPTLHGPTQATAPQPPVAEALPKPAPPKEPSAALPE QAKAPVADVEPKQPKTTETLTDTPSSAAATTKPDILSSQAQSQAQVKTAPPLKTDSAKPS QSFPPTGDKITPLDSKAMPRPASDSKIVSHPGPTSESKDPVQKKEEPKKAQTKVTTKPDT KPVPKGPPTPSGTRPTTGQATPQSQQPLKPQEQSRRFSLNLGGITDAPKSQPTTPQETVT GKLFGFGASIFSQASNLISTAGQQAPHPQTGPAAPSKQAPAPSQTPAAQGPPKSTGQHPS APAKATAVKKETKAPAAENVESKPEQAPTVKKAEKDKKPPPGKVSKPPPTEPEKAVLAQK PDKTTKPKPACPLCRTELNIGSQDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLN CQTQRAISGQLGDMDKMPPASSGPKASPVPAPAEPSPQKTPTAAHAKGKKKETEVKTETE KPIPEKETPSIEKTPPAVTTDQKLEESEVTKSQVSALLEKKPSEEEKALPADKKEKKPPA AEQPPLEEKKPIPDDQKLPPDAKPSASEGEEKRDLQAHIQIPEEGPIGKVASLACEGEQQ PDTRPEDLPGATPQTLPKDRQKESREVTQPQAEGTAKDGRGEPSKDRTEKEEDKSDTSTS QQPKSPQGLSDTGYSSDGISGSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAK LESTVLSILEAQASTLVGEKAEKKTQPQKVSPEQPQDQQKTQTPSEAQDISISEEEIKES QEKKVSSKKESAQGFPPRKEHKEKPELVDDLSPRRASYDSVEDSSESENSPVARRKRRTS VGSSSSEEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDEEFIRSQLKEIGGVTESQ KREETKGKGKSPAGKHRRLTRKSSTSFDDDAGRRHSWHDEEEDETFDESPELKFRETKSQ ESEELVVAGGGGLRRFKTIELNSTVTDKYSAESSQKKTTLYFDEEPELEMESLTDSPEDR SRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIE DSSEEEELREEEELLKEQEKQRELEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLS PIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVS LYSPTDEQSVMQKEGAQKALKSAEEMYEEMMHKPHKYKAFPAANERDEVFEKEPLYGGML IEDYIYESLVEDTYNGSVDGSLLTRQDEQNGFMQQRGREQKIRLQEQIYDDPMQKITDLQ KEFYELESLHSIVPQEDIVSSSYIIPESHEIVDLGSMVTSTSEEKKLLDADAAYEELMKR QQMQVTDGSSLIQTTMGDDIAESTLDFDRVQDASLTSSILSGASLTDSTSSATLSIPDVK ITQHFSTEEFEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSISSV CTTDSSSPVTTLDSLTTVYTEPADVITKFKDSEEISSTYFPGSIIDYPEDIGASLDRTIT PESRTNADQVMIPFSGIAPSITESVPTKPERPQADTISTDLPISEKDLIKGKKETGDGII LEVLDAYKDKREESEAELTKISLPETGLAPTPSSQTKEQPGSPYSVSGEISGQEKPTYRS PSGSLPVSTHPSKSHPFFRSSSLDISAQPPPPPPPPPPPPPPPLPPATSPKPPTYPKRKL AAAAPVAPTAIVTTHVDAIPTVEATAARRSNGLPATKICAAAPPPVPPKPSSIPTGLVFT HRPEASKPPIAPKPAVPQIPVTTQKTTDTCPKPTGLPLTSNMSLNLVTSADYKLPSPTSP LSPHSNKSSPRYSKSLMETYVVITLPSEPGTPTDSSAAQAITSWPLGSPPKDLVSLETVF SVVPPMTSTEIPSASQPTLYTSGALGAFSVTPAVTASLFQTVPTSLMQFLPAEASKPEVS AVRSTVPSVAPRSVSIPIPPEPLALDRHQYKENGKLPLIGDAIDLRTIPKSEVKVTEKCM DLSASAMDVKRQTTVNEVYRRQISAVQPSIMNLSAASSLGTPVTMDPKTVAVVTCTDTTV YTTGTESQVGIEHAVTSPLQLTTSKHAELQYRKPSSQAFPMIRDEAPINLSLGPSTQAVT LAVTKPVTVPPVGVTNGWTDSTMSQGITDGEVVDLSTSKSHRTVVTMDESTSNVVTKIIE DDEKPVDLTAGRRAVCCDMVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGY RGIGGMKPSMSDTNLAEAGHFFYKSKNAFDYSGGTESAVDLTSGRVSTGEVMDYSSKTTG PYPETRQVISGVGISTPQYSTARMTPPPGPQYGVGSVLRSSNGVVYSSVATPIPSTFAIT TQPGSIFSTTVRDLSGIHTTDAITSLSALHQSQPMPRSYFITTGASETDISVTSVDINAS LQTITMETLPAETMDVVPTLTTASEVFSEVVGEESTLLIVPDEDKQQQQLDLERELLELE KIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQE TLAQQQLQLEQIQQLQQQLHQQLEEQKLRQIYQYNYEPSGTASPQTTTEQAILEGQYVAT EGSQFWATEDATTTASTVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVV KEEKQPKKRSSGAKVRGQYDEMGESMADDPRNLKKIVDSGVQTDDEETADRTYASRRRRT KKSVDTSVQTDDEDQDEWDMPSRSRRKARTGKYGDSTAEGDKTKPPSKVSSVAVQTVAEI SVQTEPLGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTETDSDTQSPPYMGAT SPPKDKKRPTPLEIGYSSSHLRADPTVQLAPSPPKSPKVLYSPISPLSPGNALEPAFVPY EKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYSEGF TTKGSQTITASGTQKKVKRTLPNPPPEEASTGTQSTYSTMGTASRRRMCRTNTMARAKIL QDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAY LQGVAEDRDYMSDSEVSSTRPSRVESQHGIERPRTAPQTEFSPFIPPQTQTEAQLVPPTS PYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQVSPYQTQPTFQAVATMSFTPQAQPT PAPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSTYEVIRNQPLMIAPVSTDNTYAVSHLG SKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHTSRNYVLIDDIGDITKGTAALS SAFSLHEKDLSKTDRLLRTTETRRSQDVTDFLAPLQTSSRLHSYVKAEEDPMEDPYELKL LKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAI LYQKQSKHKKALIDPKMSKFSPIQESRDLEPDYPTYLSSSTSSIGGISSRARLLQDDITF GLRKNITDQQKFMGSSLGSGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDL SIKRDSSSSSLRLKAQEAEALDVSFGHSSSSARTKPTSLPISQSRGRIPIVAQNSEEESP LSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMD DFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQILQM NGKTMHYIFPHARIKITRDSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSA EHSGKLIEGMQVLEWNGIPLTSKTYEEVQSIINQQSGEAEICVRLDLNMLSDSENPQHLE LHEPPKVVDKAKSPGVDPKQLAAELQKVSLQQSPLVMSSVVEKGSHAHSGPTSAGSSSVP SPGQPGSPSVSKKKHGGTKPTDVSKTASHPITGEIQLQINYDLGNLIIHILQARNLVPRD NNGYSDPFVKVYLLPGRGQVMVVQNASVEYKRRTKYVQKSLNPEWNQTVIYKSISMEQLM KKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQNS QQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTS VAQTHLEDAGAAIAAAEAAVQQLRIQPTKPTNHRPAESSVSTGSSGSSVGSGYSVDSEGS SCVAGEPNLLPIPRIGKMGQNGQDPVKQPGMGATDTEAKTQVMGEIKLALKKEMKTDGEQ LIVEILQCRNITYKFKSPDHLPDLYVKIYVINIATQKKVIKKKTRVCRHDREPSFNETFR FSLSPAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLMSPTQTH NT seq 15294 nt NT seq  +upstreamnt  +downstreamnt atgggcaacgaggcgagcttggaaggggaagggctccccgaagggttggcggcggccgca ggcggggctggcggctcggggagcgccctgcacccggggatcccagccggcatggaggcg gacctgagccagctgagcgaggaggagaggagacagatcgctgctgtcatgtcaagggcg caggggctgcccaagggaagcgtccccgcggccgctgcggagtcgccctccatgcacagg aaacaagagttggatagtagtcaggctccacagcaacccggaaagccaccggaccctggg cgtcccactcagcctggtcttagcaaaagcagaaccacggacacgtttaggtcagagcag aagctgcctggaaggagtccgtccactattagcttgaaagaatccaagtccagaactgat tttaaggaagaatacaagtctagtatgatgcctggtttcttctcagatgttaatccttta agtgctgtctcctctgttgtaaataaattcaacccttttgatttgatatcagactccgag gcagtccaggaggaaactacaaagaaacaaaaagttgctcagaaggaccaagggaaatcg gaaggagtcacaaaacctcccttacagcagccatcacccaagttgatccctaaacagcaa ggaccagtgaaggaagcaatccagcaggatatccctcccaagtcagtatcctcccagcaa gcagaaaaaataaaaccacaagcccctggcacagcaaaaccttcccagcagagtccagcc caaacaccagctcagcaagcaagtcctgcaaaacctgcagcccaacagcctggacctgca aaggccacagtccagcaaccagggccagcaaagtccccagctcaaccagcagggacaggg aagtccccagcacaacctccagtgacagccaagcccccagctcaacaggctggcttagag aagacctcattgcagcagcctgggccaaagtctctagctcagactcctggtcagggaaag tttccaccagggccagcaaagtccccagcccagcagccagggacagctaaactcccagcc caacagcctggcccacagactgcagctaaggtacctgggcctacaaaaactccagctcag ccatctggacctggaaaaacaccagctcaacagcctggtccaacgaagccttcacctcag cagcccattccagcaaagccccagcctcaacaacctgttgccacaaaacctcaacctcaa cagccagccccagcaaagccccagcctcaacacccaactccagcaaagccccagcctcaa cacccaactccagcaaagccccagcctcaacagccagccccagcaaagccccagcctcaa cacccaactccagcaaagcctcagcctcaacaacctaccccagcaaagccccagcctcaa cagccagccccagcaaaaccccagcctcaacagccagccccagcaaagccccagcctcaa cagcccaccccagcaaagccccagcctcaacagcccaccccagcaaagccccagcctcaa cagccaggcctggcaaaaccttcagctcaacaacctactaaatcaataagccaaacggta actggaagacctctgcaaccaccaccaacttctgcagcacagactccagcacaaggcctc tctaaaaccatctgtcctctttgcaacaccactgagcttctgttgcatactccagaaaag gccaattttaacacatgtactgagtgtcaaagcaccgtctgtagcctctgtggttttaac cccaatcctcacttaactgagatcaaagagtggctctgtttaaactgtcagatgcaaaga gctctgggaggtgaactggcagcaatcccatcctcaccgcagccaactccaaaggctgcc tcagtacagccaacaacagccagcaaatcacctgtaccatcacagcaggcttccccaaag aaggaccctccatccaaacaggacagccccaaaaagccaccggagtccaaaaagccaccg ccactggtgaaacagccaacccttcatggacctacccaggctacagccccacagcctcca gtggcagaggccttacctaagccagcccctcccaaggagccttctgcagccctacctgaa caagcaaaggcccctgttgcagatgttgaaccaaagcaaccgaagacgacagagacactc acagataccccatcttcagcagcagcaactacaaagcctgatattctgagctctcaagcg cagtcacaggctcaagtgaaaacagcccctcctttgaaaacagactctgccaaaccttca cagagtttcccaccaacaggagataaaattaccccacttgattctaaagccatgcccagg cctgcatcagactcaaaaattgtttcccatcctgggcccacttctgagagcaaggatcca gttcagaagaaggaggagcctaagaaagcacaaaccaaggtgaccactaaaccagataca aagccagtaccaaaaggacccccaacaccgtctggcacacgacctaccactggccaagcc acaccccagtcccagcagcccctgaagcctcaggagcagtcaagacggttcagtttgaat ctgggtggtatcactgatgcccccaaatcacagcccacaactcctcaagaaactgtgaca gggaaactattcgggtttggagcatccatctttagccaagcatcaaacttaatttccaca gcaggtcagcaagcacctcatccacagactgggccagctgccccatcaaagcaagcccct gccccatcccagactccggctgctcagggaccacccaagtccacaggtcagcacccatca gcacctgccaaggcgactgctgtgaagaaggaaacaaaagccccagcagctgaaaacgta gagtccaaacctgagcaagctccaacagtgaagaaggcagagaaagacaagaagccccca cctgggaaggtcagcaaacctccacctacagagcccgagaaggctgtcctcgcccagaag ccagacaagaccaccaaacccaaaccagcctgtcctctctgcagaactgaactcaacata gggtctcaggatcctcccaacttcaacacctgcacagaatgcaagaatcaagtttgcaat ctctgtggatttaacccaacaccccacctgactgagattcaagaatggctttgtttaaac tgtcagacacagagagcaatatcaggacaacttggagatatggacaaaatgccacctgca tcctcaggacccaaagcatccccagtgcctgcccctgcagagccctcacctcagaaaaca ccaacagctgcccacgcgaaaggtaaaaagaaggaaacagaagtaaaaacagaaactgaa aaaccgatcccagaaaaagaaacaccatcaattgagaaaacccctccagcagtcaccaca gatcaaaaactagaagaaagtgaagtaaccaaaagccaagtttcggcccttctggaaaag aaaccatccgaagaagaaaaagccctacctgcagataaaaaggaaaagaagccacctgct gcagaacagccaccacttgaagaaaagaagccgatccctgatgatcagaaattaccccca gacgcaaaaccatcggcctcagagggggaagagaaacgtgatctacaagctcacattcaa attcccgaagaaggacccataggcaaagtggcttcactggcttgtgaaggagagcagcag ccagacaccaggcctgaagatctgccaggcgccacacctcagacgttacccaaggacaga cagaaggaaagcagagaggtaacacagcctcaggcagaaggcacggcaaaggacggccga ggggagcccagcaaagacaggacagaaaaggaagaggacaaatcagacacgtccacttct cagcaacccaagagcccacaaggcctgagtgacacagggtattcttctgacggaatatcc ggttctcttggggaaatcccaagtcttatacccagtgatgagaaagatttgctaaaagga ctcaaaaaagactctttctcacaagaaagcagcccttccagcccctcagacttagcaaag ttggaaagtacagtactgtccattttggaagctcaggcaagtacacttgtaggtgaaaag gcagaaaagaaaacacagccccagaaggtttctcctgaacagcctcaggaccagcagaaa acccagactccatctgaagcacaggatatttctatttcagaagaagagatcaaagagagt caagaaaagaaagtgagttcaaaaaaggagagtgcacaaggttttcctcccaggaaggag cacaaagagaagcctgagctggtcgatgacctaagtccgcgaagagcatcctatgattcg gttgaagacagcagcgaaagtgaaaactcccctgttgcacgcaggaagcggagaactagc gttggctcctcaagcagcgaggagtataagcaggaagacagtcaaggctcgggggaagag gaggacttcattcgaaaacagattatagaaatgagcgctgatgaggatgcttcaggctct gaggatgaagagttcatcaggagtcagctcaaagagattggtggtgttactgagagccag aagagggaggaaacaaaggggaaaggaaaaagcccagcagggaaacacagacgactgact cgaaagagtagtaccagcttcgacgatgatgctgggagacgccattcctggcatgatgag gaggaggatgaaacttttgatgaaagtcctgaactcaaattccgagaaactaaaagccag gagagtgaagaactagttgttgctggtggaggagggttacgtcgatttaagactatagaa ctcaacagtacagtaacagataagtactctgcagagtcctctcagaaaaagacaactttg tattttgatgaagagccagaattagaaatggaaagtctgacggactcacccgaggacagg tctagaggagagggatcctcgagtctccatgcatccagcttcactcctggcacatcccct acctcagtatcatcacttgatgaagacagtgacagtagcccaagtcacaaaaagggagaa agcaagcagcagcgcaaagctcggcacaggtcacacggccctcttttacctaccattgaa gattcttccgaggaggaagaactaagagaggaagaagaattattaaaagagcaagagaag cagagagaactggagcagcagcagaggaagagttctagtaagaaatcgaagaaagacaaa gatgaacttcgagctcagaggaggagagaaagaccaaagacaccacccagtaatctgtct cccatcgaggatgcatctcccacagaagaattgcgccaggcggcagaaatggaggagctt cataggtcctcttgttctgagtactcacctagcatagaatcagacccagaaggatttgaa ataagccccgagaaaataatagaagttcaaaaagtttataaattgcccacagctgtgtct ttatactcaccaacagatgagcaatctgttatgcagaaagaaggtgctcagaaggcttta aaaagtgctgaggaaatgtatgaagaaatgatgcacaaaccccacaaatataaagctttt ccagctgcaaatgaacgagacgaagtgtttgaaaaagagccattgtatggtggtatgtta atagaggactacatttatgaatctttagtagaggacacatacaatgggtcagtagatggc agcctgctcaccaggcaagatgaacaaaatggatttatgcagcagagaggaagagagcaa aaaataagactacaggagcagatttatgatgatcctatgcagaaaattacagacctccag aaagagttttatgaattagaaagcttacattctattgtgcctcaagaagacattgtttca agctcttatatcattccagaaagccatgagatagtggatctgggtagcatggtaacttct accagtgaagaaaagaaattgttagatgcagatgctgcttacgaagaactcatgaagcgg caacaaatgcaagtaacagatggatccagcctcatacagactaccatgggggatgacata gccgagtccactctggactttgacagggtacaagatgcatctttgacatcaagtatcctt tctggagcatctcttacagactcaaccagcagtgcaactctctctatcccagatgttaag ataacccaacatttttcaacagaagaatttgaggatgaatatgtaactgattatacaaga gaaattcaagagataattgcccatgaatctctgatattgacctactctgaaccttcagaa agtgctacgtctgtcccaccttctgacacaccttctctcacatcatctatttcttcagtt tgtaccacagatagctcctcacctgtcactaccctcgatagcctaacaactgtttatacg gagccagcagatgtaataactaaatttaaagattctgaggaaatttcttcaacatatttt ccaggcagcattatcgactatccagaagatataggtgcatctttagatagaaccatcaca ccagaaagtagaactaatgctgatcaggttatgattcctttttctggtatagcaccatct atcacagaatctgtaccaactaaacctgagaggccacaagctgacaccatttccactgac ttacctatatctgaaaaagatttgataaaaggcaagaaagaaactggggatggaattatt ctggaagttttggatgcttacaaagataaaagggaagagtctgaggctgaactaacaaaa attagcttacctgagactgggttggccccaacaccttcttctcaaactaaggagcaacct ggatccccatattctgtatctggagagatctcgggtcaggaaaagcccacatacaggtcg ccgtctggcagtcttcctgtttctacccatccatccaaatctcacccatttttccgaagt tcttctttggacatatcagcccagccacctcctcctcctccaccccctcctcctcccccg cccccaccgttgcctccagcaacttctcctaagccacccacttatcctaaaagaaagttg gcagctgcagctccagtggctccaactgctattgttacaacccatgttgatgctatccct actgtagaggccacagctgcccgcaggagcaatgggttacctgcaactaaaatatgtgct gctgcccctcctcctgtccctcctaagccttcttcaattccaactggacttgtatttaca catagaccagaggcaagcaaacctccaattgcccccaagccagcagttcctcagattcca gtgactacacagaaaacaacagatacgtgccccaaaccaacaggtctacctttaacatca aatatgtccttaaatttagtgacttcagcagactacaaactgccgtcccctacctctcca ctttccccacactctaataaatcctcgccgagatattctaagtctctcatggagacttat gtggtcattacgttgccctctgaacctgggactccaacagattcttctgctgctcaagcc attacaagttggcccttgggatcacccccaaaagatctggtttcccttgaaacggtattt tctgtagttcctcccatgacatctacagaaattccaagtgcttcacagccaaccctatat acatctggagctttgggggcattttctgttacccctgctgtaacagcctctctgtttcaa acagtaccgacttcacttatgcagtttcttccagcagaagcttcaaaacctgaagtttct gcagtgagaagtacagtcccaagtgttgctcccagaagtgtttccataccaattcctcca gagcctcttgctctagacaggcatcagtataaggaaaatggaaagttgccacttattgga gatgccatcgatttgcgtacaataccaaaatcagaagttaaagtaacggaaaaatgtatg gatctttctgcttctgcaatggatgtgaaaaggcagaccacagtaaatgaagtttacagg cgacaaattagtgctgtccaaccttctatcatgaacctcagtgcagcttcctccttagga actccagtcaccatggaccctaagacagtggctgttgtcacgtgcacagacactacagtt tacacaacaggcacagaaagccaagtgggtatagaacatgcagtaacatcaccactgcag cttactacatcaaaacatgctgagttacaatacagaaaacctagtagccaggcttttccc atgattcgggatgaagcaccaataaacttatccttagggccttccactcaggcagtaaca ttggctgtcacaaagcctgtcactgtacctcctgttggtgttacaaatggatggactgac agcaccatgtctcaggggatcactgatggagaagtggtagatctcagcacatcaaagtct cataggactgttgtgacaatggacgaatctacttcaaatgtcgtgactaaaatcatagaa gatgatgaaaagccagttgatttgactgcaggaagacgagctgtgtgctgtgacatggtt tacaagttgcctttcggacggagctgcacagcacagcagcctgcaaccacccttcctgaa gaccgttttggttatagggatgaccactatcaatatgacagatcagggccgtatggttac agagggattggtggaatgaagccttccatgtcagacactaatttagcagaagctggacat tttttctataaaagcaagaatgcttttgactattctggaggaactgagtcagcagtagat ctaacttcagggagagtgtctacaggtgaggtaatggattattcaagcaagactacaggc ccatacccagaaacacgccaagtcatttcgggagttgggattagtaccccgcagtattcc acagcaagaatgactccacctcctggaccacagtatggtgtgggaagtgttttaaggtca tctaatggtgttgtctattcttcagtagcaactccaatcccctccacatttgctatcacc actcaacctggctccattttcagcaccacggtcagggatttatcgggcattcatacaaca gatgcaataacttcattatcagccctgcatcaaagccagccaatgcctagatcgtatttc ataacaacaggtgcatcagaaacagacatctcagtaaccagtgttgacatcaatgccagc ctgcaaactattactatggaaactcttcctgctgagacaatggatgttgttcctacctta accaccgcctctgaggtgttttctgaggtggttggagaggaaagcactcttttgattgtc cctgatgaagacaaacaacaacagcaacttgacttggagcgagagctcctggaactggag aaaattaagcaacaacgttttgctgaggaactggagtgggaacgtcaggagattcaaagg ttccgagaacaagaaaagatcatggttcaaaagaagctagaagagctgcagtctatgaag cagcaccttctctaccaacaagaggaagagcggcaggcccagttcatgatgagacaggag acactagctcaacaacagttacagcttgagcagatccaacagctgcaacaacagctccat cagcagcttgaggaacaaaaacttcgccagatctaccagtataactacgaaccctctggg actgcttctccacaaaccaccactgaacaggcaattttggagggtcagtatgttgctaca gagggcagtcagttttgggccactgaagatgccaccacaacagcgtctactgtggtagcc attgaaataccacagagccaaggatggtacacggttcagtctgatggtgtgactcagtac attgctccacctggcatcttgagcactgtttcagagatacctctgacagatgttgttgta aaagaggagaaacaacccaaaaagagaagttctggagctaaagttcggggacagtatgac gagatgggggaaagcatggcagatgatccacggaatttaaaaaagatagtggacagtggt gtgcaaactgacgatgaagaaactgctgatcggacttatgcaagtaggagaagaagaact aaaaagagcgttgataccagtgtccaaactgatgatgaagatcaggatgagtgggatatg ccttctaggtccaggagaaaagcgcgaacagggaaatacggagatagcacggcagagggt gacaagaccaaacccccttccaaagtctccagtgtagcagttcaaacagtcgcagagata tctgtgcaaactgagccattgggaaccataagaacaccttccatacgagcacgggtggat gccaaggtagaaataattaaacacatttcagcgcctgaaaagacttacaaagggggcagt ttaggatgccaaacagaaacagattcagacacacagagccctccatatatgggtgccaca tctccacccaaagacaagaaacgcccaacacctttagagattggttactcttcttctcac cttcgggcagaccccacagtccagctggctccttccccacccaaatctccaaaagtcctt tactcacccatctcaccactttccccaggcaacgccttagaaccagcctttgtaccttat gaaaagcccctccctgatgacataagtccacagaaagtactccatccagatatggctaaa gttcccccggcaagccctaagacagccaagatgatgcagcgttcaatgtctgaccccaag cctctgagtccaacagcagacgaaagttccagggctccttttcagtattccgagggcttc acgactaaaggttctcaaacaataacagcctctggtactcagaaaaaagtgaagagaaca ctgccaaatccccctcctgaggaagcatccacgggaacacagtcaacttacagcaccatg ggcactgcttctaggcgacgaatgtgcagaaccaataccatggctcgagccaaaattctc caggacatagaccgagagctcgacctcgtggaaagagagtctgccaagcttagaaagaag caagcagaacttgatgaagaagaaaaggagattgatgccaagctacggtatctggaaatg ggaattaacaggagaaaagaagctctattaaaggagagagaaaaaagagagcgtgcctac ctgcagggggtagccgaggaccgtgattatatgtctgacagtgaggtcagcagtaccaga cccagccgagtagaaagccagcatggcattgagcggccaagaacagctcctcaaactgaa ttcagcccgttcataccaccacaaacgcaaacagaagctcaactagttcctccgacaagt ccgtacacacaataccagtactcatcacctgcgcttcccacccaagccccgaccccgtac acgcaacaatctcattttcaacagcagacattgtaccatcagcaagtgtcaccttatcag actcaaccaaccttccaagctgtggccaccatgtccttcacaccccaggctcaacctact ccagctccacaaccatcctatcaattaccatcacagatgatggtgatacaacaaaagcct cggcaaaccacattgtatttggagcctaagataacttctacctatgaagtgattcgtaac caacccctgatgattgctccagtttctactgataatacgtatgctgtttcccatcttggg agtaagtacaatagtttagacttgagaataggtttggaggaaagaagcagtatggcaagc agtccaatatcaagcatatctgcagactccttctatgcagacattgaccaccatacttca aggaattatgtcctaatagatgacattggagacattaccaaagggacagcagctttgagc tctgcatttagtctccatgaaaaggatctgtccaaaacagatcgtctccttagaaccact gagacacggaggtctcaagacgtgacagacttcctagcgcctttgcagacttcctccaga ctgcatagctatgtgaaggcagaggaggatccgatggaggatccttatgagttaaagctt ctgaaacatcagattaagcaagaattccgtagaggcacagagagcttagatcaccttgct ggtctttcacattattaccatgctgatactagctatagacacttccccaagtctgaaaag tatagcatcagtagactcaccctggaaaagcaagctgccaaacaattgcctgcagccata ctttaccaaaagcaatcaaagcataagaaagcattaattgaccctaaaatgtctaagttt tcacctattcaagaaagtagagaccttgaacctgactatcccacttacttgagttctagc acttcatccattggtggtatttcttctagggcaaggcttcttcaagatgatatcacattt ggcctcagaaaaaatattacagatcaacaaaaattcatgggttcatcacttgggtcagga ctgggcacgttaggaaataccatccggtcggctctacaggatgaagcagataagccatac agcagtggaagcaggtccaggccttcctctaggccttcctctgtctatgggcttgattta tcaattaagagggattcttccagctcatcactaagattgaaagctcaagaggctgaagct ctggatgtctcttttggccattcttcatcttctgccagaactaagcccaccagcttacca atcagccagagtagaggaagaataccaattgtggcccagaattcagaagaagaaagccca ctaagtcccgttggccagccaatgggcatggccagggctgcggctggacctttgccaccc atatctgcagataccagggatcaatttggatcaagtcactcattgcctgaagttcagcaa cacatgagagaagagtcacggacaaggggttatgaccgtgacatagcattcatcatggat gacttccaacatgctatgtctgacagtgaagcctatcacttgcgtcgggaggaaacggat tggtttgataaacccagggagtctcggttggaaaatggccatggtctggaccggaaactg ccagaaagactggttcactctagacccctcagtcaacatcaagagcaaattctgcagatg aatgggaagacaatgcactacatctttcctcatgcaaggataaaaataaccagagactct aaggatcacacagtttcaggtaatgggctaggaattagaattgttggtggtaaagaaatt cctggacatagtggagaaattggagcctatattgctaagattcttcctggtggaagtgca gaacactcagggaaacttatagaagggatgcaagttttggaatggaatggaatcccctta acttctaaaacatacgaagaagtgcagagcatcattaatcagcaaagtggggaagcagaa atatgtgtaagactggacctcaatatgttgtcagactccgaaaatccgcagcatctggaa cttcatgagccaccaaaagttgtggataaggcaaagtctccaggcgtggatcccaagcag ctggcggcagagctgcagaaagtctcactccagcagtccccattggtcatgtcatcagtt gtggagaaagggtctcatgctcactcaggtcccacatcggcaggatccagttctgttccc agccccgggcagccagggtcaccttcagtaagcaaaaagaagcatggcggcaccaagcct actgatgtgtccaagactgcgtctcatccaattacaggagagattcagcttcaaatcaac tatgatcttggaaatcttataatacatattcttcaagcaagaaacctagtgcccagagac aacaatggctactctgacccatttgttaaggtgtacttacttccaggacgaggtcaagtc atggttgtccagaatgcaagtgttgagtacaagagaaggactaaatatgtccagaaaagt cttaatcccgagtggaatcaaacagtaatttataaaagtatttccatggagcagctcatg aagaagaccttggaggtgacagtttgggattatgatagattctcgtccaacgacttcctt ggagaggtattgattgatttatctagcacatctcatctggacaacactcctcggtggtat ccgctgaaagaacagactgaaagcattgaccatggcaagtctcactccagtcaaaacagc cagcagtccccaaagccctctgtgatcaaaagcagaagccacggtatcttccctgaccca tccaaggatatgcaggttcccaccattgagaaatcccacagtagtcctggtagctcaaaa tcatcatctgaaggccatctccgatctcacggaccatctcgcagtcaaagcaaaaccagt gtcgcccagacccatctggaagatgcaggggcggccatagccgcagctgaagccgctgtg cagcaactccgcattcaaccaacaaagcccaccaaccaccggcctgcagagagctccgtg tccactggctcctcgggcagcagcgttggcagtgggtatagcgtggacagtgaaggaagc agctgtgtggcaggggagcctaatctacttcctatcccaaggataggaaagatgggacag aatggccaagaccctgtgaaacagccaggaatgggagcaacagacacggaggctaaaact caagtaatgggagaaatcaagctagcactgaaaaaggaaatgaaaacagatggtgaacaa ctaatagttgaaattctccagtgcagaaatattacctacaaatttaagtctccggatcat ttaccagatttatatgtgaaaatatatgtgataaacattgctacccaaaaaaaggttatt aaaaagaaaacaagggtatgtcgacatgatcgagagccttccttcaatgaaacctttaga ttcagcctaagtcctgcaggccactcacttcagattttacttttctccaatggcgggaag tttatgaagaagactttgattggagaagcttgtatctggcttgacaaagtggatctgaga aaaagaatagtcaattggcacaaactgttgatgagtcctactcaaacacattga

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