Mus caroli (Ryukyu mouse): 110301030
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Entry
110301030 CDS
T05910
Symbol
Gclc
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
mcal
Mus caroli (Ryukyu mouse)
Pathway
mcal00270
Cysteine and methionine metabolism
mcal00480
Glutathione metabolism
mcal01100
Metabolic pathways
mcal01240
Biosynthesis of cofactors
mcal04216
Ferroptosis
Module
mcal_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
mcal00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
110301030 (Gclc)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
110301030 (Gclc)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
110301030 (Gclc)
Enzymes [BR:
mcal01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
110301030 (Gclc)
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
110301030
NCBI-ProteinID:
XP_021026907
Ensembl:
MGP_CAROLIEiJ_G0032456
UniProt:
A0A6P5QAG6
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Position
9:74721083..74760963
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AA seq
637 aa
AA seq
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MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENRKVQLLLNGGDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRKEATSVLGEHQALCTITSFPRLGCPGFTLPEHRPNPEEGGASKSLFFPDEAI
NKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDAEASKASQPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNRFRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLE
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKMAQKRDAVL
QGMFYFRKDICKGGNAVVDGCSKAQSSSEPAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEINYS
LIWKCNQIANELCECPELLGSGFRKAKYSGGKSDPSA
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccaaggctcgccactgagctgggaagagacccagcgccacgccgac
cacgtgcggaggcacggcatcctccagttcctgcacatctaccacgcagtcaaggaccgg
cacaaggacgtgctcaagtggggtgacgaggtggagtacatgttggtgtccttcgatcat
gaaaataggaaagtccagttgttactgaatggaggcgatgttcttgagactctgcaggag
aagggggagaggacaaaccccaaccatccgaccctctggagaccagagtatgggagttac
atgatcgaaggaacgcctggccagccctacggaggaacaatgtctgagtttaacactgtg
gaggccaacatgaggaaacgccggaaggaggctacttctgtactaggggagcatcaggct
ctctgcaccatcacttcattccccagactaggctgtcctggattcacactgccagagcac
agacccaacccagaggaaggaggcgcatcaaagtccctcttctttccagatgaagccata
aacaagcacccccgcttcggtactctaacaagaaacatccggcataggagaggagaaaag
gttgtcatcaatgtgccaatattcaaggacaagaatacaccatctccatttgtagaaaca
tttcctgaagatgcagaggcatcaaaggcttctcagccagaccatatctacatggatgcc
atgggattcgggatgggcaactgctgtctccaggtgacattccaagcctgcagcatatct
gaggcaagatacctttatgatcagctggccactatctgcccaattgtcatggctttgagt
gctgcatctccattttaccgaggctacgtgtcagacattgattgtcgctggggagtgatt
tctgcatctgtagatgatagaacacgggaggagagaggactggagcctctgaagaacaat
cgctttaggatcagtaagtctcggtatgactcaatagatagctacctgtctaagtgtggg
gagaagtacaatgacatcgacctgaccatcgataaggagatctacgagcagctcctggag
gaaggcatcgatcatcttctggcacagcacgttgctcatctctttattagagacccactc
accctttttgaagagaaaatacacctggatgatgccaacgagtctgaccattttgagaat
attcagtccacaaactggcagacaatgaggtttaagcctcctcctccaaactcagatatt
ggatggagagtagagttccgaccaatggaggtgcagttaacagactttgagaactctgcc
tatgtggtattcgtggtactgctcactagggtgatcctctcatacaaactagacttcctc
attccactgtccaaggttgacgagaacatgaaaatggcacagaagcgagatgctgtcttg
caggggatgttttatttcaggaaagacatctgcaaaggcggcaacgctgtggtggatggg
tgcagcaaggcccagagcagctcggagccagctgcagaggagtacaccctgatgagcata
gacaccatcatcaatgggaaggaaggggtgtttcctggactcatccccattctgaactcc
tatctggagaacatggaagtcgatgtggacacccgatgcagtattctgaactacctaaag
ctaattaagaagagagcatctggagaactaatgactgttgccaggtggatgagagagttc
attgcaaaccatcctgactataagcaagacagtgtaataactgatgaaatcaactatagc
ctcatttggaagtgcaaccaaattgcaaatgagctgtgtgaatgtccagagttacttgga
tcaggatttagaaaagcaaagtatagtggaggtaaaagcgacccttcagcctag
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