Mus caroli (Ryukyu mouse): 110308440 Help Entry 110308440         CDS       T05910                                  Symbol Ryr2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism mcal  Mus caroli (Ryukyu mouse) Pathway mcal04020   Calcium signaling pathway mcal04024   cAMP signaling pathway mcal04260   Cardiac muscle contraction mcal04261   Adrenergic signaling in cardiomyocytes mcal04371   Apelin signaling pathway mcal04713   Circadian entrainment mcal04911   Insulin secretion mcal04921   Oxytocin signaling pathway mcal04972   Pancreatic secretion mcal05020   Prion disease mcal05022   Pathways of neurodegeneration - multiple diseases mcal05410   Hypertrophic cardiomyopathy mcal05412   Arrhythmogenic right ventricular cardiomyopathy mcal05414   Dilated cardiomyopathy mcal05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mcal00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110308440 (Ryr2)    04020 Calcium signaling pathway     110308440 (Ryr2)    04024 cAMP signaling pathway     110308440 (Ryr2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     110308440 (Ryr2)    04921 Oxytocin signaling pathway     110308440 (Ryr2)   09153 Circulatory system    04260 Cardiac muscle contraction     110308440 (Ryr2)    04261 Adrenergic signaling in cardiomyocytes     110308440 (Ryr2)   09154 Digestive system    04972 Pancreatic secretion     110308440 (Ryr2)   09159 Environmental adaptation    04713 Circadian entrainment     110308440 (Ryr2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     110308440 (Ryr2)    05022 Pathways of neurodegeneration - multiple diseases     110308440 (Ryr2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     110308440 (Ryr2)    05412 Arrhythmogenic right ventricular cardiomyopathy     110308440 (Ryr2)    05414 Dilated cardiomyopathy     110308440 (Ryr2)    05415 Diabetic cardiomyopathy     110308440 (Ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mcal04040]     110308440 (Ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:mcal04990]     110308440 (Ryr2) Ion channels [BR:mcal04040]  Voltage-gated cation channels   Ryanodine receptor    110308440 (Ryr2) Domain-containing proteins not elsewhere classified [BR:mcal04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    110308440 (Ryr2) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  110308440 NCBI-ProteinID:  XP_029324152 Ensembl:  MGP_CAROLIEiJ_G0018220 UniProt:  A0A6P7PV85 LinkDB All DBs Position 13:complement(7956591..8519284) Genome browser AA seq 4980 aa AA seqDB search MADAGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSI CYIQHVDTGLWLTYQAVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKLPTTDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLDAPDQDHASRAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKSVAG GLPGAGFYGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRIDKDKETPKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGR IKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLV QCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSH VDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLF PDENKKHGLPGIGLSTSLRPRMRFSSPSFVSISNDCYQYSPEFPLDILKAKTIQMLTEAV KEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAAIPEE EGGTPEKEISIEDAKLEGDEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHR IEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKD DKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYLKK KQAEKPVASDSRKSSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRA LPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNL MRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYL LENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLL SKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGN GLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDKFPESDIEEEEDDTIHMGNAIMTFYAAL IDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPD MSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALA LNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLS ICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASE EELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSM DSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQP LMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSI DAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYD TLTAKEKAKDREKAQDIFKFLQISGYVVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDE AHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGH ASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKS ALRAFLDNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQH QFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHL DKHNVYSIYNTRSSRERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGIRYTQMPYMM EVVLPMLCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAW MKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLI LDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKRE EQNFVVQNEINNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIVAALKRLLP IGLNICAPGDQELIALAKNRFSLKDTEEEVRDIIRSNIHLQDKLEDPAIRWQMALYKDLP NRTEGTSDPERTVERVLDIANVLFHLEQKSKYTGRGYFSLVEHPQRSKKAVWHKLLSKQR KRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAELPEED EAMKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFE VTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILN GGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGE KVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISD FYWYYSGKDIIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGF LHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESS NNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLL SCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLN YFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKME LFVNFCEDTIFEMQLAAQISESDLNERLANKEESEKERPEEQAPRMGFFSLLTIQSALFA LRYNVLTLVRMLSLKSLKKQMKRMKKMTVKDMVLAFFSSYWSVFVTLLHFVASVCRGFFR IVSSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLK ELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPVPVPEVQEKFQEQKAKEE KGEKEETKPEPEKAEGEDGEKEEKAKDDKSKQKLRQLHTHRYGEPEVPESAFWKKIIAYQ QKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRTNSDTAKVTISL DSSPHRIIAVHYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVA RKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRIS ELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMT MSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFN FFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFD ITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFET HTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14943 nt NT seq  +upstreamnt  +downstreamnt atggctgatgcgggcgaaggcgaggatgagatccagttcctgagaactgatgatgaggtg gttctgcagtgcacagcgaccatccacaaagaacagcagaagctgtgcttggcagcagaa ggatttggcaacagactttgttttttggagtctacttccaattccaagaatgttcccccg gacctgtctatctgcacctttgtgctggagcagtccctgtcagtacgggccctgcaggag atgctggccaacacagtggaaaagtcagaagggcaggtggatgtggaaaaatggaagttc atgatgaagactgctcaaggtggaggccaccggacactcctctatggacacgccatattg ctacgccattcctacagtggtatgtatctttgctgtctctccacctcccggtcttccact gacaaactggccttcgatgttggccttcaagaggataccacaggggaggcttgctggtgg accatacatcctgcctctaagcagagatcagaaggagaaaaagtgcgtgttggagatgat ctcatcttggtcagcgtgtcctcagaaaggtacttgcacttgtcatatggcaacagcagc tggcatgtggatgctgccttccagcagaccctctggagcgtggcccctatcagctcagga agtgaagcagcccaaggatatctcattggcggtgatgttctccgactgctgcatgggcac atggatgaatgtctcactgtcccttcaggagagcatggtgaagaacaacggagaacagtt cattatgaaggtggtgctgtatcagttcatgcacgctccctctggagactggagacccta agagtcgcgtggagtggaagccacataagatggggccagccattccgactccggcatgtc acgacaggaaaatacttaagcctcatggaagacaagaaccttctactcatggacaaagag aaagcagatgtaaaatcaacagcgtttgccttccggtcttccaaggaaaaattggacgtg ggggtgaggaaagaagtcgatggcatgggaacctcagaaatcaagtatggagactccatt tgctacatacaacatgtggatacaggcctgtggctaacctaccaggctgtggatgtgaaa tcagcacggatgggatccatccagcgtaaggctatcatgcaccacgaaggccacatggac gatggtttgaacttatccagatcgcagcatgaggagtcccgcactgcccgcgtcattcgg agcacagtgttcctctttaataggttcataaggggcctggatgctctcagcaagaaagta aagctacccaccactgacttgcccatcgagtctgtgagcctgagtttgcaagacctcatc ggctacttccaccccccagacgagcacttggagcatgaggacaagcagaacaggctgcga gccctgaagaacaggcagaatctcttccaggaagagggaatgatcaacctggttctggag tgcatcgaccgcctgcatgtctacagcagtgcagcccactttgcagatgtcgcaggacga gaagcaggagagtcttggaaatccatcctgaattctctgtatgagttgctggcggctcta attagaggaaatcgtaaaaactgtgctcagttttctggctccctcgactggctgatcagc agactggaaagactggaagcatcctcgggtatcctggaggtcctccactgtgtgttagtg gagagcccagaagctctgaatatcatcaaagaagggcatatcaagtccattatctcgctt ttagacaagcatgggagaaaccacaaggtcctggatgtgctgtgttctctctgtgtatgc catggagttgctgtccgctctaatcagcacctcatctgtgataatctcctgccaggacga gatctcttactgcagacccgtcttgtgaatcatgtcagtagcatgaggcctaatattttc ctgggtgtcagcgaaggctcagcacagtataagaagtggtactacgagctcatggtggac cacacagaaccctttgtgacagcagaagccactcacctgcgagtgggctgggcttccact gaagggtattctccatacccaggtggaggtgaagagtggggtggcaatggcgttggtgac gacctcttctcctatgggtttgacggccttcacctctggtcaggttgtatagctcgaacc gtgagctcccccaaccagcacctgctgagaactgacgatgtcatcagttgttgtttagat ctaagtgcccccagcatctcgtttcgcattaatggacaaccggtgcaaggaatgtttgag aacttcaatatcgatggcctgttctttccagttgtcagtttctctgcaggaataaaggtt cgctttttgcttgggggaagacatggagaattcaagtttctccctccacctggctatgca gcttgctatgaagctgttctgcccaaagagaaattgaaggtggaacacagccgagaatat aagcaagagaggacatacacacgagacctgctggggcctacagtgtccctgacccaagct gccttcacacctgttcctgtggacaccagccagattgtgttgcctcctcacctggaaaga ataagagaaagactggcagagaatatccacgagctctgggttatgaataaaattgagctt ggctggcagtatggtccggttagagatgacaacaagagacagcacccatgtctggtggag ttctgcaagcttccagaacaggaacgcaactataatttgcagatgtcacttgaaaccctc aagactttgctggcattgggatgtcacgtgggtatagctgatgaacatgctgaagagaag gtaaagaaaatgaagctgcccaagaattaccagctgaccagtggatacaagcctgcccca atggatctgagctttataaaactaaccccgtctcaggaagcaatggtggacaagttggct gaaaatgctcacaatgtgtgggcccgggaccgaatccggcaaggctggacttacggcatc cagcaggatgtaaagaatagaagaaaccctcgtctcgtcccctacactcttctggatgac agaaccaagaagtccaacaaagacagtctccgagaggcagtgcgcacactgctgggctac ggctaccacctggacgctcctgatcaggaccatgcctcgagagccgaggtgtgcagtggt actggggagaggttccgaatcttcagggcagagaagacctatgcggtgaaggctgggcgc tggtactttgaatttgaggctgtcactgctggagacatgcgggtgggctggagcaggcca ggctgccaaccggatctagaactgggttctgatgaccgtgcctttgcttttgatggcttt aaggctcagcggtggcaccagggcaatgaacactacgggcgctcatggcaagctggtgat gtcgtgggctgcatggttgatatgaatgaacacaccatgatgttcactctgaacggcgag atcctgctggatgattcgggctctgagctggcattcaaggactttgatgttggtgatgga ttcatccctgtgtgtagcctcggggtggcacaagtaggcaggatgaactttggaaaggac gtcagtactttgaaatattttaccatctgtggcttacaagaaggctatgagccatttgct gttaatacaaatagggacatcaccatgtggctgagcaagcggcttcctcagttcctccag gtcccatcaaaccatgaacacattgaggtgaccagaatagatggcaccatagacagttct ccatgtctgaaggtcactcagaagtcctttggttctcagaacagcaacactgacatcatg ttttaccgcctgagtatgcccattgaatgtgccgaggtcttctcaaagtcggtggcggga gggctgcctggtgccggcttctacgggcccaagaatgatttggaggactttgatgtggac tctgactttgaggttctgatgaagacagctcatggtcatcttgtgcctgaccgcatcgac aaggacaaagagacccccaagccagagttcaataaccacaaagattatgctcaggaaaag ccctcacgactaaagcaaagattcttacttagaaggaccaagccagattacagcacaagc cactctgcaagactcactgaagatgtccttgccgatgaccgggatgactacgagtacctg atgcagacgtccacatactattactcggtgaggatctttcctggacaagaaccagctaat gtctgggtgggctggattacatctgacttccaccagtacgacaccggctttgatttggac agagtgcgcacagtgacggtcaccctcggagatgaaaaaggaaaagtgcatgagagcatc aaacgcagcaactgctatatggtgtgtgcaggagagagcatgagccccgggcaaggacga aacaacagcaacgggttggagattggctgtgtggtggatgctgccagtgggctgctcaca ttcatagccaatggcaaggagctaagcacttactatcaggtggagccaagcacaaagcta tttcctgccgttttcgcgcaagctacaagtcccaatgttttccagtttgagttgggcaga ataaagaatgtgatgcctctctccgcgggactgtttaagagcgagcacaaaaaccccgtg ccccagtgtcctccacgtctgcatgtgcagttcctgtcacatgtcctgtggagccggatg cccaaccagttcttgaaggtggacgtctctcgaatcagtgaacgccaaggctggctggtg caatgtctagatcctctgcagttcatgtccctccatatacctgaggagaacagatctgtt gacatcttagagctgacagagcaggaggagttgttgcagtttcactatcacaccctccgc ctctactctgctgtctgcgcccttgggaatcatcgggtggctcacgcactgtgcagccac gtggacgaacctcagctgctctacgccattgagaacaagtacatgcctggcttgctgcga gctggctactatgacctgctgattgacatccacctcagctcctatgccactgccaggctc atgatgaacaacgagttcattgtccctatgacagaggagacaaagagcatcaccctcttc cctgatgagaacaagaaacatggcctcccaggcataggcctcagcacctccctccggcct cggatgcgcttttcctccccgagttttgtgagcattagcaacgactgttatcagtacagt cccgagtttcccctggacatcctcaaggccaagaccatccagatgctcacagaagcggtg aaggagggcagcctccatgctcgggatcctgtgggcgggaccacggagttcctctttgtg cccctcatcaagctgttctacaccctgctcatcatgggcatctttcacaatgaggatctg aaacacatcctccagttgatcgagcccagtgtgtttaaggaagctgccattccagaggag gaaggaggcacccccgagaaggagatcagtatagaagacgccaagctggaaggcgacgaa gaagccaaagggggtaaaaggcccaaggaaggcttgctccagatgaaactcccggagcca gttaaactacagatgtgcctcttgcttcagtacctctgtgactgtcaggttaggcaccgg atcgaagccattgtagccttttcagatgactttgtagctaaactccaagacaaccaacgg ttcaggtataatgaagtcatgcaagccttaaacatgtctgctgcactcactgccaggaaa accaaggagttccgatcaccaccgcaggagcagattaacatgcttctcaattttaaggat gacaaaagtgaatgcccctgccctgaagaaatccgagaccaactcctagatttccacgag gacctgatgactcactgtggaattgaactggacgaggatggatccctagatggaagcaat gacttaacaatcagaggacgcctgctgtctctggtagaaaaggtgacctacctgaagaag aagcaagctgaaaaaccagttgcaagtgactccagaaagtcctccagcctccagcaactc atttctgagactatggtacggtgggctcaagagtctgtcattgaggaccctgagctggtg agggccatgtttgtgctgctacatcggcagtatgatggcatcgggggtctagtccgagcg ctgccaaagacctacactatcaacggggtctctgtggaggacaccatcaatctgcttgct tcgctcggtcagatccgatctctgctgagtgtgaggatgggcaaagaagaggagaagctg atgatccgtggactaggggatatcatgaataacaaagtgttttaccagcatcccaatctc atgcgggcccttgggatgcatgagacagtgatggaagtcatggtgaacgtccttggaggt ggggagtccaaggaaatcaccttccccaagatggtggccaactgctgccgttttctctgt tacttctgtcgtataagtagacagaatcaaaaagccatgtttgatcatctcagttattta ctggaaaacagcagtgttggtcttgcatcaccagccatgagaggttcaactcctttagac gtggccgcagcttcagtgatggataacaatgagcttgcccttgctctacgagagccggat ctggagaaggtcgttcgctatctggctggctgtggcctgcagagttgtcagatgctgctg tctaagggttacccagacattgggtggaatccagttgaaggagagcgataccttgacttt ctcagatttgcagtcttctgtaacggggagagtgtggaagagaatgcaaatgtcgtggtg aggttgctcatccggagacccgagtgctttggtcctgccttgagaggagaaggtggtaat ggtctccttgcagccatggaagaagccataaaaatagctgaggatccttctagagatggt ccctctccaaccagtggctccagcaaaaccctggacaaattccccgaaagtgatatagaa gaggaggaagatgataccatccacatggggaacgcgatcatgaccttctacgcagctttg attgacctgcttgggcgctgtgctcctgaaatgcacttgattcatgctggaaagggagaa gccatccgaattaggtccattttgcgatctctgattccattgggagacttggtgggtgtc atcagcattgcatttcagatgccaacaatagccaaagatgggaaggtggtggagcctgac atgtccgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagggtc tatggaattgaggtgcaagatttcctcctccatctccttgaggttggctttctgccagat cttcgagcggctgcctctctagacacggctgcactaagtgctacagacatggccttggcc ctcaaccggtacctctgcacagctgtcctacctttgttaacgaggtgtgctcccctgttt gctggaacagagcaccatgcttccctcattgactctctgctacacactgtatatagactc tctaagggatgctcccttaccaaagctcagcgggactctatagaagtgtgcctgctctct atatgtggccaactgagaccatctatgatgcaacacctactccgaaggctggtgtttgat gttccactgttgaatgagcatgcaaagatgcctctgaagctgctgacgaatcattatgaa agatgctggaaatattattgcctacctggagggtggggcaactttggtgctgcctcggaa gaagaacttcatttatcaagaaaattattttggggcatctttgatgctttgtctcaaaag aaatatgaacaagaacttttcaaactggccctgccttgcctgagtgcagttgcgggagct ttacctccagactacatggagtcaaactatgtcagtatgatggaaaaacagtcatccatg gattctgaagggaactttaacccacaacctgttgatacctcaaacattacaattccagag aagttggaatacttcattaacaaatatgcagaacattcccatgataaatggtccatggac aagttggcaaatggatggatttatggggaaatatattcagactcttctaagatccaaccg ctaatgaagccatataaactcttgtctgaaaaggaaaaagaaatttatcgttggccaatc aaggagtctttgaaaacaatgctggcttggggttggagaattgagagaacacgggagggg gacagcatggccctttataaccggactcgacgaatttctcagacaagccaggtgtctata gatgctgcacatggatacagcccccgtgctattgacatgagtaatgttacactctctcga gacctgcatgctatggcagagatgatggctgaaaactaccacaacatatgggccaagaaa aagaaactggagctggaatccaaaggagggggaaaccaccccctgctggtgccttatgac acactgacagccaaggagaaagccaaggacagagaaaaagcccaagacatcttcaagttc ctacagatcagtggttatgtggtatccagagggttcaaggacctggatctagacacacct tcgattgagaagcgatttgcctatagtttcctgcagcagctgatccgatacgtggatgag gcgcatcagtacatcctggagtttgatggtggcagcagaagcaaaggagaacacttcccg tacgagcaagaaatcaagttctttgccaaagttgttcttcctttaattgatcagtatttc aaaaaccaccgtctgtacttcttgtctgctgcaagcaggcctctctgcactggaggacat gcatccaacaaagagaaggagatggtgacaagcctgttctgcaaacttggagttcttgtc aggcataggatctcactgtttgggaatgatgccacctcaattgtgaactgtctgcacatt ttgggtcagactttggatgcaaggactgtgatgaagacaggcctagacagcgtgaaaagt gctctcagggcctttctggacaatgctgcggaggatttggaaaagacaatggaaaacctg aagcagggccagtttactcacaccaggagccagcccaagggcgtgactcagatcatcaac tacaccactgtggcactcctgcccatgctctcctccctgttcgaacacatcggccagcat cagtttggagaagatctgatattggaggatgtacaggtgtcttgttatagaatcctgacc agcttgtatgccctgggaaccagcaagagcatctacgtggagaggcaacgatctgcactt ggggaatgcttagctgcctttgctggtgccttccctatcgcctttttggaaacccacctg gacaaacataacgtttactccatctacaacaccagatcttcacgagaaagagcagctctc agtttacctgcaaatgtggaggatgtctgcccaaatataccatccctggagaagcttatg actgagattatagagctggcagagtcaggaatccgctacactcagatgccatacatgatg gaggttgtactgcccatgttatgcagctacatgtcaaggtggtgggaacacggtcctgag aaccatccagagagggctgagatgtgctgtacagccctcaactcagagcacatgaacaca ctgctgggcaacattctcaaaatcatctacaacaacctggggattgatgaaggagcctgg atgaagcgcttggcagtgttttcacagcctatcatcaacaaagtgaaacctcagctcttg aaaactcatttcttacccttgatggagaagctaaagaaaaaggctgccatggtagtgtct gaggaagaccacctgaaagccgaagcccgaggggacatgtctgaggccgagctgctcatt ctagatgagttcaccacactggccagggatctctatgccttctacccactcctgatccga tttgtggactataacagggcaaagtggctgaaggagcccaacccagaagcagaggagcta tttcgaatggtggctgaagtcttcatctactggtccaaatctcataatttcaaaagagaa gaacagaactttgtggtgcagaatgaaatcaacaacatgtcctttctcatcactgacaca aagtccaagatgtccaaggcagccatttctgatcaagaaaggaagaaaatgaagcgcaaa ggggaccggtattctatgcagacatctttgattgtggcagctctgaagagattactaccc attgggctgaacatctgtgcccctggtgaccaagagctcattgctttggccaaaaataga tttagcttgaaagacaccgaggaggaagtacgtgatataatccgcagtaatatacactta caagacaagctggaagaccctgcaatcaggtggcagatggctctctacaaagacttgcca aacaggacagaaggcacctcagacccagagaggacagtggagcgtgtcctggatatagca aatgtgctttttcaccttgagcagaaatctaagtatactggccggggatatttcagcctg gtggaacatcctcagagatcaaagaaagctgtgtggcacaaactactctctaagcagaga aaaagagctgttgtggcctgcttccggatggcgcccttgtacaatctgccaaggcatcgg gcagtcaatctttttcttcagggatatgaaaagtcttggattgaaacagaagaacattac tttgaggataaattgattgaagatttagcgaaaccaggggctgagctcccagaagaagat gaagccatgaaaagagttgatcccctccatcaacttattcttctgttcagtcgcacagcc ctaacggagaaatgcaaactggaggaagattttctatacatggcgtatgcagacattatg gcaaagagttgtcacgatgaagaagatgatgatggtgaagaagaagtgaagagctttgaa gtcacaggatcccaacgcagcaaggaaaaggaaatggaaaagcagaaactgctgtaccag caagccagactgcatgaccgcggggccgcagagatggtactgcagactatcagtgccagc aaaggtgaaactggaccaatggtggctgctactttgaagctgggcattgctattttaaat ggtggcaactccacggtgcagcagaagatgctggattacctgaaggaaaaaaaggatgta ggcttcttccagagtctggcaggcctcatgcagtcgtgcagtgtcctggacctgaatgcc tttgagaggcaaaacaaagcagaaggacttgggatggtgactgaggaaggatcaggggag aaggttctgcaggatgacgagttcacctgtgacctcttccgattcctgcagctgctttgt gaggggcacaactcagactttcagaattacctgagaactcagacgggcaacaacaccaca gttaatatcatcatctctaccgtggactacctccttcgagtgcaggagtccattagtgat ttctattggtactactctggcaaggacatcatagatgagcaggggcagcgtaacttttcc aaagccattcaagtggcgaagcaggtgttcaacacgctcacggagtacatccagggccct tgtactggaaatcagcagagcctggcacacagcaggctgtgggatgctgttgtgggcttc cttcatgtatttgcacacatgcagatgaagctgtctcaggattccagccagattgagctc ttaaaagaacttatggatctccagaaggacatggtggtcatgctgctgtctatgctagaa ggtaatgtggtgaatggaacaataggcaaacagatggtggacatgcttgtggagtcgtcc aacaatgtagagatgatcctcaagttctttgacatgtttctgaagctgaaggacttaaca tcctctgacacattcaaagagtatgaccctgatggcaaaggggtcatttccaagagagac ttccacaaagccatggagagccacaagcactacacccagtcagagactgagttcctgctg tcctgtgcagagacagatgaaaacgagacacttgactatgaagagtttgtcaagaggttc catgagcctgccaaggacattggcttcaacgtggctgttctgctgaccaacctctcagag cacatgcccaatgacacgaggctgcagaccttcttggagttggcagagagtgtcctcaac tacttccaacctttcctgggtcgcattgagatcatgggcagtgccaagcgcattgaaagg gtctattttgagatcagtgaatccagccgaacccagtgggaaaaaccccaggttaaggag tccaagaggcagttcatattcgatgtggtcaacgagggtggggagaaggagaagatggag ctctttgtgaacttttgtgaggacaccatctttgagatgcagttggcagctcagatctca gagtctgatctcaatgagaggttggcgaataaagaagagagtgagaaggagaggccagag gagcaggccccacggatgggcttcttctccctcctcaccatccagtcagccctgtttgct ctcaggtacaatgtcctaaccctcgtgaggatgctcagcctgaagagtctgaagaagcag atgaagaggatgaagaagatgacagtgaaggacatggtcttggccttcttctcatcctac tggagtgtgtttgtcaccctcttgcacttcgtggccagtgtctgcaggggcttcttccgc attgtctccagcctgttgctggggggcagcctagtggaaggtgctaagaaaatcaaagtg gcagaacttctagctaacatgccagaccccactcaggatgaggtgcgaggagatgaggag gagggagagaggaagcccttagagtcagccctgccctctgaagacctgacagacttgaag gaactgacagaggagagtgaccttctttctgacatattcggcttggatctgaagagagaa ggagggcagtacaaactaattcctcacaacccaaatgccggcctcagtgacctcatgacc aaccctgtccctgtccctgaggtacaagaaaagtttcaggagcagaaggcgaaagaggaa aagggagaaaaggaagaaaccaagcctgaaccagagaaagctgaaggggaggatggagaa aaagaagaaaaagccaaagatgataagagcaaacagaagttgaggcagcttcatacacat cgctatggggagccggaagtccctgagtcagcattctggaagaaaatcatagcctaccaa cagaagctgctgaactattttgctcgcaacttttacaacatgagaatgctggccttgttt gttgccttcgccatcaatttcatcctgctcttctacaaggtctccacttcttctgtggtt gaaggaaaggagctgcctacccgaaccaacagcgatactgctaaagtgaccatcagccta gacagcagcccccacaggatcattgctgttcactacgtcctggaggagagcagtggctac atggaacccaccctgcgcatcttagccatccttcacaccatcatctccttcttttgcatc attggatactactgcttgaaagtccccttggttatttttaagcgagagaaggaagtggca cggaagttggagtttgacgggctttatataacggagcagccatcagaagatgatatcaaa ggccagtgggacagacttgtgatcaacacacagtcatttcccaataactactgggataaa tttgtgaaaagaaaggtaatggataaatatggagagttttatgggagagacagaatcagt gagttactgggcatggataaggctgcactagatttcagcgatgcaagagagaagaagaag cccaagaaagacagctccttgtctgctgtattgaattctattgacgtgaagtaccagatg tggaaacttggagtcgtgttcacagacaattccttcctctacctagcctggtacatgacc atgtctgttcttggacattataacaactttttttttgctgctcacctccttgacatcgcg atgggattcaagaccttgagaactatcctgtcctcagttacccataatggcaaacagctc gtgttaactgttggcttattggctgttgttgtatacctgtacactgtcgtggcattcaat ttcttccgaaaattctacaataaaagtgaggatggtgacacaccggacatgaaatgtgat gacatgctgacgtgttacatgttccacatgtatgtgggcgttcgtgctggagggggcatt ggtgatgaaattgaagacccagcaggagacgagtatgagatctaccgcatcatctttgac atcacattcttcttcttcgtgattgtcatccttctggctatcatacaaggtttgatcatt gatgcttttggagaactcagagaccaacaagagcaagtcaaggaagacatggagaccaag tgtttcatctgtgggattggcaacgattattttgatacagtgccacatggctttgaaacc catactttacaggaacacaacctggccaactacctgttttttctgatgtatctcataaac aaggatgaaacagaacacacaggacaggaatcttatgtctggaagatgtaccaagagagg tgttgggaatttttcccagcaggagattgtttccggaaacagtatgaagatcagttaaat taa

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