KEGG PATHWAY: mcc03060

KEGG

PATHWAY: mcc03060

Entry

mcc03060                    Pathway

Name

Protein export - Macaca mulatta (rhesus monkey)

Description

The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.

Class

Genetic Information Processing; Folding, sorting and degradation

Pathway map

Protein export

Other DBs

GO:	0043952 0043953

Organism

Macaca mulatta (rhesus monkey) [GN:mcc]

Gene

SEC61A2; protein transport protein Sec61 subunit alpha isoform 2 [KO:K10956]

SPCS3; signal peptidase complex subunit 3 [KO:K12948] [EC:3.4.-.-]

WRB; tail-anchored protein insertion receptor WRB [KO:K22384]

SRP19; signal recognition particle 19 kDa protein isoform X3 [KO:K03105]

SPCS2; signal peptidase complex subunit 2 [KO:K12947] [EC:3.4.-.-]

SRP54; signal recognition particle 54 kDa protein [KO:K03106] [EC:3.6.5.4]

SRP72; signal recognition particle subunit SRP72 [KO:K03108]

SEC11A; signal peptidase complex catalytic subunit SEC11A [KO:K13280] [EC:3.4.21.89]

[KO:K13280] [EC:3.4.21.89]

IMMP1L; mitochondrial inner membrane protease subunit 1 [KO:K09647] [EC:3.4.21.-]

GET4; Golgi to ER traffic protein 4 homolog isoform X1 [KO:K23387]

SPCS1; signal peptidase complex subunit 1 [KO:K12946] [EC:3.4.-.-]

SEC11C; signal peptidase complex catalytic subunit SEC11C isoform X1 [KO:K13280] [EC:3.4.21.89]

SEC62; translocation protein SEC62 [KO:K12275]

TMEM208; transmembrane protein 208 [KO:K27164]

SEC63; translocation protein SEC63 homolog [KO:K09540]

SRP9; signal recognition particle 9 kDa protein [KO:K03109]

UBL4A; ubiquitin-like protein 4A [KO:K23388]

UBL4B; ubiquitin-like protein 4B [KO:K23388]

SRP14; signal recognition particle 14 kDa protein [KO:K03104]

IMMP2L; mitochondrial inner membrane protease subunit 2 [KO:K09648] [EC:3.4.21.-]

HSPA5; 78 kDa glucose-regulated protein precursor [KO:K09490] [EC:3.6.4.10]

SRP68; signal recognition particle subunit SRP68 isoform X1 [KO:K03107]

[KO:K12947] [EC:3.4.-.-]

SEC61A1; protein transport protein Sec61 subunit alpha isoform 1 [KO:K10956]

OXA1L; mitochondrial inner membrane protein OXA1L [KO:K03217]

SRPRA; signal recognition particle receptor subunit alpha [KO:K13431]

SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]

ASNA1; ATPase ASNA1 [KO:K01551] [EC:7.3.2.7 7.3.-.-]

SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]

SRPRB; signal recognition particle receptor subunit beta [KO:K12272]

BAG6; large proline-rich protein BAG6 isoform X8 [KO:K23390]

SGTA; small glutamine-rich tetratricopeptide repeat-containing protein alpha [KO:K16365]

Reference

Authors

Dalbey RE, Robinson C.

Title

Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.

Journal

Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4

Reference

Authors

Berks BC, Sargent F, Palmer T.

Title

The Tat protein export pathway.

Journal

Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x

Reference

Authors

Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.

Title

TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.

Journal

J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200

Reference

Authors

Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.

Title

TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.

Journal

J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200

Reference

Authors

Rapoport TA

Title

Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.

Journal

Nature 450:663-9 (2007)
DOI:10.1038/nature06384

Reference

Authors

Flower AM

Title

The SecY translocation complex: convergence of genetics and structure.

Journal

Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001

Reference

Authors

Osborne AR, Rapoport TA, van den Berg B

Title

Protein translocation by the Sec61/SecY channel.

Journal

Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214

Reference

Authors

Paetzel M, Karla A, Strynadka NC, Dalbey RE

Title

Signal peptidases.

Journal

Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y

Reference

Authors

Paetzel M, Dalbey RE, Strynadka NC

Title

The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.

Journal

Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4

Reference

Authors

Ng SY, Chaban B, VanDyke DJ, Jarrell KF

Title

Archaeal signal peptidases.

Journal

Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0

Reference

Authors

Desvaux M, Hebraud M, Talon R, Henderson IR

Title

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.

Journal

Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004

Reference

Authors

Nakatogawa H, Murakami A, Ito K

Title

Control of SecA and SecM translation by protein secretion.

Journal

Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001

KO pathway

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