KEGG   Macaca mulatta (rhesus monkey): 715337
Entry
715337            CDS       T01028                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc00140  Steroid hormone biosynthesis
mcc01100  Metabolic pathways
mcc04913  Ovarian steroidogenesis
mcc04925  Aldosterone synthesis and secretion
mcc04927  Cortisol synthesis and secretion
mcc04934  Cushing syndrome
Module
mcc_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
mcc_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mcc_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mcc_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    715337
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    715337
   04925 Aldosterone synthesis and secretion
    715337
   04927 Cortisol synthesis and secretion
    715337
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    715337
Enzymes [BR:mcc01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     715337
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     715337
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 Polysacc_synt_2 GDP_Man_Dehyd NAD_binding_10 RmlD_sub_bind NmrA Ub-Mut7C
Other DBs
NCBI-GeneID: 715337
NCBI-ProteinID: XP_015004772
Ensembl: ENSMMUG00000047765
LinkDB
Position
1:complement(104878510..104886164)
AA seq 373 aa
MTGWSCLVTGAGGFLGQRIICLLVEKTELKEIRALDKAFRPGLREEFSKLQNKTKLTVLE
GGILDEPFLKRACQDVLVVIHTSCIIDVFGVPHRESIMNVNVNGTQLLLEACVQASVPVF
IYPSALGVAGPNSYKEIIENRETQASLENTRSAPYPHSKKLTEKAVLAANGWTLKNGDTF
YTCALRPMCIYGEGGPFLTANINEALNNNEILSSVGKFSTVNPVYAGNVAWAHILALRAL
WDPKKALSVRGQFYYISGDTPHQSYDNLSYTLSKEFSLRLDSRWSLPLSLMYWIGFLLEI
VTLLLRPICTYQPPFNHHTVTLSNSVFTFSYKKTQQDLAYEPLYSWEEAQQKTVEWVGSL
VDRHKETLKSKTQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgacaggctggagctgccttgtgacaggagcaggagggtttctgggtcagaggatcatc
tgcctgttggtggagaagacagagctgaaggagatcagggccttggacaaggccttcaga
ccaggactgagggaggaattttctaagctccagaacaagaccaagctgacagtgctggaa
ggaggcattctggatgagccattcctgaagagagcctgccaggacgtcttggtcgtcatc
cacacctcctgtatcattgatgtcttcggtgtccctcacagagagtccatcatgaatgtc
aatgtgaatggtactcagctcctgttggaggcctgtgtccaagccagtgtgccagtcttc
atctaccccagtgccctaggggtagccgggcccaactcctacaaggaaatcatcgagaat
agagaaacacaagcctctctggaaaacacacggtctgctccatatccacacagtaaaaag
ctcactgagaaggctgtgctggcagctaatgggtggactctgaaaaatggtgataccttt
tacacttgtgccttaagacccatgtgtatctatggggaaggaggcccatttcttactgcc
aatataaatgaagccctgaacaacaatgagatcctgtcaagtgttggcaagttctccact
gtcaacccagtctatgctggcaatgtggcctgggcccacattctggccttgagggccctg
tgggaccccaagaaggccctaagtgtccgagggcagttctactatatctcaggtgacacg
cctcaccaaagctatgataaccttagttacaccctgagcaaagagttcagcctccgcctt
gattccagatggagccttcctttatccctgatgtactggattggcttcctgctggaaata
gtgactctcctgctcaggccaatttgcacctatcaaccgcccttcaaccatcacacagtg
acattgtcaaatagcgtgttcaccttctcttacaagaagactcagcaagatctggcgtat
gagccgctctacagctgggaggaagcccagcagaaaaccgtggagtgggtgggttccctt
gtggaccggcacaaggagaccctgaagtccaagactcagtga

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