KEGG T01028: 722483

Macaca mulatta (rhesus monkey): 722483

Entry

722483            CDS       T01028

Name

(RefSeq) aldo-keto reductase family 1 member C4

K00037

3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]

Organism

mcc Macaca mulatta (rhesus monkey)

Pathway

mcc00120

Primary bile acid biosynthesis

mcc00140

Steroid hormone biosynthesis

mcc01100

Metabolic pathways

mcc05208

Chemical carcinogenesis - reactive oxygen species

Module

mcc_M00104

Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate

mcc_M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Brite

KEGG Orthology (KO) [BR:mcc00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    722483
   00140 Steroid hormone biosynthesis
    722483
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    722483
Enzymes [BR:mcc01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50  3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
     722483
    1.1.1.225  chlordecone reductase
     722483
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     722483

SSDB

Motif

Pfam:

Aldo_ket_red

Other DBs

NCBI-GeneID:

722483

NCBI-ProteinID:

XP_015001861

LinkDB

Position

9:6394548..6415986

AA seq 228 aa
MDPKYQRVELNDGHFMPVLGFGTYVPPEPGETLLPKDENGKVIFDTVDLCAIWEAMEKCK
DAGLAKSIGVSNFNRRQLEMILNNPGLKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVA
HSALGTQRHKLWVDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQ
RIRENVQVFEFQLTSEDMKVLDGLNGNFRYAVMDFLVDHPDYPFSDEY

NT seq 687 nt +upstreamnt +downstreamnt
atggatcccaaatatcagcgtgtggagctaaatgatggtcatttcatgcctgtattagga
tttggcacctatgtgcctccagagccaggtgagacgctactaccaaaagatgaaaatgga
aaagtaatattcgacacagtggatctctgtgccatatgggaggccatggagaagtgtaag
gatgcaggattggccaagtccatcggggtgtcaaacttcaaccgcagacagctggagatg
atcctcaacaacccaggactcaagtacaagcccgtctgcaaccaggtggaatgtcatcct
tacctcaaccagagccaactgctggatttctgcaagtcagaagacattgtcctggttgcc
catagtgctctgggaacccaacgacataaactatgggtggaccagaactccccagctctt
ttggaagacccagttctttgcgccttagcaaagaagcacaaaccatccccagccctgatt
gccttgcgctaccagctgcagcgtggggttgtggtcctggccaagagctacaatgaacag
cggatcagagaaaacgtccaggtttttgaattccagttgacttcggaggatatgaaagtt
ctagatggcctaaacggaaattttcgatatgctgtcatggattttcttgtggaccaccct
gattatccattttcagatgaatattag

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